Validation of IMACS and PRINTO Definitions of Improvement
Lisa Rider, NIEHS, NIH
Natural history study
Types & Number of IIM Studied:
Adult and Juvenile Dermatomyositis, Polymyositis, Overlap Myositis, Inclusion Body Myositis (> 100 patients)
Probable or definite Bohan and Peter criteria; Griggs et al. 1995 Annals of Neurology Inclusion Body Myositis criteria
IMACS Core Set Measures Included:
All: Physician and Patient Global Activity and Damage Assessments, Manual Muscle Testing, Childhood Myositis Assessment Scale, [Childhood] Health Assessment Questionnaire, muscle enzymes, Myositis Disease Activity Assessment Tool, Myositis Damage Index; Health Related Quality of Life by SF-36 and Child Health Questionnaire
Other Measures Included:
Disease Activity Score, demographic and treatment data, extended measures
IMACS and PRINTO Definitions of Improvement
Baseline and 6 - 9 month evaluation. Open
Ongoing. Extramural centers may apply for enrollment into IMACS registry by obtaining local IRB approval of this protocol.
- Lisa G. Rider, M.D.
- Frederick W. Miller, M.D., Ph.D.
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