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A longitudinal, integrated clinical, histological and mRNA profiling study of resistance exercise in myositis

Study Title:

A longitudinal, integrated clinical, histological and mRNA profiling study of resistance exercise in myositis

Principal Investigator:

Ingrid Lundberg, M.D., Ph.D.

Study Hypothesis:

Resistance exercise should improve strength in patients with polymyositis or dernatomyositis

Study Design:

Open label

Types & Number of IIM Studied:

9 patients with adult dermatomyositis or polymyositis

Entry Criteria:

a) Diagnosis of definite or probable PM or DM according to the Bohan and Peter criteria (Bohan 1975 part 1), b) Disease duration > 12 months, c) Unchanged disease activity according to the physicians judgement and d) Stable medication for three months. Exclusion criteria were: a) Diagnosis of inclusion body myositis (IBM), b) Comorbidities preventing vigorous exercise, c) Severe osteoporosis, d) Active malignant disease, and e) Doing exercise more than once a week

IMACS Core Set Measures Included:

Physician Global Activity-VAS, Patient Global Activity-VAS, Muscle Strength Testing-MMT, Functional Assessment Tools-HAQ, Laboratory-Muscle Enzymes, Extramuscular Assessment-Myositis Disease Activity Assessment Tool (MDAAT)

Other Measures Included:

10 VRM, Functional Index-2, Grip strength, The Borg CR-10 scale, The Myositis Activities Profile (MAP)

Primary Outcome:

Improvement criteria were set to 20% or more for at least two of the variables 10 VRM, the FI-2 and the Grippit.

Secondary Outcomes:

MAP, Disease activity, gene expression profiles in muscle tissue, maximal oxygen uptake

Key Trial Dates:

Completed and Published

Funding Sources:

Supported by the Vårdal Foundation, The Swedish Rheumatism Association, Swedish Research Council 2001-74-X14045, Gustaf V:th 80-year Foundation, Professor Nanna Svartz Foundation, Magnus Bergvalls stiftelse, Stiftelsen Clas Groschinskys Minnesfond, and Karolinska Institutet Foundation.

Publications:

Alemo Munters L, Dastmalchi M, Katz A, Esbjörnsson M, Loell I, Hanna B, Lidén M, Westerblad H, Lundberg IE, Alexanderson. Improved exercise performance and increased aerobic capacity after endurance training of patients with stable polymyositis and dermatomyositis., Arthritis Res Ther, 2013 Aug 13;15(4):R83.[Abstract]

Contact:

Ingrid Lundberg, M.D., Ph.D.
Rheumatology Unit
Department of Medicine
Karolinska University Hospital
Solna, Karolinska Institutet
SE- 171 76 Stockholm, Sweden
Tel +46-8-5177-3080
Fax +46-8-5177-3080
Ingrid.Lundberg@medks.ki.se

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