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Your Environment. Your Health.

Validation of IMACS and PRINTO Definitions of Improvement

Principal Investigator:

Lisa G. Rider, M.D.
Deputy Chief
Environmental Autoimmunity Group
Tel (301) 451-6272,1-888-271-3207
Fax (301) 451-5588


Study Design:

Natural history study


Types & Number of IIM Studied:

Adult and Juvenile Dermatomyositis, Polymyositis, Overlap Myositis, Inclusion Body Myositis


Entry Criteria:

Probable or definite Bohan and Peter criteria; Griggs et al. 1995 Annals of Neurology Inclusion Body Myositis criteria


IMACS Core Set Measures Included:

All: Physician and Patient Global Activity and Damage Assessments, Manual Muscle Testing, Childhood Myositis Assessment Scale, [Childhood] Health Assessment Questionnaire, muscle enzymes, Myositis Disease Activity Assessment Tool, Myositis Damage Index; Health Related Quality of Life by SF-36 and Child Health Questionnaire


Other Measures Included:

Disease Activity Score, demographic and treatment data, extended measures


Primary Outcome:

IMACS and PRINTO Definitions of Improvement


Study Duration:

Baseline and 6 - 9 month evaluation. Open






Ongoing. Extramural centers may apply for enrollment into IMACS registry by obtaining local IRB approval of this protocol.



Lisa G. Rider, M.D.
Frederick W. Miller, M.D., Ph.D. (


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