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Your Environment. Your Health.

Validation of IMACS and PRINTO Definitions of Improvement

Principal Investigator:

Lisa G. Rider, M.D.
Deputy Chief
Environmental Autoimmunity Group
Tel (301) 451-6272,1-888-271-3207
Fax (301) 451-5588
riderl@mail.nih.gov

 

Study Design:

Natural history study

 

Types & Number of IIM Studied:

Adult and Juvenile Dermatomyositis, Polymyositis, Overlap Myositis, Inclusion Body Myositis

 

Entry Criteria:

Probable or definite Bohan and Peter criteria; Griggs et al. 1995 Annals of Neurology Inclusion Body Myositis criteria

 

IMACS Core Set Measures Included:

All: Physician and Patient Global Activity and Damage Assessments, Manual Muscle Testing, Childhood Myositis Assessment Scale, [Childhood] Health Assessment Questionnaire, muscle enzymes, Myositis Disease Activity Assessment Tool, Myositis Damage Index; Health Related Quality of Life by SF-36 and Child Health Questionnaire

 

Other Measures Included:

Disease Activity Score, demographic and treatment data, extended measures

 

Primary Outcome:

IMACS and PRINTO Definitions of Improvement

 

Study Duration:

Baseline and 6 - 9 month evaluation. Open

 

Funding:

NIEHS, NIH

 

Comments:

Ongoing. Extramural centers may apply for enrollment into IMACS registry by obtaining local IRB approval of this protocol.

 

Contact:

Lisa G. Rider, M.D.
riderl@mail.nih.gov
Frederick W. Miller, M.D., Ph.D. (http://www.niehs.nih.gov/research/clinical/ea/index.cfm)
millerf@mail.nih.gov

 

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