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IMACS Studies

Over the last decade IMACS has undertaken a number of projects aimed at achieving its goals of improving the lives of children and adults who suffer from myositis by discovering better therapies and understanding the causes of these diseases. Central to these efforts have been a number of studies to develop consensus and standards on the conduct and reporting of adult and juvenile myositis investigations, including outcome measures, clinical trial design and classification of patients with myositis. Listed here is information on the studies that IMACS has reviewed and endorsed. Feel free to contact the Lead Investigators to learn more about these studies.

IMACS Studies (17KB)


Completed IMACS Research Projects


IMACS Project I. Developing and validating core set measures of myositis disease activity and damage

Primary Objectives: 
Develop and validate new tools to assess disease activity and damage for patients with adult and juvenile dermatomyositis and polymyositis

Start Date: 2000
Completion Date: 2010

Lead Investigators:

Publications: 
None
 

IMACS Project II. Determining clinically meaningful change in core set activity measures and developing preliminary definitions of improvement

Primary Objectives: 

  1. Determine clinically meaningful change in core set activity measures
  2. Develop preliminary definitions of improvement as response criteria for adult and juvenile dermatomyositis and polymyositis

Start Date: 2002
Completion Date: 2004

Lead Investigators: 

Publications: 
None
 

IMACS Research Project III. Consensus guidelines for the design and conduct of myositis clinical trials

Primary Objectives: 
Develop consensus in the design of myositis clinical trials, including classification criteria for myositis

Start Date: 2002
Completion Date: 2005

Lead Investigators: 

Publications: 
None
 

IMACS Project VI. Dyslipidemia in Myositis Survey

Primary Objectives: 
To examine the frequency of lipid profile abnormalities in patients with myositis.

Start Date: 2009
Completion Date: 2010

Lead Investigators:

Publications: 
None
 

ACR-EULAR Project to Revise the Definition of Improvement and Major Clinical Response for Adult and Juvenile Dermatomyositis and Adult Polymyositis

Primary Objectives: 
To develop new response criteria for adult and juvenile dermatomyositis and polymyositis, including criteria for minimal and major response for use as endpoints in myositis therapeutic trials.

Start Date: 2012
Completion Date: 2015

Lead Investigators:

Publications: 
None
 

Ongoing IMACS Research Projects


IMACS Project IV. IMACS Outcomes Data Repository

Primary Objectives: 
Develop a repository of databases of myositis natural history studies and therapeutic trials that have all collected the IMACS disease activity and damage core set measures, as well as core demographic and clinical data, for use by myositis researchers.

For further information on the IMACS Outcomes Data Repository, including use of the data that has been deposited, please see: IMACS Outcomes Repository Data Use Guidelines.

Start Date: 2004
Completion Date: Ongoing

Lead Investigators:

Publications: 
None
 

IMACS Project V. International Myositis Classification Criteria Project

Primary Objectives: 
To develop new preliminarily validated classification criteria for adult and juvenile dermatomyositis, adult polymyositis and inclusion body myositis.

For further information on the International Myositis Classification Criteria Project, please see: International Myositis Classification Criteria Project.

Start Date: 2004
Completion Date:
Ongoing

Lead Investigators:

Publications: 
None
 

IMACS Project VII. Standards of Treatment for Adults with Myositis and different Phenotypes - STAMP

Primary Objectives: 
To define standard approaches to treat myositis phenotypes

Start Date: 2011
Completion Date: Ongoing

Lead Investigators:

Publications: 
None
 

IMACS Project VIII. Defining Myositis Phenotypes and Therapies that Achieve Complete Clinical Responses and Remission

Primary Objectives: 
To define which therapies are useful in which phenotypes to achieve complete clinical responses and remission

Start Date: 2011
Completion Date: Ongoing

Lead Investigators: 

Publications: 
None
 

IMACS Project X. Identification of a candidate core-set of fitness and strength tests for patients with childhood or adult idiopathic inflammatory myopathies

Primary Objectives:
To develop consensus on a candidate core-set of fitness and strength tests for children and adults with myositis

Start Date: 2013
Completion Date: Ongoing

Lead Investigators:

Publications: 
None
 

IMACS Project XI. Development of an internationally agreed minimal dataset for juvenile dermatomyositis (JDM) for clinical and research use

Primary Objectives: 
To develop consensus on minimal elements to include in a JDM dataset to be used for clinical and research purposes

Start Date: 2014
Completion Date: Ongoing

Lead Investigators:

Publications: 
None
 

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