Validation of IMACS and PRINTO Definitions of Improvement
Principal Investigator:
-
Lisa G. Rider, M.D.
Deputy Chief
Environmental Autoimmunity Group -
Tel (301) 451-6272,1-888-271-3207
Fax (301) 451-5588
riderl@mail.nih.gov
Study Design:
Natural history study
Types & Number of IIM Studied:
Adult and Juvenile Dermatomyositis, Polymyositis, Overlap Myositis, Inclusion Body Myositis
Entry Criteria:
Probable or definite Bohan and Peter criteria; Griggs et al. 1995 Annals of Neurology Inclusion Body Myositis criteria
IMACS Core Set Measures Included:
All: Physician and Patient Global Activity and Damage Assessments, Manual Muscle Testing, Childhood Myositis Assessment Scale, [Childhood] Health Assessment Questionnaire, muscle enzymes, Myositis Disease Activity Assessment Tool, Myositis Damage Index; Health Related Quality of Life by SF-36 and Child Health Questionnaire
Other Measures Included:
Disease Activity Score, demographic and treatment data, extended measures
Primary Outcome:
IMACS and PRINTO Definitions of Improvement
Study Duration:
Baseline and 6 - 9 month evaluation. Open
Funding:
NIEHS, NIH
Comments:
Ongoing. Extramural centers may apply for enrollment into IMACS registry by obtaining local IRB approval of this protocol.
Contact:
- Lisa G. Rider, M.D.
- riderl@mail.nih.gov
- Frederick W. Miller, M.D., Ph.D. (http://www.niehs.nih.gov/research/clinical/ea/index.cfm)
- millerf@mail.nih.gov
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