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 Stavros Garantziotis, M.D.
Staff Clinician Tel (919) 541-0133 Fax (919) 541-4133 garantziotis@niehs.nih.gov P.O. Box 12233 Mail Drop E1-03 Research Triangle Park, North Carolina 27709 Delivery Instructions Stavros Garantziotis, M.D., recently joined the NIEHS as a Staff Clinician with the Clinical Research Unit and the Laboratory of Respiratory Biology. Garantziotis obtained his M.D. degree at the Albert-Ludwigs University in Freiburg, Germany, in 1994. After an internship in Internal Medicine at the University Hospital in Munich, Germany, he completed his residency in Internal Medicine in 1999 at the Albert-Einstein College of Medicine in New York, New York, and received his Board Certification in Internal Medicine in 1999. He subsequently completed a fellowship in Pulmonary, Allergy and Critical Care Medicine at Duke University Medical Center from 1999-2000 and 2002-2004, which included a two-year hiatus for mandatory military service in the Greek Medical Corps. He remained a faculty member in the Division of Pulmonary, Allergy and Critical Care Medicine at Duke University Medical Center from 2004-2007. He received Board Certification in Pulmonary Medicine in 2003 and Critical Care Medicine in 2005. Clinically, Garantziotis was active in the field of lung transplantation and pulmonary fibrosis, both in the inpatient service as well as in the pulmonary clinic. His basic research has focused on two areas: (1) extracellular matrix factors affecting lung injury and repair, and (2) innate immune activation of alloimmune lung injury. Garantziotis is currently a recipient of an American Thoracic Society-American Society of Transplantation Grant to investigate the role of innate immunity in lung rejection in a novel mouse model. His clinical research has been in the field of lung transplantation. At the NIEHS, Garantziotis will devote 80 percent of his time to setting up and supervising the newly developed Clinical Research Unit (CRU). The focus of the CRU will be to allow intramural investigators of all specialties to engage in translational research with human subjects. Garantziotis will supervise day-to-day operations, patient recruitment and patient interactions, and will collaborate closely with intramural PI's in the conception and implementation of research protocols. He will devote 20 percent of his time to basic research. The focus of his work will be cell-matrix interactions in the pulmonary response to environmental or alloimmune lung injury. Garantziotis has identified novel interactions and functions for a serum protein, called inter-alpha-trypsin inhibitor, which can bind to extracellular components such as complement, hyaluronan or vitronectin and thus influence the development of inflammation, angiogenesis, re-epithelialization and stem cell growth after injury. His research at the NIEHS will expand these findings and investigate the framework in which extracellular matrix can influence the cellular response to environmental injury. Selected Publications
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