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Your Environment. Your Health.

Kristen R. Ryan, Ph.D.

Systems Toxicology Group

Kristen R. Ryan, Ph.D.
Kristen Ryan, Ph.D.
Tel (919) 541-9468
530 Davis Dr
Keystone Building
Durham, NC 27713

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Kristen Ryan, Ph.D. is an Intramural Research Training Award Fellow in the Toxicology Branch of the Division of National Toxicology Program (NTP) at the National Institute of Environmental Health Sciences. As a trainee study scientist, Ryan collaborates with members of the Toxicology Branch as well as various intramural and extramural partners to investigate the safety of chemical agents nominated to the NTP toxicity testing program. Her primary responsibilities are to design and coordinate studies to evaluate the potential toxicity and carcinogenicity of various chemicals, pharmaceutical and herbal agents. In addition, Ryan is responsible for communicating study results by peer-reviewed publication in NTP Technical Reports and manuscripts in scientific journals.


Ryan’s research interests include examining the relationship between exposure to various chemicals in the environment and developmental neurotoxicity or neurodegeneration. She participates in activities to enhance neurotoxicity testing within the NTP through protocol design and interpretation of large-scale animal studies. Additionally, Ryan has interest in alternative animal testing models for the prioritization and predication of potential neurotoxic agents.


Ryan received a B.S. in Biology from the University of Pittsburgh in 2004 and in 2012 Ryan obtained her Ph.D. in Toxicology from the University of Colorado Denver Anschutz Medical Campus (Advisor: Dr. Manisha Patel) investigating the role of mitochondrial oxidative stress and dysfunction in progressive neurological disorders such as Parkinson’s disease and Temporal Lobe Epilepsy.


Selected Publications

  • Ryan K, Backos DS, Reigan P, Patel M.  2012. Post-translational oxidative modification and inactivation of mitochondrial complex I in epileptogenesis. J Neurosci. Aug 15;32(33):11250-8. [Abstract]
  • Harbison RA*, Ryan KR*, Wilkins HM, Schroeder EK, Loucks FA, Bouchard RJ, Linseman DA. 2011. Calpain plays a central role in 1-methyl-4-phenylpyridinium (MPP(+))-induced neurotoxicity in cerebellar granule neurons. Neurotox Res. Apr; 19(3):374-88.  *=co-first authorship [Abstract]
  • Loucks FA, Le SS, Zimmermann AK, Ryan KR, Barth H, Aktories K, Linseman DA. 2006. Rho family GTPase inhibition reveals opposing effects of mitogen-activated protein kinase kinase/extracellular signal-regulated kinase and Janus kinase/signal transducer and activator of transcription. J Neurochem. May; 97(4):957- 67. [Abstract]
  • Butts BD, Hudson HR, Linseman DA, Le SS, Ryan KR, Bouchard RJ, Heidenreich KA. 2005.  Proteasome inhibition elicits a biphasic  effect on neuronal apoptosis via differential regulation of pro-survival and pro-apoptotic transcription factors. Mol Cell Neurosci. Oct, 30(2):279-89. [Abstract]

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