Richard Irwin, Ph.D. is a chemist in the Toxicology Branch with an adjunct appointment in the Host Susceptibility Branch. He received a B.S. degree from Baldwin Wallace College and a Ph.D. in biochemistry from the University of Tennesse in Knoxville. His recent research has focused on the application of genomics, and in particular, transcriptional profiling to examine mechanisms of hepatotoxicity as well as the integration of genomics into toxicological and carcinogenesis testing. He is also lead scientist in the DNA Products Program, a joint effort with the FDA to evaluate the safety of viral based gene therapy vectors.
Selected Publications
Irwin, R.D., Boorman,G.A., Cunningham, M.L., Heinloth, A.N., Malarkey, D.E., Paules, R.S. Application of Toxicogenomics to Toxicology: Basic Concepts in the Analysis of Microarray Data. Toxicologic Pathology, 32(Suppl. 1):1-12, 2004.[Abstract](http://www.ncbi.nlm.nih.gov/pubmed/15209406?ordinalpos=16&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Irwin, R.D., Parker, J.S., Lobenhofer, E.K., Burka, L.,Blackshear, P.E., Vallant, M.K., Lebetkin, E.H., Gerken, D.F., Boorman, G.A. Transcriptional Profiling of the left and median Lobes of Male F344/N rats Following Exposure to Acetaminophen. Toxicologic Pathology 33: 1-7, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/pubmed/15805062?ordinalpos=13&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Boorman, G.A., Irwin, R.D., Vallant, M.K., Gerken, D.E., Lobenhofer, E.K., Hejtmancik, M.R., Hurban, P., Brys, A.M., Travelos, G.S., Parker, J.S., Portier, C.J. Variation in the hepatic gene expression in individual Male Fisher Rats. Toxicologic Pathology, 33: 1-9, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/pubmed/15805061?ordinalpos=14&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Doi, A..M., Irwin, R.D., Bucher, J.R. Influence of Functional Group Substitutions on the Carcinogenicity of Anthraquinone in Rats and Mice: Analysis of Long-Term Bioassyas by The National Cancer Institute and The National Toxicology program. Journal of Toxicology and Environmental Health, part B 8: 100-126, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/pubmed/15804751?ordinalpos=15&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Boorman, G.A., Blackshear, P.E., Parker, J.S., Lobenhofer, E.K., Malarkey, D.E., Vallant, M.K., Gerken, D.K., Irwin, R.D. Hepatic gene expression changes throughout the day in the fischer rat: implications for toxicogenomic experiments. Toxicological Sciences 86(1): 183-193, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/pubmed/15814895?ordinalpos=12&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Zheng, C., Voutetakis, A., Kok, M.R., Goldsmith, C.M., Smith, G.B.J., Vallant, M., Irwin, R.D., Baum, B.J. Toxicity and biodistribution of a first generation recombinant adenoviral vector, in the presence of hydroxychloroquine, following retroductal delivery to a single rat submandibular gland.Oral diseases, 11, 1-8, 2006. [Abstract](http://www.ncbi.nlm.nih.gov/pubmed/16476034?ordinalpos=10&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Toyoshiba, H., Sone, H., Yamanaka, T. Parham, F.M., Irwin, R.D., Boorman, G.A., Portier, C.J. Gene interaction network analysis suggests differences between high and low doses of acetaminophen. Toxicol. Appl. Pharmacol. 2006. [Abstract](http://www.ncbi.nlm.nih.gov/pubmed/16701773?ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Zheng, C., Goldsmith, C.M., Mineshibi, F., Chiorini, J.A., Kerr, a., Wenk, M.L., Vallant, M., Irwin, R.D., Baum, B. Toxicity and biodistribution of a first generation recombinant adenoviral vector, encoding aquaporin-1, after retroductal delivery o a single rat submandibular gland. Human gene therapy 17: 1122-1133, 2006. [Abstract](http://www.ncbi.nlm.nih.gov/pubmed/17069536?ordinalpos=8&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Irwin, R.D. A review of evidence leading to the prediction that 1,4-butanediol is not a carcinogen. J. Applied Toxicology 26:72-80, 2006. [Abstract](http://www.ncbi.nlm.nih.gov/pubmed/16193534?ordinalpos=11&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Portier CJ, Toyoshiba H, Sone H, Parham F, Irwin RD, Boorman GA. Comparative analysis of gene networks at multiple doses and time points in livers of rats exposed to acetaminophen. ALTEX. 2006; 23 Suppl:380-4. [Abstract](http://www.ncbi.nlm.nih.gov/pubmed/17492217?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Mori, K., Blackshear, P.E., Lobenhofer, E.K., Parker, J.S., Orzech, D.P., Roycroft, J.H., Wlaker, K.L., Johnson, K.A., Marsh, T.A., Irwin, R.D, Boorman, G.A. Hepatic Transcript Levels for Genes Coding for Enzymes Associated with Xenobiotic Metabolism are Altered with Age. Toxicologic Pathology 35: 1-10, 2007. [Abstract](http://www.ncbi.nlm.nih.gov/pubmed/17366318?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Voutetakis A, Zheng C, Wang J, Goldsmith CM, Afione S, Chiorini JA, Wenk ML, Vallant M, Irwin RD, Baum BJ. Gender differences in serotype 2 adeno-associated virus biodistribution after administration to rodent salivary glands. Hum Gene Ther. 2007 Nov;18(11):1109-18. [Abstract](http://www.ncbi.nlm.nih.gov/pubmed/17939749?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Lobenhofer, E.K., Auman, J.T., Blackshear, P.E., Boorman, G.A., Bushel, P.R., Cunningham, M.L., Fostel, J.M., Gerrish, K., Heinloth, A.N., Irwin, R.D., Malarkey, D.E., Merrick, B.A., Sieber, S.O., Tucker, C.J., Ward, S.M., Wilson, R.E., Hurban, P., Tennant, R.W., Paules, R.S. Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype. Genome Biology 9: 100, 2008. [Abstract](http://www.ncbi.nlm.nih.gov/pubmed/18570634?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Sanders, V., Elwell, M., Heath, J.E., Collins, B.J., Dunnick, J.K., Rao, G.N., Prejean, D., Lindamood, C., Irwin, R.D. Induction of thymic lymphoma in mice admnistered the dideoxynucleoside ddC. Fundam. and Appl. Toxicol. 27: 132-139, 1995. [Abstract](http://www.ncbi.nlm.nih.gov/pubmed/8529822?ordinalpos=26&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
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