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Your Environment. Your Health.

Experimental Toxicology Group

Michael DeVito, Ph.D.
Michael DeVito, Ph.D.
Group Leader
Tel (919) 541-4142
devitom@niehs.nih.gov
Experimental toxicology graphic

Research Summary

The Experimental Toxicology Group, headed by Michael DeVito, Ph.D., characterizes the toxicologic and/or carcinogenic potential of chemicals and agents nominated to the National Toxicology Program (NTP) for assessment. The group also coordinates the pharmacokinetic modeling efforts at the NTP and is actively involved in the preparation and publication of the NTP Technical Reports. The Experimental Toxicology Group also presents its research findings at national and international scientific meetings and publishes in peer-reviewed journals.

Major Areas of Research

  • Initiate and coordinate research projects that investigate the mechanisms underlying chemical-mediated toxicity and carcinogenicity
  • Cardiotoxicity – develop approaches and biomarkers for studying cardiotoxicants
  • Cell Phones- Develop approaches for studying the potential hazards of cell phone use
  • Targeted Testing in Tox21 – the development of high through-put screening approaches is evaluated using targeted testing studies designed and implemented by the Experimental Toxicology Group

Current Projects

  • Toxicologic and Carcinogenic assessments of:
    • Herbal products/Dietary Supplements
    • Brominated Flame Retardants
    • Brominated Dioxins
    • Cell Phones
  • Evaluation and interpretation of toxicity and carcinogenicity data for publication as NTP technical reports.

 

Michael DeVito, Ph.D., leads the Experimental Toxicology Group. He is also the discipline leader for pharmacokinetic modeling efforts of the National Toxicology Program which is housed at the National Institute of Environmental Health Sciences.

 

Prior to coming to NIEHS/NTP in 2009, DeVito was a principal investigator in the Pharmacokinetics Branch of the National Health and Environmental Effects Research Laboratory at the US Environmental Protection Agency. From 2002-2009 DeVito was Chief of the Pharmacokinetic Branch. DeVito served as one of the lead health effects researchers on the US EPA’s Dioxin Reassessment from 1991-2009.

 

DeVito’s research interests include developing quantitative model to understand the relationships between exposure to environmental chemicals, tissue dose and toxicity for use in risk assessments.

 

DeVito received a Ph.D. in toxicology from the Joint Graduate Program in Toxicology at Rutgers, the State University of New Jersey in 1992.

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