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Selected Publications

Developmental and Reproductive Toxicology Group

  1. Dere E, Anderson LM, Coulson M, McIntyre BS, Boekelheide K, Chapin RE. (2013). SOT Symposium Highlight: Translatable Indicators of Testicular Toxicity: Inhibin B, MicroRNAs, and Sperm Signatures. Toxicol Sci. Dec;136(2):265-73. doi: 10.1093/toxsci/kft207. Epub 2013 Sep 19. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/24052563) ]
  2. Enright BP, McIntyre BS, Barat SA, Treinen KA, Kopytek SJ. (2012). Effects of SCH 486757, a nociceptin-1 receptor agonist, on fertility and reproductive hormone levels in female CRL:CD®[SD] Rats. Birth Defects Res B Dev Reprod Toxicol. Feb;95(1):12-22. doi: 10.1002/bdrb.20334. Epub 2011 Sep 15. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/21922640/) ]
  3. Enright BP, Leach MW, Pelletier G, LaBrie F, McIntyre BS, Losco PE. (2010). Effects of an antagonist of neurokinin receptors 1, 2 and 3 on reproductive hormones in male beagle dogs. Birth Defects Res B Dev Reprod Toxicol. Dec;89(6):517-25. doi: 10.1002/bdrb.20274. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/21086439) ]
  4. Enright BP, McIntyre BS, Thackaberry EA, Treinen KA, Kopytek SJ. (2010). Assessment of hydroxypropyl methylcellulose, propylene glycol, polysorbate 80, and hydroxypropyl-?-cyclodextrin for use in developmental and reproductive toxicology studies. Birth Defects Res B Dev Reprod Toxicol. Dec;89(6):504-16. doi: 10.1002/bdrb.20273. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/21058332) ]
  5. Enright BP, Gu YZ, Snyder RD, Dugyala RR, Obert LA, Treinen KA, McIntyre BS, Veneziale RW. (2010). Effects of the histamine H1 antagonist chlorcyclizine on rat fetal palate development. Birth Defects Res B Dev Reprod Toxicol. Dec;89(6):474-84. doi: 10.1002/bdrb.20261. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/21058326) ]
  6. Enright B.P., Compton D.R., Collins N., Davis T., and B.S. McIntyre. (2009). Comparative effects of interferon alpha-2b and pegylated interferon alpha-2b on menstrual cycles and ovarian hormones in cynomolgus monkeys. Birth Defects Res B Dev Reproductive Toxicology. Feb;86(1):29. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/19243028) ]  
  7. Chapin R.E., Adams J., Boekelheide K., Gray L.E. Jr, Hayward S.W., Lees P.S., McIntyre B.S., Portier K.M., Schnorr T.M., Selevan S.G., Vandenbergh J.G., Woskie S.R. (2008). NTP-CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A. Birth Defects Research B Developmental Reproductive Toxicology. 83(3):157-395. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/18613034) ]  
  8. Barlow, N.J., McIntyre, B.S., and P.M.D. Foster. (2004). Male reproductive tract lesions at 6, 12, and 18 months of age following in utero exposure to di(n-butyl)phthalate Toxicological Pathology 32: 79-90. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/14713552) ]  
  9. McIntyre, B.S., Vancutsem, P.M., Treinen, K.A., and R.E. Morrissey. (2003). Effects of perinatal loratadine exposure on male rat reproductive organ development. Reproductive Toxicology 17: 691-697. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/14613821) ]  
  10. Turner, K.J., McIntyre, B.S., Phillips, S.L., Barlow, N.J., Bowman, C.J. and P.M.D. Foster. (2003). Altered gene expression during rat Wolffian duct development in response to in utero exposure to the antiandrogen linuron. Toxicological Sciences 74:114-28. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/12730624) ]  
  11. McIntyre, B.S., Barlow, N.J., Sar, M., Wallace, D.G., and P.M.D. Foster. (2002). Effects of in utero linuron exposure on rat Wolffian duct development. Reproductive Toxicology 16:131-139. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/11955944) ]  
  12. You, L., Sar, M., Bartolucci, E., McIntyre, B.S., and R Sriperumbudur. (2002). Modulation of mammary gland development in prepubertal male rats exposed to genistein and methoxychlor. Toxicological Sciences 66: 216-225. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/11896288) ]  
  13. Foster P.M.D and B.S. McIntyre. (2002). Endocrine active agents: implications of adverse and non-adverse changes. Toxicological Pathology 30: 59-65. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/11892727) ]  
  14. McIntyre, B.S., Barlow, N.J., and P.M.D Foster. (2002). Male rats exposed to linuron in utero exhibit permanent changes in anogenital distance, nipple retention, and epididymal malformations that results in subsequent testicular atrophy Toxicological Sciences 65: 62-70. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/11752686) ]  
  15. Sylvester, P.W., McIntyre, B.S., Gapor, A., and K.P. Briski. (2001). Vitamin E inhibition of normal mammary epithelial cell proliferation is associated with a reduction in Protein Kinase C activation. Cell Proliferation 34: 347-358. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/11736999) ]  
  16. McIntyre, B.S., Barlow, N.J., and P.M.D Foster. (2001). Androgen-mediated development in male rat offspring exposed to flutamide in utero: Permanence and correlation of early postnatal changes in anogenital distance and nipple retention with malformations in androgen-dependent tissues. Toxicological Sciences 62: 236-249. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/11452136) ]  
  17. McIntyre, B.S., Barlow, N.J., Wallace, D.G., Maness, S. C., Gaido, K.W., and P.M.D Foster. (2000). Effects of in utero exposure to linuron on androgen-dependent reproductive development in the male Crl:CD(SD)BR rat. Toxicology and Applied Pharmacology 167: 87-99. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/10964759) ]  
  18. McIntyre, B.S., Briski, K.P., Gapor, A., and P.W. Sylvester. (2000). Antiproliferative and apoptotic effects of tocopherols and tocotrienols on preneoplastic and neoplastic mammary epithelial cells. Proceedings of the Society for Experimental Biology and Medicine 224: 292-301. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/10964265) ]  
  19. McIntyre, B.S., Briski, K.P., Tirmenstein, M., Gapor, A., Fariss M. W., and P.W. Sylvester. (2000). Antiproliferative and apoptotic effects of tocopherols and tocotrienols on normal mouse mammary epithelial cells. Lipids 35: 171-180. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/10757548) ]  
  20.   Mealey, K.L., Barhoumi, R., Burghardt, R.C., McIntyre, B.S., Sylvester, P.W., Hosick, H.L., and D.T. Kochevar. (1999). Immunosuppressant inhibition of P-glycoprotein is independent of drug-induced suppression of peptide-prolyl isomerase and calcineurin activity. Cancer Chemotherapy and Pharmacology 44: 152-158. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/10412950) ]  
  21.   McIntyre, B.S. and P.W. Sylvester. (1998). Genistein and erbstatin inhibition of normal mammary epithelial cell proliferation is associated with EGF-receptor downregulation. Cell Proliferation 31: 35-46. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/9666817) ]  
  22. McIntyre, B.S., Briski, K.P., Hosick, H.L., and P.W. Sylvester. (1998). Effects of tyrosine phosphatase inhibitors on EGF- and insulin-dependent mammary epithelial cell growth. Proceedings of the Society for Experimental Biology and Medicine 217: 180-187. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/9452142) ]  
  23. Birkenfeld, H.P., McIntyre, B.S., Briski K.P., and P.W. Sylvester. (1996). Protein kinase C isoenzyme expression in normal mouse mammary epithelial cells grown in primary culture. Proceedings of the Society for Experimental Biology and Medicine 213: 65-70. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/8820825) ]  
  24. Birkenfeld H.P., McIntyre, B.S., Briski K.P., and P.W. Sylvester. (1996). Role of protein kinase C in modulating epidermal growth factor-and phorbol ester-induced mammary epithelial cell growth in vitro. Experimental Cell Research 223: 183-191. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/8635491) ]  
  25.   McIntyre, B.S., Birkenfeld H.P., and P.W. Sylvester. (1995). Relationship between epidermal growth factor receptor levels, autophosphorylation, and mitogenic-responsiveness in normal mouse mammary epithelial cells in vitro. Cell Proliferation 28: 45-56. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/7833385) ]  

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