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Suramya Waidyanatha, Ph.D.

Program Operations Branch

Suramya Waidyanatha, Ph.D.
Suramya Waidyanatha, Ph.D.
Chemist, Group Leader
Tel (919) 541-2144
Fax (919) 541-3687
waidyanathas@niehs.nih.gov
P.O. Box 12233
Mail Drop K2-07
Research Triangle Park, NC 27709

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Suramya Waidyanatha, Ph.D. is the discipline leader for Chemistry and ADME (absorption, distribution, metabolism and excretion) and oversees the activities of the Chemistry and ADME (absorption, distribution, metabolism and excretion) Resources Group (CARG) in support of the National Toxicology Program’s mission. She designs the research needs in analytical chemistry, ADME and toxicokinetics for chemicals of interest to NTP and facilitates the use of ADME and toxicokinetic data in the design, interpretation, and reporting of NTP toxicity and carcinogenicity studies. She also manages contracts conducting ADME studies, toxicokinetics studies and analytical chemistry activities in support of the NTP toxicity and carcinogenicity studies.  She serves as the NTP toxicokinetics faculty chair.

 

Waidyanatha’s research interests include:  development, validation, and application of analytical methods to quantitate trace analytes in complex matrices; metabolism and disposition of xenobiotics and the kinetic parameters describing these processes in rodents in vivo and rodents and humans in vitro; mechanism(s) of interactions of xenobiotics and/or their metabolites with cellular macromolecules resulting in toxicity.

 

Waidyanatha received her B.S. (Honors) in Chemistry from University of Colombo, Sri Lanka in 1985, her M.S in Biochemistry from University of Illinois, Chicago in 1987 and her Ph.D. in Analytical Chemistry from University of Maine in 1990. She worked as an analytical chemistry resource support person for Glaxo Inc., RTP, North Carolina briefly prior to joining the School of Public Health at the University of North Carolina at Chapel Hill in 1991 as a Postdoctoral Fellow. She continued her career at the university as a Laboratory Director and then as a Senior Scientist. During her 17 years at the university, she investigated biomarkers of exposure to xenobiotics and their utility in elucidating xenobiotic metabolism and disposition which advanced her knowledge in toxicology, epidemiology and biostatistics. She joined NTP in 2008 as a staff scientist and currently holds an adjunct appointment at the University of North Carolina at Chapel Hill.

 

She is listed as an author in over 70 peer-reviewed research articles in scientific journals. She is a member of Society of Toxicology and American Chemical Society.

 

Selected Publications

  1. Waidyanatha S, Ryan K. Disposition of fragrance ingredient [(14)C]1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone in male Fisher rats following oral administration and dermal application. Xenobiotica; the fate of foreign compounds in biological systems 2014 44(8):749-756.[Abstract]
  2. Matthews JM, Brown SS, Patel PR, Black SR, Banks TT, Etheridge AS, Fennell TR, Snyder RW, Blystone CR, Waidyanatha S. Metabolism and disposition of [14C]n-butyl-p-hydroxybenzoate in male and female Harlan Sprague Dawley rats following oral administration and dermal application. Xenobiotica; the fate of foreign compounds in biological systems 2013 43(2):169-181.[Abstract]
  3. Hong S.P., Fuciarelli A.F., Johnson J.D., Graves S.W., Bates D.J., Waidyanatha S., Smith C.S. (2012) Toxicokinetics of methyleugenol in F344 rats and B6C3F(1) mice. Xenobiotica, 43(3):293-302.[Abstract]
  4. Mathews J.M., Brown S.S., Patel P.R., Black S.R., Banks T.T., Etheridge A.S., Fennell T.R., Snyder R.W., Blystone C.R., Waidyanatha S. (2012) Metabolism and disposition of [(14)C]n-butyl-p-hydroxybenzoate in male and female Harlan Sprague Dawley rats following oral administration and dermal application. Xenobiotica, 43(2):169-181.[Abstract]
  5. Mathews J.M., Zhan Q., Etheridge A.S., Patel P.R., Black S.R., Banks T.T., Fennell T.R., Snyder R.W., Burgess J.P., Warren S.D., Surh I., Waidyanatha S. (2012) Metabolism and disposition of 2-methoxy-4-nitoaniline in male and female Harlan Sprague Dawley rats and B6C3F1/N mice. Xenobiotica, 42(12):1213-1224.[Abstract]
  6. Pleil J.D., Blount B.C., Waidyanatha S., Harper M. (2012) Establishing exposure science as a distinct scientific discipline. J Expo Sci Environ Epidemiol, 22(4):317-319.[Abstract]
  7. Fennell T., Watson S., Snyder R., Jeffcoat R., Waidyanatha S. (2011) Disposition and Metabolism of N,N-dimethylacetoacetamide in male F344 rats and Wistar-Han rats and female B6C3F1 mice. Xenobiotica, 41(11):1013-1020.[Abstract]
  8. Waidyanatha, S., Johnson, J.D., Hong, S.P., Godfrey-Robinson, V.D., Graves, S.W., Cristy, T., Dunnick, J.K., and  Smith, C. (2011) Toxicokinetics of Bis(2-chloroethoxy)methane Following Intravenous Administration and Dermal Application in Male and Female F344/N Rats and B6C3F1 Mice. Toxicology letters,  205(2):215-226.[Abstract]
  9. Xing C., Marchetti F., Li G., Weldon R.H., Kurtovich E., Young S., Schmid T.E., Zhang L., Rappaport S., Waidyanatha S., Wyrobek A.J., Eskenazi B. (2010) Benzene exposure near the U.S. permissible limit is associated with sperm aneuploidy. Environ Health Perspect 118(6):833-839.[Abstract]
  10. Rappaport S.M., Kim S., Lan Q., Vermeulen R., Waidyanatha S., Zhang L., Li G., Yin S., Hayes R.B., Rothman N., Smith M.T. (2009) Evidence that humans metabolize benzene via two pathways. Environ Health Perspect 117(6):946-952.[Abstract]
  11. Onyemauwa F, Rappaport SM, Sobus JR, Gajdosová D, Wu R, Waidyanatha S. (2009) Using liquid chromatography-tandem mass spectrometry for quantitation of monohydroxyl metabolites of polycyclic aromatic hydrocarbons in urine. J Chromatogr B Analyt Technol Biomed Life Sci 877(11-12):1117-1125.[Abstract]
  12. Sobus J.R., Waidyanatha S., McClean M.D., Herrick R.F., Smith T.J., Garshick E., Laden F., Hart J.E., Zheng Y., Rappaport S.M. (2009) Urinary naphthalene and phenanthrene as biomarkers of occupational exposure to polycyclic aromatic hydrocarbons. Occup Environ Med 66(2):99-104.[Abstract]
  13. Funk, W.E., Waidyanatha, S., Chaing, S.H. and Rappaport, S.M. (2008) Hemoglobin adducts of benzene oxide in neonatal and adult dried blood spots. Cancer Epidemiol. Biomarkers Prev., 17: 1896-1901.[Abstract]
  14. Fustinoni, S., Campo, L., Manini, P., Buratti, M., Waidyanatha, S., DePalma, G., Mutti, A., Foa, V., Colombi, A. and Rappaport, S.M. (2008) An integrated approach to biomonotoring exposure to styrene and styrene-(7,8)-oxide using repeated measurements sampling design. Biomarkers, 15: 1-19.[Abstract]
  15. Waidyanatha, S. and Rappaport, S.M. (2008) Hemoglobin and albumin adducts of naphthalene-1,2-oxide, 1,2- and 1,4-naphthoquinone in Swiss Webster mice. Chem-Biol. Intercat., 172:105-114.[Abstract]
  16. Kim, S., Lan, Q., Waidyanatha, S., Chanock, S., Johnson, B.A., Vermeulen, R., Smith, M.T., Zhang, L., Li, G., Shen, M., Yin, S., Rothman, N., and Rappaport, S.M. (2007) Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrations. Pharmacogenet. Genomics. 17, 789-801.[Abstract]
  17. Lin, Y.S., Vermeulen, R., Tsai, C.H., Waidyanatha, S., Lan, Q., Rothman, N., Smith, M.T., Zhang, L., Shen, M., Li, G.,Yin, S., Kim, S. and Rappaport, S.M. (2007) Albumin adducts of electrophilic benzene metabolites in benzene exposed and control workers. Environ. Health Perspect., 115:28-34.[Abstract]
  18. Kim, S., Vermeulen, R., Waidyanatha, S., Johnson, B., Lan, Q., Rothman, N., Smith, M.T., Zhang, L., Li, G., Shen, M., Yin, S. and Rappaport, S.M. (2006) Modeling human metabolism of benzene following occupational and environmental exposures. Cancer Epidemiol. Biomarkers Prev., 15:2246-2252.[Abstract]
  19. Kim, S., Vermeulen, R., Waidyanatha, S., Johnson, B., Lan, Q., Rothman, N., Smith, M.T., Zhang, L., Li, G., Shen, M., Yin, S. and Rappaport, S.M. (2006) Using urinary biomarkers to elucidate dose-related patterns of human benzene metabolism. Carcinogenesis, 27:772-781.[Abstract]
  20. Lin, Y.S., McKelvey, W., Waidyanatha, S. and Rappaport, S.M. (2006) Variability of albumin adducts of 1,4-benzoquinone, a toxic metabolite of benzene, in human volunteers. Biomarkers, 11: 14-27.[Abstract]
  21. Yokley, K., Tran, H.T., Pekari, K., Rappaport, S., Riihimaki, V., Rothman, N., Waidyanatha, S. and Schlosser, P.M. (2006) Physiologically-based pharmacokinetic modeling of benzene in humans: a Bayesian approach. Risk. Anal., 26, 925-943.[Abstract]
  22. Wu, R., Waidyanatha, S., Henderson, A.P., Serdar, B., Zheng, Y. and Rappaport, S.M. (2005) Determination of hihydroxynapthalenes in human urine by gas chromatography-mass spectrometry. Journal of Chromatography (B), 826:206-213.[Abstract]
  23. Waidyanatha, S., Sangaiah, R.and Rappaport, S.M. (2005) Characterization and quantification of cystenyl adducts of benzene diol epoxide. Chem. Res. Toxicol., 18: 1178-1185.[Abstract]
  24. Henderson, A.P.,Waidyanatha, S., Delany, K., Lindstrom, A.B., Bleasdale, C., Watson, W.P., Golding, B.T. and Rappaport, S.M. (2005) Evidence for the formation of Michael adducts from (E,E)-muconaldehyde with glutathione and other thiols. Biorganic Chem., 33: 363-373.[Abstract]
  25. Rappaport, S.M., Waidyanatha, S., Yeowell-O'Connell1, K., Rothman, N., Smith, M.T., Zhang, L., Qu, Q., Shore, R., Li, G. and Yin, S. (2005) Protein adducts as biomarkers of human benzene metabolism. Chem-Bio.l Interact., 153-154: 103-109.[Abstract]
  26. Waidyanatha, S. and Rappaport, S.M. (2005) Investigation of cystenyl protein adducts of benzene diol epoxide. Chem-Bio.l Interact., 153-154: 261-266.[Abstract]
  27. Lan,Q., Zhang,L., Li,G., Vermeulen,R., Weinberg,R.S., Dosemeci,M., Rappaport,S.M., Shen,M., Alter,B.P., Wu,Y., Kopp,W., Waidyanatha,S., Rabkin,C., Guo,W., Chanock,S., Hayes,R.B., Linet,M., Kim,S., Yin,S., Rothman,N. and Smith,M.T. (2004) Hematotoxicity in workers exposed to low levels of benzene. Science, 306: 1774-1776.[Abstract]
  28. Rappaport, S.M., Waidyanatha, S. and Serdar, B. (2004) Naphthalene and its biomarkers as measures of occupational exposure to polycyclic aromatic hydrocarbons, J. Environ. Monit., 6:413-416.[Abstract]
  29. Waidyanatha, S., Rothman, N., Li, G., Smith, M.T., Yin, S. and Rappaport, S.M. (2004) Rapid determination of six urinary benzene metabolites in occupationally-exposed and unexposed subjects, Anal. Biochem., 327:184-199.[Abstract]
  30. Waidyanatha, S., Zheng, Y., Serdar, B., Rappaport, S.M. (2004) Albumin adducts of naphthalene metabolites as biomarkers of exposure to polycyclic aromatic hydrocarbons, Cancer Epidemiol. Biomarkers Prev., 13:117-124.[Abstract]
  31. Rappaport, S.M., Waidyanatha, S., Qu, Q., Shore, R., Jin, X., Cohen, B., Chen, L.C., Melikian, A.A., Li, G., Yin, S., Yan, H., Xu, B., Mu, R., Li, Y., Zhang, X. and Li, K. (2002) Albumin adducts of benzene oxide and 1,4-benzoquinone as measures of human benzene metabolism, Cancer Research, 62: 1330-1337.[Abstract]
  32. Waidyanatha, S., Rothman, N., Fustinoni, S., Smith, M.T., Hayes, R.B., Bechtold, W., Dosemeci, M., Li, G., Yin, S. and Rappaport, S.M. (2001) Urinary benzene as a biomarker of exposure among occupationally exposed and unexposed subjects, Carcinogenesis, 22: 279-286.[Abstract]

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