P.O. Box 12233
Mail Drop K2-07
Research Triangle Park, North Carolina 27709 Delivery Instructions
Suramya Waidyanatha, Ph.D., is a chemist and serves as the ADME (absorption, distribution, metabolism and excretion) Discipline Leader. She also is a project officer in POB’s Metabolism and Disposition Workgroup. Waidyanatha provides NTP with expertise in ADME of xenobiotics and designs the research needs in that area for individual chemicals of interest to the program. She also facilitates the use of ADME data in the design, interpretation and reporting of NTP toxicity and carcinogenicity studies in rodents. She serves as NTP Toxicokinetics Faculty Chair and is a member of the NIEHS/NTP Scientific Review Group for Report on Carcinogens.
Waidyanatha’s research interest is in understanding the fate of xenobiotics in the body and the mechanism of chemical toxicity. Studies include the following investigations:
ADME of xenobiotics and the kinetic parameters describing these processes in rodents in vivo
Metabolism of xenobiotics in human in vitro models
Mechanism(s) of interactions of xenobiotics and/or their metabolites with cellular macromolecules resulting in toxicity
Waidyanatha received her B.S. (Honors) in chemistry from University of Colombo, Sri Lanka, her M.S in biochemistry from University of Illinois, Chicago and her Ph.D. in chemistry from University of Maine. She joined the School of Public Health at the University of North Carolina at Chapel Hill as a postdoctoral fellow in 1991. She continued her career at the university as a Laboratory Director and then as a Senior Scientist. During her17 years at the university, she investigated biomarkers of exposure to xenobiotics and their utility in elucidating xenobiotic metabolism, which advanced her knowledge in toxicology, epidemiology and biostatistics. She joined NTP in 2008 as a staff scientist, and currently holds an adjunct appointment at the University of North Carolina at Chapel Hill as a visiting scholar.
She is listed as an author in over 50 research articles in peer-reviewed scientific journals. She is a member of American Society for Mass Spectrometry and American Association of Cancer Research.
Selected Publications
Funk, W.E., Waidyanatha, S., Chaing, S.H. and Rappaport, S.M. (2008) Hemoglobin adducts of benzene oxide in neonatal and adult dried blood spots. Cancer Epidemiol. Biomarkers Prev., 17: 1896-1901. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/18708378?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Fustinoni, S., Campo, L., Manini, P., Buratti, M., Waidyanatha, S., DePalma, G., Mutti, A., Foa, V., Colombi, A. and Rappaport, S.M. (2008) An integrated approach to biomonotoring exposure to styrene and styrene-(7,8)-oxide using repeated measurements sampling design. Biomarkers, 15: 1-19. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/18608187?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Waidyanatha, S. and Rappaport, S.M. (2008) Hemoglobin and albumin adducts of naphthalene-1,2-oxide, 1,2- and 1,4-naphthoquinone in Swiss Webster mice. Chem-Biol. Intercat., 172:105-114. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/18291356?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Kim, S., Lan, Q., Waidyanatha, S., Chanock, S., Johnson, B.A., Vermeulen, R., Smith, M.T., Zhang, L., Li, G., Shen, M., Yin, S., Rothman, N., and Rappaport, S.M. (2007) Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrations. Pharmacogenet. Genomics. 17, 789-801. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/17885617?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Lin, Y.S., Vermeulen, R., Tsai, C.H., Waidyanatha, S., Lan, Q., Rothman, N., Smith, M.T., Zhang, L., Shen, M., Li, G.,Yin, S., Kim, S. and Rappaport, S.M. (2007) Albumin adducts of electrophilic benzene metabolites in benzene exposed and control workers. Environ. Health Perspect., 115:28-34. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/17366815?ordinalpos=81&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Kim, S., Vermeulen, R., Waidyanatha, S., Johnson, B., Lan, Q., Rothman, N., Smith, M.T., Zhang, L., Li, G., Shen, M., Yin, S. and Rappaport, S.M. (2006) Modeling human metabolism of benzene following occupational and environmental exposures. Cancer Epidemiol. Biomarkers Prev., 15:2246-2252. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/17119053?ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Kim, S., Vermeulen, R., Waidyanatha, S., Johnson, B., Lan, Q., Rothman, N., Smith, M.T., Zhang, L., Li, G., Shen, M., Yin, S. and Rappaport, S.M. (2006) Using urinary biomarkers to elucidate dose-related patterns of human benzene metabolism. Carcinogenesis, 27:772-781. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/16339183?ordinalpos=29&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Lin, Y.S., McKelvey, W., Waidyanatha, S. and Rappaport, S.M. (2006) Variability of albumin adducts of 1,4-benzoquinone, a toxic metabolite of benzene, in human volunteers. Biomarkers, 11: 14-27. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/16484134?ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Yokley, K., Tran, H.T., Pekari, K., Rappaport, S., Riihimaki, V., Rothman, N., Waidyanatha, S. and Schlosser, P.M. (2006) Physiologically-based pharmacokinetic modeling of benzene in humans: a Bayesian approach. Risk. Anal., 26, 925-943. [Abstract] (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Yokley%20K%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus)
Wu, R., Waidyanatha, S., Henderson, A.P., Serdar, B., Zheng, Y. and Rappaport, S.M. (2005) Determination of hihydroxynapthalenes in human urine by gas chromatography-mass spectrometry. Journal of Chromatography (B), 826:206-213. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/16169295?ordinalpos=12&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Waidyanatha, S., Sangaiah, R.and Rappaport, S.M. (2005) Characterization and quantification of cystenyl adducts of benzene diol epoxide. Chem. Res. Toxicol., 18: 1178-1185. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/16022511?ordinalpos=13&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Henderson, A.P.,Waidyanatha, S., Delany, K., Lindstrom, A.B., Bleasdale, C., Watson, W.P., Golding, B.T. and Rappaport, S.M. (2005) Evidence for the formation of Michael adducts from (E,E)-muconaldehyde with glutathione and other thiols. Biorganic Chem., 33: 363-373. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/16005934?ordinalpos=14&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Rappaport, S.M., Waidyanatha, S., Yeowell-O'Connell1, K., Rothman, N., Smith, M.T., Zhang, L., Qu, Q., Shore, R., Li, G. and Yin, S. (2005) Protein adducts as biomarkers of human benzene metabolism. Chem-Bio.l Interact., 153-154: 103-109. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/15935805?ordinalpos=16&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Waidyanatha, S. and Rappaport, S.M. (2005) Investigation of cystenyl protein adducts of benzene diol epoxide. Chem-Bio.l Interact., 153-154: 261-266. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/15935825?ordinalpos=15&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Lan,Q., Zhang,L., Li,G., Vermeulen,R., Weinberg,R.S., Dosemeci,M., Rappaport,S.M., Shen,M., Alter,B.P., Wu,Y., Kopp,W., Waidyanatha,S., Rabkin,C., Guo,W., Chanock,S., Hayes,R.B., Linet,M., Kim,S., Yin,S., Rothman,N. and Smith,M.T. (2004) Hematotoxicity in workers exposed to low levels of benzene. Science, 306: 1774-1776. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/15576619?ordinalpos=18&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Rappaport, S.M., Waidyanatha, S. and Serdar, B. (2004) Naphthalene and its biomarkers as measures of occupational exposure to polycyclic aromatic hydrocarbons, J. Environ. Monit., 6:413-416. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/15152308?ordinalpos=19&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Waidyanatha, S., Rothman, N., Li, G., Smith, M.T., Yin, S. and Rappaport, S.M. (2004) Rapid determination of six urinary benzene metabolites in occupationally-exposed and unexposed subjects, Anal. Biochem., 327:184-199. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/15051535?ordinalpos=20&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Waidyanatha, S., Zheng, Y., Serdar, B., Rappaport, S.M. (2004) Albumin adducts of naphthalene metabolites as biomarkers of exposure to polycyclic aromatic hydrocarbons, Cancer Epidemiol. Biomarkers Prev., 13:117-124. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/14744742?ordinalpos=21&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Rappaport, S.M., Waidyanatha, S., Qu, Q., Shore, R., Jin, X., Cohen, B., Chen, L.C., Melikian, A.A., Li, G., Yin, S., Yan, H., Xu, B., Mu, R., Li, Y., Zhang, X. and Li, K. (2002) Albumin adducts of benzene oxide and 1,4-benzoquinone as measures of human benzene metabolism, Cancer Research, 62: 1330-1337. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/11888901?ordinalpos=30&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Waidyanatha, S., Rothman, N., Fustinoni, S., Smith, M.T., Hayes, R.B., Bechtold, W., Dosemeci, M., Li, G., Yin, S. and Rappaport, S.M. (2001) Urinary benzene as a biomarker of exposure among occupationally exposed and unexposed subjects, Carcinogenesis, 22: 279-286. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/11181449?ordinalpos=35&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
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