P.O. Box 12233
Mail Drop K2-07
Research Triangle Park, North Carolina 27709 Delivery Instructions
Mike Sanders, Ph.D., is a toxicologist in the Programs Operations Branch of the National Toxicology Program (NTP) located at the National Institute of Environmental Health Sciences (NIEHS). He serves as the project officer for metabolism and disposition (ADME) studies conducted under contract at the Lovelace Respiratory Research Institute in Albuquerque, New Mexico. Duties include designing studies, monitoring fiscal and technical performance, and providing guidance and problem resolution to NTP staff utilizing the contract resources. Sanders also serves as a project leader (Study Scientist), and in that capacity is involved in the design, conduct, interpretation, and reporting of research and testing activities investigating toxicity of NTP study chemicals. Additionally, he provides expertise to other NTP staff in the design and interpretation of ADME studies of chemicals undergoing toxicological evaluation by the NTP.
Sanders brings over 25 years of laboratory experience at NIEHS to his position in the NTP. He has designed and conducted ADME studies of diverse chemicals such as components of natural products, industrial and commercial chemicals, and environmental contaminants. His research interests center around the characterization of metabolism-dependent mechanisms of chemical toxicity.
Sanders has both a M.S. (1988) and Ph.D. in toxicology (2006) from North Carolina State University in Raleigh, North Carolina. He has authored numerous peer-reviewed articles during his tenure at NIEHS
Selected Publications
Sanders JM, Bucher JR, Peckham JC, Kissling GE, Hejmancik MR, Chhabra RS. Carcinogenesis studies of cresols in rats and mice. Toxicology 2009; 257(1-2):33-39. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=19114085)
Hoehle SI, Knudsen GA, Sanders JM, and Sipes IG. Absorption, distribution, metabolism, and excretion of 2, 2-bis(bromomethyl)-1, 3-propanediol in male Fischer-344 rats. Drug Metab Dispos 2009; 37(2):408-416. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=19029203)
Sanders JM, Lebetkin EH, Chen L-J, Burka LT. Disposition of 2,2',4,4',5,5'- hexabromodiphenyl ether (BDE153) and its interaction with other PBDEs in rodents. Xenobiotica 2006; 36:824-837. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/16971346?ordinalpos=19&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Chen L-J, Lebetkin EH, Sanders JM, Burka LT. Metabolism and disposition of 2,2',4,4',5-pentabromodiphenyl ether (BDE99) following a single or repeated administration to rats or mice. Xenobiotica 2006; 36:515-534. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/16769647?ordinalpos=21&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Sanders JM, Chen L-J, Lebetkin EH, Burka LT. Metabolism and disposition of 2,2',4,4'-tetrabromodiphenyl ether following administration of single or multiple doses to rats and mice. Xenobiotica 2006; 36:103-117. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/16507516?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Sanders JM, Burka LT, Smith CS, Black W, James R, Cunningham ML. Differential expression of CYP1A, 2B, and 3A genes in the F344 rat following exposure to a polybrominated diphenyl ether mixture or individual components. Toxicol Sci 2005; 88:127-133. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/16107549?ordinalpos=29&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Sanders JM, Cunningham ML. Determination of tamoxifen and metabolites in mouse fetal tissue using nonaqueous capillary electrophoresis chromatography. Electrophoresis 2002; 23, 502-505. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/11870753?ordinalpos=50&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Sanders JM, Burka LT, Chanas B, Matthews HB. Comparative xenobiotic metabolism between Tg.AC and p53+/- genetically altered mice and their respective wildtypes. Toxicol Sci 2001; 61, 54-61. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/11294974?ordinalpos=53&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Sanders JM, Chen L-J, Burka LT, Matthews HB. Metabolism and disposition of luminol in the rat. Xenobiotica 2000; 30:263-272. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/10752641?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Ghanayem BI, Sanders JM, Chanas, B, Burka LT, Gonzalez FJ. Role of cytochrome P450 CYP2E1 in methacrylonitrile metabolism and disposition. J Pharmacol Exp Ther 1999; 289:1054-9. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/10215687?ordinalpos=61&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
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