Aris G. Martone, Ph.D.
Program Operations Branch
Aris G. Martone, Ph.D.
Tel (919) 541-7756
P.O. Box 12233
Mail Drop K2-07
Research Triangle Park, North Carolina 27709
Aris Gallon Martone is a Chemist and serves as a Contract Officer Representative (COR) in the Chemistry and ADME Resources Group, Programs Operations Branch (POB) for the National Toxicology Program (NTP) where she manages a chemistry contract that supports toxicology studies. Martone provides NTP with expertise in the areas of Free Radical Organic Chemistry, Mass Spectrometry, ADME/TK analysis and GLP’s.
As a COR, Martone is involved in the design, conduct, interpretation and reporting of NTP/POB Chemistry activities. Martone has extensive experience in mass spectrometry and utilizes her expertise to facilitate the identification of unknown metabolites in Toxicology studies to assist in the understanding of the mode of action. Martone’s interests are in the understanding of the mechanism of chemical toxicity in the body. She has developed expertise in chemical, protein and DNA analysis in order to monitor the fate of chemicals in vivo. She applies this knowledge in the understanding of the metabolism of chemicals and the mechanism of reaction of chemicals and their metabolites in vivo.
Martone received her B.S. degree in Chemistry in 1984 and her Ph.D. in Bio-Organic Chemistry in 1990 from Louisiana State University in Baton Rouge Louisiana. She joined Dow Chemical in 1990 as a Senior Research Scientist providing mass spectrometry expertise in support of Research and Development and Manufacturing. In 1997, Martone joined Rhone-Poulenc, as a Sr. Research Scientist and became the Team Leader in 1998 providing GLP mass spectrometry support to the Metabolism, Residue, Discovery Chemistry and Formulation groups. In 2003, Martone accepted a position in the Plant Biotechnology group managing the budget and providing GLP mass spectrometry, protein isolation, SDS-PAGE, Western blot, DNA isolation, Southern blot and PCR analysis to the characterization of proteins and DNA. In 2006, she became a Study Director conducting GLP Plant Biotechnology studies for Regulatory Submissions. Martone joined NTP in 2012 as a Chemist.
- Herouet-Guicheney C, Rouquie D, Freyssinet M, Currier T, Martone A, Zhou J, Bates E, Ferullo JM, Hendrickx K, Rouan D. 2009. Safety Evaluation of the Double Mutant 5-enol Pyruvylshikimate-3-phosphate Synthase (2mEPSPS) from Maize that Confers Tolerance to Glyphosate Herbicide in Transgenic Plants. Regulatory Toxicology and Pharmacology, vol. 54, issue 2.
- Tissot G, Canard H, Nadai M, Martone A, Botterman J, Dubald M. 2008. Translocation of Aprotinin, a Therapeutic Protease Inhibitor, into the Thylakoid Lumen of Genetically Engineered Tobacco Chloroplasts. Plant Biotechnol J, 6(3):309-30. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/18266824) ]
- Gallon AA, Pryor WA. 1994. The Reaction of Low Levels of Nitrogen Dioxide with Methyl Linoleate in the Presence and Absence of Oxygen. Lipids. Mar, 29(3). [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/8170286) ]
- Gallon AA, Pryor WA. 1993. The Identification of the Allylic Nitrite and Nitro Derivatives of Methyl Linoleate and Methyl Linolenate by Negative Chemical Ionization Mass Spectrometry. Lipids. Feb; 28(2). [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/8441338) ]
- Gallon A. 1990. The Mechanism of Low Levels of Nitrogen Dioxide Reaction with Unsaturated Fatty Acid Esters. Dissertation.