P.O. Box 12233
Mail Drop K2-06
Research Triangle Park, North Carolina 27709 Delivery Instructions
Joseph Roycroft, Ph.D., is a toxicologist and serves as a project officer in the administration and monitoring of contracts for NTP toxicology and carcinogenicity studies. Roycroft serves as a resource for NTP staff and management on study design and cost, as a technical expert for evaluation of technical and business contract proposals, as well as the central resource of expertise on comprehensive health and safety-related matters for NTP contract activities.
As a toxicologist, Roycroft is involved in the design, conduct, interpretation, and reporting of NTP research and testing activities that investigate the toxicology, carcinogenicity and mode of action of environmental substances in rodent models. These data serve as a resource to state and federal regulatory agencies for predicting potential health effects in humans. His primary research interest is the effect of inhaled chemicals on the respiratory tract. Over the past 25 years, he has served as the primary staff scientist and/or project officer for NTP inhalation toxicity and carcinogenicity studies.
Roycroft received a B.A. in botany from the University of North Carolina at Chapel Hill, a B.S. in zoology from North Carolina State University and a Ph.D. in pharmacology from the University of North Carolina at Chapel Hill. He was an NIH postdoctoral fellow in toxicology at Duke University, Duke University Medical Center, Department of Physiology and Pharmacology.
Selected Publications
Melnick, R.L., Nyska, A., Foster, P.M., Roycroft, J.H., and Kissling, G.E. Toxicity and carcinogenicity of the water disinfection byproduct, dibromoacetic acid, in rats and mice. Toxicology 2007 230 (2-3), 126-136. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/17157429?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Dill, J. A., Fuciarelli, A. F., Lee, K. M., Mellinger, K. M., Burka, L. T., and Roycroft, J. H. Toxicokinetics of propylene glycol mono-t-butyl ether following intravenous or inhalation exposure in rats and mice. Inhalation Toxicology 2004 16[5], 271-290.
[Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/15371180?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Doi, A. M., Roycroft, J. H., Herbert, R. A., Haseman, J. K., Hailey, J. R., Chou, B. J., Dill, J. A., Grumbein, S. L., Miller, R. A., Renne, R. A., and Bucher, J. R Inhalation toxicology and carcinogenesis studies of propylene glycol mono-t-butyl ether in rats and mice. Toxicology 2004 199[1], 1-22. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/15125995?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Dill, J. A., Lee, K. M., Mellinger, K. H., Bates, D. J., Burka, L. T., and Roycroft, J. H. Lung deposition and clearance of inhaled vanadium pentoxide in chronically exposed F344 rats and B6C3F1 mice. Toxicological Sciences 2004 77[1], 6-18. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/14600283?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Dill, J. A., Fuciarelli, A. F., Lee, K. M., Mellinger, K. M., Chan, P. C., Burka, L. T., and Roycroft, J. H. Single administration toxicokinetic studies of decalin (decahydronaphthalene) in rats and mice. Toxicological Sciences 2003 72[2], 210-222.
[Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/12660358?ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Dill, J.A., Lee, K. M., Renne, R. A., Miller, R.A., Fuciarelli, A. F., Gideon, K. M., Chan, P.C., Burka, L.T., and Roycroft, J.H. Alpha (2u)-globulin nephropathy and carcinogenicty following exposure to decalin (decahydronapthalene) in F344/N rats. Toxicological Sciences 2003 72[2], 223-234. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/12660359?ordinalpos=8&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Devereux, T.R., Holliday, W., Anna, C., Ress, N., Roycroft, J., and Sills, R.C. Map kinase activation correlates with K-ras mutation and loss of heterozygocity on chromosome 6 in alveolar bronchiolar carcinomas from B6C3F1 mice exposed to vanadium pentoxide for 2 years. Carcinogenesis 2002 23[10], 1737-1743. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/12376484?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Long PH, Maronpot RR, Ghanayem BI, Roycroft JH, Nyska A. Dental pulp infarction in female rats following inhalation exposure to 2-butoxyethanol. Toxicol Pathol. 2000 Mar-Apr;28(2):246-52. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/10805142?ordinalpos=10&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
van Birgelen AP, Chou BJ, Renne RA, Grumbein SL, Roycroft JH, Hailey JR, Bucher JR. Effects of glutaraldehyde in a 2-year inhalation study in rats and mice. Toxicol Sci. 2000 May;55(1):195-205. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/10788574?ordinalpos=11&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Nyska A, Maronpot RR, Long PH, Roycroft JH, Hailey JR, Travlos GS, Ghanayem BI Disseminated thrombosis and bone infarction in female rats following inhalation exposure to 2-butoxyethanol. Toxicol Pathol. 1999 May-Jun;27(3):287-94. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/10356705?ordinalpos=12&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Melnick RL, Sills RC, Portier CJ, Roycroft JH, Chou BJ, Grumbein SL, Miller RA. Multiple organ carcinogenicity of inhaled chloroprene (2-chloro-1,3-butadiene) in F344/N rats and B6C3F1 mice and comparison of dose-response with 1,3-butadiene in mice. Carcinogenesis. 1999 May; 20(5):867-78. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/10334205?ordinalpos=13&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Dill JA, Lee KM, Bates DJ, Anderson DJ, Johnson RE, Chou BJ, Burka LT, Roycroft JH. Toxicokinetics of inhaled 2-butoxyethanol and its major metabolite, 2-butoxyacetic acid, in F344 rats and B6C3F1 mice. Toxicol Appl Pharmacol. 1998 Dec;153(2):227-42.
[Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/9878593?ordinalpos=14&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Lee KM, Dill JA, Chou BJ, Roycroft JH. Physiologically based pharmacokinetic model for chronic inhalation of 2-butoxyethanol. Toxicol Appl Pharmacol. 1998 Dec;153(2):211-26. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/9878592?ordinalpos=15&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Chan PC, Herbert RA, Roycroft JH, Haseman JK, Grumbein SL, Miller RA, Chou BJ. Lung tumor induction by inhalation exposure to molybdenum trioxide in rats and mice. Toxicol Sci. 1998 Sep;45(1):58-65. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/9848111?ordinalpos=16&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Hong HH, Devereux TR, Roycroft JH, Boorman GA, Sills RC. Frequency of ras mutations in liver neoplasms from B6C3F1 mice exposed to tetrafluoroethylene for two years. Toxicol Pathol. 1998 Sep-Oct;26(5):646-50. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/9789951?ordinalpos=17&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Chhabra RS, Herbert RA, Roycroft JH, Chou B, Miller RA, Renne RA. Carcinogenesis studies of tetrahydrofuran vapors in rats and mice. Toxicol Sci. 1998 Feb;41(2):183-8. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/9520354?ordinalpos=18&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
|