Cynthia S. Smith, Ph.D.

Program Operations Branch

Cynthia S. Smith, Ph.D.
Chemist and Acting Chief, Program Operations Branch

Tel (919) 541-3473
Fax (919) 541-3687
smith19@niehs.nih.gov

P.O. Box 12233
Mail Drop K2-07
Research Triangle Park, North Carolina 27709
Delivery Instructions

Cynthia Smith, Ph.D., is an analytical chemist and Acting Chief of the Program Operations Branch in the National Toxicology Program (NTP) at the National Institute of Environmental Health Sciences. As such, she is responsible for directing the work of chemists, toxicologists and information specialists involved in the study conduct portion of the testing program. She also serves as Chemistry Discipline Leader for NIEHS studies conducted under the NTP. In this capacity, she provides expertise in analytical chemistry for the design of NTP studies and is a resource for oversight of contract laboratory chemistry activities.

As a chemist, Smith’s research interests include the development and use of techniques and methodology for separating and quantitating components of complex mixtures. A current focus is on NTP studies of herbal products, which have been a challenge. The studies require the development of a considered approach to characterization of NTP test articles and formulations. Smith is also active in the Tox21 collaboration for High Throughput Screening in toxicology and serves as co-chair of the Chemical Selection Committee. Her interest in this area is in devising quality control (QC) approaches that are compatible with the high throughput scale and wide variety of test articles in the program.

Smith received a bachelor’s degree (magna cum laude) in chemistry from North Georgia College in Dahlonega, Georgia in 1972 and a doctorate in analytical chemistry from the University of South Carolina in Columbia, South Carolina, in 1986. Before joining NIEHS in 1996, she worked with contract research organizations developing methods and instrument and performance evaluation standards for suites compounds of environmental concern in air, water and soil. Her efforts at NIEHS have resulted in honors including several NIH Merit Awards and an NIEHS Unsung Hero award. She is a member of the American Chemical Society, the Association of Analytical Chemists (AOAC), and the Society of Toxicology.

Selected Publications

1. Weber, HA, Hodges, AE, Guthrie, JR, O’Brien, BM, Robaugh, D, Clark, AP, Harris, RK, Algaier, JW, Smith, CS. Comparison of Proanthocyanidins in Commercial Antioxidants: Grape Seed and Pine Bark Extracts. J. Agric. Food Chem. 55(1) 148, (2007). [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/17199326?ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
2. Kissling, GE, Bernheim, NJ, Hawkins, WE, Wolfe, MJ, Jokinin, MP, Smith, CS, Herbert, RA, Boorman, GA. The Utility of the Guppy (Poecilia reticulate) and Medaka (Oryzias latipes) in Evaluation of Chemicals for Carcinogenicity. Toxicol. Sci. 92: 143, 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/16581948?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
3. Sanders, JM, Burka, LT, Smith, CS, Black, W, James, R, Cunningham, ML. Differential Expression of CYP1A, 2B, and 3A Genes in the F344 Rat Following Exposure to a Polybrominated Diphenyl Ether Mixture or Individual Components. Tox. Sci. 88(1), 127, 2005. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/16107549?ordinalpos=13&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
4. Gray, DE, Messer, D, Porter, A, Ferguson, S, Harris, RK, Clark, AP, Algaier, JA, Overstreet, JD, and Smith, CS. Simultaneous Quantitation of Terpenelactones and Flavonol Aglycones in Hydrolyzed Ginkgo biloba Extract by High-Performance Liquid Chromatography with In-Line Ultraviolet and Evaporative Light Scattering Detection. JAOAC Int 88(6); 1613, 2005. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/16526440?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
5. Morgan, D.L., Su, YF, Dill, JA, Turnier, JC, Westerberg, RB, and Smith, CS, Chemical and Physical Characteristics of Cellulose Insulation Particulates, and Evaluation of Potential Acute Pulmonary Toxicity. Amer. J. Ind. Med. 46: 554 (2004). [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/15551371?ordinalpos=23&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
6. Weber, HA, Zart, MK, Hodges, AE, White, KD, Barnes, SM, Moody, LA, Clark, AP, Harris, RK, Overstreet, JD, and Smith, CS. Method Validation for Determination of Alkaloid Content in Goldenseal Root Powder. J. AOAC Int. 86(3):476 (2003). [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/12852562?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
7. Weber, HA, Zart, MK, Hodges, AE, Molloy, HM, O’Brien, BM, Moody, LA, Clark, AP, Harris, RK, Overstreet, JD, and Smith, CS. Chemical Comparison of Goldenseal (Hydrastis canadensis L.) Root Powder from Three Commercial Suppliers. J. Agric. Food Chem., 51: 7352 (2003) [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/14640583?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
8. Johnson JD, Reichelderfer DL, Burback BL, Walters DL, Zutshi A, Graves SW, and Smith CS. Toxicokinetics of 2-Methylimidazole in Male and Female F344 Rats. J. Toxicol. Environ. Health, 65 (12): 869 (2002). [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/12079612?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
9. Weber, HA, Zart, MK, Ferguson, SL, Greaves, JG, Clark, AP, Harris, RK, Overstreet, JD, and Smith, CS. Separation and Quantitation of Isoquinoline Alkaloids Occuring in Goldenseal. J. Liq. Chrom. & Rel. Technol., 24(1): 87 (2001).
10. Tully DB, Collins BJ, Overstreet JD, Smith CS, Mumtaz MM, and Chapin RE. Identification of Biomarkers of Toxicity for Four High Priority Heavy Metal Pollutants in Recombinant HepG2 Cells. Toxicol. Appl. Pharmacol., 168, 79 (2000).
11. M. Yan, Moore RJ, Wagnon KB, Pierce JT, Debban KH, Smith CS, Dill JA, and Fuciarelli AF. Analysis of α_2µ-Globulin in Rat Urine and Kidneys by Liquid Chromatography-Electrospray Ionization Mass Spectrometry. Chem. Res. Tox, 11(9): 953, 1998. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/9705758?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
12. Voyksner RD, Smith CS and Knox PC. Optimization and Application of Particle Beam High-Performance Liquid-Chromatography Mass-Spectrometry to Compounds of Pharmaceutical Interest. Biomed. and Environ. Mass Spectrometry, 19(9):523, 1990. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/2224179?ordinalpos=23&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
13. Raymer JH, Smith CS, Pellizari ED, and Velez G. Pyrolysis Coupled with Capillary Supercritical Fluid Chromatography. J. Liq. Chromatogr. 13(7): 11261, 1990.

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