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Your Environment. Your Health.

Selected Publications

Metabolism & Molecular Mechanisms Group

  1. Trivedi DB, Loftin CD, Clark J, Myers P, DeGraff LM, Cheng J, Zeldin DC, Langenbach R. ß-Arrestin-2 deficiency attenuates abdominal aortic aneurysm formation in mice. Circulation research 2013 112(9):1219-1229.[Abstract ]
  2. Lao HC, Akunda JK, Chun KS, Flake GP, Yuspa SH, Langenbach R. Genetic ablation of cyclooxygenase-2 in keratinocytes produces a cell-autonomous defect in tumor formation. Carcinogenesis 2012 33(11):2293-2300.[Abstract ]
  3. Lee JK, Sayers BC, Chun KS, Lao HC, Shipley-Phillips JK, Bonner JC, Langenbach R. Multi-walled carbon nanotubes induce COX-2 and iNOS expression via MAP Kinase-dependent and -independent mechanisms in mouse RAW264.7 macrophages. Particle and fibre toxicology 2012 9:14-.[Abstract ]
  4. Chun KS, Langenbach R. The Prostaglandin E2 receptor, EP2, regulates survivin expression via an EGFR/STAT3 pathway in UVB-exposed mouse skin. Mol. Carcinog. 2011;50(6):439-448.[Abstract ]
  5. Chun KS, Lao HC, Langenbach R. The Prostaglandin E2 receptor, EP2, stimulates keratinocyte proliferation in mouse skin by G protein-dependent and {beta}-arrestin1-dependent signaling pathways. J Biol Chem 2010;285(51):39672-39681.[Abstract ]
  6. Langenbach R, Lao HC, Chun KS, Trempus C, Okada M. The prostaglandin receptor EP2 activates multiple signaling pathways and beta-arrestin1 complex formation during mouse skin papilloma development. Carcinogenesis 2009;30(9):1620-1627.[Abstract ]
  7. Chun KS, Akunda, JK, Langenbach, R. Cyclooxygenase-2 inhibits UVB-induced apoptosis in mouse skin by activating the prostaglandin E2 receptors, EP2 and EP4. Cancer Res. 2007;67(5):2015-21.[Abstract ]
  8. Toscano CD, Prabhu VV, Langenbach R, Becker KG, Bosetti F. Differential gene expression patterns in cyclooxygenase-1 and cyclooxygenase-2 deficient mouse brain. Genome Biol. 2007;8(1):R14.[Abstract ]
  9. Akunda JK, Chun KS, Sessoms AR, Lao HC, Fischer SM, Langenbach R. Cyclooxygenase-2 deficiency increases epidermal apoptosis and impairs recovery following acute UVB exposure. Mol. Carcinog. 2007;46:354-262.[Abstract ]
  10. Fischer SM, Pavone A, Mikulec C, Langenbach R, Rundhaug JE. Cyclooxygenase-2 expression is critical for chronic UV-induced murine skin carcinogenesis. Mol. Carcinog. 2007;46:363-371.[Abstract ]
  11. Akunda AK, Lao H-C, Lee CA, Sessoms AR, Slade R, Langenbach R. Deficiency or Pharmacological Inhibition of Cyclooxygenase-1 or -2 Induces Mouse Keratinocyte Differentiation in-vivo and in-vitro. FASEB J. 2004;18:185-187.[Abstract ]
  12. Gray T, Nettesheim P, Loftin C, Tiano H, Koo J.-S, Langenbach R. IL-1 _ Induced MUC5AC Mucin Production in Normal Human Airway Epithelium is Mediated by EP Receptor:c-AMP/PKA Signaling. Mol. Pharmacol. 2004;66:337-346.[Abstract ]
  13. Okeda H, Oshima H, Chulada PC, Langenbach R, Oshima M, Taketo MM. Cooperation of cyclooxygenase 1 and Cyclooxygenase 2 in Intestinal polyposis. Cancer Res. 2003;63:4872-4877. [Abstract ]
  14. Loftin CD, Trivedi D, Tiano HF, Langenbach R. Cyclooxygenase-1-Selective Inhibition Prolongs Gestation in Mice and Lacks Adverse Effects on the Ductus Arteriosus. J. Clin. Invest. 2002;110:549-557. [Abstract ]
  15. Tiano H, Loftin C, Akunda J, Lee C, Spalding J, Sessoms A, Dunson D, Rogan E, Morham S, Smart R, Langenbach R. Deficiency of Cyclooxygenase-1 or Cyclooxygenase-2 Alters Epidermal Differentiation and Reduces Mouse Skin Tumorigenesis. Cancer Res. 2002;62:3395-3401. [Abstract ]
  16. Bonner JC, Rice AB, Moomaw CR, Nyska A, Bradbury A, Chulada PC, Morgan DL, Zeldin DC, Langenbach R. Susceptibility of Cyclooxygenase (COX)-2 Deficient Mice to Pulmonary Fibrogenesis. Amer. J. Pathol. 2002;161:459-470. [Abstract ]
  17. Loftin CD, Tiano HF, Trivedi DB, Clark JA, Lee CA, Epstein JA, Breyer MD, Morham SG, Koller BH, Smithies O, Langenbach R. Failure of Ductus Arteriosus Closure and Remodeling in Neonatal Mice Deficient in Both Cyclooxygenase-1 and Cyclooxygenase-2. Proc. Natl. Acad. Sci. USA. 2001;98:1059-1064.[Abstract ]
  18. Chulada PC, Thompson MB, Mahler JF, Doyle CM, Gaul BW, Lee C, Tiano HF, Morham SG, Smithies O, Langenbach R. Genetic Disruption of Ptgs-1 , as well as of Ptgs-2 , Reduces Intestinal Tumorigenesis in Min Mice. Cancer Res. 2000;60:4705-4708.[Abstract ]

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