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Selected Publications

Free Radical Metabolism Group

  1. Sipe HJ Jr, Lardinois OM, Mason RP. Free radical metabolism of methyleugenol and related compounds. Chemical research in toxicology 2014 27(4):483-489.[Abstract ]
  2. Sinha BK, Leinisch F, Bhattacharjee S, Mason RP. DNA Cleavage and Detection of DNA Radicals Formed from Hydralazine and Copper (II) by ESR and Immuno-Spin Trapping. Chemical research in toxicology 2014 27(4):674-682[Abstract ]
  3. Lardinois, O.M., Detweiler, C.D., Tomer, K.B., Mason, R.P., Deterding, L.J. Identifying the site of spin trapping in proteins by a combination of liquid chromatography, ELISA and off-line tandem mass spectrometry. Free Radical Biology & Medicine 44(5):893-906; 2008.[Abstract ]
  4. Connor, H.D., Sturgeon, B.E., Mottley, C., Sipe, H.J., Mason, R.P. L-tryptophan radical cation electron spin resonance studies: connecting solution-derived hyperfine coupling constants with protein spectral interpretations. J Am Chem Soc. 130: 6381-6387; 2008.[Abstract ]
  5. Cassina, P., Cassina, A., Pehar, M., Castellanos, R., Gandelman, M., de León, A., Robinson, K.M., Mason, R.P., Beckman, J.S., Barbeito, L., Radi, R. Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants. J Neurosci. 28(16):4115-22; 2008.[Abstract ]
  6. Siraki, A.G., Deterding, L., Bonini, M.G., Jiang, J.J., Ehrenshaft, M., Mason, R.P. Procainamide but not N-acetylprocainamide induces protein free radical formation on myeloperoxidase: A potential mechanism of agranulocytosis. Chemical Research in Toxicology 21(5):1143-1153; 2008.[Abstract ]
  7. Rehman, H., Connor, H.D., Ramshesh, V.K., Theruvath, T.P., Mason, R.P. Wright, G.L., Lemasters, J.J., Zhong, Z. Ischemic preconditioning prevents free radical production and mitochondrial depolarization in small-for-size rat liver grafts. Transplantation 85(9):1322-1331; 2008.[Abstract ]
  8. Bonini, M.G., Stadler, K., Silva, S.O., Corbett, J., Dore, M., Petranka, J., Fernandes, D.C., Tanaka, L.Y., Duma, D., Laurindo, F.R.M, Mason, R.P. Constitutive nitric oxide synthase activation is a significant route for nitroglycerin-mediated vasodilation. Proceedings of the National Academy of Sciences of the United States of America 105(25):8569-8574; 2008.[Abstract ]
  9. Liu, J., Qian, S.Y., Guo, Q., Jiang, J., Waalkes, M.P., Mason, R.P., Kadiiska, M.B. Cadmium generates reactive oxygen-and carbon-centered radical species in rats: insights from in vivo spin-trapping studies. Free radical biology & medicine 45(4):475-481; 2008.[Abstract ]
  10. Stadler, K., Bonini, M.G., Dallas, S., Duma, D., Mason, R.P., Kadiiska, M.B. Direct evidence of iNOS-mediated in vivo free radical production and protein oxidation in acetone-induced ketosis. American journal of physiology. Endocrinology and metabolism 295(2):E456-E462; 2008.[Abstract ]
  11. Lardinois, O.M., Tomer, K.B., Mason, R.P., Deterding, L.J. Identification of protein radicals formed in the human neuroglobin-H2O2 reaction using immuno-spin trapping and mass spectrometry. Biochemistry 47(39):10440-10448; 2008.[Abstract ]
  12. Stadler, K., Bonini, M.G., Dallas, S., Jiang, J.J., Radi, R., Mason, R.P., Kadiiska, M. Involvement of inducible nitric oxide synthase in hydroxyl radical-mediated lipid peroxidation in streptozotocin-induced diabetes. Free radical biology & medicine 45(6):866-874; 2008.[Abstract ]
  13. Ranguelova, K., Suarez, J., Magliozzo, R.S., and Mason, R.P.: Spin trapping investigation of peroxide-and isoniazid-induced radicals in Mycobacterium tuberculosis catalase-peroxidase. Biochemistry 47:11377-11385, 2008.[Abstract ]
  14. Ramirez, D.C., Gomez-Mejiba, S.E., Corbett, J.T., Deterding, L.J., Tomer, K.B., Mason, R.P. Cu,Zn-superoxide dismutase-driven free radical modifications: copper- and carbonate radical anion-initiated protein radical chemistry. Biochem J. 417(1):341-353; 2009.[Abstract ]
  15. Brimfield, A.A., Mancebo, A.M., Mason, R.P., Jiang, J., Sirak, A.G., Novak, M.J. Free radical production from the interaction of 2-chloroethyl vesicants (mustard gas) with pyridine nucleotide-driven flavoprotein electron transport systems. Toxicology and applied pharmacology 234(1):128-134; 2009.[Abstract ]
  16. Chatterjee, S., Ehrenshaft, M., Bhattacharjee, S., Deterding, L.J., Bonini, M.G., Corbett, J., Kadiiska, M., Tomer, K.B., Mason, R.P. Immuno-spin trapping of a post-translational carboxypeptidase B1 radical formed by a dual role of xanthine oxidase and endothelial nitric oxide synthase in acute septic mice. Free radical biology & medicine 46(4):454-461; 2009.[Abstract ]
  17. Ehrenshaft, M., de Oliveira Silva, S., Perdivara, I., Bilski, P., Sik, R.H., Chignell, C.F., Tomer, K.B., Mason, R.P. Immunological detection of N-formylkynurenine in oxidized proteins. Free radical biology & medicine 46(9):1260-1266; 2009.[Abstract ]
  18. Miyakawa H., Mason R.P., Jiang J.-J., Kadiiska M.B. Lipid-derived free radical production in superantigen-induced interstitial pneumonia. Free radical biology & medicine 47(3):241-249; 2009.[Abstract ]
  19. Lardinois, O.M., Maltby, D.A., Medzihradszky, K.F., Ortiz de Montellano, P.R., Tomer, K.B., Mason, R.P., Deterding, L.J. Spin Scavenging Analysis of Myoglobin Protein-Centered Radicals Using Stable Nitroxide Radicals: Characterization of Oxoammonium Cation-Induced Modifications. Chemical Research in Toxicology 22(6):1034-1049; 2009.[Abstract ]
  20. Ranguelova, K. and Mason R.P.: New insights into the detection of sulfur trioxide anion radical by spin trapping: radical trapping versus nucleophilic addition. Free Radical Biol. Med. 47:128–134, 2009.[Abstract ]
  21. Bonini, M.G., Gabel, S.A., Ranguelova, K., Stadler, K., Derose, E.F., London, R.E., and Mason R.P.: Direct magnetic resonance evidence for peroxymonocarbonate involvement in the Cu, Zn-superoxide dismutase peroxidase catalytic cycle. J. Biol. Chem. 284:14618-14627, 2009.[Abstract ]
  22. Chatterjee, S., Lardinois, O., Bonini, M.G., Bhattacharjee, S., Stadler, K., Corbett, J., Deterding, L. J., Tomer, K.B., Kadiiska, M., and Mason, R.P.: Site-specific carboxypeptidase B1 tyrosine nitration and pathophysiological implications following its physical association with nitric oxide synthase-3 in experimental sepsis. J. Immunology 183:4055–4066, 2009.[Abstract ]
  23. Kojima C, Ramirez DC , Tokar EJ, Himeno S , Drobná Z, Stýblo M, Mason R.P., Waalkes MP. Requirement of arsenic biomethylation for oxidative DNA damage. Journal of the National Cancer Institute 2009 101(24):1670-81.[Abstract ]
  24. Siraki, A.G., Jiang, J., and Mason, R.P.: Investigating the mechanisms of aromatic amine-induced protein free radical formation by quantitative structure-activity relationships: implications for drug-induced agranulocytosis. Chem. Res. Toxicol. 23:880–887, 2010.[Abstract ]
  25. Gomez-Mejiba, S.E., Zhai, Z., Gimenez, M.S., Ashby, M.T., Chilakapati, J., Kitchin, K., Mason, R.P., and Ramirez, D.C.: Myeloperoxidase-induced genomic DNA-centered radicals. J. Biol. Chem. 285:20062-20071, 2010.[Abstract ]
  26. Ranguelova K., Bonini M.G., Mason R.P. (Bi)sulfite Oxidation by Copper,Zinc-Superoxide Dismutase: SulfiteDerived, Radical-Initiated Protein Radical Formation. Environmental health perspectives 118(7):970-975; 2010.[Abstract ]
  27. Ehrenshaft, M., Bonini, M.G., Feng, L., Chignell, C.F., and Mason, R.P.: Partial colocalization of oxidized, N-formylkynurenine-containing proteins in mitochondria and Golgi of keratinocytes. Photochem. Photobiol. 86:752–756, 2010.[Abstract ]
  28. Ranguelova, K., Chatterjee, S., Ehrenshaft, M., Ramirez, D.C., Summers, F.A., Kadiiska, M.B., and Mason, R.P.: Protein radical formation resulting from eosinophil peroxidase-catalyzed oxidation of sulfite. J. Biol. Chem. 285:24195–24205, 2010.[Abstract ]
  29. Lardinois, O.M., Chatterjee, S., Mason, R.P., Tomer, K.B., Deterding, L.J. Biotinylated analogue of the spin-trap 5,5-dimethyl-1-pyrroline-N-oxide for the detection of low-abundance protein radicals by mass spectrometry. Analytical Chemistry 82(22):9155-9158; 2010.[Abstract ]
  30. Chatterjee, S., Lardinois, O., Bhattacharjee, S., Tucker, J., Corbet, J., Deterding. L,, Ehrenshaft, M., Bonini, M., Mason, R.P. Oxidative stress induces protein and DNA radical formation in follicular dendritic cells (FDCs) of the germinal center and modulates its cell death patterns in late sepsis. Free radical biology & medicine 50(8):988-999; 2011.[Abstract ]
  31. Bhattacharjee, S., Deterding, L.J., Chatterjee, S., Jiang, J.J., Ehrenshaft, M., Lardinois, O., Ramirez, D.C., Tomer, K.B., Mason, R.P. Site-specific radical formation in DNA induced by Cu(II)-H2O2 oxidizing system, using ESR, Immuno-spin trapping, LC-MS and MS/MS. Free radical biology & medicine 50(11):1536-1545; 2011.[Abstract ]
  32. Zhao, B., Ranguelova, K., Jiang, J.J., Mason, R.P. Studies on the photosensitized reduction of resorufin and implications for the detection of oxidative stress with Amplex Red. Free radical biology & medicine 51(1):153-159; 2011.[Abstract ]
  33. Ganini, D., Christoff, M., Ehrenshaft, M., Kadiiska, M.B., Mason, R.P., and Bechara, E.J.: Myoglobin-H2O2 catalyzes the oxidation of β-ketoacids to α-dicarbonyls: Mechanism and implications in ketosis. Free Radical Biol. Med. 51:733-743, 2011.[Abstract ]
  34. Duma, D., Fernandes, D., Bonini, M.G., Stadler, K., Mason, R.P., and Assreuy, J.: NOS-1-derived NO is an essential triggering signal for the development of systemic inflammatory responses. Eur. J. Pharmacol. 668:285–292, 2011.[Abstract ]
  35. Kadiiska MB, Hatch GE, Nyska A, Jones DP, Hensley K, Stocker R, George MM, Van Thiel DH, Stadler K, Barrett JC, Mason R.P. Biomarkers of oxidative stress study IV: Ozone exposure of rats and its effect on antioxidants in plasma and bronchoalveolar lavage fluid. Free Radic Biol Med. 51(9):1636-42; 2011.[Abstract ]
  36. Sun, Y., Kojima, C., Chignell, C., Mason, R.P., and Waalkes, M.P.: Arsenic transformation predisposes human skin keratinocytes to UV-induced DNA damage yet enhances their survival apparently by diminishing oxidant response. Toxicol. Appl. Pharmacol. 255:242–250, 2011.[Abstract ]
  37. Ehrenshaft, M., Zhao, B., Andley, U.P., Mason, R.P., Roberts, J.E. Immunological Detection of N-formylkynurenine in Porphyrin-Mediated Photooxided Lens α-crystallin. Photochemistry and photobiology 87(6):1321-1329; 2011.[Abstract ]
  38. Leinisch, F., Jiang, J., Deterding, L.J., and Mason, R.P.: Simplified synthesis of isotopically labeled 5,5-dimethylpyrroline N-oxide. Molecules 16:8428-8436, 2011.[Abstract ]
  39. Leinisch F, Ranguelova K, DeRose EF, Jiang J, Mason R.P. Evaluation of the Forrester-Hepburn mechanism as an artifact source in ESR spin-trapping. Chemical research in toxicology. 24(12):2217-26; 2011.[Abstract ]
  40. Mao, M., Varadarajan, S., Ansenberger-Fricano, K., Fernendes, D.C., Tanaka, L.Y., Fukai, T., Laurindo, F.R.M., Mason, R.P., Vasquez-Vivar, J., Minshall, R.D., Stadler, K., and Bonini, M.G.: Nitroglycerin drives endothelial nitric oxide synthase activation via the phosphatidylonositol 3-kinase/protein B pathway. Free Radical Biol. Med. 52:427-435, 2012.[Abstract ]
  41. Ranguelova, K., Rice, A.B., Khajo, A., Triquigneaux, M., Garantziotis, S., Magliozzo, R.S., and Mason, R.P.: Formation of reactive sulfite-derived free radicals by the activation of human neutrophils: An ESR study. Free Radical Biol. Med. 52:1264-1271. 2012.[Abstract ]
  42. Sato, K., Corbett, J., Mason, R.P., and Kadiiska, M.B.: In vivo evidence of free radical generation in the mouse lung after exposure to Pseudomonas aeruginosa bacterium: An ESR spin-trapping investigation. Free Radical Research 46:645-655, 2012.[Abstract ]
  43. Chatterjee, S., Rana, R., Corbett, J., Kadiiska, M.B., Goldstein, J., and Mason, R.P.: P2X7 receptor-NADPH oxidase axis mediates protein radical formation and Kupffer cell activation in carbon tetrachloride-mediated steatohepatitis in obese mice. Free Radical Biol. Med. 52:1666-1679, 2012.[Abstract ]
  44. Bhattacharjee S, Chatterjee S Jiang JJ , Sinha BK, Mason R.P. Detection and imaging of the free radical DNA in cells--site-specific radical formation induced by Fenton chemistry and its repair in cellular DNA as seen by electron spin resonance, immuno-spin trapping and confocal microscopy. Nucleic Acids Research. 40(12):5477-86; 2012.[Abstract ]
  45. Khoo, N.K.H., Cantu-Medellin, N., Devlin, J.E., Croix, C.M., Watkins, S.C., Fleming, A.M., Champion, H.C., Mason, R.P., Freeman, B.A., and Kelley, E.E.: Obesity-induced tissue free radical generation: An in vivo immuno-spin trapping study. Free Radical Biol. Med. 52:2312–2319, 2012.[Abstract ]
  46. Zhai, Z., Gomez-Mejiba, S.E., Gimenez, M.S., Deterding, L.J., Tomer, K.B., Mason, R.P., Ashby, M.T., and Ramirez, D.C.: Free radical-operated proteotoxic stress in macrophages primed with lipopolysaccharide. Free Radical Biol. Med. 53:172–181, 2012.[Abstract ]
  47. Towner, R.A., Smith, N., Saunders, D., Henderson, M., Downum, K., Lupu, F., Silasi-Mansat, R., Ramirez, D.C., Gomez-Mejiba, S.E., Bonini, M.G., Ehrenshaft, M., and Mason, R.P.: In vivo imaging of immunospin-trapped radicals with molecular magnetic resonance imaging in a mouse diabetes model. Diabetes. 61:2405–2413, 2012.[Abstract ]
  48. Ranguelova, K., Ganini, D., Bonini, M.G., London, R.E., and Mason, R.P..: Kinetics of the oxidation of reduced Cu,Zn-superoxide dismutase by peroxymonocarbonate. Free Radical Biol. Med. 53:589–594, 2012.[Abstract ]
  49. Yin, J.J., Liu, J., Ehrenshaft, M., Roberts, J.E., Fu, P.P., Mason, R.P., and Zhao B.: Phototoxicity of nano titanium dioxides in HaCaT keratinocytes - generation of reactive oxygen species and cell damage. Toxicol. Appl. Pharmacol. 263:81-88, 2012.[Abstract ]
  50. Zhao, B., Summers, F.A., and Mason, R.P.: Photooxidation of Amplex red to resorufin: Implications of exposing the Amplex red assay to light. Free Radical Biol. Med. 53:1080–1087, 2012.[Abstract ]
  51. Ganini D, Canistro D, Jang J, Stadler K, Mason R.P., Kadiiska MB. Ceruloplasmin (ferroxidase) oxidizes hydroxylamine probes: Deceptive implications for free radical detection. Free radical biology & medicine  53(7):1514-21, 2012.[Abstract ]
  52. Triquigneaux, M.M., Ehrenshaft, M., Roth, E., Silman, I., Ashani, Y., Mason, R.P., Weiner, L., and Deterding, L.J.: Targeted oxidation of Torpedo californica acetylcholinesterase by singlet oxygen: Identification of N-formylkynurenine tryptophan derivatives within the active-site gorge of its complex with the photosensitizer methylene blue. Biochem. J. 448:83–91, 2012.  [Abstract ]
  53. Davis, M.F., Zhou, L., Ehrenshaft, M., Ranguelova, K., Gunawardena, H.P., Chen, X., Bonini, M.G., Mason, R.P., and Campbell, S.L.: Detection of Ras GTPase protein radicals through immuno-spin trapping. Free Radical Biol. Med. 53:1339-1345, 2012.[Abstract ]
  54. Uehara, T., Kosyk, O., Jeannot, E., Bradford, B.U., Tech, K., Macdonald, J.M., Boorman, G.A., Chatterjee, S., Mason, R.P., Melnyk, S.B., Tryndyak, V.P., Pogribny, I.P., and Rusyn, I.: Acetaminophen-induced acute liver injury in HCV transgenic mice. Toxicol. Appl. Pharmacol. 266:224-232, 2013.[Abstract ]
  55. Ansenberger-Fricano, K., Ganini, D., Mao, M., Chatterjee, S., Dallas, S., Mason, R.P., Stadler, K., Santos, J.H., and Bonini, M.G.: The peroxidase activity of mitochondrial superoxide dismutase. Free Radical Biol. Med. 54:116-124, 2013.[Abstract ]
  56. Dalsgaard, T.K., Triquigneaux, M., Deterding, L.J., Summers, F., Ranguelova, K., Mortensen, G., and Mason, R.P.: Site-specific detection of radicals on a α-lactalbumin after a riboflavin-sensitized reaction – detected by immune-spin trapping, ESR, and MS. J. Agric. Food Chem. 61:418-426, 2013.[Abstract ]
  57. Summers, F.A., Mason, R.P., and Ehrenshaft, M.: Development of immunoblotting techniques for DNA radical detection. Free Radic Biol Med. 56:64-71, 2013.[Abstract ]
  58. Chatterjee S, Ganini D, Tokar EJ, Kumar A, Das S, Corbett J, Kadiiska M, Waalkes M, Diehl AM, Mason RP. Leptin is key to peroxynitrite-mediated oxidative stress and Kupffer cell activation in experimental non-alcoholic steatohepatitis. Journal of hepatology 2013 58(4):778-784.[Abstract ]
  59. Ranguelova, K., Rice, A.B., Lardinois, O.M., Triquigneaux, M., Steinckwich, N., Deterding, L.J., Garantziotis, S., and Mason, R.P.: Sulfite-mediated oxidation of myeloperoxidase to a free radical: Immuno-spin trapping detection in human neutrophils. Free Radic Biol Med. 60:98-106, 2013.[Abstract ]
  60. Sinha B.K., Bhattacharjee S., Chatterjee S., Jiang J., Motten A.G., Kumar A., Espey M.G., Mason R.P. Role of nitric oxide in the chemistry and anticancer activity of etoposide (VP-16,213). Chemical research in toxicology 26(3):379-387, 2013. [Abstract ]
  61. Das S., Kumar A., Seth R.K., Tokar E.J., Kadiiska M., Waalkes M.P., Mason R.P., Chatterjee S. Proinflammatory adipokine leptin mediates disinfection byproduct bromodichloromethane-induced early steatohepatitic injury in obesity. Toxicology and Applied Pharmacology 269(3):297-306, 2013.[Abstract ]
  62. Ehrenshaft M, Roberts JE, Mason RP. Hypericin-mediated photooxidative damage of α-crystallin in human lens epithelial cells. Free Radical Biology & Medicine  60():347-354; 2013.[Abstract ]
  63. Brar SS, Petrovich RM, Williams JG, Mason JM. Phosphorylation at Serines 216 and 221 Is Important for Drosophila HeT-A Gag Protein Stability. PloS one 2013 8(9):e75381-.[Abstract ]
  64. Sinha BK, Kumar A, Bhattacharjee S, Espey MG, Mason RP. Effect of nitric oxide on the anticancer activity of the topoisomerase-active drugs etoposide and adriamycin in human melanoma cells. The Journal of pharmacology and experimental therapeutics 347(3):607-614, 2013[Abstract ]
  65. Leinisch F, Jiang J, DeRose EF, Mason R.P. Investigation of spin-trapping artifacts formed by the Forrester-Hepburn mechanism. Free radical biology & medicine 65(December):1497-1505, 2013.[Abstract ]

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