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Your Environment. Your Health.

Selected Publications

Comparative Genomics Group

  1. Meyer, J.N., Boyd, W.A., Azzam, G.A., Haugen, A.C., Freedman, J.H., and Van Houten, B. (2007) Decline of nucleotide excision repair capacity in aging Caenorhabditis elegans. Genome Biol. 8, R70.
  2. Cui, Y., McBride, S.J., Boyd, W.A., Alper, S., and Freedman, J.H. (2007) Toxicogenomic analysis of Caenorhabditis elegans reveals novel genes and pathways involved in the resistance to cadmium toxicity. Genome Biol. 8, R122.
  3. .Alper, S., Laws, R., Lackford, B., Boyd, W.A., Dunlap, P., Freedman, J.H., and Schwartz, D.A. (2008) Identification of innate immunity genes and pathways using a comparative genomics approach. Proc. Natl. Acad. Sci., U.S.A.105, 7016-7021.
  4. Jin, Y.h., Dunlap, P., Al-Refai1, H., McBride, S.J., Bushel, P., and Freedman, J.H. (2008) Global transcriptome and deletome profiles of yeast exposed to transition metals. PLoS Genet. 4, e1000053.
  5. Mattie, M.D., McElwee, M., and Freedman, J.H. (2008) Mechanism of copper-activated transcription: Activation of AP-1, and the JNK/SAPK and p38 signal transduction pathways. J. Mol. Biol. 383, 1008-1018.
  6. Song, M.O., Li, J., and Freedman, J.H. (2009) Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiological genomics. 38(3):386-401.[Abstract ]
  7. McElwee, M.K., Song, M.O., and Freedman, J.H. (2009) Copper activation of NF-ĸB signaling in HepG2 cells. J. Mol. Biol. 393, 1013–1021
  8. Cui, Y., and Freedman, J.H. (2009) Cadmium induces retinoic acid signaling by regulating retinoic acid metabolic gene expression. Journal of Biological Chemistry. 284(37):24925-24932.[Abstract ]
  9. Boyd, W.A., Crocker, T.L., Rodriguez, A.M., Leung, M.C., Lehmann, D.W., Freedman, J.H., Van Houten, B., and Meyer, J.N. (2010) Nucleotide excision repair genes are expressed at low levels and are not detectably inducible in Caenorhabditis elegans somatic tissues, but their function is required for normal adult life after UVC exposure. Mutat. Res. 683, 57-67
  10. Tvermoes, B.E., Boyd, W.A., and Freedman, J.H. (2010) Molecular characterization of numr-1 and numr-2: genes that increase both resistance to metal-induced stress and lifespan in Caenorhabditis elegans. Journal of cell science. 123(Pt 12):2124-2134.[Abstract ]
  11. Tvermoes, B.E., Bird, G.S., and Freedman, J.H. (2011) Cadmium induces transcription independent of calcium mobilization.  PLoS ONE. 6(6), e20542[Abstract ]
  12. McElwee, M.K., Freedman, J.H. (2011) Comparative toxicology of mercurials in caenorhabditis elegans. Environmental toxicology and chemistry / SETAC 30(9):2135-41.[Abstract ]
  13. Asagoshi, K., Lehmann, W., Braithwaite, E., Santana dos Santos, L., Prasad, R., Freedman J.H., Van Houten, B., and Wilson S. H. (2012) Single-nucleotide base excision repair DNA polymerase activity in C. elegans in the absence of DNA polymerase b.  Nucleic Acids Res. 40, 670 -681
  14. Hall, J., Haas, K.L., and Freedman, J.H. (2012) Role of MTL-1 and MTL-2 and CDR-1 in mediating cadmium sensitivity in C. elegansToxicol. Sci. 128, 418-426[Abstract ]
  15. Sturzenbaum, S. R., Aschner, M., and Freedman, J.H., eds (2012)Toxicogenomics in non-mammalian species in Frontiers in Toxicogenomics, Frontiers Research Foundation, Lausanne, Switzerland.
  16. Song. MO, Lee CH, Yang HO, Freedman JH. (2012) Endosulfan upregulates AP-1 binding and ARE-mediated transcription via ERK1/2 and p38 activation in HepG2 cells. Toxicology  292(1):23-32.[Abstract ]
  17. Harrington J.H., Boyd W.A., Smith M.V., Rice J.R., Freedman J.H., Crumbliss A.L. (2012) Amelioration of metal-induced toxicity in Caenorhabditis elegans: utility of chelating agents in the bioremediation of metals. Toxicological Sciences 129(1):49-56.[Abstract ]
  18. Wang J, Lu J, Mook RA, Zhang M, Zhao S, Barak LS, Freedman JH, Lyerly HK, Chen W. (2012) The insecticide synergist piperonyl butoxide inhibits hedgehog signaling: assessing chemical risks. Toxicological Sciences 128(2):517-23.[Abstract ]
  19. McElwee MK, Ho LA, Chou JW, Smith MV, Freedman JH. Comparative toxicogenomic responses of mercuric and methyl-mercury. BMC Genomics 2013 14:698-.[Abstract ]
  20. Song MO, Mattie MD, Lee CH, Freedman JH. (2014) The role of nrf1 and nrf2 in the regulation of copper-responsive transcription. Experimental cell research 322(1):39-50.[Abstract ]

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