Polypeptide Hormone Action Group
Mechanisms of Signal Transduction
Perry J. Blackshear, M.D., Ph.D.
The Polypeptide Hormone Action Group studies the roles of a small family of CCCH tandem zinc finger proteins, exemplified by tristetraprolin or TTP, in the physiological regulation of mRNA turnover. Group members also study the functions of the MARCKS family of protein kinase C substrate proteins in the normal development of the brain and retina, and the role of a recently described transcription factor, Rfx4_v3, in brain development. Methods used in this research range from structural biology and enzyme kinetics to mouse and human genetics.
The Polypeptide Hormone Action Group is interested in the mechanisms by which signals are transduced after the binding of polypeptide hormones and other agonists to their surface receptors on cells, later resulting in a wide variety of cellular responses.
Major areas of research:
- The involvement of a small family of CCCH tandem zinc finger proteins in mRNA turnover
- The roles of a small family of protein kinase C substrates and a novel transcription factor in the development of the central nervous system
- Protein Kinase C substrates and CNS development
- Zinc finger proteins and mRNA turnover
- RFX4_v3 and brain development
Perry J. Blackshear, M.D., D.Phil., heads the Polypeptide Hormone Action Group within the Laboratory of Signal Transduction. He received his Doctor of Philosophy degree from Oxford University in 1974, and his M.D. from Harvard Medical School in 1977. He has published more than 200 peer-reviewed articles in leading biomedical journals, as well as several book chapters. He served as an Investigator with the Howard Hughes Medical Institute at Duke University, where he was also a Professor of Medicine and of Biochemistry, before joining NIEHS in 1997.