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Selected Publications

Molecular Endocrinology Group

  1. Bortner CD, Cidlowski JA. Ion channels and apoptosis in cancer. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2014 369(1638):20130104-. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/24493752?dopt=Abstract) ]
  2. Gruver-Yates AL, Quinn MA, Cidlowski JA. Analysis of glucocorticoid receptors and their apoptotic response to dexamethasone in male murine B cells during development. Endocrinology 155(2):463-474, 2014. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/24196358?dopt=Abstract) ]
  3. Franco R, Bortner CD, Schmitz I, Cidlowski JA. Glutathione depletion regulates both extrinsic and intrinsic apoptotic signaling cascades independent from multidrug resistance protein 1. Apoptosis: an international journal on programmed cell death 19(1):117-134, 2014. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/24146141?dopt=Abstract) ]
  4. Oakley RH, Cidlowski JA. The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease. Journal of Allergy and Clinical Immunology 2013 132(5):1033-1044. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/24084075?dopt=Abstract) ]
  5. Whirledge S, Cidlowski JA. A role for glucocorticoids in stress-impaired reproduction: beyond the hypothalamus and pituitary. Endocrinology 154(12):4450-4468, 2013. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=24064362) ]
  6. Revollo JR, Oakley RH, Lu NZ, Kadmiel M, Gandhavadi M, Cidlowski JA. HES1 Is a Master Regulator of Glucocorticoid Receptor–Dependent Gene Expression. Science Signaling 6(304):ra103-, 2013. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=24300895) ]
  7. Smith LK, Tandon A, Shah RR, Mav D, Cidlowski JA. Deep Sequencing Identification of Novel Glucocorticoid-Responsive miRNAs in Apoptotic Primary Lymphocytes. PloS one 8(10):e78316-, 2013. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=24250753) ]
  8. Whirledge S, Xu X, Cidlowski JA. Global gene expression analysis in human uterine epithelial cells defines new targets of glucocorticoid and estradiol antagonism. Biology of Reproduction 89(3):66, 2013. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/23843231) ]
  9. Oakley RH, Ren R, Cruz-Topete D, Bird GS, Myers PH, Boyle MC, Schneider MD, Willis MS, Cidlowski JA. Essential role of stress hormone signaling in cardiomyocytes for the prevention of heart disease. Proceedings of the National Academy of Sciences of the United States of America 110(42):17035-40, 2013. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/24082121) ]
  10. Oakley RH, Revollo J, Cidlowski JA. Glucocorticoids regulate arrestin gene expression and redirect the signaling profile of G protein-coupled receptors. Proceedings of the National Academy of Sciences of the United States of America 109(43):17591-6, 2012. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/23045642?dopt=Abstract) ]
  11. Ren R, Oakley RH, Cruz-Topete D, Cidlowski JA. Dual role for glucocorticoids in cardiomyocyte hypertrophy and apoptosis. Endocrinology  153(11):5346-60, 2012. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=22989630) ]
  12. Jewell CM, Scoltock AB, Hamel BL, Yudt MR, Cidlowski JA. Complex human glucocorticoid receptor dim mutations define glucocorticoid induced apoptotic resistance in bone cells. Endocrinology 26(2):244-56, 2012. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=22174376) ]
  13. Bortner CD, Scoltock AB, Sifre MI, Cidlowski JA. Osmotic stress resistance imparts acquired anti-apoptotic mechanisms in lymphocytes.. The Journal of biological chemistry 287(9):6284-95, 2012.  [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/22228768) ]
  14. Gross KL, Oakley RH, Scoltock AB, Jewel CM, Cidlowski JA. Glucocorticoid receptor alpha isoform-selective regulation of antiapoptotic genes in osteosarcoma cells: a new mechanism for glucocorticoid resistance. Molecular Endocrinology 25(7):1087-1099, 2011. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=21527497) ]
  15. Bortner CD, Cidlowski JA. Life and death of lymphocytes: a volume regulation affair. Cell Physiol Biochem 28(6):e1002059, 2011. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/22178997?dopt=Abstract2011) ]
  16. Busillo JM, Azzam KM, Cidlowski JA. Glucocorticoids sensitize the innate immune system through regulation of the NLRP3 inflammasome. The Journal of biological chemistry 286(44):38703-13, 2011. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=21940629" target="_blank") ]
  17. Whirledge S, Cidlowski JA. Glucocorticoids, Stress, and Fertility. Minerva endocrinologica 2010 35(2):109-25. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=20595939) ]
  18. Smith LK, Shah RR, Cidlowski JA. Glucocorticoids modulate microRNA expression and processing during lymphocyte apoptosis. The Journal of biological chemistry 285(47):36698-36708, 2010. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=20847043) ]
  19. Ajiro K, Scoltock A , Smith LK, Ashasima M, Cidlowski JA. Reciprocal Epigenetic Modification of Histone H2B occurs in Chromatin during Apoptosis in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America 17(6):984-993, 2010. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=20057502) ]
  20. Gross KL, Lu NZ, Cidlowski JA. Molecular mechanisms regulating glucocorticoid sensitivity and resistance. Mol Cell Endocrinol, 2008. [Epub ahead of print]. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/19000736?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum) ]
  21. Franco R, Dehaven WI, Sifre MI, Bortner CD, Cidlowski JA. Glutathione depletion and disruption of intracellular ionic homeostasis regulate lymphoid cell apoptosis. J Biol Chem 283(52):36071-36087, 2008. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/18940791?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum) ]
  22. Galliher-Beckley AJ, Williams JG, Collins JB, Cidlowski JA. Glycogen synthase kinase 3beta-mediated serine phosphorylation of the human glucocorticoid receptor redirects gene expression profiles. Molecular and cellular biology 28(24):7309-7322, 2008. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18838540) ]
  23. Gross KL, Cidlowski JA. Tissue-specific glucocorticoid action: A family affair. Trends in endocrinology and metabolism: TEM   19(9):331-339, 2008. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18805703) ]
  24. Bortner CD, Sifre MI, Cidlowski JA. Cationic gradient reversal and cytoskeleton-independent volume fegulatory pathways define an early stage of apoptosis. The Journal of Biological Chemistry 283(11):7219-7229, 2008. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18187415) ]
  25. Lu NZ, Collins JB, Grissom SF, Cidlowski JA. Selective regulation of bone cell apoptosis by translational isoforms of the glucocorticoid receptor. Molecular and Cellular Biology 27(20):7143-7160, 2007. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17682054) ]
  26. Franco R, Panayiotidis MI, Cidlowski JA. Glutathione depletion is necessary for apoptosis in lymphoid cells independent of reactive oxygen species formation. Journal of Biological Chemistry 282(42):30452-30465, 2007. [Abstract (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17724027&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum) ]
  27. Lewis-Tuffin LJ, Jewell CM, Bienstock RJ, Collins JB and Cidlowski JA. Human glucocorticoid receptor ? binds RU-486 and is transcriptionally active.  Molecular and Cellular Biology p. 2266-2282, Mar 2007. [Abstract (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17242213&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum) ]
  28. Lu NZ and Cidlowski JA.  Glucocorticoid receptor isoforms generate transcription specificity.  Trends in Cell Biology 16(6):301-307, 2006. [Abstract (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16697199&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum) ]
  29. Franco R, Bortner CD and Cidlowski JA.  Potential roles of electrogenic ion transport and plasma membrane depolarization in apoptosis. J. of  Membrane Biology 209: 43-58, 2006. [Abstract (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16685600&ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum) ]
  30. Franco R and Cidlowski JA.  SLCO/OATP-like transport of glutathione in FasL-induced apoptosis.  Journal of Biological Chemistry 281 (40):29542-29557, 2006. [Abstract (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16857677&ordinalpos=25&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum) ]
  31. Smoak K and Cidlowski JA.  Glucocorticoids regulate tristetetraprolin synthesis and posttrancriptionally regulate tumor necrosis factor alpha inflammatory signaling.  Molecular and Celullar Biology 26(23):9126-9135, 2006. [Abstract (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16982682&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum) ]
  32. G. Heimlich and Cidlowski JA. Selective role of intracellular chloride in the regulation of the intrinsic but not extrinsic pathway of apoptosis in Jurkat T-cells. J. Biol. Chem. 281: 2232-2241, 2006. [Abstract (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16299378&ordinalpos=14&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum) ]
  33. Schaaf MJM, Lewis-Tuffin LJ and Cidlowski JA. Ligand-Selective Targeting of the Glucocorticoid Receptor to Nuclear Subdomains is associated with Decreased Receptor Mobility. Molecular Endocrinology 19(6): 1501-1515, 2005. [Abstract (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=15705660&ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum) ]
  34. Lu NZ and Cidlowski JA. Translational Regulatory Mechanisms Generate N-terminal Glucocorticoid Receptor Isoforms with Unique Transcriptional Target Genes. Molecular Cell. Vol.18, 331-342 April 29, 2005. [Abstract (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=15866175&ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum) ]
  35. Hermoso MA, Matsuguchi T, Smoak K and Cidlowski JA. Glucocorticoids and Tumor Necrosis Factor Alpha Cooperatively Regulate Toll-Like Receptor 2 Gene Expression. Molecular and Cellular Biology, p.4743-4756, June 2004. [Abstract (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=15143169&ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum) ]

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