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Selected Publications

Inositol Signaling Group

  1. Tsuzuki S., Matsumoto H., Furihata S., Ryuda M., Tanaka H., Sung, E.J., Bird G.S., Zhou Y., Shears SB, Hayakawa Y. (2014) Switching between humoral and cellular immune responses in Drosophila is guided by the cytokine GBP. Nat Commun. 5:4628. doi: 10.1038/ncomms5628.[Abstract ]
  2. Capolicchio S., Wang H., Thakor D.T., Shears S.B., Jessen H.J. (2014) Synthesis of Densely Phosphorylated Bis-1,5-Diphospho-myo-Inositol Tetrakisphosphate and its Enantiomer by Bidirectional P-Anhydride Formation.  Angew Chem Int Ed Engl. doi: 10.1002/anie.201404398. [Abstract ]
  3. Wang H., DeRose E.F., London R.E., Shears S.B. (2014) IP6K structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase family.  Nat Commun. 5:4178. doi: 10.1038/ncomms5178. [Abstract ]
  4. Wang H., Godage H.Y., Riley A.M., Weaver J.D., Shears S.B., Potter BV. (2014) Synthetic Inositol Phosphate Analogs Reveal that PPIP5K2 has a Surface-Mounted Substrate Capture Site that is a Target for Drug Discovery. Chemistry & Biology  21(5):689-699.[Abstract ]
  5. Stentz, R., Osborne, S., Horn, N., Li, A.W.H., Hautefort, I., Bongaerts, R., Rouyer, M., Bailey, P., Shears, S.B., Hemmings, A.M., Brearley, C.A., Carding, S.R. (2014) A Bacterial Homolog of a Eukaryotic Inositol Phosphate Signaling Enzyme Mediates Cross-kingdom Dialog in the Mammalian Gut. Cell Reports 6:646-656[Abstract ]
  6. Pulloor, N.K., Nair, S., Kostic, A.D., Bist, P., Weaver, J.D., Riley, A.M., Tyag, R., Uchil, P.D., York, J.D., Snyder, S.H., Garcıa-Sastre, A., Potter, B.V.L., Lin, R., Shears, S.B., Xavier, R.J., Krishnan, M.N. (2014) Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response. PlOS Pathogens 10(2): e1003981. doi:10.1371/journal.ppat.1003981[Open Access ]
  7. Wang, L.-D., Bi, X., Song, X., Pohl, N.M., Cheng, Y., Zhou, Y., Shears, S.B., Ansong, E., Xing, M., Wang, S., 7, Xu, X.-C., Huang, P., Xu, L., Wang, L., Fan, Z., Zhao, X., Dong, H., Meltzer, S.J., Ding, I., Yang, W. A (2013) Sequence Variant in the Phospholipase C epsilon C2 Domain Is Associated with Esophageal Carcinoma and Esophagitis. Molecular Carcinogenesis 52:80-86.[Abstract ]
  8. Weaver J.D., Wang H., Shears S.B. (2013) The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment. Bioscience Reports. 33(2):229-241[Abstract ]
  9. Brehm, M.A., Williams, J., Wunderberg, T., Mayr, G.W., Shears, S.B. (2013) A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate 2-kinase in the synthesis of ribosomal RNA. J Cell Sci. 126(Pt 2):437-44.[Abstract ]
  10. Kilari, R.S., Weaver, J.D., Shears, S.B., Safrany, S.T. (2013) Understanding inositol pyrophosphate metabolism and function: Kinetic characterization of the DIPPs.  FEBS letters 587(21):3464-3470.
    [Abstract ( ]
  11. Gokhale N, Zaremba A, Janoshazi, AK, Weaver JD, Shears SB. (2013) PPIP5K1 Modulates Ligand Competition Between Diphosphoinositol Polyphosphates and PtdIns(3,4,5)P3 for Polyphosphoinositide-Binding Domains. The Biochemical journal. 453(3):413-426.[Abstract ]
  12. Ganapathi, S.B., Wei, S.G., Zaremba, A, Lamb, F.S., Shears, S.B. (2013) Functional Regulation of ClC-3 in the Migration of Vascular Smooth Muscle Cells. Hypertension 61(1):174-179.[Abstract ]
  13. Riley, A.M., Wang, H., Weaver, J.,D, Shears, S.B., Potter, B.V. (2012) First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase. Chem. Commun. 48:11292-11294[Abstract ]
  14. Zhou, Y., Wu, S., Wang, H., Hayakawa, Y., Bird, G.S., Shears, S.B. (2012) Activation of PLC by an Endogenous Cytokine (GBP) in Drosophila S3 cells and its Application as a Model for Studying Inositol Phosphate Signaling through ITPK1. Biochem J. 448:273-283[Abstract ]
  15. Shears, S.B., Ganapathi, S.B., Gokhale, N.A., Schenk, T.M., Wang, H., Weaver, J.D., Zaremba, A., Zhou, Y. (2012) Defining signal transduction by inositol phosphates. Subcell Biochem. 59:389-412.[Abstract ]
  16. Wang H, Falck JR, Hall, TM, Shears SB. (2011) Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding. Nature Chemical Biology.  8(1):111-6.[Abstract ]
  17. Shears, S.B., Gokhale, N.A., Wang, H., Zaremba, A. (2011) Diphosphoinositol polyphosphates: what are the mechanisms? Adv Enzyme Regul. 51:13-25.[Abstract ]
  18. Gokhale, N., Zaremba, A., Shears, S. (2011) Receptor-dependent compartmentalization of PPIP5K1, a kinase with a cryptic polyphosphoinositide binding domain. Biochem. J. 434(3):415-426.[Abstract ]
  19. Shears, S.B. (2010) The Long-Awaited Demonstration of Protein Pyrophosphorylation by IP7 in vivo? Proc. Natl. Acad. Sci. USA 107(5):E17-.[Abstract ]
  20. Lin, H., Friday, P.C., Ribiero, A.A., Choi, J.H., Barma, D.K., Vogel, G., Falck, J.R., Shears, S.B., York, J.D., Mayr, G.W. (2009) Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases. J. Biol. Chem. 284(3):1863-1872.[Abstract ]
  21. Mitchell, J., Wang, X., Zhang, G., Gentzsch, M., Nelson, D.J., Shears, S.B. (2008) An expanded biological repertoire for Ins(3,4,5,6)P4 through its modulation of ClC-3 function. Curr Biol. 18(20):1600-1605.[Abstract ]
  22. Stiles, A.R, Qian, X., Shears, S.B., Grabau, E.A. (2008) Metabolic and signaling properties of an Itpk gene family in Glycine max. FEBS Lett. 582:1853-1858.[Abstract ]
  23. Choi, K., Mollapour, E., Choi, J.H., Shears, S.B. (2008) Cellular energetic status supervises the synthesis of bis-diphosphoinositol tetrakisphosphate independently of AMP-activated protein kinase. Mol. Pharm. 74(2):527-536.[Abstract ]
  24. Cho, J., King, J., Qian, X., Harwood, A.J., Shears, S.B. (2008) Dephosphorylation of 2,3-bisphosphoglycerate by MIPP expands the regulatory capacity of the Rapoport-Luebering glycolytic shunt. Proc. Natl. Acad. Sci. USA 105(16):5998-6003.[Abstract ]
  25. Yang, L., Reece, J.M., Cho, J., Bortner, C.D., Shears, S.B. (2008) The nucleolus exhibits an osmotically regulated gatekeeping activity that controls the spatial dynamics and functions of nucleolin. J. Biol. Chem. 283(17):11823-11831.[Abstract ]
  26. Chamberlain, P., Qian, X., Stiles, A.R., Cho, J., Jones, D., Lesley, S., Grabau, E.A., Shears, S. B. and Spraggon, G. (2007) Integration of inositol phosphate signaling pathways by ITPK1 J. Biol. Chem. 282 28117-28125.[Abstract ]
  27. Brehm, M.A., Schenk, T.M.H., Zhou, X., Fanick, W., Lin, H., Windhorst, S., Nalaskowski, M.M., Kobras, M., Shears, S.B., Mayr, G.W. (2007) Intracellular localization of human Inositol 1,3,4,5,6-pentakisphosphate 2-kinase. Biochem. J. 408(3):335-345.[Abstract ]
  28. Choi, J.H., Williams, J., Cho, J., Falck, J.R., Shears, S.B. (2007) Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress. J. Biol. Chem. 42: 30763-30775.[Abstract ]

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