Skip Navigation
 

Selected Publications

Inositol Signaling Group

  1. Ganapathi, S.B., Wei, S.G., Zaremba, A, Lamb, F.S., Shears, S.B. (2013) Functional Regulation of ClC-3 in the Migration of Vascular Smooth Muscle Cells. Hypertension 61(1):174-179. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed?term=23150504) ]
  2. Riley, A.M., Wang, H., Weaver, J.,D, Shears, S.B., Potter, B.V. (2012) First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase. Chem. Commun. 48:11292-11294 [Abstract (http://www.ncbi.nlm.nih.gov/pubmed?term=23032903) ]
  3. Zhou, Y., Wu, S., Wang, H., Hayakawa, Y., Bird, G.S., Shears, S.B. (2012) Activation of PLC by an Endogenous Cytokine (GBP) in Drosophila S3 cells and its Application as a Model for Studying Inositol Phosphate Signaling through ITPK1. Biochem J. 448:273-283 [Abstract (http://www.ncbi.nlm.nih.gov/pubmed?term=22928859) ]
  4. Shears, S.B., Ganapathi, S.B., Gokhale, N.A., Schenk, T.M., Wang, H., Weaver, J.D., Zaremba, A., Zhou, Y. (2012) Defining signal transduction by inositol phosphates. Subcell Biochem. 59:389-412. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/22374098) ]
  5. Wang H, Falck JR, Hall, TM, Shears SB. (2011) Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding. Nature Chemical Biology.  8(1):111-6. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=22119861) ]
  6. Shears, S.B., Gokhale, N.A., Wang, H., Zaremba, A. (2011) Diphosphoinositol polyphosphates: what are the mechanisms? Adv Enzyme Regul. 51:13-25. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed?term=21035493) ]
  7. Gokhale, N., Zaremba, A., Shears, S. (2011) Receptor-dependent compartmentalization of PPIP5K1, a kinase with a cryptic polyphosphoinositide binding domain. Biochem. J. 434(3):415-426. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=21222653) ]
  8. Shears, S.B. (2010) The Long-Awaited Demonstration of Protein Pyrophosphorylation by IP7 in vivo? Proc. Natl. Acad. Sci. USA 107(5):E17-. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=20133826) ]
  9. Lin, H., Friday, P.C., Ribiero, A.A., Choi, J.H., Barma, D.K., Vogel, G., Falck, J.R., Shears, S.B., York, J.D., Mayr, G.W. (2009) Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases. J. Biol. Chem. 284(3):1863-1872. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18981179) ]
  10. Mitchell, J., Wang, X., Zhang, G., Gentzsch, M., Nelson, D.J., Shears, S.B. (2008) An expanded biological repertoire for Ins(3,4,5,6)P4 through its modulation of ClC-3 function. Curr Biol. 18(20):1600-1605. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18951024) ]
  11. Stiles, A.R, Qian, X., Shears, S.B., Grabau, E.A. (2008) Metabolic and signaling properties of an Itpk gene family in Glycine max. FEBS Lett. 582:1853-1858. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18474240) ]
  12. Choi, K., Mollapour, E., Choi, J.H., Shears, S.B. (2008) Cellular energetic status supervises the synthesis of bis-diphosphoinositol tetrakisphosphate independently of AMP-activated protein kinase. Mol. Pharm. 74(2):527-536. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18460607) ]
  13. Cho, J., King, J., Qian, X., Harwood, A.J., Shears, S.B. (2008) Dephosphorylation of 2,3-bisphosphoglycerate by MIPP expands the regulatory capacity of the Rapoport-Luebering glycolytic shunt. Proc. Natl. Acad. Sci. USA 105(16):5998-6003. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18413611) ]
  14. Yang, L., Reece, J.M., Cho, J., Bortner, C.D., Shears, S.B. (2008) The nucleolus exhibits an osmotically regulated gatekeeping activity that controls the spatial dynamics and functions of nucleolin. J. Biol. Chem. 283(17):11823-11831. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18299322) ]
  15. Chamberlain, P., Qian, X., Stiles, A.R., Cho, J., Jones, D., Lesley, S., Grabau, E.A., Shears, S. B. and Spraggon, G. (2007) Integration of inositol phosphate signaling pathways by ITPK1 J. Biol. Chem. 282 28117-28125. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/17616525?ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum) ]
  16. Brehm, M.A., Schenk, T.M.H., Zhou, X., Fanick, W., Lin, H., Windhorst, S., Nalaskowski, M.M., Kobras, M., Shears, S.B., Mayr, G.W. (2007) Intracellular localization of human Inositol 1,3,4,5,6-pentakisphosphate 2-kinase. Biochem. J. 408(3):335-345. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17705785) ]
  17. Choi, J.H., Williams, J., Cho, J., Falck, J.R., Shears, S.B. (2007) Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress. J. Biol. Chem. 42: 30763-30775. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17702752) ]
  18. Cho, J., Choi, K., Darden, T., Reynolds, P.R., Petitte, J.N., Shears, S.B. (2006) Avian multiple inositol polyphosphate phosphatase is an active phytase that can be engineered to help ameliorate the planet's "phosphate crisis”. J Biotechnol. 126: 248-59. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16759730&query_hl=1&itool=pubmed_docsum) ]
  19. Riley, A.M., Trusselle, M., Kuad, P., Borkovec, M., Cho, J., Choi, K., Qian, X., Shears, S.B., Spiess, B., Potter, B.V. (2006) Scyllo-inositol pentakisphosphate as an analogue of myo-inositol 1,3,4,5,6-pentakisphosphate: chemical synthesis, physicochemistry and biological applications. Chembiochem. 7: 1114-22. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16755629&query_hl=1&itool=pubmed_docsum) ]
  20. Pathogenicity of Salmonella: SopE-Mediated Membrane Ruffling is Independent of Inositol Phosphate Signals. Deleu, S., Reece, J.M. and Shears, S.B. (2006) FEBS Lett. 580 pp 1709-1715. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16500648&query_hl=1&itool=pubmed_docsum) ]
  21. Yang, L., Reece, J., Gabriel, S.E., Shears, S.B. (2006) Apical localization of ITPK1 enhances its ability to be a modifier gene product in a murine tracheal cell model of cystic fibrosis. J. Cell. Sci. 119 pp1320-1328. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16537650&query_hl=1&itool=pubmed_docsum) ]
  22. Riley, A.M., Deleu, S., Qian, X., Mitchell, J., Chung, S.-K., Adelt, S., Vogel, G., Potter, B.V.L., Shears, S.B. (2006) On the contribution of stereochemistry to human ITPK1 specificity; Ins(1,4,5,6)P4 is not a physiologic substrate. FEBS Letters 580 324-330. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16376887&query_hl=7&itool=pubmed_docsum) ]
  23. Deleu, S., Choi, K., Pesesse, X., Cho, J., Sulis, M.L., Parsons, R., Shears, S.B. (2006) Physiologically-relevant levels of PTEN control the size of the cellular Ins(1,3,4,5,6)P5 pool. Cellular Signalling 18 488-498. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15979280&query_hl=7&itool=pubmed_docsum) ]

Back to Top