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Selected Publications

Inositol Signaling Group

  1. Wang H., Godage H.Y., Riley A.M., Weaver J.D., Shears S.B., Potter BV. Synthetic Inositol Phosphate Analogs Reveal that PPIP5K2 has a Surface-Mounted Substrate Capture Site that is a Target for Drug Discovery. Chemistry & biology 2014 21(5):689-699.[Abstract ]
  2. Stentz, R., Osborne, S., Horn, N., Li, A.W.H., Hautefort, I., Bongaerts, R., Rouyer, M., Bailey, P., Shears, S.B., Hemmings, A.M., Brearley, C.A., Carding, S.R. (2014) A Bacterial Homolog of a Eukaryotic Inositol Phosphate Signaling Enzyme Mediates Cross-kingdom Dialog in the Mammalian Gut. Cell Reports 6:646-656[Abstract ]
  3. Pulloor, N.K., Nair, S., Kostic, A.D., Bist, P., Weaver, J.D., Riley, A.M., Tyag, R., Uchil, P.D., York, J.D., Snyder, S.H., Garcıa-Sastre, A., Potter, B.V.L., Lin, R., Shears, S.B., Xavier, R.J., Krishnan, M.N. (2014) Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response. PlOS Pathogens 10(2): e1003981. doi:10.1371/journal.ppat.1003981[Open Access ]
  4. Wang, L.-D., Bi, X., Song, X., Pohl, N.M., Cheng, Y., Zhou, Y., Shears, S.B., Ansong, E., Xing, M., Wang, S., 7, Xu, X.-C., Huang, P., Xu, L., Wang, L., Fan, Z., Zhao, X., Dong, H., Meltzer, S.J., Ding, I., Yang, W. A (2013) Sequence Variant in the Phospholipase C epsilon C2 Domain Is Associated with Esophageal Carcinoma and Esophagitis. Molecular Carcinogenesis 52:80-86.[Abstract ]
  5. Weaver J.D., Wang H., Shears S.B. (2013) The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment. Bioscience Reports. 33(2):229-241[Abstract ]
  6. Brehm, M.A., Williams, J., Wunderberg, T., Mayr, G.W., Shears, S.B. (2013) A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate 2-kinase in the synthesis of ribosomal RNA. J Cell Sci. 126(Pt 2):437-44.[Abstract ]
  7. Kilari, R.S., Weaver, J.D., Shears, S.B., Safrany, S.T. (2013) Understanding inositol pyrophosphate metabolism and function: Kinetic characterization of the DIPPs.  FEBS letters 587(21):3464-3470.
    [Abstract ( ]
  8. Gokhale N, Zaremba A, Janoshazi, AK, Weaver JD, Shears SB. (2013) PPIP5K1 Modulates Ligand Competition Between Diphosphoinositol Polyphosphates and PtdIns(3,4,5)P3 for Polyphosphoinositide-Binding Domains. The Biochemical journal. 453(3):413-426.[Abstract ]
  9. Ganapathi, S.B., Wei, S.G., Zaremba, A, Lamb, F.S., Shears, S.B. (2013) Functional Regulation of ClC-3 in the Migration of Vascular Smooth Muscle Cells. Hypertension 61(1):174-179.[Abstract ]
  10. Riley, A.M., Wang, H., Weaver, J.,D, Shears, S.B., Potter, B.V. (2012) First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase. Chem. Commun. 48:11292-11294[Abstract ]
  11. Zhou, Y., Wu, S., Wang, H., Hayakawa, Y., Bird, G.S., Shears, S.B. (2012) Activation of PLC by an Endogenous Cytokine (GBP) in Drosophila S3 cells and its Application as a Model for Studying Inositol Phosphate Signaling through ITPK1. Biochem J. 448:273-283[Abstract ]
  12. Shears, S.B., Ganapathi, S.B., Gokhale, N.A., Schenk, T.M., Wang, H., Weaver, J.D., Zaremba, A., Zhou, Y. (2012) Defining signal transduction by inositol phosphates. Subcell Biochem. 59:389-412.[Abstract ]
  13. Wang H, Falck JR, Hall, TM, Shears SB. (2011) Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding. Nature Chemical Biology.  8(1):111-6.[Abstract ]
  14. Shears, S.B., Gokhale, N.A., Wang, H., Zaremba, A. (2011) Diphosphoinositol polyphosphates: what are the mechanisms? Adv Enzyme Regul. 51:13-25.[Abstract ]
  15. Gokhale, N., Zaremba, A., Shears, S. (2011) Receptor-dependent compartmentalization of PPIP5K1, a kinase with a cryptic polyphosphoinositide binding domain. Biochem. J. 434(3):415-426.[Abstract ]
  16. Shears, S.B. (2010) The Long-Awaited Demonstration of Protein Pyrophosphorylation by IP7 in vivo? Proc. Natl. Acad. Sci. USA 107(5):E17-.[Abstract ]
  17. Lin, H., Friday, P.C., Ribiero, A.A., Choi, J.H., Barma, D.K., Vogel, G., Falck, J.R., Shears, S.B., York, J.D., Mayr, G.W. (2009) Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases. J. Biol. Chem. 284(3):1863-1872.[Abstract ]
  18. Mitchell, J., Wang, X., Zhang, G., Gentzsch, M., Nelson, D.J., Shears, S.B. (2008) An expanded biological repertoire for Ins(3,4,5,6)P4 through its modulation of ClC-3 function. Curr Biol. 18(20):1600-1605.[Abstract ]
  19. Stiles, A.R, Qian, X., Shears, S.B., Grabau, E.A. (2008) Metabolic and signaling properties of an Itpk gene family in Glycine max. FEBS Lett. 582:1853-1858.[Abstract ]
  20. Choi, K., Mollapour, E., Choi, J.H., Shears, S.B. (2008) Cellular energetic status supervises the synthesis of bis-diphosphoinositol tetrakisphosphate independently of AMP-activated protein kinase. Mol. Pharm. 74(2):527-536.[Abstract ]
  21. Cho, J., King, J., Qian, X., Harwood, A.J., Shears, S.B. (2008) Dephosphorylation of 2,3-bisphosphoglycerate by MIPP expands the regulatory capacity of the Rapoport-Luebering glycolytic shunt. Proc. Natl. Acad. Sci. USA 105(16):5998-6003.[Abstract ]
  22. Yang, L., Reece, J.M., Cho, J., Bortner, C.D., Shears, S.B. (2008) The nucleolus exhibits an osmotically regulated gatekeeping activity that controls the spatial dynamics and functions of nucleolin. J. Biol. Chem. 283(17):11823-11831.[Abstract ]
  23. Chamberlain, P., Qian, X., Stiles, A.R., Cho, J., Jones, D., Lesley, S., Grabau, E.A., Shears, S. B. and Spraggon, G. (2007) Integration of inositol phosphate signaling pathways by ITPK1 J. Biol. Chem. 282 28117-28125.[Abstract ]
  24. Brehm, M.A., Schenk, T.M.H., Zhou, X., Fanick, W., Lin, H., Windhorst, S., Nalaskowski, M.M., Kobras, M., Shears, S.B., Mayr, G.W. (2007) Intracellular localization of human Inositol 1,3,4,5,6-pentakisphosphate 2-kinase. Biochem. J. 408(3):335-345.[Abstract ]
  25. Choi, J.H., Williams, J., Cho, J., Falck, J.R., Shears, S.B. (2007) Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress. J. Biol. Chem. 42: 30763-30775.[Abstract ]
  26. Cho, J., Choi, K., Darden, T., Reynolds, P.R., Petitte, J.N., Shears, S.B. (2006) Avian multiple inositol polyphosphate phosphatase is an active phytase that can be engineered to help ameliorate the planet's "phosphate crisis”. J Biotechnol. 126: 248-59.[Abstract ]
  27. Riley, A.M., Trusselle, M., Kuad, P., Borkovec, M., Cho, J., Choi, K., Qian, X., Shears, S.B., Spiess, B., Potter, B.V. (2006) Scyllo-inositol pentakisphosphate as an analogue of myo-inositol 1,3,4,5,6-pentakisphosphate: chemical synthesis, physicochemistry and biological applications. Chembiochem. 7: 1114-22.[Abstract ]
  28. Pathogenicity of Salmonella: SopE-Mediated Membrane Ruffling is Independent of Inositol Phosphate Signals. Deleu, S., Reece, J.M. and Shears, S.B. (2006) FEBS Lett. 580 pp 1709-1715.[Abstract ]
  29. Yang, L., Reece, J., Gabriel, S.E., Shears, S.B. (2006) Apical localization of ITPK1 enhances its ability to be a modifier gene product in a murine tracheal cell model of cystic fibrosis. J. Cell. Sci. 119 pp1320-1328.[Abstract ]
  30. Riley, A.M., Deleu, S., Qian, X., Mitchell, J., Chung, S.-K., Adelt, S., Vogel, G., Potter, B.V.L., Shears, S.B. (2006) On the contribution of stereochemistry to human ITPK1 specificity; Ins(1,4,5,6)P4 is not a physiologic substrate. FEBS Letters 580 324-330.[Abstract ]
  31. Deleu, S., Choi, K., Pesesse, X., Cho, J., Sulis, M.L., Parsons, R., Shears, S.B. (2006) Physiologically-relevant levels of PTEN control the size of the cellular Ins(1,3,4,5,6)P5 pool. Cellular Signalling 18 488-498.[Abstract ]

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