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Leesa Deterding

Mass Spectrometry Group

Leesa J. Deterding, Ph.D.
Leesa J. Deterding, Ph.D.
Staff Scientist
Director of the Collaborative Mass Spectrometry Support Group
Tel (919) 541-3009
Fax (919) 541-0220
P.O. Box 12233
Mail Drop F0-03
Research Triangle Park, North Carolina 27709
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As director of the Collaborative Mass Spectrometry Support Group at NIEHS, Leesa J. Deterding, Ph.D., oversees the day-to-day operations of the group, manages fiscal and human resources, establishes workflows, and spends time at the mass spectrometers.


The group, which does mass spectrometric research and development, offers proteomic and metabolomics research to investigators at NIEHS and provides quantitative information regarding big and small molecules. Deterding also maintains a research interest focused on the application of mass spectrometric techniques to questions in structural biology and performs mass spectrometric method development to aid in answering those questions. Most recently, her research efforts are directed to understanding the mechanisms for the development of autoimmune diseases.


Additionally, Deterding’s research efforts include the characterization of the tertiary structure of proteins, determination of the sites of in vitro and in vivo modifications of proteins, the interactions of proteins with other biomolecules, and the identification of protein complexes via immunoprecipitates. Collectively, mass spectrometric-based approaches are currently being applied to the following research areas:

  • Structural characterization of autoantigens and their biomolecular interactions
  • Determining the extent of and changes in, sites of PTMs of proteins
  • Determining the mechanisms of free radical formation on proteins as a result of oxidative stress
  • Characterizing biomolecular interactions of proteins


Leesa J. Deterding, Ph.D., is a staff scientist and head of the Collaborative Mass Spectrometry Support Group within the Laboratory of Structural Biology. She earned her B.A. degree in chemistry and math from Hastings College, her M.S. degree in chemistry from the University of Nebraska-Lincoln, and a Ph.D. in chemistry from North Carolina State University.

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