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Selected Publications

Genome Stability Structural Biology Group

Publications (2009-Present)
*Correspondence:  williamsrs@niehs.nih.gov

  1. Gao R, Schellenberg MJ , Huang SY, Abdelmalak M, Marchand C, Nitiss KC, Nitiss JL, Williams RS, Pommier Y. Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2┬ĚDNA and Top2┬ĚRNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2). The Journal of biological chemistry 2014 289(26):17960-17969.[Abstract ]
  2. Deshpande RA, Williams GJ, Limbo O, Williams RS, Kuhnlein J, Lee JH, Classen S, Guenther G, Williams RS, Russell P , Tainer JA, Paull TT. ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling. The EMBO journal 33(5):482-500 (2014). 
    [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/24493214?dopt=Abstract) ]
  3. Tumbale P, Williams JS, Schellenberg MJ, Kunkel TA, Williams RS. Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity. Nature 506(7486):111-115 (2014).[Abstract ]
  4. Crown NK, Savytskyy OP, Malik SB, Logsdon J , Williams RS, Tainer JA, Zolan ME. A Mutation in the FHA Domain of Coprinus cinereus Nbs1 Leads to Spo11-Independent Meiotic Recombination and Chromosome Segregation. G3 (Bethesda, Md.) 2013 3(11):1927-1943.[Abstract ]
  5. Sharifi R, Morra R, Appel CD, Tallis , Chioza B , Jankevicius G , Simpson MA, Matic I , Ozkan E, Golia B , Schellenberg MJ, Weston R, Williams JG, Rossi MN, Galehdari H, Krahn J, Wan A , Trembath RC, Crosby AH, Ahel D, Hay R, Ladurner AG, Timinszky G, Williams RS, Ahel I. Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease. The EMBO journal 32(9):1225-1237 (2013).[Abstract ]
  6. Schellenberg MJ, Appel CD, Adhikari S, Robertson PD, Ramsden DA, Williams RS. Mechanism of repair of 5'-topoisomerase II-DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2. Nature structural & molecular biology 19(12):1363-71 (2012). [Abstract ]
  7. Schellenberg, M.J. and Williams, R.S. DNA end processing by polynucleotide kinase/phosphatase. Proc Natl Acad Sci USA 108(52):20855-20856 (2011).[Abstract ]
  8. Adhikari, S., Karmahapatra, S.K., Elias, H., Dhopeschwarkar, P., Williams, R.S., Byers, S., Uren, A., Roy, R. Development of a novel assay for human tyrosyl DNA phosphodiesterase 2. Anal Biochem 416(1):112-116 (2011).[Abstract ]
  9. Tumbale, P., Appel, D.C., Kraehenbuehl, R., Robertson, P.D., Williams, J.S., Krahn, J., Ahel, I., and Williams, R.S. Structure of an Aprataxin-DNA complex with insights into AOA1 Neurodegenerative Disease. Nature Structural & Molecular Biology 18(11):1189-1195 (2011).[Abstract ]
  10. Williams, R.S., and Kunkel, T.A. Fen Nucleases: Bind, Bend, Fray, Cut. Cell 145(2):171-172 (2011).[Abstract ]
  11. Williams, G.J., Williams, R.S., Williams, J.S., Moncalian, G., Arvai, A.S., Limbo, O., Guenther, G., SilDas, S., Hammel, M., Russell, P., and Tainer, J.A. ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair. Nature Structural and Molecular Biology 18(4): 423-431 (2011).[Abstract ]
  12. Rahal, E.A., Henricksen, L.A., Li, Y., Williams, R.S., Tainer, J.A. and Dixon, K. ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining. Cell Cycle 12(9): 14 (2010).  [Abstract ]
  13. Lee, M.S., Green, R., Marsillac. S.M, Williams, R.S., Coquelle, N. Yeung, T., Foo, D., Hau,D.D, Hui, B., Monteiro, A.N.A., and Glover, J.N.M. Comprehensive analysis of missense variations in the BRCT domain of BRCA1 by structural and functional assays. Cancer Res. 70(12): 4880-4890 (2010).[Abstract ]
  14. Williams, J.S., Williams, R.S., Dovey, C.L., Guenther, G., Tainer, J.A., and Russell, P. gammaH2A binds Brc1 to maintain genome integrity during S-phase. EMBO J. 29(6): 1136-48 (2010).[Abstract ]
  15. Williams, R.S., Dodson, G.E., Limbo, O., Yamada, Y., Williams, J.S., Guenther, G., Classen, S., Glover, J.N., Iwasaki, H., Russell, P., and Tainer, J.A. Nbs1 is an extended flexible arm Binding to Ctp1 and Mre11-Rad50 to coordinate dsDNA break processing. Cell 139(1): 87-99 (2009).[Abstract ]

    Publications (2001-2008)

  16. Williams, R.S., Williams, G.J., and Tainer, J.A. A charged performance by gp17 in viral packaging. Cell 135 (7):1169-1171 (2008).[Abstract ]
  17. Acharya, S., Many, A.M., Schroeder, A., Kennedy, F., Savytskyy, O.P., Grubb, J., Vincent, J., Friedle, E., Celerin, M., Maillet, D., Palmerini, H.J., Greischar, M.A., Moncalian, G., Williams, R.S., Tainer, J.A., and Zolan, M.E. Coprinus cinereus Rad50 mutants reveal an essential structural role for Rad50 in axial element and synaptonemal complex formation, homolog pairing, and meiotic recombination. Genetics 180(4):1889-1907 (2008).[Abstract ]
  18. Edwards, R.A., Lee, M.S., Tsutakawa, S.E., Williams, R.S., Nazeer, I., Keliman, F.E., Tainer, J.A., and Glover, J.N. The Bard1 C-terminal domain structure and interactions with polyadenylation factor, CstF-50. Biochemistry 47(44):11446-11456 (2008).[Abstract ]
  19. Williams, R.S., Moncalian, G., Williams, J.S., Yamada, Y, Limbo, O., Shin, D.S., Groocock, L.M., Cahill., D., Hitomi, C., Guenther, G., Moiani, D., Carney, J.P., Russell, P., and Tainer, J.A. Mre11 dimers coordinate DNA end bridging and nuclease processing in DNA double strand break repair. Cell 135 (1):97-109 (2008).  [Abstract ]
  20. Williams, R.S., Williams, J.S., and Tainer, J.A. Mre11/Rad50/Nbs1 is a keystone complex connecting DNA repair machinery, double strand break signaling, and the chromatin template. Biochemistry and Cell Biology 85 (4):509-520 (2007).[Abstract ]
  21. Williams, R.S., and Tainer, J.A. Learning our ABCs: Rad50 directs MRN repair functions via Adenylate Kinase activity from the conserved ATP Binding Cassette. Molecular Cell 25 (6):789-791 (2007).[Abstract ]
  22. Simons, A.M., Horwitz, A.A., Starita, L.M., Griffin, K., Williams, R.S., Glover, J.N., and Parvin, J.D. BRCA1 DNA-binding activity is stimulated by BARD1. Cancer Research 66(4):2012-2018 (2006).[Abstract ]
  23. Williams, R.S, Bernstein, N., Lee, M.S., Rakovszky, M.L., Cui, D., Green, R., Weinfeld, M., and Glover, J.N. Structural basis for phosphorylation-dependent signaling in the DNA damage response. Biochemistry and Cell Biology 83(6):721-727 (2005).[Abstract ]
  24. Williams, R.S., and Tainer, J.A. A Nanomachine for Making Ends Meet: MRN is a flexing scaffold for the repair of DNA double strand breaks. Molecular Cell 19(6):724-726 (2005).[Abstract ]
  25. Bernstein, N.K., Williams, R.S., Rakovszky, M.L, Cui, D., Green, R., Karimi-Busheri, F., Mani, R.S, Galicia, S., Koch C.A., Cass, C.E, Durocher, D., Weinfeld, M., and Glover, J.N. The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase. Molecular Cell 17(5):657-670 (2005).[Abstract ]
  26. Glover, J.N.M, Williams, R.S., and Lee, MS. BRCT repeat-phosphoprotein interactions: tangled up in two. Trends in Biochemical Sciences 29(11):579-585 (2004).[Abstract ]
  27. Williams, R.S., Lee, M.S., Hau., D.D., and Glover, J.N.M. Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1. Nature Structural and Molecular Biology 11(6):519-525 (2004).[Abstract ]
  28. Dubin M.J., Stokes, P., Sum, E.Y.M, Williams, R.S., Valova, V., Robinson, P.,Lindeman, G.J., Glover, J.N., Visvader, J.E., and Matthews, J.M. Dimerization of CtIP, a BRCA1- and CtBP-interacting protein, is mediated by an N-terminal coiled-coil motif. Journal of Biological Chemistry 279(26):26932-26938 (2004).[Abstract ]
  29. Williams, R.S., Hau, D, Chasman, D., Hui, B., and Glover, J.N.M. Detection of protein folding defects caused by BRCA1-BRCT truncation and missense mutations. Journal of Biological Chemistry 278(52):53007-53016 (2003).[Abstract ]
  30. Williams, R.S., and Glover, J.N.M. Structural consequences of a cancer-causing BRCA1-BRCT missense mutation. Journal cover feature. Journal of Biological Chemistry 278(4):2630-2635 (2003).[Abstract ]
  31. Hamilton, K.S., Ellison, M.J., Barber, K.R., Williams, R.S., Huzil, J.T., McKenna, S., Ptak, C., Glover, M., and Shaw, G.S. Structure of a conjugating enzyme-ubiquitin thiolester intermediate reveals a novel role for the ubiquitin tail. Structure 9:897-904 (2001).[Abstract ]
  32. Williams, R.S., Green, R., and Glover, J.N.M. Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1. Nature Structural Biology 8(10):838-842 (2001).[Abstract ]

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