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Selected Publications

Receptor Biology Group

  1. Korach, K.S., Emmen, J.M.A., Walker, V.R., Hewitt, S.C., Yates, M., Hall, J.M., Swope, D.L., Harrell, J.C., Couse, J.F., Update on animal models developed for analyses of estrogen receptor biological activity. J. Steroid Biochem Mol Biol 86: 387-391, 2003 [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/14623535) ]
  2. Abraham, I.M., Todman, M.G., Korach, K.S., Herbison, A.E., Critical in vivo roles for classical estrogen receptors in rapid estrogen actions on intracellular signaling in the mouse brain. Endocrinology 145:3055-3061, 2004 [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/14976146) ]
  3. Grummer, R, Hewitt, S.W., Traub, O., Korach, K.S., Winterhager, E., Different Regulatory Pathways of Endometrial Connexin Expression: Pre-implantation Hormonal Mediated Pathway Versus Embryo Implantation Initiated Pathway. Biol Reprod 71: 273-281, 2004 [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15028626) ]
  4. Mueller, S.O., Simon, S., Chae, K., Metzler, M., Korach, K.S., Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor ERα and ER?. Toxicol Sci. 80: 14-25, 2004. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15084758?dopt=Abstract) ]
  5. DeRoo, B.J., Hewitt, S.C., Korach, K.S., Estradiol regulates the thioredoxin antioxidant system in the mouse uterus. Endocrinology 145: 5485-5492, 2004. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15345672?dopt=Abstract) ]
  6. Santen, R.J., Yue, W., Boccinfuso, W., Korach, K.S., Wang, J-P., Rogan, E.G., Li, Y., Cavalieri, E., Russo, J., Devanesan, P., Verderame, M., Estradiol-induced carcinogenesis via formation of genotoxic metabolites, In: Advances in endocrine therapy of breast cancer. Ingle, J.N., Dowsett, M. (eds), Marcel Dekker, new York, 163-178, 2004.
  7. Couse, J.F., Korach, K.S., Estrogen receptor-αlpha mediates the detrimental effects of neonatal diethylstilbestrol (DES) exposure in the murine reproductive tract. Toxicology 205: 55-63, 2004. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15458790?dopt=Abstract) ]
  8. Walker, V.R., Korach, K.S., Estrogen receptor knockout mice as a model for endocrine research. ILAR Journal 45: 455-461, 2004. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15454684?dopt=Abstract) ]
  9. Couse, J.F., Yates, M.M., Sanford, R., Nyska, A., Nilson, J.H., Korach, K.S., Formation of cystic ovarian follicles associated with elevated luteinizing hormone requires estrogen receptor-beta. Endocrinology 145: 4693-4702, 2004. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15231698?dopt=Abstract) ]
  10. Mueller, S.O., Katzenellenbogen, J.A., Korach, K.S., Endogenous estrogen receptor beta is transcriptionally active in primary ovarian cells from estrogen receptor knockout mice. Steroids 69: 681-686, 2004. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15465114?dopt=Abstract) ]
  11. Kavaliers, M., Agmo, A., Choleris, E., Gustafsson, J-A., Korach, K.S., Muglia, L.J., Pfaff, D.W., Ogawa, S., Oxytocin and estrogen receptor alpha and beta knockout mice provide discriminably different odor cues in behavioral assays. Gene Brain Behav. 3: 189-195, 2004. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15307217?dopt=Abstract) ]
  12. Pelzer, T., Loza, P-A.A., Hu, K., Bayer, B., Dienesch, C., Calvillo, L., Korach, K.S., Neyses, L., Ertl, G., Increased mortality and aggravation of heart failure in estrogen receptor-beta knockout mice after myocardial infarction. Circulation 111: 1492-1498, 2005. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15781739?dopt=Abstract) ]
  13. Hewitt, S.C., Collins, J., Grissom, S., Deroo, B., Korach, K.S., Global uterine genomics in vivo: microarray evaluation of the estrogen receptor alpha-growth factor cross-talk mechanism. Mol Endocrinol 19: 657-668, 2005. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15528273?dopt=Abstract) ]
  14. Skavdahl, M., Steenbergen, C., Clark, J., Myers, P., Demianeko, T., Mao, L., Rockman, H.A., Korach, K.S., Murphy, E., Estrogen receptor-beta mediates male-female differences in the development of pressure overload hypertrophy. Am. J. Physiol.: Heart and Circulatory Physiology 288: H469-476, 2005. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15374829?dopt=Abstract) ]
  15. Ardelt, A.A., McCullough, L.D., Korach, K.S., Wang, W.M., Munzenmaier, D.H., Hurn, P.D., Estradiol regulates angiopoietin-1 mRNA expression through estrogen receptor-alpha in a rodent experimental stroke model. Stroke 36: 337-341, 2005. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15637314?dopt=Abstract) ]
  16. Gougelet, A., Bouclier,C., Marsaud, V., Maillard, S., Mueller, S.O., Korach, K.S., Renoir, J-M, Estrogen receptor a and b subtype expression and transactivation capacity are differentially affected by receptor-, hsp90- and immunophilin-ligands in human breast cancer cells. J. Steroid Biochem Mol Biol 94: 71-81, 2005. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15862952?dopt=Abstract) ]
  17. Jayachandran, M., Karnicki,K., Miller,R.S., Owen,W.G., Korach,K.S., Miller,V.M., Platelet Characteristics Change with Aging: Role of Estrogen Receptor beta. J Gerontol: Biol Sci. 60: 815-819, 2005. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/16079202?dopt=Abstract) ]
  18. Emmen, J.M.A., Couse, J.F., Elmore, S.A., Yates, M.M., Kissling, G.E., Korach, K.S., In vitro growth and ovulation of follicles from ovaries of estrogen receptor (ER){alpha} and ER{beta} null mice indicate a role for ER{beta} in follicular maturation. Endocrinology 146: 2817-2826, 2005. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15731357?dopt=Abstract) ]
  19. Hewitt, S.C., Deroo, B.J., Korach, K.S., Signal transduction: a new mediator for an old hormone?, Science 307: 1572-1573, 2005. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15761144?dopt=Abstract) ]
  20. Couse, J.F., Yates, M.M., Deroo, B.J., Korach, K.S., Estrogen receptor-beta is critical to granulosa cell differentiation and the ovulatory response to gonadotropins. Endocrinology 146: 3247-3262, 2005. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15831568?dopt=Abstract) ]
  21. Aoyama, H., Couse, J.F., Curtis, S.W., Korach, K.S., Haseman, J., Dixon, D. Upregulation of estrogen receptor expression in the uterus of ovariectomized B6C3F1 mice and Ishikawa cells treated with bromoethane. Tox Appl Pharmacol 209:226-235, 2005. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15922381?dopt=Abstract) ]
  22. Tekmal, R.R., Liu, Y.G., Nair, H.B., Jones, J., Perla, R.P., Lubahn, D.B., Korach, K.S., Kirma, N., Estrogen receptor-α is required for mammary development and the induction of mammary hyperplasia and epigenetic alterations in aromatase transgenic mice. J. Steroid Biochem Mol Biol 95: 9-15, 2005. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15955696?dopt=Abstract) ]
  23. Hewitt, S.C., Harrell, J.C., Korach, K.S., Lessons in Estrogen Biology from Knockout and Transgenic Animals, Ann. Rev. Physiol. 67: 285-308, 2005. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15709960?dopt=Abstract) ]
  24. Yue, W., Wang, J.P., Li, Y., Bocchinfuso, W.P., Korach, K.S., Devanesan, P.D., Rogan, E., Cavalieri, E., Santen, R. J., Tamoxifen versus aromatase inhibitors for breast cancer prevention. Clin Cancer Res. 11: 925s-930s, 2005. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15701888?dopt=Abstract) ]
  25. Nomura, M., Andersson, S., Korach, K.S., Gustafsson, J-A, Pfaff, D. W., Ogawa, S., Estrogen receptor-beta gene disruption potentiates estrogen-inducible aggression but not sexual behavior in male mice. Neuroscience 23: 1860-1868, 2006. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/16623843?dopt=Abstract) ]
  26. LeMay, C., Chu, K., Hu, M., Oretga, C.S., Simpson, E.R., Korach, K.S., Tsai, M-J., Mauvais-Jarvis, F., Estrogens protect pancreatic β-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice. Proc. Natl. Acad. Sci. 103: 9232-9237, 2006. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/16754860?dopt=AbstractPlus) ]
  27. Szego, E.M., Barabas, K., Balog, J., Szilagyi, N., Korach, K.S., Juhasz, G., Abraham, I.M., Estrogen induces estrogen receptor alpha dependent CREB phosphorylation via MAPK pathway in basal forebrain cholinergic neurons in vivo. J. Neuroscience 26: 4104-4110, 2006. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/16611827?dopt=AbstractPlus) ]
  28. Couse, J.F., Yates, M.M., Rodriguez, K.F., Johnson, J.A., Poireir, D., Korach, K.S., The intraovarian actions of estrogen receptor-α (ER-α) are necessary to repress the formation of morphological and functional leydig cells in the female gonad. Endocrinology 147:  3666-3678, 2006. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/16627580?dopt=AbstractPlus) ]
  29. Yamamoto, Y., Moore, R., Hess, H.A., Guo, G.L., Gonzalez, F.J., Korach, K.S., Maronpot, R.R., Negishi, M., Estrogen receptor alpha mediates 17alpha-ethynylestradiol-causing hepatotoxicity. J. Biol. Chem. 281: 16625-16631, 2006. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/16606610?dopt=AbstractPlus) ]
  30. Qiu, J., Bosch, M.A., Tobias, S.C., Krust, A., Graham, S.M., Murphy, S.J., Korach, K.S., Chambon, P., Scanlan, T.S., Ronnekleiv, O.K., Kelly, M.J., A G protein-coupled estrogen receptor is involved in hypothalamic control of energy homeostasis. J. Neuroscience 26: 5649-5655, 2006. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/16723521?dopt=AbstractPlus) ]
  31. Lindzey, J., Jayes, F.L., Yates, M.M., Couse, J.F., Korach, K.S., The bi-modal effects of estradiol on gonadotropin synthesis and secretion in female mice are dependent on estrogen receptor-α (ER-α). J. Endocrinology 191: 309-317, 2006 [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/17065413?dopt=AbstractPlus) ]
  32. Choleris, E., Ogawa, S., Kavaliers, M.,Gustafsson, J.-Å, Korach, K.S., Muglia,  L. J., Pfaff, D.W., Involvement of estrogen receptor alpha, beta and oxytocin in social discrimination: A detailed behavioral analysis with knockout female mice. Genes Brain Behav. 5:528-539, 2006. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/17010099?dopt=AbstractPlus) ]
  33. O’Brien, J.E., Peterson, T.J., Tong, M.H., Lee, E-J., Pfaff, L.E., Hewitt, S.C., Korach, K.S., Weiss, J., Jameson, J.L., Estrogen induced proliferation of uterine epithelial cells is independent of estrogen receptor a binding to classical estrogen response elements. J. Biol. Chem. 281: 26683-26692, 2006. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/16847062?dopt=AbstractPlus) ]
  34. Dahlman-Wright, K., Cavailles, V.,  Fuqua, S.A., Jordan, V.C., Katzenellenbogen, J.A., Korach, K.S., Maggi, A., Muramatsu, M., Parker, M.G., Gustafsson, J.A., International union of pharmacology. LXIV. Estrogen Receptors. Pharmacol Rev. 58: 773-781, 2006. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/17132854?dopt=AbstractPlus) ]
  35. Henley, D.V., Korach, K.S., Endocrine-disrupting chemicals use distinct mechanisms of action to modulate endocrine system function. Endocrinology 147: 25s-32s, 2006. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/16690802?dopt=Abstract) ]
  36. Couse, J.F., Hewitt, S.C., Korach, K.S., Steroid Receptors in the Ovary and Uterus, In: Knobil and Neill: Physiology of Reproduction 3rd Edition, Neill, J.D. (ed.), Academic Press, New York, New York, p 593-678, 2006.
  37. Lindzey, J., Korach, K.S., Environmental agents and the reproductive system, In: DeGroot, L.J. Jameson, L.J. (eds.), Endocrinology, W.B. Saunders, Co., New York, New York, pp 2759-2777, 2006.
  38. Taniguchi, F., Couse, J.F., Rodriguez, K.F., Poirier, D., Korach, K.S., Estrogen receptor-α (ERa) mediates an intraovarian negative feedback loop on thecal cell androgen synthesis via modulation of Cyp17a1 expression. FASEB J. 21: 586-595, 2007. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/17158782?dopt=AbstractPlus) ]
  39. Henley, D.V., Lipson, N., Korach, K.S., Bloch, C.A., Prepubertal gynecomastia and lavender and tea tree oils. New Eng. J. Med. 356: 479-485, 2007. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/17267908?dopt=AbstractPlus) ]
  40. Carey, M.A., Card, J.W., Bradbury, J.A., Moorman, M.P., Haykal-Coates, N., Gavett, S.H., Graves,J.P., Walker,V.R., Flake,G.P., Voltz, J.W., Zhu, D., Jacobs ,E.R., Dakhama, A., Larsen, G.L., Loader, J.L., Gelfand, E.W., Germolec, D.R., Korach, K.S., Zeldin,D.C., Spontaneous airway hyperresponsiveness in estrogen receptor-α deficient mice. Am J. Respiratory and Critical Care Medicine 175: 126-135, 2007. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/17095746?dopt=AbstractPlus) ]
  41. Hewitt, S.C., O'Brien, J., Jameson, L., Kissling, G., Korach, K.S. Selective disruption of ER{alpha} DNA-binding activity alters uterine responsiveness to estradiol. Molecular endocrinology (Baltimore, Md.) 23(12):2111-2116, 2009. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/19812388?dopt=Abstract) ]
  42. Winuthayanon, W., Piyachaturawat, P., Suksamrarn, A., Ponglikitmongkol, M., Arao, Y., Hewitt, S.C., Korach, K.S. Diarylheptanoid phytoestrogens isolated from the medicinal plant Curcuma comosa: Biological actions in vivo and in vitro indicate ER-dependent mechanisms. Environmental health perspectives 117(7):1155-1161, 2009. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/19654927?dopt=Abstract) ]
  43. Deroo, B.J., Couse, J.F., Hamilton, K.J., Rodriguez, K.F., Collins, J.B., Grissom, S.F., Korach, K.S. Estrogen receptor beta is required for optimal cAMP production in mouse granulosa cells. Molecular endocrinology (Baltimore, Md.) 23(7):955-965, 2009. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/19324971?dopt=Abstract) ]
  44. Hewitt, S.C., Li, Y., Li, L., Korach, K.S. Estrogen Regulation of Igf1 and Uterine Growth Involves Direct Binding of Estrogen Receptors to Estrogen Responsive Elements. Journal of Biological Chemistry 285(4):2676-2685, 2010. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/19920132?dopt=Abstract) ]
  45. Bernardo, G.M., Lozada, K.L., Miedler, J.D., Harburg, G., Hewitt, S.C., Mosley, J.D., Godwin, A.K., Korach, K.S., Visvader, J.E., Kaestner, K.H., Abdul-Karim, F.W., Montano, M.M., Keri, R.A. FOXA1 is an essential determinant of ERalpha expression and mammary ductal morphogenesis. Development (Cambridge, England) 137(12):2045-2054, 2010. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/20501593?dopt=Abstract) ]
  46. Hewitt, S.C., Kissling, G.E., Fieselman, K.E., Jayes, F.L., Gerrish, K.E., Korach, K.S. Biological and biochemical consequences of global deletion of exon 3 from the ER{alpha} gene. The FASEB journal 24(12):4660-4667, 2010. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/20667977?dopt=Abstract) ]
  47. Winuthayanon, W., Hewitt, S.C., Orvis, G.D., Behringer, R.R., Korach, K.S. Uterine Epithelial Estrogen Receptor alpha is Dispensable for Proliferation But Essential for Complete Biological and Biochemical Responses. Proceedings of the National Academy of Sciences of the United States of America 107(45):19272-19277, 2010. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/20974921?dopt=Abstract) ]
  48. Hewitt, S.C., Korach, K.S. Estrogenic Activity of Bisphenol A and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE) Demonstrated in Mouse Uterine Gene Profiles. Environmental health perspectives 119(1):63-70, 2011. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/20826375?dopt=Abstract) ]
  49. Ribas, V., Drew, B.G., Le, J.A., Soleymani, T., Daraei, P., Sitz, D., Mohammad, L., Henstridge, D.C., Febbraio, M.A., Hewitt, S.C., Korach, K.S., Bensinger, S..J, Hevener, A.L. Myeloid-specific estrogen receptor alpha deficiency impairs metabolic homeostasis and accelerates atherosclerotic lesion development. Proceedings of the National Academy of Sciences of the United States of America  108(39):16457-16462, 2011. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=21900603) ]  
  50. Hewitt, S.C., Korach, K.S. A hand to support the implantation window. Science  331(6019):683-684, 2011. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=21330520) ]  
  51. Stewart, A.C., Fisher, S.J., Wang, Y., Stewart, M.D., Hewitt, S.C., Rodriguez, K.F., Korach, K.S., Behringer, R.R. Uterine gland formation in mice is a continuous process, requiring the ovary after puberty, but not after parturition. Biology of Reproduction 2011 85(5):954-964. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/21734259) ]
  52. Hart-Unger S, Korach KS. Estrogens and obesity: is it all in our heads? Cell metabolism 14(4):435-6, 2011. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=21982701) ]

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