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Selected Publications

Receptor Biology Group

  1. Korach, K.S., Emmen, J.M.A., Walker, V.R., Hewitt, S.C., Yates, M., Hall, J.M., Swope, D.L., Harrell, J.C., Couse, J.F., Update on animal models developed for analyses of estrogen receptor biological activity. J. Steroid Biochem Mol Biol 86: 387-391, 2003[Abstract ]
  2. Abraham, I.M., Todman, M.G., Korach, K.S., Herbison, A.E., Critical in vivo roles for classical estrogen receptors in rapid estrogen actions on intracellular signaling in the mouse brain. Endocrinology 145:3055-3061, 2004[Abstract ]
  3. Grummer, R, Hewitt, S.W., Traub, O., Korach, K.S., Winterhager, E., Different Regulatory Pathways of Endometrial Connexin Expression: Pre-implantation Hormonal Mediated Pathway Versus Embryo Implantation Initiated Pathway. Biol Reprod 71: 273-281, 2004[Abstract ]
  4. Mueller, S.O., Simon, S., Chae, K., Metzler, M., Korach, K.S., Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor ERα and ER?. Toxicol Sci. 80: 14-25, 2004.[Abstract ]
  5. DeRoo, B.J., Hewitt, S.C., Korach, K.S., Estradiol regulates the thioredoxin antioxidant system in the mouse uterus. Endocrinology 145: 5485-5492, 2004.[Abstract ]
  6. Santen, R.J., Yue, W., Boccinfuso, W., Korach, K.S., Wang, J-P., Rogan, E.G., Li, Y., Cavalieri, E., Russo, J., Devanesan, P., Verderame, M., Estradiol-induced carcinogenesis via formation of genotoxic metabolites, In: Advances in endocrine therapy of breast cancer. Ingle, J.N., Dowsett, M. (eds), Marcel Dekker, new York, 163-178, 2004.
  7. Couse, J.F., Korach, K.S., Estrogen receptor-αlpha mediates the detrimental effects of neonatal diethylstilbestrol (DES) exposure in the murine reproductive tract. Toxicology 205: 55-63, 2004.[Abstract ]
  8. Walker, V.R., Korach, K.S., Estrogen receptor knockout mice as a model for endocrine research. ILAR Journal 45: 455-461, 2004.[Abstract ]
  9. Couse, J.F., Yates, M.M., Sanford, R., Nyska, A., Nilson, J.H., Korach, K.S., Formation of cystic ovarian follicles associated with elevated luteinizing hormone requires estrogen receptor-beta. Endocrinology 145: 4693-4702, 2004.[Abstract ]
  10. Mueller, S.O., Katzenellenbogen, J.A., Korach, K.S., Endogenous estrogen receptor beta is transcriptionally active in primary ovarian cells from estrogen receptor knockout mice. Steroids 69: 681-686, 2004.[Abstract ]
  11. Kavaliers, M., Agmo, A., Choleris, E., Gustafsson, J-A., Korach, K.S., Muglia, L.J., Pfaff, D.W., Ogawa, S., Oxytocin and estrogen receptor alpha and beta knockout mice provide discriminably different odor cues in behavioral assays. Gene Brain Behav. 3: 189-195, 2004.[Abstract ]
  12. Pelzer, T., Loza, P-A.A., Hu, K., Bayer, B., Dienesch, C., Calvillo, L., Korach, K.S., Neyses, L., Ertl, G., Increased mortality and aggravation of heart failure in estrogen receptor-beta knockout mice after myocardial infarction. Circulation 111: 1492-1498, 2005.[Abstract ]
  13. Hewitt, S.C., Collins, J., Grissom, S., Deroo, B., Korach, K.S., Global uterine genomics in vivo: microarray evaluation of the estrogen receptor alpha-growth factor cross-talk mechanism. Mol Endocrinol 19: 657-668, 2005.[Abstract ]
  14. Skavdahl, M., Steenbergen, C., Clark, J., Myers, P., Demianeko, T., Mao, L., Rockman, H.A., Korach, K.S., Murphy, E., Estrogen receptor-beta mediates male-female differences in the development of pressure overload hypertrophy. Am. J. Physiol.: Heart and Circulatory Physiology 288: H469-476, 2005.[Abstract ]
  15. Ardelt, A.A., McCullough, L.D., Korach, K.S., Wang, W.M., Munzenmaier, D.H., Hurn, P.D., Estradiol regulates angiopoietin-1 mRNA expression through estrogen receptor-alpha in a rodent experimental stroke model. Stroke 36: 337-341, 2005.[Abstract ]
  16. Gougelet, A., Bouclier,C., Marsaud, V., Maillard, S., Mueller, S.O., Korach, K.S., Renoir, J-M, Estrogen receptor a and b subtype expression and transactivation capacity are differentially affected by receptor-, hsp90- and immunophilin-ligands in human breast cancer cells. J. Steroid Biochem Mol Biol 94: 71-81, 2005.[Abstract ]
  17. Jayachandran, M., Karnicki,K., Miller,R.S., Owen,W.G., Korach,K.S., Miller,V.M., Platelet Characteristics Change with Aging: Role of Estrogen Receptor beta. J Gerontol: Biol Sci. 60: 815-819, 2005.[Abstract ]
  18. Emmen, J.M.A., Couse, J.F., Elmore, S.A., Yates, M.M., Kissling, G.E., Korach, K.S., In vitro growth and ovulation of follicles from ovaries of estrogen receptor (ER){alpha} and ER{beta} null mice indicate a role for ER{beta} in follicular maturation. Endocrinology 146: 2817-2826, 2005.[Abstract ]
  19. Hewitt, S.C., Deroo, B.J., Korach, K.S., Signal transduction: a new mediator for an old hormone?, Science 307: 1572-1573, 2005.[Abstract ]
  20. Couse, J.F., Yates, M.M., Deroo, B.J., Korach, K.S., Estrogen receptor-beta is critical to granulosa cell differentiation and the ovulatory response to gonadotropins. Endocrinology 146: 3247-3262, 2005.[Abstract ]
  21. Aoyama, H., Couse, J.F., Curtis, S.W., Korach, K.S., Haseman, J., Dixon, D. Upregulation of estrogen receptor expression in the uterus of ovariectomized B6C3F1 mice and Ishikawa cells treated with bromoethane. Tox Appl Pharmacol 209:226-235, 2005.[Abstract ]
  22. Tekmal, R.R., Liu, Y.G., Nair, H.B., Jones, J., Perla, R.P., Lubahn, D.B., Korach, K.S., Kirma, N., Estrogen receptor-α is required for mammary development and the induction of mammary hyperplasia and epigenetic alterations in aromatase transgenic mice. J. Steroid Biochem Mol Biol 95: 9-15, 2005.[Abstract ]
  23. Hewitt, S.C., Harrell, J.C., Korach, K.S., Lessons in Estrogen Biology from Knockout and Transgenic Animals, Ann. Rev. Physiol. 67: 285-308, 2005.[Abstract ]
  24. Yue, W., Wang, J.P., Li, Y., Bocchinfuso, W.P., Korach, K.S., Devanesan, P.D., Rogan, E., Cavalieri, E., Santen, R. J., Tamoxifen versus aromatase inhibitors for breast cancer prevention. Clin Cancer Res. 11: 925s-930s, 2005.[Abstract ]
  25. Nomura, M., Andersson, S., Korach, K.S., Gustafsson, J-A, Pfaff, D. W., Ogawa, S., Estrogen receptor-beta gene disruption potentiates estrogen-inducible aggression but not sexual behavior in male mice. Neuroscience 23: 1860-1868, 2006.[Abstract ]
  26. LeMay, C., Chu, K., Hu, M., Oretga, C.S., Simpson, E.R., Korach, K.S., Tsai, M-J., Mauvais-Jarvis, F., Estrogens protect pancreatic β-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice. Proc. Natl. Acad. Sci. 103: 9232-9237, 2006.[Abstract ]
  27. Szego, E.M., Barabas, K., Balog, J., Szilagyi, N., Korach, K.S., Juhasz, G., Abraham, I.M., Estrogen induces estrogen receptor alpha dependent CREB phosphorylation via MAPK pathway in basal forebrain cholinergic neurons in vivo. J. Neuroscience 26: 4104-4110, 2006.[Abstract ]
  28. Couse, J.F., Yates, M.M., Rodriguez, K.F., Johnson, J.A., Poireir, D., Korach, K.S., The intraovarian actions of estrogen receptor-α (ER-α) are necessary to repress the formation of morphological and functional leydig cells in the female gonad. Endocrinology 147:  3666-3678, 2006.[Abstract ]
  29. Yamamoto, Y., Moore, R., Hess, H.A., Guo, G.L., Gonzalez, F.J., Korach, K.S., Maronpot, R.R., Negishi, M., Estrogen receptor alpha mediates 17alpha-ethynylestradiol-causing hepatotoxicity. J. Biol. Chem. 281: 16625-16631, 2006.[Abstract ]
  30. Qiu, J., Bosch, M.A., Tobias, S.C., Krust, A., Graham, S.M., Murphy, S.J., Korach, K.S., Chambon, P., Scanlan, T.S., Ronnekleiv, O.K., Kelly, M.J., A G protein-coupled estrogen receptor is involved in hypothalamic control of energy homeostasis. J. Neuroscience 26: 5649-5655, 2006.[Abstract ]
  31. Lindzey, J., Jayes, F.L., Yates, M.M., Couse, J.F., Korach, K.S., The bi-modal effects of estradiol on gonadotropin synthesis and secretion in female mice are dependent on estrogen receptor-α (ER-α). J. Endocrinology 191: 309-317, 2006[Abstract ]
  32. Choleris, E., Ogawa, S., Kavaliers, M.,Gustafsson, J.-Å, Korach, K.S., Muglia,  L. J., Pfaff, D.W., Involvement of estrogen receptor alpha, beta and oxytocin in social discrimination: A detailed behavioral analysis with knockout female mice. Genes Brain Behav. 5:528-539, 2006.[Abstract ]
  33. O’Brien, J.E., Peterson, T.J., Tong, M.H., Lee, E-J., Pfaff, L.E., Hewitt, S.C., Korach, K.S., Weiss, J., Jameson, J.L., Estrogen induced proliferation of uterine epithelial cells is independent of estrogen receptor a binding to classical estrogen response elements. J. Biol. Chem. 281: 26683-26692, 2006.[Abstract ]
  34. Dahlman-Wright, K., Cavailles, V.,  Fuqua, S.A., Jordan, V.C., Katzenellenbogen, J.A., Korach, K.S., Maggi, A., Muramatsu, M., Parker, M.G., Gustafsson, J.A., International union of pharmacology. LXIV. Estrogen Receptors. Pharmacol Rev. 58: 773-781, 2006.[Abstract ]
  35. Henley, D.V., Korach, K.S., Endocrine-disrupting chemicals use distinct mechanisms of action to modulate endocrine system function. Endocrinology 147: 25s-32s, 2006.[Abstract ]
  36. Couse, J.F., Hewitt, S.C., Korach, K.S., Steroid Receptors in the Ovary and Uterus, In: Knobil and Neill: Physiology of Reproduction 3rd Edition, Neill, J.D. (ed.), Academic Press, New York, New York, p 593-678, 2006.
  37. Lindzey, J., Korach, K.S., Environmental agents and the reproductive system, In: DeGroot, L.J. Jameson, L.J. (eds.), Endocrinology, W.B. Saunders, Co., New York, New York, pp 2759-2777, 2006.
  38. Taniguchi, F., Couse, J.F., Rodriguez, K.F., Poirier, D., Korach, K.S., Estrogen receptor-α (ERa) mediates an intraovarian negative feedback loop on thecal cell androgen synthesis via modulation of Cyp17a1 expression. FASEB J. 21: 586-595, 2007.[Abstract ]
  39. Henley, D.V., Lipson, N., Korach, K.S., Bloch, C.A., Prepubertal gynecomastia and lavender and tea tree oils. New Eng. J. Med. 356: 479-485, 2007.[Abstract ]
  40. Carey, M.A., Card, J.W., Bradbury, J.A., Moorman, M.P., Haykal-Coates, N., Gavett, S.H., Graves,J.P., Walker,V.R., Flake,G.P., Voltz, J.W., Zhu, D., Jacobs ,E.R., Dakhama, A., Larsen, G.L., Loader, J.L., Gelfand, E.W., Germolec, D.R., Korach, K.S., Zeldin,D.C., Spontaneous airway hyperresponsiveness in estrogen receptor-α deficient mice. Am J. Respiratory and Critical Care Medicine 175: 126-135, 2007.[Abstract ]
  41. Hewitt, S.C., O'Brien, J., Jameson, L., Kissling, G., Korach, K.S. Selective disruption of ER{alpha} DNA-binding activity alters uterine responsiveness to estradiol. Molecular endocrinology (Baltimore, Md.) 23(12):2111-2116, 2009.[Abstract ]
  42. Winuthayanon, W., Piyachaturawat, P., Suksamrarn, A., Ponglikitmongkol, M., Arao, Y., Hewitt, S.C., Korach, K.S. Diarylheptanoid phytoestrogens isolated from the medicinal plant Curcuma comosa: Biological actions in vivo and in vitro indicate ER-dependent mechanisms. Environmental health perspectives 117(7):1155-1161, 2009.[Abstract ]
  43. Deroo, B.J., Couse, J.F., Hamilton, K.J., Rodriguez, K.F., Collins, J.B., Grissom, S.F., Korach, K.S. Estrogen receptor beta is required for optimal cAMP production in mouse granulosa cells. Molecular endocrinology (Baltimore, Md.) 23(7):955-965, 2009.[Abstract ]
  44. Hewitt, S.C., Li, Y., Li, L., Korach, K.S. Estrogen Regulation of Igf1 and Uterine Growth Involves Direct Binding of Estrogen Receptors to Estrogen Responsive Elements. Journal of Biological Chemistry 285(4):2676-2685, 2010.[Abstract ]
  45. Bernardo, G.M., Lozada, K.L., Miedler, J.D., Harburg, G., Hewitt, S.C., Mosley, J.D., Godwin, A.K., Korach, K.S., Visvader, J.E., Kaestner, K.H., Abdul-Karim, F.W., Montano, M.M., Keri, R.A. FOXA1 is an essential determinant of ERalpha expression and mammary ductal morphogenesis. Development (Cambridge, England) 137(12):2045-2054, 2010.[Abstract ]
  46. Hewitt, S.C., Kissling, G.E., Fieselman, K.E., Jayes, F.L., Gerrish, K.E., Korach, K.S. Biological and biochemical consequences of global deletion of exon 3 from the ER{alpha} gene. The FASEB journal 24(12):4660-4667, 2010.[Abstract ]
  47. Arao Y, Carpenter K, Hewitt S, Korach KS. Estrogen down-regulation of the Scx gene is mediated by the opposing strand-overlapping gene Bop1. The Journal of biological chemistry 285(7):4806-4814, 2010.[Abstract ]
  48. Arao Y, Hamilton KJ , Ray MK, Scott GJ, Mishina Y, Korach K. Estrogen receptor α AF-2 mutation results in antagonist reversal and reveals tissue selective function of estrogen receptor modulators. Proceedings of the National Academy of Sciences of the United States of America, 108(36):14986-14991, 2011.[Abstract ]
  49. Winuthayanon, W., Hewitt, S.C., Orvis, G.D., Behringer, R.R., Korach, K.S. Uterine Epithelial Estrogen Receptor alpha is Dispensable for Proliferation But Essential for Complete Biological and Biochemical Responses. Proceedings of the National Academy of Sciences of the United States of America 107(45):19272-19277, 2010.[Abstract ]
  50. Hewitt, S.C., Korach, K.S. Estrogenic Activity of Bisphenol A and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE) Demonstrated in Mouse Uterine Gene Profiles. Environmental health perspectives 119(1):63-70, 2011.[Abstract ]
  51. Ribas, V., Drew, B.G., Le, J.A., Soleymani, T., Daraei, P., Sitz, D., Mohammad, L., Henstridge, D.C., Febbraio, M.A., Hewitt, S.C., Korach, K.S., Bensinger, S..J, Hevener, A.L. Myeloid-specific estrogen receptor alpha deficiency impairs metabolic homeostasis and accelerates atherosclerotic lesion development. Proceedings of the National Academy of Sciences of the United States of America  108(39):16457-16462, 2011.[Abstract ]  
  52. Burns KA, Li Y, Arao Y, Petrovich RM, Korach KS. Selective mutations in estrogen receptor alpha D-domain alters nuclear translocation and non-estrogen response element gene regulatory mechanisms. The Journal of biological chemistry 286(14):12640-12649, 2011.[Abstract ]
  53. Hewitt, S.C., Korach, K.S. A hand to support the implantation window. Science  331(6019):683-684, 2011.[Abstract ]  
  54. Stewart, A.C., Fisher, S.J., Wang, Y., Stewart, M.D., Hewitt, S.C., Rodriguez, K.F., Korach, K.S., Behringer, R.R. Uterine gland formation in mice is a continuous process, requiring the ovary after puberty, but not after parturition. Biology of Reproduction 2011 85(5):954-964.[Abstract ]
  55. Hart-Unger S, Korach KS. Estrogens and obesity: is it all in our heads? Cell metabolism 14(4):435-6, 2011.[Abstract ]
  56. Li Y., Burns K.A., Arao Y., Luh C.J., Korach K.S. Differential estrogenic actions of endocrine-disrupting chemicals bisphenol A, bisphenol AF, and zearalenone through estrogen receptor α and β in vitro. Environmental health perspectives 120(7):1029-1035, 2012. [Abstract ]
  57. Burns K.A., Rodriguez K.F., Hewitt S.C., Janardhan K.S., Young S.L., Korach K.S. Role of estrogen receptor signaling required for endometriosis-like lesion establishment in a mouse model. Endocrinology 153(8):3960-3971, 2012.[Abstract ]
  58. Arao Y., Hamilton K.J., Goulding E.H., Janardhan K.S., Eddy E.M., Korach K.S. Transactivating function (AF) 2-mediated AF-1 activity of estrogen receptor α is crucial to maintain male reproductive tract function. Proceedings of the National Academy of Sciences of the United States of America 109(51):21140-21145, 2012.[Abstract ]
  59. Davis VL, Newbold RR, Couse JF, Rea SL, Gallagher KM, Hamilton KJ, Goulding EH, Jefferson W, Eddy EM, Bullock BC, Korach KS. Expression of a dominant negative estrogen receptor alpha variant in transgenic mice accelerates uterine cancer induced by the potent estrogen diethylstilbestrol. Reproductive toxicology (Elmsford, N.Y.) 34(4):512-521, 2012[Abstract ]
  60. Li Y, Luh CJ, Burn KA, Arao Y, Jiang Z, Teng CT, Tice EE, Korach KS. Endocrine-disrupting chemicals (EDCs): in vitro mechanism of estrogenic activation and differential effects on ER target genes. Environ Health Perspect 2013; 121(4): 459-466.[Abstract ]
  61. Wall EH, Hewitt SC, Liu L, del Rio R, Case LK, Lin CY, Korach KS, Teuscher C. Genetic control of estrogen-regulated transcriptional and cellular responses in mouse uterus. FASEB journal: official publication of the Federation of American Societies for Experimental Biology 27(5):1874-1886, 2013.[Abstract ]
  62. Binder AK, Rodriguez KF, Hamilton KJ, Stockton PS, Reed CE, Korach KS. The absence of ERβ results in altered gene expression in ovarian granulosa cells isolated from in vivo preovulatory follicles. Endocrinology 154(6):2174-2187, 2013.[Abstract ]
  63. Arao Y., Hamilton K.J., Coons L.A., Korach K.S. Estrogen Receptor α L543A,L544A Mutation Changes Antagonists to Agonists, Correlating with the Ligand Binding Domain Dimerization Associated with DNA Binding Activity. The Journal of biological chemistry 288(29):21105-21116, 2013.[Abstract ]
  64. Winuthayanon W, Piyachaturawat P, Suksamrarn A, Burns KA, Arao Y, Hewitt SC, Pedersen LC, Korach KS. The natural estrogenic compound diarylheptanoid (D3): in vitro mechanisms of action and in vivo uterine responses via estrogen receptor α. Environmental health perspectives 121(4):433-439, 2013.[Abstract ]
  65. Arao Y, Hamilton KJ, Korach KS. The Transactivating Function 2 (AF-2) of Estrogen Receptor (ER) α Is Indispensable for ERα-Mediated Physiological Responses and AF-1 Activity. Open Journal of Endocrine and Metabolic Diseases 3(4B):12-19, 2013. [Abstract ]
  66. Burns KA, Zorrilla LM, Hamilton KJ, Reed CE, Birnbaum LS, Korach KS. A Single Gestational Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Disrupts the Adult Uterine Response to Estradiol in Mice. Toxicological Sciences 2013 136(2):514-526.[Abstract ]
  67. Jayes FL, Burns KA, Rodriguez KF, Kissling GE, Korach KS. The naturally occurring luteinizing hormone surge is diminished in mice lacking estrogen receptor Beta in the ovary. Biology of reproduction 2014 90(2):24-.[Abstract ]
  68. Hewitt SC, Li L, Grimm SA, Winuthayanon W, Hamilton KJ, Pockette B, Rubel CA, Pedersen LC, Fargo D, Lanz RB, DeMayo FJ, Schütz G, Korach KS. Novel DNA motif binding activity observed in vivo with an estrogen receptor α mutant mouse. Molecular endocrinology (Baltimore, Md.) 2014 28(6):899-911. [Abstract ]

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