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Selected Publications

Pharmacogenetics Group

Nuclear Receptor CAR

  1. Gotoh S, Negishi M. Serum- and glucocorticoid-regulated kinase 2 determines drug-activated pregnane X receptor to induce gluconeogenesis in human liver cells. The Journal of pharmacology and experimental therapeutics 2014 348(1):131-140.[Abstract ]
  2. Sueyoshi T, Li L, Wang H, Moore R, Kodavanti PR, Lehmler HJ, Negishi M, Birnbaum LS. Flame Retardant BDE-47 Effectively Activates Nuclear Receptor CAR in Human Primary Hepatocytes. Toxicological sciences: an official journal of the Society of Toxicology 2014 137(2):292-302.[Abstract ]
  3. Kodama S, Negishi M. Sulfotransferase genes: regulation by nuclear receptors in response to xeno/endo-biotics. Drug metabolism reviews 2013 45(4):441-449. 
    [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/24025090?dopt=Abstract) ]
  4. Saito K, Moore R, Negishi M. p38 Mitogen-activated protein kinase regulates nuclear receptor CAR that activates the CYP2B6 gene. Drug metabolism and disposition: the biological fate of chemicals 2013 41(6):1170-1173. [Abstract ]
  5. Shindo S, Moore R, Flake G, Negishi M. Serine 216 phosphorylation of estrogen receptor α in neutrophils: migration and infiltration into the mouse uterus. PloS one 2013 8(12):e84462-.[Abstract ]
  6. Saito K, Moore R, Negishi M. Nuclear receptor CAR specifically activates the two-pore K+ channel Kcnk1 gene in male mouse livers, which attenuates phenobarbital-induced hepatic hyperplasia. Toxicological sciences: an official journal of the Society of Toxicology 2013 132(1):151-161.[Abstract ]
  7. Sobhany M, Kakuta Y, Sugiura N, Kimata K, Negishi M. The structural basis for a coordinated reaction catalyzed by a bifunctional glycosyltransferase in chondroitin biosynthesis. The Journal of biological chemistry 2012 287(43):36022-36028.[Abstract ]
  8. Kamino H, Negishi M. The nuclear receptor constitutive active/androstane receptor (CAR) arrests DNA-damaged human hepatocellular carcinoma Huh7 cells at the G2/M phase. Molecular carcinogenesis 2012 51(2):206-12.[Abstract ]
  9. Kodama, S., Hosseinpour, F., Goldstein, J.A., and Negishi, M. Liganded pregnane X receptor represses the human sulfotransferase SULT1E1 promoter through disrupting its chromatin structure. Nucleic Acids Research 2011 39(19):8392-8403.[Abstract ]
  10. Osabe, M., Negishi, M. Active ERK1/2 protein interacts with the phosphorylated nuclear constitutive active/androstane receptor (CAR; NR1I3), repressing dephosphorylation and sequestering CAR in the cytoplasm. The Journal of biological chemistry 2011 286(41):35763-35769.[Abstract ]
  11. Yamazaki, Y., Moore, R., Negishi, M. Nuclear receptor CAR (NR1I3) is essential for DDC-induced liver injury and oval cell proliferation in mouse liver. Lab Invest 2011 91(11):1624-1633.[Abstract ]
  12. Kamino, H., Moore, R., and Negishi, M. The role of a novel CAR-induced gene TUBA8 in hepatocellular carcinoma cell lines. Cancer genetics 2011 204(7):382-391.[Abstract ]  
  13. Sueyoshi, T., Green, W.D., Vinal, K., Woodrum, T.S., Moore, R., and Negishi, M. Garlic extract diallyl sulfide (DAS) activates nuclear receptor CAR to induce the Sult1e1 gene in mouse liver. PLOS ONE 2011 6(6):e21229-.[Abstract ]  
  14. Kodama, S., and Negishi, M.: Pregnane X Receptor PXR Activates the GADD45{beta} Gene, Eliciting the p38 MAPK Signal and Cell Migration. The Journal of biological chemistry 2011 286(5):3570-3578.[Abstract ]
  15. Kamino, H., Yamazaki, Y., Saito, K., Takizawa, D., Kakizaki, S., Moore, R., and Negishi, M.: Nuclear receptor CAR-regulated expression of the FAM84A gene during the development of mouse liver tumors. International Journal of Oncology 2011 38(6):1511-1520.[Abstract ]
  16. Yao, R., Yasuoka, A., Kamei, A., Kitagawa, Y., Tateishi, N., Tsuruoka, N., Kiso, Y., Sueyoshi, T., Negishi, M., Misaka, T., and Abe, K.: Dietary flavonoids activate constitutive androstane receptor, CAR. Journal of agricultural and food chemistry 2010 58(4):2168-2173.[Abstract ]
  17. Konno, Y., Kamino, H., Moore, R., Lih, F., Tomer, K.B., Zeldin, D.C., Goldstein, J.A., and Negishi, M.: The nuclear receptors constitutive active/androstane receptor and pregnane x receptor activate the Cyp2c55 gene in mouse liver. Drug Metabolism and Disposition 2010 38(7):1177-1182.[Abstract ]
  18. Yamamoto, Y., Moore, R., Flavell, R.A., Lu, B., and Negishi, M.: Nuclear receptor CAR represses TNFalpha-induced cell death by interacting with the anti-apoptotic GADD45B. PloS one 2010 5(4):e10121.[Abstract ]
  19. Konno, Y., Kodama, S., Moore, R., Kamiya, N., and Negishi, M.: Nuclear xenobiotic receptor pregnane X receptor locks corepressor silencing mediator for retinoid and thyroid hormone receptors (SMRT) onto the CYP24A1 promoter to attenuate vitamin D3 activation. Molecular pharmacology 2009 75(2):265-271.[Abstract ]
  20. Yeung, E.Y., Sueyoshi, T., Negishi, M., and Chang, T.K.: Identification of ginkgo biloba as a novel activator of pregnane X receptor. Drug metabolism and disposition: the biological fate of chemicals 2008 36(11):2270-2276.[Abstract ]
  21. Sobhany M, Kakuta Y, Sugiura N, Kimata K, Negishi M.: The chondroitin polymerase K4CP and the molecular mechanism of selective bindings of donor substrates to two active sites. The Journal of biological chemistry 2008 283(47):32328-32333.[Abstract ]
  22. Yamamoto, Y., and Negishi, M.: The antiapoptotic factor growth arrest and DNA-damage-inducible 45 beta regulates the nuclear receptor constitutive active/androstane receptor-mediated transcription. Drug metabolism and disposition: the biological fate of chemicals 2008 36(7):1189-1193.[Abstract ]
  23. Li, L., Chen, T., Stanton, J.D., Sueyoshi, T., Negishi, M., and Wang, H.: The peripheral benzodiazepine receptor ligand 1-(2-chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide is a novel antagonist of human constitutive androstane receptor. Mol. Pharmacol. 2008 74(2):443-453.[Abstract ]
  24. Konno, Y., Negishi, M., and Kodama, S.: The roles of nuclear receptors CAR and PXR in hepatic energy metabolism. Drug metabolism and pharmacokinetics 2008 23(1):8-13.[Abstract ]
  25. Inoue, K.: Nuclear receptor CAR requires early growth response 1 to activate the human cytochrome P450 gene. The Journal of biological chemistry 2008 283(16):10425-10432.[Abstract ]
  26. Hosseinpour, F., Timsit, Y., Koike, C., Matsui, K., Yamamoto, Y., Moore, R., and Negishi, M.: Overexpression of the Rho-guanine nucleotide exchange fractor ECT2 inhibits nuclear translocation of nuclear receptor CAR in the mouse liver. FEBS letters 581(25):4937-4942, 2007.[Abstract ]
  27. Kodama, S., Moore, R., Yamamoto, Y., and Negishi, M.: Human nuclear pregnane X receptor cross-talk with CREB to repress cAMP activation of the glucose-6-phosphatase gene. Biochem J 407:373–381, 2007.[Abstract ]
  28. Tien, E., Matsui, K., Moore, R., and Negishi, M.: The nuclear receptor constitutively active/androstane receptor regulates type 1 deiodinase and thyroid hormone activity in regenerating liver. J. Pharmacol. Exp. Ther. 320: 307-313, 2007.[Abstract ]
  29. Yamamoto, Y., Moore, R., Goldsworthy, T. L., Negishi, M., and Maronpot, R. R.: The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice. Can. Res. 64: 7197-7200, 2004.[Abstract ]
  30. Kodama, S., Koike, C., Negishi, M., and Yamamoto, Y.: Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug metabolizing and gluconeogenic enzymes. Mol. Cell. Biol. 24: 7931-7940, 2004.[Abstract ]
  31. Kobayashi, K., Sueyoshi, T., Inoue, K., Moore, R., and Negishi, M.: Cytoplasmic accumulation of the nuclear receptor CAR by a tetratricopeptide repeat protein in HepG2 cells. Mol. Pharmacol. 64: 1069-1075, 2003.[Abstract ]
  32. Ueda, A., Hamadeh, H. K., Webb, H.K., Yamamoto, Y., Sueyoshi, T., Afshari, C.A., Lehmann, J., and Negishi, M.: Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital. Mol. Pharmacol. 61: 1-6, 2002.[Abstract ]
  33. Kawamoto, T., Sueyoshi, T., Zelko, T., and Negishi, M.: Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene. Mol. Cell. Biol.19: 6318-6322, 1999.[Abstract ]
  34. Sueyoshi, T., Kawamoto, T., Zelko, I., Honkakoski, P., and Negishi, M.: The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene. J. Biol. Chem. 274: 6043-6046, 1999.[Abstract ]
  35. Honkakoski, P., Zelko, I., Sueyoshi, T., and Negishi, M.: The nuclear receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene. Mol. Cell. Biol.18: 5652-5658, 1998.[Abstract ]

 

Molecular Glycobiology

  1. Sobhany M, Kakuta Y, Sugiura N, Kimata K, Negishi M.: The chondroitin polymerase K4CP and the molecular mechanism of selective bindings of donor substrates to two active sites. The Journal of biological chemistry 2008 283(47):32328-32333.[Abstract ]
  2. Sobhany, M., Dong, J., and Negishi, M.: Two-step mechanism that determines the donor binding specificity of human N-acetylhexosaminyltransferase. J. Biol. Chem. 280: 23441-23445, 2005.[Abstract ]
  3. Pedersen, L.C., Dong, J., Taniguchi, F., Kitagawa, H., Krahn, J., Pedersen, L.G., Sugahara, K., and Negishi, M.: Crystal structure of an alpha 1, 4-N-acetylhexosaminyltransferase (EXTL2), a member of the exostosin gene family involved in heparan sulfate biosynthesis. J. Biol. Chem. 278: 14420-14428, 2003.[Abstract ]
  4. Pedersen, L.C., Darden, T.A., and Negishi, M.: Crystal structure of beta 1,3-glucuronyltransferase I in complex with active donor substrate UDP-GlcUA. J. Biol. Chem. 277: 21869-21873, 2002.[Abstract ]

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