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Your Environment. Your Health.

Selected Publications


  1. Whitehead GS, Thomas SY, Cook DN. Modulation of distinct asthmatic phenotypes in mice by dose-dependent inhalation of microbial products. Environmental health perspectives 122(1):34-42, 2014.[Abstract ]
  2. Nakano H, Burgents J, Nakano K, Whitehead G, Cheong C, Bortner C, Cook D. Migratory properties of pulmonary dendritic cells are determined by their developmental lineage. Mucosal Immunology 6(4):678-691, 2013.[Abstract ]
  3. Draper DW, Gowdy KM, Madenspacher JH, Wilson RH, Whitehead GS, Nakano H, Pandiri AR, Foley JF, Remaley AT, Cook DN, Fessler MB. ATP binding cassette transporter G1 deletion induces IL-17-dependent dysregulation of pulmonary adaptive immunity. Journal of Immunology 188(11):5327-2336, 2012.[Abstract ]
  4. Wilson RH, Maruoka S, Whitehead GS, Foley JF, Flake GP, Sever ML, Zeldin DC, Kraft M, Garantziotis S, Nakano H, Cook DN. The TLR5 ligand, bacterial flagellin, promotes asthma by priming allergic responses to indoor allergens. Nat Med. Nov;18(11):1705-10, 2012.[Abstract ]
  5. Nakano H, Free ME, Wilson RH, Maruoka S, Whitehead GS, Cook DN. Lung resident CD103+ dendritic cells selectively prime Th2 responses to inhaled antigens. Mucosal Immunol. 2012 Jan;5(1):53-65, 2012.[Abstract ]
  6. Whitehead GS, Wilson RH, Nakano K, Burch LH, Nakano H, Cook DN. IL-35 production by inducible costimulator (ICOS)-positive regulatory T cells reverses established IL-17-dependent allergic airways disease. Journal of Allergy and Clinical Immunology 2012 129(1):207-15.[Abstract ]
  7. Hollingsworth, JW, Free, ME, Li, Z, Andrews, LN, Nakano, H, Cook, DN. Ozone activates pulmonary dendritic cells and promotes allergic sensitization through a Toll-like receptor 4-dependent mechanism. Journal of Allergy and Clinical Immunology 125(5):1167-1170, 2010.[Abstract ]
  8. Wilson, RH, Whitehead, GS, Nakano, H, Free, ME, Kolls, JK, Cook, DN. Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness. Am J Respir Crit Care Med. 2009 Oct 15;180(8):720-30. Epub 2009 Aug 6.[Abstract ]
  9. Cook, DN, Bottomly, K. Innate immune control of pulmonary dendritic cell signaling. Proceedings of the American Thoracic Society 4(3):234-239, 2007.[Abstract ]
  10. Hollingsworth, JW, Whitehead, GS, Lin, KL, Nakano, H, Gunn, MD, Schwartz, DA, Cook, DN. TLR4 signaling attenuates ongoing allergic inflammation. J Immunol. 176(10):5856-62, May 15, 2006.[Abstract ]
  11. Whitehead, GS, Wang, T, Degraff, LM, Card, JW, Lira, SA, Graham, GJ, Cook, DN. (2006) The chemokine receptor D6 has opposing affects on allergic inflammation and airway reactivity. Am J Respir Crit Care Med. 2006 Nov 9; [Epub ahead of print], PMID: 17095748 [PubMed - as supplied by publisher].[Abstract ]
  12. Jamison, T, Cook, DN, Nibbs, RJ, Antal Rot, Noxon, C, McLean, P, Alcami, A, Lira, SA, Wiekowski, M, and Graham, GJ. The chemokine receptor D6 limits the inflammatory response in vivo. Nature Immunology 6:403-11, 2005.[Abstract ][Full Text ][PDF ]
  13. Cook, DN, Pisetsky, DS, Schwartz, DA. Toll-like receptors and the pathogenesis of human disease. Nature Immunology 5:975-9, 2004.[Abstract ][Full Text ][PDF ]
  14. Lukacs, NW, Prosser, DM, Wiekowski, M, Lira, SA and Cook, DN (2001). Requirement for the chemokine receptor CCR6 in allergic pulmonary inflammation. Journal of Experimental Medicine 194:551-6, 2001.[Abstract ][Full Text ][PDF ]
  15. Cook, DN, Prosser, DM, Reinhold Forster, Jiwen Zhang, Kuklin, NA, Abbondanzo, SJ, Xiao-Da, Niu, Chen, S, Manfra, DJ, Wiekowski, MT, Sullivan, LM, Smith, SR, Greenberg, HB, Narula, SK, Martin Lipp, Lira, SA. CCR6 mediates dendritic cell localization, lymphocyte homeostasis and immune responses in mucosal tissue. Immunity 12:495-503, 2000.[Abstract ]
  16. Cook, DN, Beck, MA, Coffman, TM, Kirby, SL, Sheridan, JH, Pragnell, IB and Smithies, O. Requirement of MIP-1alpha for an inflammatory response to viral infection. Science 269:1583-1585, 1995.[Abstract ]

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