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Selected Publications

Environmental Genetics Group

Ozone (O3)-induced Pulmonary Injury and Inflammation

  1. Kleeberger SR, Levitt RC, Zhang LY, Longphre M, Harkema J, Jedlicka A, Eleff SM, DiSilvestre D, Holroyd KJ. Linkage analysis of susceptibility to ozone-induced lung inflammation in inbred mice. Nature Genetics 17:475-478, 1997. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/9398854) ]
    • [ see also, News & Views: The genetics of air pollution, Drazen JM, and Beier DR, Nature Genetics 17:365-366, 1997. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/9398826) ] ]
  2. Kleeberger SR, Reddy SPM, Zhang LY, Jedlicka AE. Genetic susceptibility to ozone-induced lung hyperpermeability: role of the toll-like receptor 4 (Tlr4). Am J Respir Cell Mol Biol 22:620-627, 2000. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/10783135) ]
  3. Cho HY, Jedlicka AE, Zhang LY, Kleeberger SR. Ozone-induced lung inflammation and hyperreactivity are mediated via tumor necrosis factor-alpha receptors. Am J Physiol Lung Cell Mol Physiol 280:L537-L546, 2001. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/11159038) ]
    • [ see also, Commentary: Scavenger receptors clear the air, EM Postlethwait, J Clin Invest 117:601-604, 2007. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/17332891) ] ]
  4. Dahl M, Bauer AK, Arredouani M, Soininen R, Trygvasson K, Kleeberger SR, Kobzik L. Protection against inhaled oxidants through scavenging of oxidized lipids by macrophage receptors MARCO and SR-AI/II. J Clin Invest 117:757-764, 2007. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/17332894) ]
  5. Cho HY, Morgan DL, Bauer AK, Kleeberger SR. Signal transduction pathways of tumor necrosis factor mediated lung injury induced by ozone in mice. Am J Respir Crit Care Med 175:829-839, 2007. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/17255564) ]
  6. Yoon HK, Cho HY, Kleeberger SR. Protective role of matrix metalloproteinase-9 in ozone-induced airway inflammation. Environ Health Perspect 115:1557-1563, 2007. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/18007984) ]
  7. Alexis NE, Zhou H, Lay JC, Harris B, Hernandez ML, Lu T, Bromberg PA, Kleeberger SR, Peden DB. The glutathione-S-transferase Mu 1 null genotype modulates ozone-induced airway inflammation in humans. J Allergy Clin Immunol 124:1222-1228, 2009. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/19796798) ]
  8. Bauer AK, Travis E, Malhotra SS, Rondini EA, Walker C, Cho HY, Trivedi S, Gladwell W, Reddy S, Kleeberger SR. Genetic susceptibility to ozone-induced inflammation: role of MCH class II genes. Eur Respir J 36(2):428-437, 2009. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/20032013) ]
  9. Backus GS, Howden R, Fostel J, Bauer AK, Cho HY, Marzec J, Peden DB, Kleeberger SR. Protective role of IL-10 in ozone-induced pulmonary inflammation. Environ Health Perspect 118(12):1721-1727, 2010. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/20826374) ]
  10. Bauer AK, Rondini EA, Hummel K, Degraff LM, Walker C, Jedlicka AE, Kleeberger SR. Pathways downstream of toll like receptor 4 in ozone-induced lung inflammation: a role for heat shock protein 70. Environ Health Perspect 119(8):1091-1097, 2011. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/21543283) ]

Mechanisms of Susceptibility to Hyperoxia-induced Lung Injury in Adults and Neonates

  1. Cho HY, Jedlicka AE, Reddy SPM, Zhang LY, Kensler TW, Kleeberger SR. Linkage analysis of susceptibility to hyperoxia: Nrf2 is a candidate gene. Am J Respir Cell Mol Biol 26:42-51, 2002. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/11751202) ]
  2. Cho HY, Jedlicka AE, Reddy SPM, Kensler TW, Yamamoto M, Zhang LY, Kleeberger SR. Role of NRF2 in protection against hyperoxic lung injury in mice. Am J Respir Cell Mol Biol 26:175-182, 2002. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/11804867) ]
    • [ see also, Perspective: The saga of leucine zippers continues, Otterbein LE, Choi AMK, Am J Respir Cell Mol Biol 26:161-163, 2002. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/11804863) ] ]
  3. Cho HY, Reddy SPM, Yamamoto M, Kleeberger SR. The transcription factor NRF2 protects against pulmonary fibrosis. FASEB J 18:1258-1260, 2004. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15208274) ]
  4. Cho HY, Reddy SPM, DeBiase A, Yamamoto M, Kleeberger SR. Microarray gene expression profiling in oxidative lung injury and NRF2-mediated protection. Free Radical Biology and Medicine 38:325-343, 2005. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15629862) ]
  5. Cho H-Y, Reddy SP, Kleeberger SR. NRF2 defends the lung from oxidative stress. Antioxid Redox Signal 8:76-87, 2006. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/16487040) ]
  6. Marzec J, Christie JD, Reddy SP, Jedlicka AE, Vuong H, Lanken PN, Aplenc R, Yamamoto T, Yamamoto M, Cho HY, Kleeberger SR. Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury. FASEB J 21:2237-2246, 2007. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/17384144) ]
  7. Wang X, Tomso DJ, Chorley BN, Cho HY, Cheung VG, Kleeberger SR, Bell DA. Identification of polymorphic antioxidant response elements in the human genome. Hum Molec Genet 16:1188-1200, 2007. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/17409198) ]
  8. Reddy NM, Suryanarayana V, Kalvakolanu DV, Yamamoto M, Kensler TW, Hassoun PM, Kleeberger SR, Reddy SP. Innate immunity against bacterial infection following hyperoxia exposure is impaired in NRF2-deficient mice. J Immunol 183:4601-4608, 2009. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/19734219) ]
  9. Reddy AJ, Christie JD, Aplenc R, Fuchs B, Lanken PN, Kleeberger SR. Association of human NAD(P)H:Quinone oxidoreductase 1 polymorphism with development of acute lung injury. J Cell Mol Med 13(8):1784-1791, 2009. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/19017358) ]
  10. Cho HY, Gladwell W, Wang X, Chorley B, Bell D, Reddy SP, Kleeberger SR. Nrf2-regulated PPAR-γ expression is critical to protection against acute lung injury in mice. Am J Respir Crit Care Med 182(2):170-182, 2010. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/20224069) ]
    • [ see also accompanying editorial, Reddy RC, Standiford TJ. Nrf2 and PPAR-γ: PPARtnering against oxidant-induced lung injury. Am J Respir Crit Care Med 182(2):134-135. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/20634499) ] ]
  11. Bauer AK, Cho HY, Miller-DeGraff L, Walker C, Helms K , Fostel J, Yamamoto M, Kleeberger SR. Targeted deletion of Nrf2 reduces urethane-induced lung tumor development in mice. PloS One 6(10):e26590, 2011. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/22039513?dopt=Abstract) ]
  12. Chorley BN, Campbell MR , Wang X , Karaca M, Sambandan D, Bangura F, Xue P, Pi J, Kleeberger SR , Bell DA. Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha. Nucleic Acids Research  40(15):7416-29, 2012. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=22581777) ]
  13. Howden, R, Cho, HY, Miller-DeGraff, L, Walker, C, Clark, JA, Myers, PH, Rouse, DC, Kleeberger, SR. Cardiac physiologic and genetic predictors of hyperoxia-induced acute lung injury in mice. American journal of respiratory cell and molecular biology. 46(4):470-8, 2012. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=22052878) ]

Mechanisms of Respiratory Syncytial Virus (RSV) Infection and Disease Severity

  1. Polack FP, Hoffman SJ, Collins PL, Laham FR, Thumar B, Hendry RM, Murphy PM, Randolph V, Karron RA, Kleeberger SR. The cysteine-rich region of respiratory syncytial virus attachment protein inhibits innate immunity elicited by the virus and endotoxin. Proc Natl Acad Sci USA 125:8996-9001, 2005. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15956195) ]
  2. Klein MI, Coviello S, Bauer G, Benitez A, Schiatti MP, Delgado MF, Serra ME, Novalli L, Kleeberger SR, Polack FP. The impact of infection with human metapneumovirus and other viruses in young infants and children at high risk for severe pulmonary disease. J Infect Dis 193:1544-1551, 2006. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/16652283) ]
  3. Melendi GA, Hoffman SJ, Karron RA, Irusta PM, Laham FR, Humbles A, Schofield B, Pan C, Rabold R, Thumar B, Thumar A, Gerard NP, Mitzner W, Barnum SR, Gerard C, Kleeberger SR, Polack FP. C5 modulates airways hyperreactivity and pulmonary eosinophilia during enhanced respiratory syncytial virus disease by decreasing C3a receptor expression. J Virol 81:991-999, 2007. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/17079327) ]
  4. Melendi GA, Laham FR, Monsalvo AC, Casellas JM, Israele V, Polack NR, Kleeberger SR, Polack FP. Cytokine profiles in the respiratory tract during primary infection with human metapneumovirus, respiratory syncytial virus, or influenza in infants. Pediatrics 120:e410-415, 2007. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/17671045) ]
  5. Klein MI, Bergel E, Coviello S, Bauer G, Benitez A, Serra ME, Delgado MF, Melendi GA, Aspres N, Irusta PM, Rodriguez S, Kleeberger SR, and Polack FP. Differential gender susceptibility to respiratory infections and to the protective effect of breast milk in premature infants. Pediatrics 121:e1510-1516, 2008. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/18519454) ]
  6. Cho HY, Imani F, Miller-Degraff L, Walters D, Melendi GA, Yamamoto M, Polack FP, Kleeberger SR. Antiviral activity of Nrf2 in a murine model of respiratory syncytial virus (RSV) disease. Am J Respir Crit Care Med 179:138-150, 2009. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/18931336) ]
  7. Miller EK, Bugna J, Libster R, Shepherd BE, Scalzo PM, Acosta PL, Hijano D, Reynoso N, Batalle JP, Coviello S, Klein MI, Bauer G, Benitez A, Kleeberger SR, Polack FP. Human rhinoviruses in severe respiratory disease in very low birth weight infants. Pediatrics. 129(1):e60-7, 2012. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=22201153) ]

Mechanisms of Susceptibility to Lung Tumorigenesis

  1. Bauer A, Malkinson A, Kleeberger SR. Susceptibility to neoplastic and non-neoplastic pulmonary diseases in mice: genetic similarities. Am J Physiol Lung Cell Mol Physiol 287:L685-L703, 2004. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15355860) ]
  2. Bauer AK, Fostel J, Degraff LM, EA Rondini, C Walker, S Grissom, J Foley, Kleeberger SR. Toll-like receptor 4 in butylated hydroxytoluene-induced mouse pulmonary inflammation and tumorigenesis. J Natl Cancer Inst (JNCI) 97:1778-1781, 2005. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/16333033) ]
  3. Bauer AK, Dixon D, Miller-DeGraf L, Walker C, Malkinson A, Kleeberger SR. Transcriptomic analysis of pathways regulated by toll-like receptor 4 (TLR4) in a murine model of chronic pulmonary inflammation and carcinogenesis. Mol Cancer 19:107, 2009. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/19925653) ]
  4. Bauer AK, Cho HY, Miller-DeGraff L, Walker C, Helms K, Fostel J, Yamamoto M, Kleeberger SR. Targeted deletion of Nrf2 reduces urethane-induced lung tumor development in mice. PLoS One, 2011. (in press)

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