Selected Publications

Cell Biology Group

1. Yan, Z-H., Karam, W.K., Staudinger, J.L., Medvedev, A., Ghanayem, B.I., and Jetten, A.M. Regulation of peroxisome proliferator-activated receptor alpha-induced transactivation by the nuclear orphan receptor TAK1/TR4. J. Biol. Chem. 273:10948-10957 (1998). [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9556573
2. Adachi, H., Adams, A., Hughes, F.M., Zhang, J., Cidlowski, J.A., and  Jetten, A.M.  Induction of apoptosis by the novel retinoid AHPN in human T cell lymphoma cells involves caspase-dependent and independent pathways.  Cell Death & Diff. 5: 973-983 (1998) [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9846184
3. Medvedev, A., Chistokhina, A., Matsuura, W., and Jetten, A.M. Regulation of the transglutaminase I gene: identification of DNA elements involved in its transcriptional control in tracheobronchial epithelial cells. J. Biol. Chem. 274: 3887-3896 (1999). [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9920944
4. Sakaue, M., Adachi, H., and Jetten, A.M. Post-transcriptional regulation of MyD118 and GADD45 in human lung carcinoma cells during 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2- naphthalene carboxylic acid-induced apoptosis. Mol. Pharmacol. 55: 668-676 (1999). [Abstract] [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10101024]
5. Matsuura, H., Sakaue, M., Subbaramaiah, K., Kamitani, H., Eling, T., Dannenberg, A.J., Tanabe, T., Inoue, H., Arata, J., and Jetten, A.M. Regulation of cyclooxygenase-2 by interferon gamma and transforming growth factor alpha in normal human epidermal keratinocytes and squamous carcinoma cells. Role of mitogen-activated protein kinases. J. Biol. Chem. 274: 29138-29148 (1999). [Abstract] [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10506169]
6. Jetten, A.M., and Suter U. The peripheral myelin protein 22 and epithelial membrane protein family. Structure, function, regulation and roles in disease. Progress in Nucl. Acids Res. and Mol. Biol. 64: 97-129 (2000) [Abstract] [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10697408]
7. Kurebayashi, S., Ueda, E., Sakaue, M., Patel, D., Medvedev, A., Zhang, F., and Jetten, A.M. Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis. Proc. Natl. Acad. Sci USA.  97: 10132- 10137 (2000) [Abstract] [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10963675]
8. Kim, S.Y., Adachi, H., Koo, J.S., and Jetten, A.M. Induction of cytochrome P450 gene CYP26 during mucous cell differentiation of normal human tracheobronchial epithelial cells. Mol. Pharm. 58: 483-490 (2000) [Abstract] [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10953040]
9. Yan, Z., and Jetten, A.M. Characterization of the repressor function of the nuclear orphan receptor retinoid receptor-related testis-associated receptor/germ cell nuclear factor. J. Biol. Chem. 275: 35077-35085 (2000) [Abstract] [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10940306]
10. Jetten, A.M., Kurebayashi, S., Ueda, E., and Sakaue, M. The ROR nuclear orphan receptor subfamily: critical regulators of multiple biological processes. Progress in Nucl. Acids Res.  and Mol. Biol. 69: 205-247 (2001) [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11550795[]
11. Sakaue, M., Adachi, H., Dawson, M., and Jetten, A.M. Induction of Egr-1 expression by the retinoid AHPN in human lung carcinoma cells is dependent on activated ERK1/2. Cell Death & Diff. 8: 411-424 (2001) [Abstract] [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11550093]
12. Zhang, F., Nakanishi, G., Kurebayashi, S., Yoshino, K., Perantoni, A., Kim, Y-S., and Jetten A.M. Characterization of Glis2, a novel gene encoding a Gli-related, Kruppel-like transcription factor with transactivation and repressor functions. Roles in kidney development and neurogenesis. Identification of transactivation and repressor functions. J. Biol. Chem. 277: 10139-10149 (2002). [Abstract] [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11741991]
13. Ueda, E., Kurebayashi, S., Sakaue, M., Backlund, M., Koller, B., and Jetten, A.M. High incidence of T cell lymphomas in mice deficient in the retinoid-related orphan receptor RORg. Cancer Res. 62: 901-909 (2002). [Abstract] [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11830550]
14. Kim, Y-S., Lewandoski, M., Perantoni, A., Kurebayashi, S., and Jetten, A.M. Identification of Glis1, a novel Gli-related, Kruppel-like zinc finger protein containing transactivation and repressor functions. J. Biol. Chem. 277: 30901-30913 (2002). [Abstract] [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12042312]
15. Yan, Z., Kim, Y-S., and Jetten, A.M. RAP80, a novel nuclear protein that interacts with the retinoid-related testis-associated receptor. J. Biol. Chem. 277: 32379-32388 (2002). [Abstract] [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12080054]
16. Jetten, A.M., and Ueda, E. Retinoid-related orphan receptors (RORs): roles in cell survival, differentiation, and disease. Cell Death & Diff. 9:1167-1171 (2002). [Abstract] [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12404115]
17. Newman, D., Sakaue, M., Koo, J.S., Baek, S.J., Eling, T., and Jetten, A.M. Differential regulation of nonsteroidal anti-inflammatory drug-activated gene in normal human tracheobronchial epithelial and lung carcinoma cells by retinoids. Mol. Pharm. 63:557-564 (2003). [Abstract] [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12606762]
18. Yang, G., Zhang, Y-L., Buchhold, G.M., Jetten, A.M., and O’Brien, D.A. Free Full Text Analysis of germ cell nuclear factor transcripts and protein expression during spermatogenesis. Biol. Reprod. 68:1620-1630 (2003). [Abstract] [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12606326]
19. Lewandoski, M., and Jetten, A.M. GLIS3, a novel member of the GLIS subfamily of Krüppel-like Zinc Finger Proteins with Repressor and Activation Functions. Nucl. Acids Res. 31: 5513-5525 (2003) [Abstract] [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14500813]
20. Daniely, Y., Liao, G., Dixon, D., Linnoila, R.I., Lori, A., Randell, S.H., Oren, M., and Jetten, A.M. Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium. Am. J. Physiol. 287:C171-C181 (2004). [Abstract] [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15189821]
21. Nakajima, T., Fujino, S., Nakanishi, G., Kim, Y-S., and Jetten, A.M.  TIP27: a novel repressor of the nuclear orphan receptor TAK1/TR4.  Nucl. Acids Res. 32:4194-4204 (2004). [Abstract] [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15302918]
22. Kim, Y-S., Nakanishi, G., Oudes, A.J., Kim, K.H., Wang, H., Kilpatrick, D.L., and Jetten, A.M.  TSP57: a novel gene induced during a specific stage of spermatogenesis. Biol. Reprod. 70:106-113 (2004). [Abstract] [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12954732]
23. Jetten, A.M. Recent advances in the mechanisms of action and physiological functions of the retinoid-related orphan receptors (RORs).  Current Drug Targets-Inflammation & Allergy 3:395-412 (2004). [Abstract] [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15584888]
24. Stapleton, C., Jaradat, M., Dixon, D., Kang, H.S., Kim, S-C., Liao, G., Carey, M.A., Cristiano, J., Moorman, M.P., and Jetten, A.M. Enhanced susceptibility of staggerer (RORasg/sg) mice to lipopolysaccharide-induced lung inflammation. Am. J. Physiol.  Lung Cell. Mol. Physiol. 289:L144-L152 (2005). [Abstract] [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15778248]
25. Kim, S-C., Kim, Y-S., and Jetten, A.M. Nucl. Acids Res. 33:6805-6815 (2005). [Abstract] []
26. Nakanishi, G., Kim, Y-S., Nakajima, T., and Jetten, A.M. J. Invest. Dermatol. 126:49-60 (2006) [Abstract] [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16417217]
27. Kang, H-S., Beak, J.Y., Kim, Y-S., and Jetten, A.M. NABP1, a novel RORg-regulated gene encoding a single-stranded nucleic acid binding protein. Biochem. J. 397:89-99 (2006) [Abstract] [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16533169]
28. Jetten, A.M., and Joo, J.H. Retinoid-related Orphan Receptors (RORs): Roles in Cellular Differentiation and Development. Adv. Develop. Biol. 16:314-354 (2006)
29. Jaradat, M., Stapleton, C., Tilley, S., Dixon, D., McCaskill, J.M., Kang, H.S., Angers, M, Liao, G., and Jetten, A.M. Modulatory role for retinoid-related orphan receptor a (RORa) in allergen-induced lung inflammation. Am. J. Resp. Crit. Care Med. 174:1299-309 (2006) [Abstract] [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16973978]
30. Jetten A.M., and Joo J.H. Retinoid-related Orphan Receptors (RORs): Roles in cellular differentiation and development. Advances in Developmental Biology 313-355 (2006). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=)
31. Tilley, S., Jaradat, M., Stapleton, C., Dixon, D., Kim, S-C., Erikson, C.J., McCaskill, J.M., Liao, G., Koller, B.H., and Jetten, A.M. Reduced Susceptibility to Allergen-induced Airway Inflammation in Mice Deficient in Retinoid-related Orphan Receptor (ROR) g. J. Immunol. 178:3208-3218 (2007)
32. Lee, S-J., Perara, L., Coulter, S., Mohrenweiser, H.W., Jetten, A.M., and Goldstein, J.A. The discovery of new coding alleles of CYP26A1 which are potentially defective in the metabolism of all-trans retinoic acid metabolism and their assessment in a recombinant cDNA expression system. Pharmacogenet. Genomics. 17:169-180 (2007)
33. Yan, J., Kim, Y-S., Yang, X-P., Albers, M., Koegl, M., and Jetten, A.M. Ubiquitin interacting motifs of RAP80 are critical in its regulation of Estrogen Receptor a. Nucl. Acids Res. 35:1673-1686 (2007)
34. Kim, Y-S., Kang, H.S., and Jetten, A.M. The Krüppel-like zinc finger protein Glis2 functions as a negative modulator of the Wnt/b-catenin signaling pathway. FEBS Letters 581:858-864 (2007)
35. Joo, J.H., Liao, G., Collins, J.B., Grissom, S.F., and Jetten, A.M. Farnesol-induced apoptosis in human lung carcinoma cells is coupled to the endoplasmic reticulum (ER) stress response. Cancer Res. 67:7929-7936 (2007)
36. Beak, J.Y., Kang, H.S., Kim, Y-S., and Jetten, A.M. Krüppel-like zinc finger protein Glis3 promotes osteoblast differentiation by regulating FGF18 expression. J. Bone Mineral Res. 22:1234-1244 (2007)
37. Nurieva, R., Yang, X.O., Panopoulos, A.D., Martinez, G., Zhang, Y., Ma, L., Schluns, K., Tian, Q., Watowich, S., Jetten, A.M., and Dong, C. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature  448:480-483 (2007)
38. Yan, J., Kim, Y-S., Yang, Y-P., Li, L-P., Liao, G., Xia, F., and Jetten, A.M. The UIM-containing protein RAP80 functions in DNA damage repair response. Cancer Res. 67:6647-6656 (2007)
39. Yan, J., Yang, X-P., Kim, Y-S., Joo, J.H., and Jetten, A.M.  RAP80 interacts with the SUMO-conjugating enzyme UBC9 and is a novel target for sumoylation. Biochem. Biophys. Res. Comm. 362:132-128 (2007)
40. Kang, H.S., Angers, M., Beak, J.Y., Wu, X., Gimble, J.M., Wada, T, Xie, W., and Jetten, A.M. Gene expression profiling reveals a regulatory role for RORa and RORg in Phase I and Phase II metabolism. Physiol. Genomics 31:281-294 (2007)
41. Beak, J.Y., Kang, H.S., Kim, Y.S., and Jetten, A.M. Krüppel-like zinc finger protein Glis3 promotes osteoblast differentiation by regulating FGF18 expression. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 8:1234-1244 (2007). Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17488195)
42. Yan, J., Kim, Y.S., Yang, X-P., Li, L.P., Liao, G., Xia, F., and Jetten, A.M. The UIM-containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response. Cancer Research 14:6647-6656 (2007). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17621610)
43. Nurieva, R., Yang, X.O., Panopoulos, A.D., Martinez, G., Zhang, Y., Ma, L., Schluns, K., Tian, Q., Watowich, S., Jetten, A.M., and Dong, C. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 7152:480-483 (2007). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17581589)
44. Kang, H.S., Angers, M., Beak, J.Y., Wu, X., Gimble, J.M., Wade, T., Xie, W., Collins, J.B., Grissom, S.F., and Jetten, A.M. Gene expression profiling reveals a regulatory role for RORa and RORy in Phase I and Phase II metabolism. Physiological Genomics 2:281-294 (2007). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17666523)
45. Beak, J.Y., Kang, H.S., Kim, Y.S., and Jetten, A.M. Functional analysis of the zinc finger and activation domains of Glis3 and mutant Glis3(NDH1). Nucleic acids research 36(5):1690-1702 (2008). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18263616)
46. Yang, X.O., Pappu, B.P., Nurieva, R., Akimzhanov, A., Kang, H.S., Chung, Y., Ma, L., Shah, B., Panopoulos, A.D., Watowich, S.S., Schluns, K.S., Tian, Q., Jetten, A.M., and Dong, C. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR(alpha) and ROR(gamma). Immunity 28(1):29-39 (2008). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18164222)
47. Yan, J., Yang, X.P., Kim, Y.S., and Jette, A.M. RAP80 responds to DNA damage induced by both ionizing radiation and UV irradiation and is phosphorylated at Ser205. Cancer research 68(11):4269-4276 (2008). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18519686)
48. Joo, J.H., and Jetten, A.M. NF-kappa B-dependent transcriptional activation in lung carcinoma cells by farnesol involves p65/RelA(Ser276) phosphorylation via the MEK-MSK1 signaling pathway. The Journal of biological chemistry 283(24):16391-16399 (2008). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18424438)
49. Yang, X.O., Nurieva, R., Martinez, G.J., Kang, H.S., Chung, Y., Pappu, B.P., Shah, B., Chang, S.H., Schluns, K.S., Watowich, S.S., Feng, X.H., Jetten, A.M., and Dong, C. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 29(1):44-56 (2008). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18585065)
50. Yan, J., and Jetten, A.M. RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damabe sites. Cancer letters 271(2):179-190 (2008). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18550271)
51. Angers, M., Uldry, M., Kong, D., Gimble, J.M., and Jetten, A.M. Mfsd2a encodes a novel major facilitator superfamily domain-containing protein induced in brown adipose tissue during fasting and adaptive thermogenesis. The Biochemical journal 416(3):347-355 (2008). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18694395)
52. Wada, T., Kang, H.S., Jetten, A.M., and Xie, W. The emerging role of nuclear receptor RORalpha and its crosstalk with LXR in xeno- and endobiotic gene regulation. Experimental biology and medicine 233(10):1191-1201 (2008). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18535165)
53. Kim, Y.S., Kang, H.S., Herbert, R., Beak, J.Y., Collins, J.B., Grissom, S.F., and Jetten, A.M. Deficient Krüppel-like zinc finger protein Glis2 expression in mice results in progressive chronic kidney disease and renal failure. Molecular and Cellular Biology 28(7):2358-2367 (2008). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18227149)
54. Kang, H.S., Beak, J.Y., Kim, Y.S., Herbert, R., and Jetten, A.M. Glis3 is associated with primary cilia and Wwtr1/TAZ and implicated in polycystic kidney disease. Molecular and cellular biology 29(10):2556-2569 (2009). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=19273592)
55. Jetten, A.M. Retinoid-related Orphan Receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism. Nuclear receptor signaling 7():e003- (2009). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=19381306)
56. Chen, Y., Coulter, S., Jetten, A.M., and Goldstein, J.A. Identification of human CYP2C8 as a retinoid-related orphan nuclear receptor target gene. J Pharmacol. Exper. Ther. 329(1):192-201 (2009). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=19164466)
57. Yan, J., Menendez, D., Yang, X-P., Reznick, M.A., and Jetten, A.M. A regulatory loop composed of Rap80-HDM2-p53 provides Rap80 enhanced p53 degradation by HDM2 in response to DNA damage. The Journal of biological chemistry 284(29):19280-19289 (2009). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=19433585)
58. Nagatake, T., Fukuyama, S., Kim, D.Y., Goda, K., Igarashi, O., Sato, S., Nochi, T., Sagara, H., Yokota, Y., Jetten, A.M., Kaisho, T., Akira, S., Mimuro, H., Sasakawa, C., Fukui, Y., Fujihashi, K., Akiyama, T., Inoue, J., Penninger, J.M., Kunisawa, J., and Kiyono, H. Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity. The Journal of experimental medicine 206(11):2351-2364 (2009). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=19822644)

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