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Selected Publications

Transmembrane Signaling Group

  1. Abramowitz, J., Grenet, D., Birnbaumer, M., Torres, H.N. and Birnbaumer, L. (2004) "XLαs, the Extralong Form of the α Subunit of the Gs G Protein is Significantly Longer than Suspected, and So is Its Companion Alex." Proc. Natl. Acad. Sci. USA 100, 8366-8371.  [Abstract ( ]
  2. Erxleben, C., Liao, Y., Gentile, S., Chin, D., Gomez-Alegria, C., Mori, Y., Birnbaumer, L. and Armstrong, D. (2006) "Cyclosporin and Timothy syndrome increase mode 2 gating of CaV1.2 calcium channels through aberrant phosphorylation of S6 helices." Proc. Natl. Acad. Sci. USA 103, 3932-3937.  [Abstract ( ]
  3. Gohla, A., Klement, K., Piekorz, R.P., Pexa, K., vom Dahl, S., Spicher, K., Dreval, V., Häussinger, D., Birnbaumer, L. and Nürnberg, B. (2007) "An obligatory requirement for the heterotrimeric G protein Gi3 in the anti-autophagic action of insulin in the liver." Proc. Nat. Acad. Sci. USA 104, 3003-3008. [Abstract ( ]
  4. Liao, Y.H., Erxleben, C., Yildirim, E., Abramowitz, J., Armstrong, D. and Birnbaumer, L. (2007) "Orai proteins interact with TRPC channels Orai proteins interact with TRPC channels and confer responsiveness to store depletion." Proc. Nat. Acad. Sci. USA 104, 4682-4687.  [Abstract ( ]
  5. Liu, X., Cheng, K.T., Bandyopadhyay, B.C., Pani, B., Dietrich, A., Paria, B.C., Swaim, W.D., Beech, D., Yildirim,E., Singh, B.B., Birnbaumer, L. and Ambudkar, I.S. (2007) "Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) mice." Proc. Natl. Acad. Sci. USA 104, 17542-17547.  [Abstract ( ]
  6. Thompson, B.D., Jin, Y., Wu, K.H., Colvin, R.A., Luster, A.D., Birnbaumer, L., Wu, M.X. (2007) "Inhibition of G alpha i2 activation by G alpha i3 in CXCR3-mediated signaling." The Journal of Biological Chemistry 282(13), 9547-9555. [Abstract ( ]
  7. Padigel UM, Stein L, Redding K, Lee JJ, Nolan TJ, Schad GA, Birnbaumer L, Abraham D. (2007) "Signaling through Gai2± protein is required for recruitment of neutrophils for antibody-mediated elimination of larval Strongyloides stercoralis in mice." Journal of leukocyte biology 81(4):1120-1126. [Abstract ( ]
  8. Liao, Y.H,, Erxleben, C., Abramowitz, J., Flockerzi, V., Zhu, M.X., Armstrong, D.L. and Birnbaumer, L. (2008) "Functional interactions among Orai1, TRPCs and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac." Proc. Natl. Acad. Sci. USA 105(8), 2895-2900.  [Abstract ( ]
  9. Zurita A., and Birnbaumer L. (2008) "The same mutation in Gsalpha and transducin (alpha) reveals behavioral differences between these highly homologous G protein alpha-subunits." Proc. Natl. Acad. Sci. USA 105(7), 2363-2368. [Abstract ( ]
  10. Edwards RA, Wang K, Davis JS, Birnabumer L . (2008) "Role for epithelial dysregulation in early-onsert colitis-assocaited colon cancer in Gi2-/- mice." Inflammatory bowel diseases14(7):898-907. [Abstract ( ]
  11. Brunk I, Blex C, Sanchis-Segura C, Sternberg J, Perreau-Lenz S , Bilbao A, Hörtnag H, Baron J , Juranek J, Laube G, Birnbaumer L, Spanagel R, Ahnert-Hilger G. (2008) "Deletion of Go2alpha abolishes cocaine-induced behavioral sensitization by disturbing the striatal dopamine system." The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 22(10), 3736-3746. [Abstract ( ]
  12. Hartmann, J., Dragicevic, E., Adelsberger, H., Henning, H., Sumser, M., Abramowitz, J., Blum, R., Dietrich, A., Freichel, M., Flockerzi, V., Birnbaumer, L., Konnerth, A. (2008) "TRPC3 channels are required for synaptic transmission and motor coordination." Neuron. USA 59(3), 392-398. [Abstract ( ] \
  13. Jin, Y.Z., Thompson, B.D., Zhou, Z.Y., Fu, Y., Birnbaumer, L., Wu, M.X. (2008) "Reciprocal function of Galphai2 and Galphai3 in graft-versus-host disease." Eur. J. Immunol. USA 38(7), 1988-1998. [Abstract ( ]
  14. Chaudhuri, P., Colles, S.M., Bhat, M., Van Wagoner, D.R., Birnbaumer, L., Graham, L.M. (2008) "Elucidation of a TRPC6-TRPC5 channel cascade that restricts endothelial cell movement." Mol. Bio. Cell. USA 19(8), 3203-3211. [Abstract ( ]
  15. Walker, M.P., DiAugustine, R.P., Zeringue, E., Bunger, M.K., Schmitt, M., Archer, T.K., Richards, R.G. (2010) An Insulin-Like Growth Factor-1 (IGF-1)/Insulin Receptor Substrate-1 (IRS-1) Pathway Stimulates a Mitotic Kinase (cdk1) in the Uterine Epithelium During the Proliferative Response to Estradiol. Journal of Endocrinology 207(2):225-235. [Abstract ( ]
  16. Li Y., Birnbaumer L., Teng C.T. (2010) Regulation of ERRa gene expression by estrogen receptor agonists and antagonists in SKBR3 breast cancer cells: Differential moleuclar mechanisms mediated by G protein-coupled receptor GPR30/GPER-1. Molecular Endocrinology 24(5):969-980. [Abstract ( ]
  17. Zurita, A., Zhang, Y., Pedersen, L., Darden, T., Birnbaumer, L. (2011)  Obligatory role in GTP hydrolysis for the amide carbonyl oxygen of the Mg(2+)-coordinating Thr of regulatory GTPases. Proceedings of the National Academy of Sciences of the United States of America  107(21):9596-9601. [Abstract ( ]  
  18. Colaneri, A., Staffa, N., Fargo, D.C., Gao, Y., Wang, T., Peddada, S.D., Birnbaumer, L. (2011) Expanded methyl-sensitive cut counting reveals hypomethylation as an epigenetic state that highlights functional sequences of the genome. Proceedings of the National Academy of Sciences of the United States of America 108(23):9715-9720. [Abstract ( ]  
  19. Liu Y, Zheng X, Mueller GA, Sobhany H, DeRose EF, Zhang Y, London RE, Birnbaumer L. (2012) Crystal structure of calmodulin binding domain of Orai1 in complex with Ca2+*calmodulin displays a unique binding mode. The Journal of biological chemistry  287(51):43030-41. [Abstract ( ]
  20. Plummer NW, Spicher K, Malphurs J, Akiyama H, Abramowitz J, Nürnberg B, Birnbaumer L. (2012) Development of the mammalian axial skeleton requires signaling through the Gαi subfamily of heterotrimeric G proteins. Proceedings of the National Academy of Sciences of the United States of America 109(52):21366-71 [Abstract ( ]
  21. Yeo M , Berglund K , Hanna M, Guo JU , Kittur J , Torres MD , Abramowitz J, Busciglio J, Gao Y, Birnbaumer L, Liedtke WB. (2013) Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter. Proceedings of the National Academy of Sciences of the United States of America 110(11):4315-4320. [Abstract ( ]
  22. Colaneri A, Wang T, Pagadala V, Kittur J, Staffa NG Jr, Peddada SD, Isganaitis E, Patti ME, Birnbaumer L. (2013). A minimal set of tissue-specific hypomethylated CpGs constitute epigenetic signatures of developmental programming. PloS One 8(9):e72670, 2013. [Abstract ( ]




  1. Birnbaumer, L., Yildirim, E. and Abramowitz, J. (2003) "A Comparison of the Genes Coding for Canonical TRP Channels and Their M, V and D Relatives." Cell Calcium 33, 419-432.  [Abstract ( ]
  2. Birnbaumer, L. (2007) "The discovery of signal transduction by G proteins. A personal account and an overview of the initial findings and contributions that led to our present understanding." Biochim. Biophys. Acta. Biomembranes 1768, 756-771.  [Abstract ( ]
  3. Birnbaumer, L. (2007) "Expansion of signal transduction by G proteins from 3 to 16 α subunits plus ?? dimers. The second 15 years or so..." Biochim. Biophys. Acta Biomembranes 1768, 772-793. [Abstract ( ]



For more: complete listing of publications from Lutz Birnbaumer, Ph.D. (244KB)

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