Synaptic & Developmental Plasticity Group

  1. Carstens KE, Lustberg DJ, Shaughnessy EK, McCann KE, Alexander GM, Dudek SM. 2021. Perineuronal net degradation rescues CA2 plasticity in a mouse model of Rett syndrome. J Clin Invest 131(16):e137221. [Abstract Carstens KE, Lustberg DJ, Shaughnessy EK, McCann KE, Alexander GM, Dudek SM. 2021. Perineuronal net degradation rescues CA2 plasticity in a mouse model of Rett syndrome. J Clin Invest 131(16):e137221.]
  2. Hartmann J, Bajaj T, Klengel C, Chatzinakos C, Ebert T, Dedic N, McCullough KM, Lardenoije R, Joëls M, Meijer OC, McCann KE, Dudek SM, Sarabdjitsingh RA, Daskalakis NP, Klengel T, Gassen NC, Schmidt MV, Ressler KJ. 2021. Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to stress via regulation of FKBP5. Cell Rep 35(9):109185. [Abstract Hartmann J, Bajaj T, Klengel C, Chatzinakos C, Ebert T, Dedic N, McCullough KM, Lardenoije R, Joëls M, Meijer OC, McCann KE, Dudek SM, Sarabdjitsingh RA, Daskalakis NP, Klengel T, Gassen NC, Schmidt MV, Ressler KJ. 2021. Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to stress via regulation of FKBP5. Cell Rep 35(9):109185.]
  3. Almeida MF, Piehler T, Carstens KE, Zhao M, Samadi M, Dudek SM, Norton CJ, Parisian CM, Farizatto KLG, Bahr BA. 2021. Distinct and dementia-related synaptopathy in the hippocampus after military blast exposures. Brain Pathol; doi: 10.1111/bpa.12936 [Online 24 February 2021]. [Abstract Almeida MF, Piehler T, Carstens KE, Zhao M, Samadi M, Dudek SM, Norton CJ, Parisian CM, Farizatto KLG, Bahr BA. 2021. Distinct and dementia-related synaptopathy in the hippocampus after military blast exposures. Brain Pathol; doi: 10.1111/bpa.12936 [Online 24 February 2021].]
  4. Squires KE, Gerber KJ, Tillman MC, Lustberg DJ, Montañez-Miranda C, Zhao M, Ramineni S, Scharer CD, Saha RN, Shu FJ, Schroeder JP, Ortlund EA, Weinshenker D, Dudek SM, Hepler JR. 2020. Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons. J Biol Chem 296:100024. [Abstract Squires KE, Gerber KJ, Tillman MC, Lustberg DJ, Montañez-Miranda C, Zhao M, Ramineni S, Scharer CD, Saha RN, Shu FJ, Schroeder JP, Ortlund EA, Weinshenker D, Dudek SM, Hepler JR. 2020. Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons. J Biol Chem 296:100024.]
  5. Carstens KE, Gloss BR, Alexander GM, Dudek SM. 2020. Modified adeno-associated virus targets the bacterial enzyme chondroitinase ABC to select mouse neuronal populations in vivo using the Cre-LoxP system. Eur J Neurosci; doi: 10.1111/ejn.15050 [Online 21 November 2020]. [Abstract Carstens KE, Gloss BR, Alexander GM, Dudek SM. 2020. Modified adeno-associated virus targets the bacterial enzyme chondroitinase ABC to select mouse neuronal populations in vivo using the Cre-LoxP system. Eur J Neurosci; doi: 10.1111/ejn.15050 [Online 21 November 2020].]
  6. Brown LY, Alexander GM, Cushman J, Dudek SM. 2020. Hippocampal CA2 Organizes CA1 Slow and Fast γ Oscillations during Novel Social and Object Interaction. eNeuro; doi: 10.1523/ENEURO.0084-20.2020 [Online 14 April 2020]. [Abstract Brown LY, Alexander GM, Cushman J, Dudek SM. 2020. Hippocampal CA2 Organizes CA1 Slow and Fast γ Oscillations during Novel Social and Object Interaction. eNeuro; doi: 10.1523/ENEURO.0084-20.2020 [Online 14 April 2020].] 
  7. McCann KE, Lustberg DJ, Shaughnessy EK, Carstens KE, Farris S, Alexander GM, Radzicki D, Zhao M, Dudek SM. 2019. Novel role for mineralocorticoid receptors in control of a neuronal phenotype. Mol Psychiatry; doi: 10.1038/s41380-019-0598-7 [Online 19 November 2019]. [Abstract McCann KE, Lustberg DJ, Shaughnessy EK, Carstens KE, Farris S, Alexander GM, Radzicki D, Zhao M, Dudek SM. 2019. Novel role for mineralocorticoid receptors in control of a neuronal phenotype. Mol Psychiatry; doi: 10.1038/s41380-019-0598-7 [Online 19 November 2019].] 
  8. Farris S, Ward JM, Carstens KE, Samadi M, Wang Y, Dudek SM. 2019. Hippocampal Subregions Express Distinct Dendritic Transcriptomes that Reveal Differences in Mitochondrial Function in CA2. Cell Rep 29(2):522-539.e6. [Abstract Farris S, Ward JM, Carstens KE, Samadi M, Wang Y, Dudek SM. 2019. Hippocampal Subregions Express Distinct Dendritic Transcriptomes that Reveal Differences in Mitochondrial Function in CA2. Cell Rep 29(2):522-539.e6.]
  9. Alexander GM, Riddick NV, McCann KE, Lustberg D, Moy SS, Dudek SM. 2019. Modulation of CA2 Neuronal Activity Increases Behavioral Responses to Fear Conditioning in Female Mice. Neurobiology of Learning and Memory 163:107044. [Abstract Alexander GM, Riddick NV, McCann KE, Lustberg D, Moy SS, Dudek SM. 2019. Modulation of CA2 Neuronal Activity Increases Behavioral Responses to Fear Conditioning in Female Mice. Neurobiology of Learning and Memory 163:107044.]
  10. Gerber KJ, Dammer EB, Duong DM, Deng Q, Dudek SM, Seyfried NT, Hepler JR. 2019. Specific Proteomes of Hippocampal Regions CA2 and CA1 Reveal Proteins Linked to the Unique Physiology of Area CA2. J Proteome Res 18(6):2571-2584. [Abstract Gerber KJ, Dammer EB, Duong DM, Deng Q, Dudek SM, Seyfried NT, Hepler JR. 2019. Specific Proteomes of Hippocampal Regions CA2 and CA1 Reveal Proteins Linked to the Unique Physiology of Area CA2. J Proteome Res 18(6):2571-2584.]
  11. Alexander GM, Brown LY, Farris S, Lustberg D, Pantazis C, Gloss B, Plummer NW, Jensen P, Dudek SM. (2018) CA2 Neuronal Activity Controls Hippocampal Low Gamma and Ripple Oscillations. eLife doi:10.7554/eLife.38052 [Online 2 November 2018]. [Abstract Alexander GM, Brown LY, Farris S, Lustberg D, Pantazis C, Gloss B, Plummer NW, Jensen P, Dudek SM. (2018) CA2 Neuronal Activity Controls Hippocampal Low Gamma and Ripple Oscillations. eLife doi:10.7554/eLife.38052 [Online 2 November 2018].]
  12. Gu B, Carstens KE, Judson MC, Dalton KA , Rougié M, Clark EP, Dudek SM, Philpot BD. (2018) Ube3a Reinstatement Mitigates Epileptogenesis in Angelman Syndrome Model Mice. The Journal of Clinical Investigation 129(1):163-168. [Abstract Gu B, Carstens KE, Judson MC, Dalton KA , Rougié M, Clark EP, Dudek SM, Philpot BD. (2018) Ube3a Reinstatement Mitigates Epileptogenesis in Angelman Syndrome Model Mice. The Journal of Clinical Investigation 129(1):163-168.]
  13. Tyssowski KM, DeStefino NR, Cho JH, Dunn CJ, Poston RG, Carty CE, Jones RD, Chang SM, Romeo P, Wurzelmann MK, Ward JM, Andermann ML, Saha RN, Dudek SM, Gray JM. (2018) Different Neuronal Activity Patterns Induce Different Gene Expression Programs. Neuron 98(3):530-546. [Abstract Tyssowski KM, DeStefino NR, Cho JH, Dunn CJ, Poston RG, Carty CE, Jones RD, Chang SM, Romeo P, Wurzelmann MK, Ward JM, Andermann ML, Saha RN, Dudek SM, Gray JM. (2018) Different Neuronal Activity Patterns Induce Different Gene Expression Programs. Neuron 98(3):530-546.]
  14. Alexander GM, Brown LY, Farris S, Lustberg D, Pantazis C, Gloss B, Plummer NW, Riddick NV, Moy SS, Jensen P, Dudek SM. (2017) CA2 Neuronal Activity Controls Hippocampal Oscillations and Social Behavior. bioRxiv doi:10.1101/190504 [Online 19 September 2017]. [Abstract Alexander GM, Brown LY, Farris S, Lustberg D, Pantazis C, Gloss B, Plummer NW, Riddick NV, Moy SS, Jensen P, Dudek SM. (2017) CA2 Neuronal Activity Controls Hippocampal Oscillations and Social Behavior. bioRxiv doi:10.1101/190504 [Online 19 September 2017].]
  15. Farris S, Wang Y, Ward JM, Dudek SM. (2017) Optimized Method for Robust Transcriptome Profiling of Minute Tissues Using Laser Capture Microdissection and Low-Input RNA-Seq. Front Mol Neurosci 10:185. [Abstract Farris S, Wang Y, Ward JM, Dudek SM. (2017) Optimized Method for Robust Transcriptome Profiling of Minute Tissues Using Laser Capture Microdissection and Low-Input RNA-Seq. Front Mol Neurosci 10:185.] 
  16. Henson MA, Tucker CJ, Zhao M, Dudek SM. (2016) Long-term depression-associated signaling is required for an in vitro model of NMDA receptor-dependent synapse pruning. Neurobiology of learning and memory S1074-7427(16):30282-30289. [Abstract Henson MA, Tucker CJ, Zhao M, Dudek SM. (2016) Long-term depression-associated signaling is required for an in vitro model of NMDA receptor-dependent synapse pruning. Neurobiology of learning and memory S1074-7427(16):30282-30289.]
  17. Carstens KE, Phillips ML, Pozzo-Miller L, Weinberg RJ, Dudek SM. (2016) Perineuronal Nets Suppress Plasticity of Excitatory Synapses on CA2 Pyramidal Neurons. J Neurosci. 36(23):6312-20. [Abstract Carstens KE, Phillips ML, Pozzo-Miller L, Weinberg RJ, Dudek SM. (2016) Perineuronal Nets Suppress Plasticity of Excitatory Synapses on CA2 Pyramidal Neurons. J Neurosci. 36(23):6312-20.]
  18. Sciolino NR, Plummer NW, Chen YW, Alexander GM, Robertson SD, Dudek SM, McElligott ZA, Jensen P (2016) Recombinase-dependent mouse lines for chemogenetic activation of genetically defined cell types. Cell Reports 15(11):2563-73. [Abstract Sciolino NR, Plummer NW, Chen YW, Alexander GM, Robertson SD, Dudek SM, McElligott ZA, Jensen P (2016) Recombinase-dependent mouse lines for chemogenetic activation of genetically defined cell types. Cell Reports 15(11):2563-73.]
  19. Alexander GM, Farris S, Pirone JR, Zheng C, Colgin LL, Dudek SM. (2016) Social and novel contexts modify hippocampal CA2 representations of space. Nature Communications 7, 10300. [Abstract Alexander GM, Farris S, Pirone JR, Zheng C, Colgin LL, Dudek SM. (2016) Social and novel contexts modify hippocampal CA2 representations of space. Nature Communications 7, 10300.]
  20. Dudek SM, Alexander GM, Farris S. (2016) Rediscovering area CA2: unique properties and functions. Nature Reviews Neuroscience 17(2):89-102. [Abstract Dudek SM, Alexander GM, Farris S. (2016) Rediscovering area CA2: unique properties and functions. Nature Reviews Neuroscience 17(2):89-102.]
  21. Evans PR, Dudek SM, Hepler JR. (2015) Regulator of G Protein Signaling 14: A Molecular Brake on Synaptic Plasticity Linked to Learning and Memory. Progress in molecular biology and translational science 133():196-206. [Abstract Evans PR, Dudek SM, Hepler JR. (2015) Regulator of G Protein Signaling 14: A Molecular Brake on Synaptic Plasticity Linked to Learning and Memory. Progress in molecular biology and translational science 133():196-206.]
  22. Pagani JH, Zhao M, Cui Z, Williams Avram SK, Caruana DA, Dudek SM, Young WS. (2015) Role of the vasopressin 1b receptor in rodent aggressive behavior and synaptic plasticity in hippocampal area CA2. Molecular psychiatry 20(4):490-499. [Abstract Pagani JH, Zhao M, Cui Z, Williams Avram SK, Caruana DA, Dudek SM, Young WS. (2015) Role of the vasopressin 1b receptor in rodent aggressive behavior and synaptic plasticity in hippocampal area CA2. Molecular psychiatry 20(4):490-499.]
  23. Saha, RN, Dudek, SM. (2013) Splitting Hares and Tortoises: a classification of neuronal immediate early gene transcription based on poised RNA polymerase II. Neuroscience 247:175-181.  [Abstract Saha, RN, Dudek, SM. (2013) Splitting Hares and Tortoises: a classification of neuronal immediate early gene transcription based on poised RNA polymerase II. Neuroscience 247:175-181. ]
  24. Caruana DA, Alexander GM, Dudek SM. (2012) New insights into the regulation of synaptic plasticity from an unexpected place: Hippocampal area CA2. Learning & memory (Cold Spring Harbor, N.Y.) 19(9):391-400. [Abstract Caruana DA, Alexander GM, Dudek SM. (2012) New insights into the regulation of synaptic plasticity from an unexpected place: Hippocampal area CA2. Learning & memory (Cold Spring Harbor, N.Y.) 19(9):391-400.]
  25. Simons, S.B., Caruana, D.A., Zhao, M. & Dudek, S.M. (2011) Caffeine-induced synaptic potentiation in hippocampal CA2 neurons. Nature Neuroscience 15(1):23-5. [Abstract Simons, S.B., Caruana, D.A., Zhao, M. & Dudek, S.M. (2011) Caffeine-induced synaptic potentiation in hippocampal CA2 neurons. Nature Neuroscience 15(1):23-5.]
  26. Vellano, C.P., Lee, S.E., Dudek, S.M. & Hepler, J.R. (2011) RGS14 at the Interface of Hippocampal Signaling and Synaptic Plasticity. Trends in Pharmacological Sciences 32(11):666-674. [Abstract Vellano, C.P., Lee, S.E., Dudek, S.M. & Hepler, J.R. (2011) RGS14 at the Interface of Hippocampal Signaling and Synaptic Plasticity. Trends in Pharmacological Sciences 32(11):666-674.]
  27. Saha, R.N., Wissink, E.M., Bailey, E., Zhao, M., Fargo, D., Hwang, J., Daigle, K.R., Fenn, J.D., Adelman, K. & Dudek, S.M. (2011) Rapid activity-induced transcription of arc and other IEGs relies on poised RNA polymerase II. Nature neuroscience 14(7):848-856. [Abstract Saha, R.N., Wissink, E.M., Bailey, E., Zhao, M., Fargo, D., Hwang, J., Daigle, K.R., Fenn, J.D., Adelman, K. & Dudek, S.M. (2011) Rapid activity-induced transcription of arc and other IEGs relies on poised RNA polymerase II. Nature neuroscience 14(7):848-856.]
  28. Adams, J.P., Robinson, R.A., Hudgins, E.D., Dudek, S.M. & Wissink, E.M. (2009) NMDA receptor-independent control of transcription factors and gene expression. Neuroreport 20(16):1429-1433. [Abstract Adams, J.P., Robinson, R.A., Hudgins, E.D., Dudek, S.M. & Wissink, E.M. (2009) NMDA receptor-independent control of transcription factors and gene expression. Neuroreport 20(16):1429-1433.]
  29. Simons, S.B., Escobedo, Y., Yasuda, R. & Dudek, S.M. (2009) Regional differences in hippocampal calcium handling provide a cellular mechanism for limiting plasticity. Proceedings of the National Academy of Sciences of the United States of America 106(33):14080-14084. [Abstract Simons, S.B., Escobedo, Y., Yasuda, R. & Dudek, S.M. (2009) Regional differences in hippocampal calcium handling provide a cellular mechanism for limiting plasticity. Proceedings of the National Academy of Sciences of the United States of America 106(33):14080-14084.]
  30. Lundquist, J.J. & Dudek, S.M. (2008) Differential activation of extracellular signal-regulated kinase 1 and a related complex in neuronal nuclei. Brain Cell Biol. 35(4-6):267-281. [Abstract Lundquist, J.J. & Dudek, S.M. (2008) Differential activation of extracellular signal-regulated kinase 1 and a related complex in neuronal nuclei. Brain Cell Biol. 35(4-6):267-281.]
  31. Bastrikova, N., Gardner, G.A., Reece, J.M., Jeromin, A. & Dudek, S.M. (2008) Synapse elimination accompanies functional plasticity in hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America 105(8):3123-3127. [Abstract Bastrikova, N., Gardner, G.A., Reece, J.M., Jeromin, A. & Dudek, S.M. (2008) Synapse elimination accompanies functional plasticity in hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America 105(8):3123-3127.]
  32. Saha, R. & Dudek, S.M. (2008) Action potentials: to the nucleus and beyond. Experimental biology and medicine 233(4):385-393. [Abstract Saha, R. & Dudek, S.M. (2008) Action potentials: to the nucleus and beyond. Experimental biology and medicine 233(4):385-393.]
  33. Zhao, M. & Dudek, S.M. (2007) Synaptic plasticity (and the lack thereof) in hippocampal CA2 neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 27(44):12025-12032. [Abstract Zhao, M. & Dudek, S.M. (2007) Synaptic plasticity (and the lack thereof) in hippocampal CA2 neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 27(44):12025-12032.]
  34. Zhao, M., Adams, J.P. & Dudek, S.M. (2005) Pattern-dependent role of NMDA receptors in action potential generation: consequences on Extracellular Signal-Regulated Kinase activation. J. Neurosci. 25, 7032-7039. [Abstract Zhao, M., Adams, J.P. & Dudek, S.M. (2005) Pattern-dependent role of NMDA receptors in action potential generation: consequences on Extracellular Signal-Regulated Kinase activation. J. Neurosci. 25, 7032-7039.]
  35. Adams, J.P. & Dudek, S.M. (2005) Late-phase long-term potentiation: getting to the nucleus, Nature Rev. Neurosci. 6, 737-743.  [Abstract Adams, J.P. & Dudek, S.M. (2005) Late-phase long-term potentiation: getting to the nucleus, Nature Rev. Neurosci. 6, 737-743. ]
  36. Dudek, S.M. & Fields, R.D. (2002) Somatic action potentials are sufficient for late-phase LTP-related cell signaling, Proc Natl Acad Sci USA 99(6), 3962-3967.  [Abstract Dudek, S.M. & Fields, R.D. (2002) Somatic action potentials are sufficient for late-phase LTP-related cell signaling, Proc Natl Acad Sci USA 99(6), 3962-3967. ]
  37. Dudek, S.M. & Fields, R.D. (2001) Mitogen-activated protein kinase/extracellular signal-regulated kinase activation in somatodendritic compartments: roles of action potentials, frequency, and mode of calcium entry, J Neurosci 21(2), RC122. [Abstract Dudek, S.M. & Fields, R.D. (2001) Mitogen-activated protein kinase/extracellular signal-regulated kinase activation in somatodendritic compartments: roles of action potentials, frequency, and mode of calcium entry, J Neurosci 21(2), RC122.]
  38. Dudek, S.M. & Friedlander, M.J. (1996) Developmental down-regulation of LTD in cortical layer IV and its independence of modulation by inhibition, Neuron 16(6), 1097-1106.  [Abstract Dudek, S.M. & Friedlander, M.J. (1996) Developmental down-regulation of LTD in cortical layer IV and its independence of modulation by inhibition, Neuron 16(6), 1097-1106. ]
  39. Dudek, S.M. & Johnson, G.V.W. (1993) Transglutaminase catalyzes the formation of sodium dodecyl sulfate insoluble, Alz-50 positive polymers of tau. J. Neurochem. 61: 1159-1162.  [Abstract Dudek, S.M. & Johnson, G.V.W. (1993) Transglutaminase catalyzes the formation of sodium dodecyl sulfate insoluble, Alz-50 positive polymers of tau. J. Neurochem. 61: 1159-1162. ]
  40. Dudek, S.M. & Bear, M.F. (1993) Bidirectional long-term modification of synaptic effectiveness in the adult and immature hippocampus. J. Neurosci. 13: 2910-2918.  [Abstract Dudek, S.M. & Bear, M.F. (1993) Bidirectional long-term modification of synaptic effectiveness in the adult and immature hippocampus. J. Neurosci. 13: 2910-2918. ]
  41. Dudek, S.M. & Bear, M.F. (1992) Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade. Proc Natl Acad Sci USA 89(10), 4363-4367. [Abstract Dudek, S.M. & Bear, M.F. (1992) Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade. Proc Natl Acad Sci USA 89(10), 4363-4367.]