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Cancer Biology Group Jen-Sung Wei, Ph.D.
Visiting Fellow Tel (919) 541-4660 Fax (919) 541-1460 wei2@niehs.nih.gov P.O. Box 12233 Research Triangle Park, North Carolina 27709 Delivery Instructions I took a doctor’s degree in Life Sciences of National Defense Medical Center, Taipei, Taiwan, R.O.C. At present, I am working as a research fellow at Dr. Raymond W. Tennant’s Cancer Biology Group group in the National Center of Toxicogenomics (NCT) in the National Institute of Environmental Health Sciences (NIEHS). The main goal of my study is to search the genes involved in the early stages of skin carcinogenesis using v-H-ras TgAC transgenic mouse model. With a combination of fluorescence-activated cell sorting (FACS), switching mechanism at the 5’ end of RNA templates cDNA amplification, mouse cDNA microarray, and anchorage-independent soft agar growth assay technologies, we identified and demonstrated two novel TPA-inducible genes, deleted in split hand/split foot gene 1 (Dss1) and nucleoside diphosphate protein kinase B (NDPK-B), whose expression changed significantly in the integrin α6+ CD34+ keratinocyte stem/progenitor cells, to be possibly involved in early skin tumorigenesis. |
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