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Selected Publications

Spontaneous Mutation & DNA Repair Group

  1. Drake JW, von Borstel RW, Hennig UGG. (2012) In memoriam R. C. (Jack) von Borstel (January 24, 1925–April 19, 2012). Environmental and molecular mutagenesis 53(7):493-94. [Abstract (http://onlinelibrary.wiley.com/doi/10.1002/em.21714/abstract) ]
  2. Drake JW. (2012) Twists and turns. DNA repair 11(9):703-13.
  3. Drake, J. W. (2012) Contrasting mutation rates from specific-locus and long-term mutation-accumulation procedures. G3 (Genes, Genomes, Genetics) 2: 483-485.
  4. García-Villada, L., and J. W. Drake (2012) The three faces of riboviral spontaneous mutation: spectrum, mode of genome replication, and mutation rate. PLoS Genet. 8(7): e1002832.
  5. Drake, J. W. (2012) Autobiographical sketch: twists and turns. DNA Repair 11: 703-713.
  6. Burch, L. H., L. Zhang, F. G. Chao, H. Xu and J. W. Drake (2011) The bacteriophage T4 rapid-lysis genes and their mutational proclivities. J. Bacteriol. 193: 3537-3545. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=21571993) ]
  7. Trzemecka, A., A. Jacewicz, G. T. Carver, J. W. Drake and A. Bebenek (2010) Reversal of a mutator activity by a nearby fidelity-neutral substitution in the RB69 DNA polymerase binding pocket. J. Mol. Biol. 404(5):778-793. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=20950625) ]
  8. García-Villada, L. and J. W. Drake (2010) Mutational clusters generated by non-processive polymerases: a case study using DNA polymerase β in vitro. DNA Repair 9:871-878. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=20627824) ]
  9. Drake, J. W. (2009) Avoiding dangerous missense: Thermophiles display especially low mutation rates. PLoS Genet. 5(6):e1000520.
  10. Mackwan, R. R., G. T. Carver, G. E. Kissling, J. W. Drake and D. W. Grogan (2008) The rate and character of spontaneous mutation in Thermus thermophilus. Genetics 180(1):17-25. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18723895) ]
  11. Schultz, G .E. Jr., and J. W. Drake (2008) Templated mutagenesis in bacteriophage T4 involving imperfect direct or indirect sequence repeats. Genetics 178(2):661-673. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18245334) ]
  12. Drake, J. W. (2007) Too many mutants with multiple mutations. Crit. Rev. Biochem. Mol. Biol. 42: 247-258. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17687667&query_hl=12&itool=pubmed_docsum) ]
  13. Mackwan, R. R., G. T. Carver, J. W. Drake and D. W. Grogan (2007) An unusual pattern of spontaneous mutations recovered in the halophilic archaeon Haloferax volcanii. Genetics 176: 697-702. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17194771&query_hl=12&itool=pubmed_docsum) ]
  14. Drake, J. W. (2006) Chaos and order in spontaneous mutation. Genetics 173: 1-8. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16723419&query_hl=12&itool=pubmed_docsum) ]
  15. Schultz, G. E., Jr., G. T. Carver and J. W. Drake (2006) A role for replication repair in the genesis of templated mutations. J. Mol. Biol. 4: 963-973.   [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16574154&query_hl=12&itool=pubmed_docsum) ]
  16. Drake, J. W., A. Bebenek, G. E. Kissling and S. Peddada (2005) Clusters of mutations from transient hypermutability. Proc. Natl. Acad. Sci. USA 102: 12849-12854. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16118275&query_hl=12&itool=pubmed_docsum) ]
  17. Bebenek, A., G. T. Carver, F. A. Kadyrov, G. E. Kissling and J. W. Drake (2005) Processivity clamp gp45 and ssDNA-binding-protein gp32 modulate the fidelity of bacteriophage RB69 DNA polymerase in a sequence-specific manner, sometimes enhancing and sometimes compromising accuracy. Genetics 169: 1815-1824. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15695359&query_hl=12&itool=pubmed_docsum) ]
  18. Kadyrov, F. A. and J. W. Drake (2004) UvsX recombinase and Dda helicase rescue stalled bacteriophage T4 DNA replication forks in vitro. J. Biol. Chem. 279: 279: 35735-35740. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15194689&query_hl=12&itool=pubmed_docsum) ]
  19. Friedman, R., J. W. Drake and A. L. Hughes (2004) Genome-wide patterns of nucleotide substitution reveal stringent functional constraints on the protein sequences of thermophiles. Genetics 167: 1507-1512. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15280258&query_hl=12&itool=pubmed_docsum) ]
  20. Kadyrov, F. A. and J. W. Drake (2003) Properties of bacteriophage T4 proteins deficient in replication repair. J. Biol. Chem. 278: 25247-25255. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12697750&query_hl=12&itool=pubmed_docsum) ]
  21. Bebenek, A., G. T. Carver, H. K. Dressman, F. A. Kadyrov, J. K. Haseman, V. Petrov, W. H. Konigsberg, J. D. Karam and J. W. Drake (2002) Dissecting the fidelity of bacteriophage RB69 DNA polymerase: site-specific modulation of fidelity by polymerase accessory proteins. Genetics 162: 162: 1003-1018. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12454051&query_hl=12&itool=pubmed_docsum) ]
  22. Malpica, J. M., A. Fraile, I. Moreno, C. I. Obies, J. W. Drake and F. García-Arenal (2002) The rate and character of spontaneous mutation in an RNA virus. Genetics 162: 1505-1511.  [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12524327&query_hl=12&itool=pubmed_docsum) ]
  23. Bebenek, A., H. K. Dressman, G. T. Carver, S. Ng, V. Petrov, G. Yang, W. H. Konigsberg, J. D. Karam and J. W. Drake (2001) Interacting fidelity defects in the replicative DNA polymerase of bacteriophage RB69. J. Biol. Chem. 276: 10387-10397. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=11133987&query_hl=12&itool=pubmed_docsum) ]
  24. Grogan, D. W., G. T. Carver and J. W. Drake (2001) Genetic fidelity under harsh conditions: analysis of spontaneous mutation in the thermoacidophilic archaeon Sulfolobus acidocaldarius. Proc. Natl. Acad. Sci. USA 98: 7928-7933. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=11427720&query_hl=12&itool=pubmed_docsum) ]

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