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Selected Publications

Environmental Genomics Group

  1. Zeron-Medina  J, Wang  X, Repapi E, Campbell MR, Su S, Castro-Giner F, Davies B, Peterse EFP, Sacilotto N, Tomlinson IP, Meinshausen N, De Val S, Bell DA, and Bond GL   A unique polymorphic p53 responsive enhancer in the KIT Ligand oncogene (KITLG) influences cancer risk and has undergone natural selection, Submitted, 2013.
  2. Joubert BR, Håberg SE, Nilsen RM , Wang X, Vollset SE, Murphy SK, Huang Z, Hoyo C, Midttun O, Cupul-Uicab LA , Ueland PM, Wu MC, Nystad W , Bell DA , Peddada SD , London SJ. (2012) 450K Epigenome-Wide Scan Identifies Differential DNA Methylation in Newborns Related to Maternal Smoking during Pregnancy.. Environmental Health Perspectives 120(10):1425-31. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=22851337) ]
  3. Chorley BN, Campbell MR , Wang X , Karaca M, Sambandan D, Bangura F, Xue P, Pi J, Kleeberger SR , Bell DA. (2012) Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha. Nucleic Acids Research. 40(15):7416-29. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=22581777) ]
  4. Millau, J-F, Bandele, O..J, Perron, J., Bastien, N., Bouchard, E.F., Gaudreau, L., Bell, D.A., and Drouin, R. (2011) Formation of stress-specific p53 binding patterns is influenced by chromatin but not by modulation of p53 binding affinity to response elements. Nucleic Acids Research  39(8):3053-3063, 2011. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=21177650) ]  
  5. Bandele, O.J., Wang, X., Campbell, M.R., Pittman, G.S., and Bell, D.A. (2010) Human single-nucleotide polymorphisms alter p53 sequence-specific binding at gene regulatory elements. Nucleic Acids Research 39(1):178-189. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=20817676) ]
  6. Wang, X., Chorley, B.N., Pittman, G.S., Kleeberger, S.R., Brothers, J., Liu, G., Spira, A., and Bell, D.A. (2010) Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer. PloS one 5(8):e11934. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=20689807) ]
  7. Noureddine, M.A., Menendez, D., Campbell, M.R., Bandele, O.J., Horvath, M.M., Wang, X., Pittman, G.S., Chorley, B.N., Resnick, M.A., and Bell, D.A. (2009) Probing the functional impact of sequence variation on p53-DNA interactions using a novel microsphere assay for protein-DNA binding with human cell extracts. PLoS Genet 5:e1000462. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/19424414?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum) ]
  8. Jordan, J.J., Menendez, D., Inga, A., Nourredine, M., Bell, D., and Resnick, M.A. (2008) Noncanonical DNA motifs as transactivation targets by wild type and mutant p53. PLoS Genet 4:e1000104 [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/18714371?ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum) ]
  9. Chorley, B.N., Wang, X., Campbell, M.R., Pittman, G.S., Noureddine, M.A., and Bell, D.A. (2008) Discovery and verification of functional single nucleotide polymorphisms in regulatory genomic regions: current and developing technologies. Mutat Res 659:147-157. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/18565787?ordinalpos=10&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum) ]
  10. Horvath, M.M., Wang, X, Resnick, M.A., and Bell, D.A. (2007) Divergent evolution of human p53 binding sites: cell cycle vs apoptosis. PloS Genet 3:e127. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/17677004?ordinalpos=14&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum) ]
  11. Wang, X., Tomso, D.J., Chorley, B.N., Cho, H.Y., Cheung, V.G., Kleeberger, S.R., and Bell, D.A. (2007) Identification of polymorphic antioxidant response elements in the human genome. Hum Mol Genet 16:1188-1200. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/17409198?ordinalpos=18&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum) ]
  12. Perera, F.P., Tang, D., Brandt-Rauf, P., Santella, R.M., Mooney, L.V., Tu, Y.H., Bendkowska, I., and Bell, D.A. (2006) Lack of associations among cancer and albumin adducts, ras p21 oncoprotein levels, and CYP1A1, CYP2D6, NAT1, and NAT2 in a nested case-control study of lung cancer within the physicians' health study. Cancer Epidemiol Biomarkers Prev 15, 1417-1419.
  13. Novak J.P., Miller, M.C. III, and Bell, D.A. (2006) Variation in fiberoptic bead-based oligonucleotide microarrays: dispersion characteristics among hybridization and biological replicate samples. Biol Direct 1, 18. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/16787528?ordinalpos=26&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum) ]
  14. Tomso, D.J., Inga, A., Menendez, D., Pittman, G.S., Campbell, M.R., Storici, R., and Bell, D.A.,  Resnick, M. A. (2005) Functionally distinct polymorphic sequences in the human genome that are targets for p53 transactivation. Proc Natl Acad Sci USA 102:6431-6436. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15843459?ordinalpos=36&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum) ]
  15. Liu, X., Campbell, M.R., Pittman, G.S., Faulkner, E.C., Watson, M.A., and Bell, D.A. (2005) Expression-based discovery of variation in the human glutathione S-transferase M3 promoter and functional analysis in a glioma cell line using allele-specific chromatin immunoprecipitation. Cancer Res 65, 99-104. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15665284?ordinalpos=38&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum) ]
  16. Tomso, D.J. and Bell, D.A. (2003) Sequence context at human single nucleotide polymorphisms: overrepresentation of CpG dinucleotide at polymorphic sites and suppression of variation in CpG islands. J Mol Biol 327, 303-308. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/12628237?ordinalpos=64&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum) ]
  17. Perera, F.P., Mooney, L.A., Stampfer, M., Phillips, D.H., and Bell, D.A. (2002) Associations between carcinogen-DNA damage, glutathione S-transferase genotypes, and risk of lung cancer in the prospective Physicians' Health Cohort Study. Carcinogenesis 23, 1641-1646. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/12376472?ordinalpos=68&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum) ]
  18. Fritsche, E., Baek, S.J., King, L.M., Zeldin, D.C., Eling, T.E., and Bell, D.A. (2001) Functional characterization of cyclooxygenase-2 polymorphisms. J Pharmacol Exp Ther 299, 468-476. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/11602656?ordinalpos=77&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum) ]
  19. Whyatt, R.M., Perera, F.P., Jedrychowski, W., Santella, R.M., Garte, S., and Bell, D.A. (2000) Association between polycyclic aromatic hydrocarbon-DNA adduct levels in maternal and newborn white blood cells and glutathione S-transferase P1 and CYP1A1 polymorphisms. Cancer Epidemiol Biomarkers Prev 9, 207-212. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/10698483?ordinalpos=99&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum) ]
  20. Fennell, T.R., MacNeela, J.P., Morris, R.W., Watson, M., Thompson, C.L., and Bell, D.A. (2000) Hemoglobin adducts from acrylonitrile and ethylene oxide in cigarette smokers: effects of glutathione S-transferase T1-null and M1-null genotypes. Cancer Epidemiol Biomarkers Prev 9, 705-712. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/10919741?ordinalpos=86&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum) ]
  21. Lunn, R.M., Langlois, R.G., Hsieh, L.L., Thompson, C.L., and Bell, D.A. (1999) XRCC1 polymorphisms: effects on aflatoxin B1-DNA adducts and glycophorin A variant frequency. Cancer Res 59, 2557-2561. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/10363972?ordinalpos=111&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum) ]
  22. Taylor, J.A., Umbach, D. M., Stephens, E., Castranio, T., Paulson, D., and Bell, D.A. (1998) The role of N-acetylation polymorphisms in smoking-associated bladder cancer: evidence of a gene-gene-exposure three-way interaction. Cancer Res 58, 3603-3610. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/9721868?ordinalpos=124&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum) ]
  23. Bell, D.A., Taylor, J.A., Paulson, D.F., Robertson, C.N., Mohler, J.L. and Lucier, G.W. (1993) Genetic risk and carcinogen exposure: a common inherited defect of the carcinogen-metabolism gene glutathione S-transferase M1 (GSTM1) that increases susceptibility to bladder cancer. J Natl Cancer Inst 85, 1159-1164. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/8320745?ordinalpos=198&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum) ]

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