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Dmitry Gordenin

Chromosome Stability Group

Dmitry Gordenin, Ph.D.
Dmitry Gordenin, Ph.D.
Senior Associate Scientist
Tel (919) 541-5190
Fax (919) 541-7593
gordenin@niehs.nih.gov
P.O. Box 12233
Mail Drop D3-01
Research Triangle Park, North Carolina 27709
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NIH Radio

Cellular damage from normal metabolism potentially causes cancer

Dmitry Gordenin

Speaker:
Dr. Gordenin

Dmitry Gordenin, Ph.D., is a Senior Associate Scientist in the Chromosome Stability Group, headed by Michael Resnick, Ph.D. Gordenin runs research programs within the Group and in collaboration with other laboratories in and outside NIEHS. He also mentors and trains postdoctoral fellows and junior staff. His research interests include identifying the mechanisms, genetic defects, and environmental factors that lead to the extreme risks of genome instability. The outcomes of his work encompass areas of DNA replication and various DNA repair pathways. Methodology includes the yeast experimental models and bioinformatics analysis of genetic instability in yeast and human genomes.

 

Gordenin received his doctorate in genetics in 1978 from St. Petersburg State University in Russia, and continued his research there as a faculty member in the Department of Genetics. A collaboration with Resnick in 1989 eventually led to Gordenin joining Resnick’s Group in 1994. Several of Gordenin’s papers have been included in the NIEHS Papers of the Year (2003, 2004, 2007, and 2009), and he received the NIEHS Outstanding Staff Scientist Award in 2009. He was promoted to Senior Associate Scientist in 2010.

 

Selected Publications

  1. Sakofsky CJ, Roberts SA, Malc E, Mieczkowski PA, Resnick MA, Gordenin DA, Malkova A. Break-induced replication is a source of mutation clusters underlying kataegis. Cell reports 2014 7(5):1640-1648.[Abstract ]
  2. Cancer Genome Atlas Research Network. Comprehensive molecular characterization of urothelial bladder carcinoma. Nature 2014 507(7492):315-322.[Abstract ]
  3. Chan K, Resnick MA, Gordenin DA. The choice of nucleotide inserted opposite random abasic sites formed within chromosomal DNA is indicative of the polymerases participating in translesion DNA synthesis. DNA repair 2013 12(11):878-889.[Abstract ]
  4. Roberts, SA, Lawrence, MS, Klimczak, LJ, Frage, D, Stojanov, P, Kiezun, A, Kryukov, GV, Carter, SL, Saksena, G, Harris, S, Shah, R, Resnick, MA, Getz, G, Gordenin, DA.  An apobec cytidine deaminase mutagenesis pattern is ubiquitous in human cancers.  Nature Genetics 45: 970-976, 2013.[Abstract ]
  5. Chan K, Sterling JF, Roberts SA, Bhagwat AS, Resnick MA, Gordenin DA. 2012. Base damage within single-strand DNA underlies in vivo hypermutability induced by a ubiquitous environmental agent. PLoS genetics 8(12):e1003149.[Abstract ]
  6. Covo S, Ma W, Westmoreland J, Gordenin DA, Resnick MA. 2012. Understanding the origins of UV-induced recombination through manipulation of sister chromatid cohesion. Cell cycle (Georgetown, Tex.) 11(21):3937-44.[Abstract ]
  7. Covo S, Westmoreland JW, Reddy AK, Gordenin DA, Resnick MA. 2012. RAD53 is limiting in double-strand break repair and in protection against toxicity associated with ribonucleotide reductase inhibition. DNA repair 11(3):317-23.[Abstract ]
  8. Roberts SA, Sterling J, Thompson C, Harris S, Mav D, Shah R, Klimczak LJ, Kryukov GV, Malc E, Mieczkowski PA, Resnick MA, Gordenin DA. 2012.  Clustered mutations in yeast and in human cancers can arise from damaged long single-strand DNA regions. Mol Cell 46(4):424-435.[Abstract ]
  9. Burch LH, Yang Y, Sterling JF, Roberts S, Chao FG, Xu H, Zhang L, Walsh J, Resnick MA, Mieczkowski PA, Gordenin DA. 2011. Damage-Induced Localized Hypermutability. Cell Cycle (Georgetown, Tex.) 10(7): 1073-1085.[Abstract ]
  10. Yang Y, Sterling J, Storici F, Resnick MA, Gordenin DA. 2008. Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae. PLoS Genet 4(11): e1000264.[Abstract ]
  11. Ma W, Resnick MA, Gordenin DA. 2008. Apn1 and Apn2 endonucleases prevent accumulation of repair-associated DNA breaks in budding yeast as revealed by direct chromosomal analysis. Nucleic Acid Res 36(6): 1836-1846.[Abstract ]
  12. Jin YH, Garg P, Stith CM, Al-Refai H, Sterling JF, Murray LJ, Kunkel TA, Resnick MA, Burgers PM, Gordenin DA. 2005. The multiple biological roles of the 3'-->5' exonuclease of Saccharomyces cerevisiae DNA polymerase delta require switching between the polymerase and exonuclease domains. Mol Cell Biol 25(1): 461-471.[Abstract ]

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