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Your Environment. Your Health.

Selected Publications (between 2006 & 2013)

Chromosome Stability Group

  1. Sakofsky CJ, Roberts SA, Malc E, Mieczkowski PA, Resnick MA, Gordenin DA, Malkova A. Break-induced replication is a source of mutation clusters underlying kataegis. Cell reports 2014 7(5):1640-1648.[Abstract ]
  2. Chan K, Resnick MA, Gordenin DA. The choice of nucleotide inserted opposite random abasic sites formed within chromosomal DNA is indicative of the polymerases participating in translesion DNA synthesis. DNA repair 2013 12(11):878-889.[Abstract ]
  3. Ma, W., Westmoreland, J., and Resnick, M.A. Homologous recombination rescues single strand DNA gaps generated by NER and reduced translesion DNA synthesis in yeast G2 cells.  Proc. Nat. Acad Sci., in press.  
  4. Menendez, D., Nguyen, T-A., Freudenberg, Mathew, V. J., Anderson, C.W., Jothi, R., and Resnick, M.A.  Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells. Nucl. Acid Res., in press.
  5. Roberts, SA, Lawrence, MS, Klimczak, LJ, Frage, D, Stojanov, P, Kiezun, A, Kryukov, GV, Carter, SL, Saksena, G, Harris, S, Shah, R, Resnick, MA, Getz, G, Gordenin, DA.  An apobec cytidine deaminase mutagenesis pattern is ubiquitous in human cancers.  Nature Genetics 45: 970-976, 2013.[Abstract ]
  6. Westmoreland JW, Resnick MA. Coincident resection at both ends of random, γ-induced double-strand breaks requires MRX (MRN), Sae2 (Ctp1), and Mre11-nuclease. PLoS Genetics 2013 9(3):e1003420.[Abstract ]
  7. Madenspacher, J., Azzam, K., Gowdy, K., Malcolm, K., Nick, J., Aloor, D. J., Draper, D., Guardiola, J., Shatz, M., Menendez, D., Lowe, J., Lu, J., Bushel, P., Li, Leping, Merrick, A., Resnick, M.A. and Fessler, M. p53 Integrates host defense and cell fate during bacterial pneumonia. J. Experimental Medicine:  891-904, 2013.  [Abstract ]
  8. Ma, W., Halweg, C. J., Menendez, D., Resnick, M.A. Differential effects of PARP inhibition and depletion on single- and double-strand break repair in human cells are revealed by changes in EBV minichromosomes. Proc. Nat. Acad. Sci. 109: 6590-5, 2012.[Abstract ]
  9. Roberts, S.A., Sterling, J., Thompson, C., Yang, Y., Harris, S., Mav, D., Shah, R., Klimczak, L., Kryukov, G. V., Malc, E., Mieczkowski, P., Resnick, M.A., and Gordenin, D. A.  Clustered simultaneous mutations in yeast and human cancers are caused by damage to long regions of single-strand DNA. Molec. Cell 25: 424-435. 2012.[Abstract ]
  10. Shatz, M., Menendez, D., Resnick, M.A.  The human TLR innate immune gene family is differentially influenced by DNA stress and p53 status in cancer cells. Cancer Research 72: 3948-57, 2012.[Abstract ]
  11. Jordan, J.J., Menendez, D., Sharav, J., Beno, I., Resnick, M.A.* and  Haran, T.E.*  Low-level expression of p53 changes the rules of transactivation and reveals super-activating sequences. Proc. Nat. Acad. Sci. 109:  14387-92, 2012. *Equal contributions[Abstract ]
  12. Chan K, Sterling JF, Roberts SA, Bhagwat AS, Resnick MA, Gordenin DA. Base damage within single-strand DNA underlies in vivo hypermutability induced by a ubiquitous environmental agent. PLoS genetics 2012 8(12):e1003149. [Abstract ]
  13. Menendez, D., Shatz, M., Garantziotis, S., Fessler, M., and Resnick, M.A.  The human Toll-like receptor family is integrated into human DNA damage and p53 network. Mar;7(3):e1001360. Epub 2011 Mar 31  [Abstract ]
  14. Ma, W., Westmoreland,  J.W., Gordenin, D.A. and Resnick, M.A.  Alkylation base damage is converted into repairable double-strand breaks and complex intermediates in G2 cells lacking AP endonuclease. PLoS Genetics Apr;7(4):e1002059. Apr 28, Epub 2011[Abstract ]
  15. Menendez, D., Inga, A., and Resnick, M.A. Estrogen receptor acting in cis enhances WT and mutant p53 transactivation at canonical and noncanonical p53 target sequences. Proc. Nat. Acad. Sci. 107: 1500-1505, 2010.[Abstract ]
  16. Covo, S., Westmoreland, J.W., Gordenin, D.A., Resnick, M.A. Cohesin Is limiting for the suppression of DNA damage-induced recombination between homologous chromosomes. PLoS Genetics 6(7):e1001006, 2010.[Abstract ]
  17. Ma, W., Panduri, V., Sterling, J.F., Van Houten, B., Gordenin, D.A., and Resnick, M.A. The transition of closely-opposed lesions to double-strand breaks during long-patch base excision repair is prevented by the coordinated action of DNA polymerase delta and Rad27/Fen1. Molec. Cell. Biol. 29: 1212-1221, 2009.[Abstract ]
  18. Menendez, D., Inga, A., and Resnick, M.A. The expanding universe of p53 targets. Invited review. Nature Reviews Cancer 9: 724-733, 2009.[Abstract ]
  19. Westmoreland, J., Ma, W., Yan, Y., van Hulle, K., Malkova, A., and Resnick, M.A. RAD50 (MRX) is required for efficient initiation of resection and recombinational repair at random, g-induced double-strand break ends. PLoS Genetics 5 (9): e1000656, 2009.[Abstract ]
  20. Larrea, A.A., Lujan, S.A., McElhinny, S. A. Mieczkowski, P.A., Resnick, M.A., Gordenin, D. A. and Kunkel, T. A.  Genome wide model for the normal eukaryotic DNA replication fork. Proc. Nat. Acad. Sci. 107: 17674-9, 2010.  [Abstract ]
  21. Jegga, A., Menendez, D., Inga, A., Aronow, B., and Resnick, M.A. Functional evolution of the p53 regulatory network through its target response elements. Proc. Nat. Acad. Sci. 105: 944-949, 2008.[Abstract ]
  22. Jordan, J.J., Menendez, D., Inga, A., Nourredine, M., Bell, D., and Resnick, M.A. Noncanonical DNA motifs as transactivation targets by wild type and mutant p53. PLoS Genetics 4(6): e1000104, 2008.[Abstract ]
  23. Argueso, J.L., Westmoreland, J., Mieczkowski, P., Gawel, M., Petes, T.D. and Resnick, M.A. Double strand breaks associated with repetitive DNA unlock genome plasticity. Proc. Nat. Acad. Sci. 105: 11845-50, 2008. (Also see PNAS commentary.)[Abstract ]
  24. Yang Y, Sterling J, Storici F, Resnick MA, Gordenin DA. 2008. Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae. PLoS Genet 4(11): e1000264.[Abstract ]
  25. Menendez, D., Inga, A., Snipe, J., Krysiak, O., Schönfelder, G., and Resnick, M.A. A single-nucleotide polymorphism in a half-binding site creates p53 and estrogen receptor control of vascular endothelial growth factor receptor 1. Mol. Cell. Biol. 27: 2590-2560, 2007.[Abstract ]
  26. Storici, F., Bebenek, K., Kunkel, T. A., Gordenin, D., and Resnick, M.A. RNA-templated DNA repair. Nature 447: 338-341, 2007.[Abstract ]
  27. Menendez, D., Krysiak, O., Inga, A., Gehrandt, B., Resnick, M.A.*, and Schönfelder, G.* *Equal contributors. A SNP in the FLT1 promoter integrates the VEGF system into the p53 transcriptional network. Proc. Nat. Acad. Sci. 103: 1406-1411, 2006.[Abstract ]
  28. Storici, F., Snipe, J.R., Chan, G.K., Gordenin, D.*, and Resnick, M.A.* *Equal contributors. Conservative repair of a chromosomal double-strand break by single-strand DNA through two steps of annealing. Mol. Cell. Biol. 26: 7645-7657, 2006.[Abstract ]

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