Menendez, D., Inga, A., and Resnick, M.A. The expanding universe of p53 targets. Invited review. Nature Reviews Cancer 9: 724-733, 2009. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/19776742?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1)
Westmoreland, J., Ma, W., Yan, Y., van Hulle, K., Malkova, A., and Resnick, M. A. RAD50 (MRX) is required for efficient initiation of resection and recombinational repair at random, g-induced double-strand break ends. PLoS Genetics 5 (9): e1000656, 2009. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/19763170?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2)
Ma, W., Panduri, V., Sterling, J.F., Van Houten, B., Gordenin, D.A., and Resnick, M. A. The transition of closely-opposed lesions to double-strand breaks during long-patch base excision repair is prevented by the coordinated action of DNA polymerase delta and Rad27/Fen1. Molec. Cell. Biol. 29: 1212-1221, 2009. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/19075004?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=5)
Noureddine, M.A., Menendez, D., Bandele, O.J., Campbell, M., Horvath, M.M., Wang, X., Pittman, G., Chorley, B.N., Resnick, M.A., and Bell, D.A. Probing the functional impact of sequence variation on p53-DNA interactions using a novel microsphere assay for protein-DNA binding with human cell extracts. PLoS Genet. 5(5): e1000462, 2009. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/19424414?dopt=Abstract)
Yan, J., Menendez, D., Yang, X-P., Resnick, M.A.*, and Jetten, A.* *Equal contributions. A regulatory loop composed of RAP80-MDM2-p53 provides RAP80 enhanced p53 degradation by Mdm2 in response to DNA damage. J. Biol. Chem. 284: 19280-19289, 2009. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/19433585?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=3)
Ma, W., Resnick, M.A., and Gordenin, D.A. Apn1 and Apn2 endonucleases prevent accumulation of repair-associated DNA breaks in budding yeast as revealed by direct chromosomal analysis. Nucleic Acid Research 36: 1836-1846, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/18267974?dopt=Abstract)
Jegga, A., Menendez, D., Inga, A., Aronow, B., and Resnick, M.A. Functional evolution of the p53 regulatory network through its target response elements. Proc. Nat. Acad. Sci. 105: 944-949, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/18187580?dopt=Abstract)
Jordan, J.J., Menendez, D., Inga, A., Nourredine, M., Bell, D.A., and Resnick, M.A. Noncanonical DNA Motifs as transactivation targets by wild type and mutant p53. PLoS Genet 4(6): e1000104, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/18714371?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=9)
Argueso, J.L., Westmoreland, J., Mieczkowski, P., Gawel, M., Petes, T.D. and Resnick, M.A. Double strand breaks associated with repetitive DNA unlock genome plasticity. Proc. Nat. Acad. Sci. 105: 11845-50, 2008. (Also see PNAS commentary.) [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/18701715?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=10)
Yang, Y., Sterling, J., Strorici, F., Resnick, M.A., and Gordenin, D. Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres. PLoS Genetics 4(11): e1000264, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/19023402?dopt=Abstract)
Horvath, M.M., Wang, X., Resnick, M.A., and Bell, D.A. Divergent evolution of human p53 binding sites: cell cycle versus apoptosis. PLOS Genetics 3: 1284-1295, 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/17677004?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=13)
Storici, F., Bebenek, K., Kunkel, T. A., Gordenin, D., Resnick, M.A. RNA-templated DNA repair. Nature 447: 338-341, 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/17429354?dopt=AbstractPlus)
Menendez, D., Inga, A., Snipe, J., Krysiak, O., Schönfelder, G., and Resnick, M.A. A single-nucleotide polymorphism in a half-binding site creates p53 and estrogen receptor control of vascular endothelial growth factor receptor 1. Mol. Cell. Biol. 27: 2590-2560, 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17242190&query_hl=16&itool=pubmed_docsum)
Menendez, D., Inga, A., Jordan, J., and Resnick, M.A. Changing the p53 master regulatory network: ELEMENTary, my dear Mr. Watson. Oncogene 26: 2191-2201, 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17401428&query_hl=20&itool=pubmed_docsum)
Storici, F., Snipe, J.R., Chan, G.K., Gordenin, D.*, and Resnick, M.A.* *Equal contributors. Conservative repair of a chromosomal double-strand break by single-strand DNA through two steps of annealing. Mol. Cell. Biol. 26: 7645-7657, 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/16908537?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=18)
Menendez, D., Inga, A., and Resnick, M.A. The biological impact of the human master regulator p53 can be altered by mutations that change the spectrum and expression of its target genes. Mol. Cell Biol. 26: 2297-2308, 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16508005&query_hl=20&itool=pubmed_docsum)
Menendez, D., Krysiak, O., Inga, A., Gehrandt, B., Resnick, M.A.*, and Schönfelder, G.* *Equal contributors. A SNP in the FLT1 promoter integrates the VEGF system into the p53 transcriptional network. Proc. Nat. Acad. Sci. 103: 1406-1411, 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16432214&query_hl=16&itool=pubmed_docsum)
Lewis, K., Karthikeyan, G., Cassiano, J., and Resnick, M.A. Reduction in nucleosome assembly during new DNA synthesis impairs both major pathways of double-strand break repair. Nucleic Acid Res. 33: 4928-4939, 2005. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16141196&query_hl=34&itool=pubmed_docsum)
Inga, A., Raemon-Buettner, S.M., Borlak, J., and Resnick, M.A. Functional dissection of sequence-specific NKX2.5 DNA binding domain mutations associated with human heart septation defects using a yeast-based system. Human Molecular Genetics 14: 1965-1975, 2005. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15917268&query_hl=38&itool=pubmed_docsum)
Tomso, D.J., Inga, A., Menendez, D., Pittman, G., Campbell, M., Bell, D.A., and Resnick, M.A. Identification of functionally distinct polymorphic sequences that are targets for p53 transactivation. Proc. Natl. Acad. Sci. USA, Proc. Natl. Acad. Sci. USA 102: 6431-6436, 2005.
[Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15843459&query_hl=42&itool=pubmed_docsum)
Jin, Y.H., Garg, P., Stith, C.M.W., Al-Refai, H., Sterling, J. F., Murray, L.J.W., Kunkel, T.A., Resnick, M. A., Burgers, P.M., and Gordenin, D.A. The multiple biological roles of the 3'-->5' exonuclease of Saccharomyces cerevisiae DNA polymerase delta require switching between the polymerase and exonuclease domains. Mol. Cell. Biol. :461-471, 2005. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15601866)
Lobachev, K., Vitriol, E., Stemple, J., Resnick, M.A., and Bloom, K. Chromosome fragmentation after induction of a double-strand break is an active process prevented by the RMX repair complex. Curr. Biol. 14: 2107-2112, 2004. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15589152)
Lewis, L.K., Storici, F., Van Komen, S., Calero, S., Sung, P., and Resnick, M.A. Role of the nuclease activity of Saccharomyces cerevisiae Mre11 in repair of DNA double-strand breaks in mitotic cells. Genetics 166; 1701-1713, 2004. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15126391)
Karthikeyan, G.K., Santos, J., Graseiwcz, M., van Houten, B., Copeland, W.C., Isaya, G., and Resnick, M.A. Reduction in frataxin causes progressive accumulation of mitochondrial damage. Human Mol. Genet. 12: 3331-3342, 2003. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14570713)
Jin, Y.H., Clark, A.B., Slebos, R.J.C., Al-Refai, H., Taylor, J.A., Kunkel, T.A., Resnick, M.A., and Gordenin, D.A. Cadmium is a mutagen that acts by inhibiting mismatch repair. Nature Genet. 34: 326-329, 2003. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12796780)
Resnick, M.A., and Inga, A. Functional mutations in the sequence-specific transcription factor p53 and implications for master genes of diversity. Proc. Nat. Acad. Sci. USA 100: 9934-9939, 2003. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12909720)
Storici, F., Durham, C.L., Gordenin, D., and Resnick, M.A. Chromosomal site-specific double strand breaks are efficiently targeted for repair by oligonucleotides in yeast. Proc. Nat. Acad. Sci. USA, 100: 14994-14999, 2003. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14630945)
Lobachev, K., Gordenin, G., and Resnick, M.A. The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements. Cell 108: 183-193, 2002. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11832209)
Storici, F., Henneke, G., Gordenin, A., Hubscher, U., and Resnick, M.A. The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair. EMBO J. 21: 5930-5942, 2002. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12411510)
Inga, A., Nahari, D., Velasco-Miguel, S., Friedberg, E.C., and Resnick, M. A. A novel mutational hotspot in the Trp53 gene in skin cancers from UV Irradiated Xpc mutant mice encodes a protein with altered transactivation functions. Oncogene 21: 5704-15, 2002. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/12173040?dopt=AbstractPlus)
Inga, A., Storici, F., Darden, T.A., and Resnick, M.A. Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence. Mol. Cell. Biol. 22: 8612-86125, 2002. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12446780&query_hl=4&itool=pubmed_docsum)
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