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Your Environment. Your Health.

Selected Publications

Transcriptional Responses to the Environment Group

2007 - present

  1. Henriques T, Gilchrist DA, Nechaev S, Bern M, Muse GW, Burkholder A, Fargo DC, Adelman K. (2013) Stable Pausing by RNA Polymerase II Provides an Opportunity to Target and Integrate Regulatory Signals. Molecular cell 52(4):517-528.[Abstract ]
  2. Gupte R., Muse G.W., Chinenov Y., Adelman K., Rogatsky I. (2013) Glucocorticoid receptor represses proinflammatory genes at distinct steps of the transcription cycle. Proc Natl Acad Sci U S A; 110(36):14616-21.[Abstract ]
  3. Fromm G., Gilchrist D.A., Adelman K. (2013) SnapShot: Transcription regulation: pausing. Cell; 153(4):930-930.
  4. Henriques T, Adelman K. (2013) Catching the waves: following the leading edge of elongating RNA polymerase II. Molecular cell 50(2):159-160.[Abstract ]
  5. Core, L.J., Waterfall, J.J., Gilchrist D.A., Fargo, D.C., Kwak, H., Adelman, K., and Lis, J.T. (2012) Defining the status of RNA polymerase at promoters. Cell Rep.; 2 (4):1025-35.[Abstract ]
  6. Adelman, K & Lis, J.T. (2012) Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans. Nat. Rev. Genet. 13(10):720-731[Abstract ]
  7. Gilchrist D.A. & Adelman, K. (2012) Coupling Polymerase Pausing and Chromatin Landscapes to Precisely Regulate Transcription. Biochim. Biophys. Acta; 1819 (7):700-6.[Abstract ]
  8. Gilchrist D.A., Fromm, G., dos Santos G., Pham, L., McDaniel I., Burkholder, A., Fargo, D.C., and Adelman, K. (2012) Regulating the Regulators: the Pervasive Effects of Pol II Pausing on Stimulus-responsive Gene Networks. Genes Dev.; 26(9):933-44.[Abstract ]
  9. Saha, R.N., Wissink, E.M., Bailey, E.R., Zhao, M., Fargo. D.C., Hwang, J.Y., Daigle, K.R., Fenn, J.D., Adelman, K & Dudek, S.M. (2011) Rapid activity-induced transcription of Arc and other IEGs relies on poised RNA polymerase II. Nat. Neurosci.; 14 (7): 848-56.[Abstract ]
  10. Nechaev S., Adelman K. (2011) Pol II waiting in the starting gates: regulating the transition from transcription initiation into productive elongation. Biochimica et biophysica acta 1809(1):34-35.[Abstract ]
  11. Gilchrist D.A., Dos Santos G., Fargo D.C., Xie B., Gao Y., Li L., Adelman K. (2010) Pausing of RNA polymerase II disrupts DNA-specified nucleosome organization to enable precise gene regulation. Cell. 143(4):540-551.[Abstract ]
  12. Bartkowiak B, Liu P, Phatnani HP, Fuda NJ, Cooper JJ, Price DH, Adelman K, Lis JT, Greenleaf AL. (2010) CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1. Genes & Development; 24(20):2303-2316.[Abstract ]
  13. Nechaev S., Fargo D.C., dos Santos G., Liu L., Gao Y. & Adelman K. (2010) Global Analysis of Short RNAs Reveals Widespread Promoter-Proximal Stalling and Arrest of Pol II in Drosophila. Science; 327 (5963): 335-8.[Abstract ]
  14. Adelman K., Kennedy M.A., Nechaev S., Gilchrist D.A., Muse G.W., Chinenov Y. & Rogatsky I. (2009) Immediate mediators of the inflammatory response are poised for gene activation through RNA polymerase stalling. Proc Natl Acad Sci USA; 106 (43): 18207-12.[Abstract ]
  15. Gilchrist D.A, Fargo D. & Adelman K. (2009) Using ChIP-chip and ChIP-seq to study the regulation of gene expression: genome-wide localization studies reveal widespread regulation of transcription elongation. METHODS; 48: 398-408.[Abstract ]
  16. Ardehali M.B., Yao J., Adelman K., Fuda N., Petesch S., Webb W.W. & Lis J.T. (2009) Spt6 enhances the elongation rate of RNA polymerase II in vivo. EMBO J.; 28 (8):1067-77.[Abstract ]
  17. Gilchrist D.A., Nechaev S., Lee C., Gosh S.K.B, Collins J., Li L., Gilmour D.S. & Adelman K. (2008) NELF-mediated stalling of Pol II can enhance gene expression by blocking promoter-proximal nucleosome assembly. Genes Dev.; 22(14): 1921-33.[Abstract ]
  18. Nechaev S. & Adelman K. (2008) Promoter-proximal Pol II: when stalling speeds things up. Cell Cycle; 7(11): 1539-1544.[Abstract ]
  19. Zeitlinger, J., Stark, A., Kellis, M., Hong, J.W., Nechaev, S., Adelman, K., Levine, M., & Young, R.A. (2007) RNA Polymerase Stalling at Developmental Control Genes in the Drosophila Embryo. Nat Genet; 39 (12): 1512-16.[Abstract ]
  20. Muse G.W., Gilchrist D.A., Nechaev S., Shah R., Parker J.S., Grissom S.F., Zeitlinger J. & Adelman K. (2007) RNA polymerase is poised for activation across the genome. Nature Genetics 39(12):1507-1511.[Abstract ]

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