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Selected Publications

Transcriptional Responses to the Environment Group

2005 - present

  1. Nechaev S., Adelman K. (2011) Pol II waiting in the starting gates: regulating the transition from transcription initiation into productive elongation. Biochimica et biophysica acta 1809(1):34-35. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=21081187) ]
  2. Nechaev S., Adelman K.(2010) Pol II waiting in the starting gates: Regulating the transition from transcription initiation into productive elongation. Biochim Biophys Acta. Nov 13. [Epub ahead of print] [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/21081187) ]
  3. Gilchrist D.A., Dos Santos G., Fargo D.C., Xie B., Gao Y., Li L., Adelman K. (2010) Pausing of RNA polymerase II disrupts DNA-specified nucleosome organization to enable precise gene regulation. Cell. 143(4):540-551. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/21074046) ]
  4. Gilchrist D.A., Adelman K. (2010) Moonshine illuminates a developmental role for regulated transcription elongation. Developmental cell; 19(1):9-10.  [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=20643345) ]
  5. Bartkowiak B, Liu P, Phatnani HP, Fuda NJ, Cooper JJ, Price DH, Adelman K, Lis JT, Greenleaf AL. (2010) CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1. Genes & Development; 24(20):2303-2316. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=20952539) ]
  6. Fromm G. & Adelman K. (2010) c: Identification of novel complexes that bring together MLL-fusion proteins and transcription elongation factors. Molecular Cell; 37(4): 449-450.   [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=20188661) ]
  7. Adelman K. & Rogatsky I. (2010) RNA polymerase II stalling mediates cytokine gene expression. Cell Cycle; 9(4): 630-631. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=20107307) ]
  8. Nechaev S., Fargo D.C., dos Santos G., Liu L., Gao Y. & Adelman K. (2009) Global Analysis of Short RNAs Reveals Widespread Promoter-Proximal Stalling and Arrest of Pol II in Drosophila. Science; Published Online December 10, 2009: Science DOI: 10.1126/science.1181421. This link also provides open access to the full-text PDF. Cookies must be enabled for this link to function properly. [Abstract (http://www.sciencemag.org/cgi/content/abstract/science.1181421?ijkey=tKh3SfTM7rv0g&keytype=ref&siteid=sci) ] [Article (http://www.sciencemag.org/cgi/rapidpdf/science.1181421?ijkey=tKh3SfTM7rv0g&keytype=ref&siteid=sci) ]
  9. Adelman K., Kennedy M.A., Nechaev S., Gilchrist D.A., Muse G.W., Chinenov Y. & Rogatsky I. (2009) Immediate mediators of the inflammatory response are poised for gene activation through RNA polymerase stalling. Proc Natl Acad Sci USA; 106 (43): 18207-12. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/19820169?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1) ]
  10. Gilchrist D.A, Fargo D. & Adelman K. (2009) Using ChIP-chip and ChIP-seq to study the regulation of gene expression: genome-wide localization studies reveal widespread regulation of transcription elongation. METHODS; 48: 398-408. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/19275938?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=3) ]
  11. Ardehali M.B., Yao J., Adelman K., Fuda N., Petesch S., Webb W.W. & Lis J.T. (2009) Spt6 enhances the elongation rate of RNA polymerase II in vivo. EMBO J.; 28 (8):1067-77. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/19279664?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1) ]
  12. Gilchrist D.A., Nechaev S., Lee C., Gosh S.K.B, Collins J., Li L., Gilmour D.S. & Adelman K. (2008) NELF-mediated stalling of Pol II can enhance gene expression by blocking promoter-proximal nucleosome assembly. Genes Dev.; 22(14): 1921-33. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/18628398?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum) ]
  13. Nechaev S. & Adelman K. (2008) Promoter-proximal Pol II: when stalling speeds things up. Cell Cycle; 7(11): 1539-1544. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/18469524?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum) ]
  14. Muse G.W., Gilchrist D.A., Nechaev S., Shah R., Parker J.S., Grissom S.F., Zeitlinger J. & Adelman K. (2007) RNA polymerase is poised for activation across the genome. Nature Genetics 39(12):1507-1511. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17994021) ]
  15. Zeitlinger J., Stark A., Kellis M., Hong J-W., Nechaev S., Adelman K., Levine M. & Young R.A. (2007) RNA polymerase stalling at developmental control genes in the drosophila melanogaster embryo. Nature Genetics; 39(12):1512-1516. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17994019) ]
  16. Adelman K., Wenxiang W., Ardehali M.B., Werner J., Zhu B., Reinberg D. & Lis J.T. (2006) The Drosophila Paf1 complex modulates chromatin structure at actively transcribed genes. (*These authors contributed equally to this work.) Mol. Cell. Biol.; 26: 250-60. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16354696) ]
  17. Adelman K., Marr M.T., Werner J., Saunders A., Ni Z., Andrulis E.D. & Lis J.T. (2005) Efficient release from promoter-proximal stall sites requires transcript cleavage factor TFIIS. Mol. Cell; 17: 103-12. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15629721&query_hl=4) ]


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Last Reviewed: March 17, 2011