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Selected Publications

Stem Cell Biology Group

  1. Zheng X, Dumitru R, Lackford B, Freudenberg JM, Singh AP, Archer TK, Jothi R, Hu G. Cnot1, Cnot2, and Cnot3 maintain mouse and human ES cell identity and inhibit extraembryonic differentiation. Stem Cells. Accepted. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/22367759) ]
  2. Zheng X, Hu G. Oct4GiP reporter assay to study genes that regulate mouse embryonic stem cell maintenance and self-renewal. J Vis Exp. Accepted.
  3. Hu G*, Luo J*. A primer on using pooled shRNA libraries for functional genomic screens. Acta Biochimica et Biophysica Sinica. 2012 Feb;44(2):103-12. *: Co-corresponding authors. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/22271906) ]
  4. Freudenberg JM, Ghosh S, Lackford B, Yellaboina S, Zheng X, Li R, Cuddapah S, Wade P, Hu G*, Jothi R*. Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity. Nucleic Acids Res. 2011 Dec 30; Epub ahead of print. *: Co-corresponding authors. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/22210859) ]
  5. Sun T, Aceto N, Meerbrey KL, Kessler JD, Zhou C, Migliaccio I, Nguyen DX, Pavlova NN, Botero M, Huang J, Bernardi RJ, Schmitt E, Hu G, Li MZ, Dephoure N, Gygi SP, Rao M, Creighton CJ, Hilsenbeck SG, Shaw CA, Muzny D, Gibbs RA, Wheeler DA, Osborne CK, Schiff R, Bentires-Alj M, Elledge SJ, Westbrook TF. Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase. Cell. 2011 Mar 4;144(5):703-18. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/21376233) ]
  6. Meerbrey KL, Hu G, Kessler JD, Roarty K, Li M, Fang JE, Herschkowitz JI, Burrows AE, Ciccia A, Sun T, Schmitt EM, Bernardi RJ, Fu X, Bland CS, Cooper TA, Rosen JM, Westbrook TF, Elledge SJ. The pInducer Lentiviral Toolkit for Inducible RNA Interference in Vitro and in Vivo. Proceedings of the National Academy of Sciences of the United States of America. 2011 108(9):3665-3670. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=21307310) ]
  7. Hu G, Kim J, Xu Q, Leng Y, Orkin SH, Elledge SJ. A Genome-wide RNAi screen identifies a new transcriptional module required for self renewal. Genes Dev. 2009 Apr 1;23(7):837-48. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/19339689?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=15) ]
  8. Ali N, Karlsson C, Aspling N, Hu G, Hacohen N, Scadden DT, Larsson J. Forward RNAi screens in primary human hematopoietic stem/progenitor cells. Blood. 2009 Apr 16;113(16):3690-5. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/19188664?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=4) ]
  9. Westbrook TF, Hu G, Ang XL, Mulligan P, Pavlova NN, Liang A, Leng Y, Maehr R, Shi Y, Harper JW, Elledge SJ. SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation. Nature. 2008 Mar 20;452(7185):370-4. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/18354483?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=7) ]
  10. Schlabach MR*, Luo J*, Solimini NL*, Hu G*, Xu Q, Li M, Zhao Z, Smogorzewska A, Sowa ME, Ang XL, Westbrook TF, Liang AC, Chang K, Hackett JA, Harper JW, Hannon GJ, Elledge SJ. Cancer proliferation gene discovery through functional genomics. Science. 2008 Feb 1;319(5863):620-4. *Authors contributed equally to this work. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/18239126?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=4) ]
  11. Silva JM, Li MZ, Chang K, Ge W, Golding MC, Rickles RJ, Siolas D, Hu G, Paddison PJ, Schlabach MR, Sheth N, Bradshaw J, Burchard J, Kulkarni A, Cavet G, Sachidanandam R, McCombie WR, Cleary MA, Elledge SJ, Hannon GJ. Second-generation shRNA libraries covering the mouse and human genomes. Nat Genet. 2005 Nov;37(11):1281-8. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/16200065?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=5) ]
  12. Stegmeier F, Hu G, Rickles RJ, Hannon GJ, Elledge SJ. A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proc Natl Acad Sci. 2005 Sep 13;102(37):13212-7.   [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/16141338?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=9) ]

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