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Selected Publications

Stem Cell Biology Group

  1. Cinghu S*, Yellaboina S*, Freudenberg JM, Ghosh S, Zheng X, Oldfield AJ, Lackford BL, Zaykin DV, Hu G, Jothi R . (2014) Integrative framework for identification of key cell identity genes uncovers determinants of ES cell identity and homeostasis. Proc Natl Acad Sci 111(16):E1581-E1590. (*Co-first authors)[Abstract ]
  2. Wang L, Du Y, Ward JM, Shimbo T, Lackford B, Zheng X, Miao YL, Zhou B, Han L, Fargo DC, Jothi R, Williams C, Wade P, Hu G. INO80-Dependent Promoter Access Facilitates Pluripotency Gene Activation by Master Transcription Factors. Cell Stem Cell. 2014 May 1;14(5):575-91.[Abstract ]
  3. Lackford B, Yao C, Charles GM, Weng L, Zheng X, Choi E, Xie X, Wan J, Xing Y, Freudenberg JM, Jothi R, Hu G*, Shi Y*. Fip1 regulates mRNA alternative polyadenylation to promote embryonic stem cell self-renewal and somatic cell reprogramming. EMBO J. 2014 Apr 16;33(8):878-89. *: Co-corresponding authors.[Abstract ]
  4. Wang L, Miao Y, Zheng X, Lackford B, Zhou B, Han L, Yao C, Ward J, Burkholder A, Lipchina I, Fargo DC,  Hochedlinger K, Shi Y, Williams CJ, Hu G. The THO Complex Regulates Pluripotency Gene mRNA Export and Controls Embryonic Stem Cell Self-renewal and Somatic Cell Reprogramming. Cell Stem Cell 13(6):676-690.[Abstract ]
  5. Tajonar A, Maehr R, Hu G, Sneddon JB, Rivera-Feliciano J, Cohen DE, Elledge SJ, Melton DA. VGLL4 Is a Novel Regulator of Survival in Human Embryonic Stem Cells. Stem Cells. 2013 Jun 14.[Abstract ]
  6. Plank M, Hu G, Silva AS, Wood SH, Hesketh EE, Janssens G, Macedo A, de Magalhães JP, Church GM. An Analysis and Validation Pipeline for Large-Scale RNAi-Based Screens. Sci Rep. 2013;3:1076.[Abstract ]
  7. Yang H, Qu F, Myers RE, Bao G, Hyslop T, Hu G, Fei F, Xing J. Genetic variations in stem cell-related genes and colorectal cancer prognosis. Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2012 43(4):584-593.[Abstract ]
  8. Zheng X, Hu G. Oct4GiP reporter assay to study genes that regulate mouse embryonic stem cell maintenance and self-renewal. Journal of visualized experiments: JoVE 2012 63():e3987-.[Abstract ]
  9. Hu G, Wade P. NuRD and Pluripotency: A Complex Balancing Act. Cell Stem Cell 2012 May 4;10(5):497-503.[Abstract ]
  10. Hu G, Luo J. A Primer on Using Pooled shRNA Libraries for Functional Genomic Screens. Acta Biochimica et Biophysica Sinica. 2012 Feb;44(2):103-12.[Abstract ]
  11. Zheng X, Dumitru R, Lackford B, Freudenberg JM, Singh AP, Archer TK, Jothi R, Hu G. Cnot1, Cnot2, and Cnot3 Maintain Mouse and Human ES Cell Identity and Inhibit Extraembryonic Differentiation. Stem Cells. 2012 May;30(5):910-22.[Abstract ]
  12. Aceto N, Sausgruber N, Brinkhaus H, Gaidatzis D, Martiny-Baron G, Mazzarol G, Confalonieri S, Quarto M, Hu G, Balwierz PJ, Pachkov M, Elledge SJ, van Nimwegen E, Stadler MB, Bentires-Alj M. Tyrosine Phosphatase SHP2 Promotes Breast Cancer Progression and Maintains Tumor-Initiating Cells via Activation of Key Transcription Factors and a Positive Feedback Signaling Loop. Nat Med. 2012 Mar 4;18(4):529-37.[Abstract ]
  13. Freudenberg JM, Ghosh S, Lackford B, Yellaboina S, Zheng X, Li R, Cuddapah S, Wade P, Hu G*, Jothi R*. Acute Depletion of Tet1-dependent 5-hydroxymethylcytosine Levels Impairs LIF/Stat3 Signaling and Results in Loss of Embryonic Stem Cell Identity. Nucleic Acids Res. 2012 Apr;40(8):3364-77. *: Co-corresponding authors.[Abstract ]
  14. Sun T, Aceto N, Meerbrey KL, Kessler JD, Zhou C, Migliaccio I, Nguyen DX, Pavlova NN, Botero M, Huang J, Bernardi RJ, Schmitt E, Hu G, Li MZ, Dephoure N, Gygi SP, Rao M, Creighton CJ, Hilsenbeck SG, Shaw CA, Muzny D, Gibbs RA, Wheeler DA, Osborne CK, Schiff R, Bentires-Alj M, Elledge SJ, Westbrook TF. Activation of Multiple Proto-Oncogenic Tyrosine Kinases in Breast Cancer via Loss of the PTPN12 Phosphatase. Cell. 2011 Mar 4;144(5):703-18.[Abstract ]
  15. Meerbrey KL#, Hu G#*, Kessler JD, Roarty K, Li M, Fang JE, Herschkowitz JI, Burrows AE, Ciccia A, Sun T, Schmitt EM, Bernardi RJ, Bland CS, Cooper TA, Rosen JM, Westbrook TF*, Elledge SJ*. The pInducer Toolkit for Inducible RNA Interference in Vitro and in Vivo. Proc Natl Acad Sci. 2011 Mar 1;108(9):3665-70. #: Equal contribution. *: Co-corresponding authors.[Abstract ]
  16. Hu G, Kim J, Xu Q, Leng Y, Orkin SH, Elledge SJ. A Genome-Wide RNAi Screen Identifies a New Transcriptional Module Required for Self-Renewal. Genes Dev. 2009 Apr 1;23(7):837-48[Abstract ]
  17. Ali N, Karlsson C, Aspling N, Hu G, Hacohen N, Scadden DT, Larsson J. Forward RNAi Screens in Primary Human Hematopoietic Stem/Progenitor Cells. Blood. 2009 Apr 16;113(16):3690-5.[Abstract ]
  18. Westbrook TF, Hu G, Ang XL, Mulligan P, Pavlova NN, Liang A, Leng Y, Maehr R, Shi Y, Harper JW, Elledge SJ. SCFbeta-TRCP Controls Oncogenic Transformation and Neural Differentiation through REST Degradation. Nature. 2008 Mar 20;452(7185):370-4.[Abstract ]
  19. Schlabach MR#, Luo J#, Solimini NL#, Hu G#, Xu Q, Li M, Zhao Zh, Smogorzewska A,  Sowa ME, Ang XL, Westbrook TF, Liang A, Chang K, Hackett JA, Harper JW, Hannon GJ, Elledge SJ. Cancer Proliferation Gene Discovery Through Functional Genomics. Science. 2008 Feb 1;319(5863):620-4. #: Equal contribution.[Abstract ]
  20. Silva JM, Li MZ, Chang K, Ge W, Golding MC, Rickles RJ, Siolas D, Hu G, Paddison PJ, Schlabach MR, Sheth N, Bradshaw J, Burchard J, Kulkarni A, Cavet G, Sachidanandam R, McCombie WR, Cleary MA, Elledge SJ, Hannon GJ. Second-Generation shRNA Libraries Covering the Mouse and Human Genomes. Nat Genet. 2005 Nov;37(11):1281-8.[Abstract ]
  21. Stegmeier F, Hu G, Rickles RJ, Hannon GJ, Elledge SJ. A Lentiviral MicroRNA-Based System for Single-Copy Polymerase II-Regulated RNA Interference in Mammalian Cells. Proc Natl Acad Sci. 2005 Sep 13;102(37):13212-7.[Abstract ]

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