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A Message from the Lab ChiefI hope that you will find the site both informative and interesting, with overviews of LMC scientific endeavors. As with all laboratories or departments within the Division of Intramural Research (DIR), LMC is committed to the mission of the NIEHS and its goal to improve human health. Our focus is on cancer and the research ranges from the very basic or fundamental, such as the role of chromatin and epigenetics, to investigating molecular therapeutics and translational and clinical studies of gene-environment interactions in cancer. The scientists within LMC use a broad range of approaches and techniques to understand the molecular mechanisms that underlie the carcinogenic process. As you navigate this Web site you will have an opportunity to read some of this original research as well as gain an appreciation of additional activities such as the LMC Seminar Series, LMC Calendar of Events and links to other NIEHS and NIH Web sites. Trevor K Archer, Ph.D.
Special RecognitionsThe LMC congratulates Mark Rubino, a biologist in the Chromatin and Gene Expression group, for his remarkable display of court prowess in the NIEHS 2009 Basketball Shootout. Mark dominated the men's field by scoring 18 out of 21 possible points in the preliminaries and duplicating the feat in the finals, missing only two shots out of 20 for the day. His two round total of 36 was a record high in the 16 years of this event. Way to go, Mark! Calendar of EventsFor more on the LMC Journal Club and Seminar Series, see below. Journal ClubsMissionThe LMC journal club has been established to foster scientific discussion on the most recent science publications of interest to the laboratory. All members are invited to pick, present and lead a discussion on a recent journal article. Notes to ParticipantsThe 2009-2010 journal club meeting dates and locations are listed below. All meetings will be held at 12:00 noon unless notified otherwise. Anyone in the LMC is welcome to present, including fellows, biologists and principle investigators. Anyone interested in leading a discussion should contact Gil Dos Santos at (919) 541-1191 or by email at dossantosg@niehs.nih.gov. (dossantosg@niehs.nih.gov). Some GuidelinesWe ask that a PDF file of the article to be discussed be emailed to the organizer for distribution at least 7 days prior to leading the meeting. We also ask if a speaker must cancel their discussion that reasonable notice be given so that the organizer can locate a substitute or rearrange the schedule.
Please be aware the schedule is subject to change. Scheduled dates as well as speaker will be updated on the Web site so stay tuned for journal club news. Retreats2009 LMC RetreatSeptember 9 - 11, 2009 2007 LMC RetreatSeptember 24-26 2006 LMC RetreatSeptember 18-20 Laboratory of Molecular Carcinogenesis
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| Date | Speaker and LMC Host |
|---|---|
| September 1 (Tuesday) Rm. D450 11:00 A.M. |
Prof. Dr. Patrick Cramer Director, Gene Center Munich Dean, Faculty of Chemistry and Pharmacy University of Munich – LMU “Molecular and genomics views of gene transcription” Host: Dr. Karen Adelman |
| September 10 | LMC Retreat September 9-11 |
| September 17 | Trevor Archer, Ph.D. Chief, Laboratory of Molecular Carcinogenesis “Chromatin and transcription” Host: Dr. Thomas Eling |
| September 24 | Traci Hall, Ph.D. Senior Investigator, Laboratory of Structural Biology “Understanding and designing gene Regulation by PUF Proteins” Host: Dr. Thomas Eling |
| October 1 | Thomas Kunkel, Ph.D. Chief, Laboratory of Structural Biology “Determinants of Leading and Lagging Strand DNA Replication Fidelity” Host: Dr. Karen Adelman |
| October 8 | Paul Wade Ph.D. Senior Investigator “Poking around in the epigenome” Host: Dr. Trevor Archer |
| October 15 | James C. Bonner, Ph.D Associate Professor Environmental and Molecular Toxicology, North Carolina State University "Environmental exposure to engineered nanomaterials as a potential cause of lung inflammation, fibrosis, and cancer” Host: Dr. Robert Langenbach |
| October 22 | Robert C. Smart, Ph.D. Professor, Director of Graduate Programs, Coordinator of Molecular and Cellular Toxicology, NCSU “Compensatory issues and functional roles of C/EBPa and C/EBPb is epithelial homeostasis and tumorigenesis” Host: Dr. Thomas Eling & Dr. Minsub Shim |
| October 29 | L. Ryan Baugh, Ph.D. Assistant Professor, Dept. of Biology, Duke University “Nutritional control of C. elegans post-embryonic development” Host: Dr. Karen Adelman |
| November 5 | Science Day - No Seminar |
| November 12 | Holiday |
| November 19 | Albert S. Baldwin, Ph.D. Professor, Cancer Cell Biology, UNC Lineberger Comprehensive Cancer Center "The Complex Roles of IKK and NF-kappaB in Oncogenesis" Host: Dr. Thomas Eling |
| November 26 | Holiday |
| December 3 | Charles Loftin, Ph.D. Associate Professor, University of Kentucky "COX-2 Dependent Inflammation in Cardiovascular and Adipose Tissue" Host: Dr. Robert Langenbach |
| December 10 | Eva Surmacz, Ph.D. Assoc. Professor of Biology, Director, Obesity and Cancer Program, Sbarro Institute for Cancer Research and Molecular Medicine, Temple University "Leptin and cancer" Host: Dr. Thomas Eling |
| December 17 | John Cidlowski, Ph.D. Chief, Laboratory of Signal Transduction "The Complex Lives of the Glucocorticoid Receptors in Health and Disease" Host: Dr. Thomas Eling |
| December 24 | Holiday |
| December 31 | Holiday |