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Selected Publications

Eicosanoid Biochemistry Group

  1. Li R, Grimm SA, Chrysovergis K, Kosak J, Wang X, Du Y, Burkholder A, Janardhan K, May D, Shah R, Eling TE, Wade PA. Obesity, rather than diet, drives epigenomic alterations in colonic epithelium resembling cancer progression. Cell metabolism 2014 19(4):702-711.[Abstract ]
  2. Wang X, Baek SJ, Eling TE. The diverse roles of nonsteroidal anti-inflammatory drug activated gene (NAG-1/GDF15) in cancer. Biochem Pharmacol. pii: S0006-2952(12)00766-6, 2012.[Abstract ]
  3. Wang X, Chrysovergis K, Bienstock RJ, Shim M, Eling TE. The H6D variant of NAG-1/GDF15 inhibits prostate xenograft growth in vivo. Prostate. 72(6):677-89, 2012.[Abstract ]
  4. Kadowaki M, Yoshioka H, Kamitani H, Watanabe T, Wade PA, Eling TE. DNA methylation-mediated silencing of nonsteroidal anti-inflammatory drug-activated gene (NAG-1/GDF15) in glioma cell lines. Int J Cancer. 130(2):267-77, 2012.[Abstract ]
  5. Wang X, Kingsley PJ, Marnett LJ, Eling TE. The role of NAG-1/GDF15 in the inhibition of intestinal polyps in APC/Min mice by sulindac. Cancer prevention research (Philadelphia, Pa.) 2011 4(1):150-60.[Abstract ]
  6. Matsuoka, T., Adair, J.E., Lih, F.B., Hsi, L.C., Rubino, M., Eling, T.E., Tomer, K.B., Yashiro, M., Hirakawa, K., Olden, K., Roberts, J.D. Elevated dietary linoleic acid increases gastric carcinoma cell invasion and metastasis in mice. British journal of cancer. 103(8):1182-1191, 2010.[Abstract ]
  7. Kang, H.S., ZeRuth, G., Lichti-Kaiser, K., Vasanth, S., Yin, Z., Kim, Y.S., and Jetten, A.M.: GLI-similar (GLIS) Krüppel-like zinc finger proteins: insights into their physiological functions and critical roles in neonatal diabetes and cystic renal disease. Histology and histopathology. 25(11):1481-1496, 2010.[Abstract ]
  8. Shim, M., Foley, J., Anna, C., Mishina, Y., and Eling, T.: Embryonic expression of cyclooxygenase-2 causes malformations in axial skeleton. J. Biol. Chem. 285: 16206-16217, 2010.[Abstract ]
  9. Ashwell, M.S., Ceddia, R.P., House, R.L., Cassady, J.P., Eisen, E.J., Eling, T.E., Collins, J.B., Grissom, S.F., and Odle, J.: Trans-10, cis-12-conjugated linoleic acid alters hepatic gene expression in a polygenic obese line of mice displaying hepatic lipidosis. J. Nutr. Biochem. 21: 848-855, 2010.[Abstract ]
  10. Kambe, A., Yoshioka, H., Kamitani, H., Watanabe, T., Baek, S.J., and Eling, T.E.: The cyclooxygenase inhibitor sulindac sulfide inhibits EP4 expression and suppresses the growth of glioblastoma cells. Cancer Prev. Res. 2: 1088-1099, 2009.[Abstract ]
  11. Cekanova, M., Lee, S.H., Donnell, R.L., Sukhthankar, M., Eling, T.E., Fischer, S.M., and Baek, S.J.: Nonsteroidal anti-inflammatory drug-activated gene-1 expression inhibits urethane-induced pulmonary tumorigenesis in transgenic mice. Cancer Prev. Res. 2: 450-458, 2009.[Abstract ]
  12. Iguchi, G., Chrysovergis, K., Kambe, A., Langenbach, A., Baek, S.J., and. Eling, T.E.: A reciprocal relationship exists between nonsteroidal anti-inflammatory drug-activated gene-1 (NAG-1) and cyclooxygenase-2. Cancer Lett. 282: 152-158, 2009.[Abstract ]
  13. Kang, H.J., Kim, H.J., Kwon, S.H., Kang, H., Eling, T.E., Lee, S.H., and Bae, I. BRCA1 modulates senstivity to 5F-203 by regulating xenobiotic stree-inducible protein levels and EROD activity. Cancer chemotherapy and pharmacology. 62(4):689-697, 2008.[Abstract ]
  14. Taniura, S., Kamitani, H., Watanabe, T., and Eling, T.E.: Induction of cyclooxygenase-2 expression by interleukin-1beta in human glioma cell line, U87MG. Neurol. Med. Chir. (Tokyo). 48: 500-505, 2008[Abstract ]
  15. Yoshioka, H., Kamitani, H., Watanabe, T., and Eling, T.E.: Nonsteroidal anti-inflammatory drug-activated gene (NAG-1/GDF15) expression is increased by the histone deacetylase inhibitor trichostatin A. J. Biol. Chem. 283: 33129-33137, 2008.[Abstract ]
  16. Zhu, H., Glasgow, W., George, M.D., Olden, K., Chrysovergis, K., Roberts, J., and Eling, T.E.: 15-Lipoxygenase-1 activates the tumor suppressor p53 independent of enzymatic activity in human colorectal cancer cells. Int. J. Cancer. 123: 2741-2749, 2008.[Abstract ]
  17. Sukhthankar, M., Yamaguchi, K., Lee, S., McEntee, M.F., Eling, T.E., Hara, Y., and Baek, S.J.: A green tea component suppresses posttranslational expression of basic fibroblast growth factor in colorectal cancer. Gastroenterology. 134: 1972-1980, 2008.[Abstract ]
  18. Kambe, A., Iguchi, G., Moon, Y. Kamitani, H., Watanabe, T., and Eling, T.: Suppression of the prostaglandin EP4 receptor expression by troglitazone requires phosphorylated Sp-1. Biochim. Biophys. Acta. 1783: 1211-1219, 2008.[Abstract ]
  19. Shim, M., Kim, J., and Eling, T.E.: Vitamin E succinate induces NAG-1 expression in prostate cancer cells via p-38 dependent increase in mRNA stability. Mol. Cancer. Ther. 7: 961-971, 2008.[Abstract ]
  20. Moon, Y., Kim, J.I., Yang, H., and Eling, T.E.: Growth compensatory role of sulindac sulfide-induced thrombospondin-1 linked with ERK1/2 and RhoA GTPase signaling pathways. Life Sci. 82: 591-599, 2008.[Abstract ]
  21. Tanno, T., Bhanu, N.V., Oneal, P.A., Goh, S.H., Staker, P., Lee, Y.T., Moroney, J.W., Reed, C.H., Luban, N.L., Wang, R.H., Eling, T.E., Childs, R., Ganz, T., Leitman, S.F., Fucharoen, S., and Miller, J.L.: High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nature medicine. 13(9):1096-1101, 2007.[Abstract ]
  22. Kang, H.J., Kim, H.J., Kwon, S.H., Kang, B.D., Eling, T.E., Lee, S.H., and Bae, I.: BRCA1 modulates sensitivity to 5F-203 by regulating xenobiotic stress-inducible protein levels and EROD activity. Cancer Chemother. Pharm. 2007.[Abstract ]
  23. Tanno, T., Bhanu, N.V., Oneal, P.A., Goh, S., Staker, P., Lee, Y.T., Moroney, J.W., Reed, C.H., Luban N. L., Wang, R., Eling, T.E., Childs, R., Ganz, T., Leitman, S.F., Fucharoen, S., and Miller, J.L.: High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat. Med. 13: 1096-1101, 2007.[Abstract ]
  24. Lee, C.R., Bottone, F.G. Jr., Krahn, J.M., Li, L., Mohrenweiser, H.W., Cook, M.E., Petrovich, R.M., Bell, D.A., Eling, T.E., and Zeldin, D.C.: Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1). Pharmacogenetics and Genomics. 17: 145-160, 2007.[Abstract ]
  25. Eling, T.E., Baek, S.J., Shim, M., and Lee, C.: NSAID activated gene (NAG-1), a modulator for tumorigenesis. J. Biochem. Mol. Biol. 39: 649-655, 2006.[Abstract ]
  26. Baek, S.J., Okazaki, R., Lee, S., Martinez, J., Kim, J., Yamaguchi, K., Mishina Y., Martin, D.W., Shoieb, A., McEntee, M.F., and Eling, T.E.: Nonsteroidal anti-inflammatory drug activated gene-1 overexpression in transgenic mice suppresses intestinal neoplasia. Gastroenterology. 131: 1553-1560, 2006.[Abstract ]
  27. Lambert, J.R., Kelly, J.A., Shim, M., Huffer, W.E., Nordeen, S.K., Baek, S.J., Eling, T.E., and Lucia, M.S.: Prostate derived factor in human prostate cancer cells: gene induction by vitamin D via a p53-dependent mechanism and inhibition of prostate cancer cell growth. J. Cell Physiol. 208: 566-574, 2006.[Abstract ]
  28. Yamaguchi, K., Lee, S., Eling, T.E., and Baek, S.J.: A novel peroxisome proliferator-activated receptor gamma ligand, MCC-555, induces apoptosis via posttranscriptional regulation of NAG-1 in colorectal cancer cells. Mol. Cancer Ther. 5: 1352-1361, 2006.[Abstract ]
  29. Martinez, J.M., Sali, T., Okazaki, R., Anna, C., Hollingshead, M., Hose, C., Monks, A., Walker, N.J., Baek, S.J., and Eling, T.E.: Drug-induced expression of nonsteroidal anti-inflammatory drug-activated gene/macrophage inhibitory cytokine-1/prostate-derived factor, a putative tumor suppressor, inhibits tumor growth. J. Pharm. Exp. Ther. 318: 899-906, 2006.[Abstract ]
  30. Okazaki, R., Moon, Y., Norimura, T., and Eling, T.: Ionizing radiation enhances the expression of the nonsteroidal anti-inflammatory drug-activated gene (NAG1) by increasing the expression of TP53 in human colon cancer cells. Radiation Res. 165: 125-130, 2006.[Abstract ]
  31. Baek, S.J. and Eling, T.E.: Changes in gene expression contribute to cancer prevention by COX inhibitors. Prog. Lipid Res. 45: 1-16, 2006.[Abstract ]
  32. Lee, S., Yamaguchi, K., Kim, J., Eling, T.E., Safe, S., Park, Y., and Baek, S.J.: Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific manner. Carcinogenesis. 27: 972-981, 2006.[Abstract ]
  33. Moon, Y., Bottone, F.G. Jr., McEntee, M.F., and Eling, T.E.: Suppression of tumor cell invasion by cyclooxygenase inhibitors is mediated by thrombospondin-1 via the early growth response gene Egr-1. Mol. Cancer Ther. 4: 1551-1558, 2005.[Abstract ]
  34. Malathi, K., Paranjape, J., Bulanova, E., Shim, M., Guenther-Johnson, J.M., Faber, P.W., Eling, T.E., Williams, B.R., and Silverman, R.H.: A transcriptional signaling pathway in IFN system mediated by 2’-5’-oligoadenylate activation of RNase L. Proc. Nat. Acad. Sci. USA. 102: 14533-14538, 2005.[Abstract ]
  35. Kim, J., Baek, S.J., Bottone, F.G. Jr., Sali, T., and Eling T.E.: Overexpression of 15-lipoxygenase-1 induces growth arrest through phosphorylation of p53 in human colorectal cancer cells. Mol. Cancer Res. 3: 511-517, 2005.[Abstract ]
  36. Moon, Y., Glasgow, W.C., and Eling, T.E.: Curcumin suppresses interleukin 1β-mediated microsomal prostaglandin E synthase 1 by altering early growth response gene 1 and other signaling pathways. J. Pharm. Exp. Ther. 315: 788-795, 2005.[Abstract ]
  37. Bottone, F.G. Jr., Moon, Y., Alston-Mills, B., and Eling, T.E.: Transcriptional regulation of activating transcription factor 3 involves the early growth response-1 gene. J. Pharm. Exp. Ther. 315: 668-677, 2005.[Abstract ]
  38. Bottone, F.G. Jr., Moon, Y., Kim, J.S., Alston-Mills, B., Ishibashi, M., and Eling, T.E.: The anti-invasive activity of cyclooxygenase inhibitors are regulated by the transcription factor ATF3 (activating transcription factor 3). Mol. Cancer Ther. 4: 693-703, 2005.[Abstract ]
  39. House, R.L., Cassady, J.P., Eisen, E.J., Eling, T.E., Collins, J.B., Grissom, S.F., and Odle, J.: Functional genomic characterization of delipidation elicited by trans-10, cis-12-conjugated linoleic acid (t10c12-CLA) in a polygenic obese line of mice. Physiol. Genomics. 21: 351-361, 2005.[Abstract ]

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