Skip Navigation

Your Environment. Your Health.

Selected Publications

Eicosanoid Biochemistry Group

  1. Wang X, Baek SJ, Eling TE. The diverse roles of nonsteroidal anti-inflammatory drug activated gene (NAG-1/GDF15) in cancer. Biochem Pharmacol. pii: S0006-2952(12)00766-6, 2012. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/23220538) ]
  2. Wang X, Chrysovergis K, Bienstock RJ, Shim M, Eling TE. The H6D variant of NAG-1/GDF15 inhibits prostate xenograft growth in vivo. Prostate. 72(6):677-89, 2012. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/21809352) ]
  3. Kadowaki M, Yoshioka H, Kamitani H, Watanabe T, Wade PA, Eling TE. DNA methylation-mediated silencing of nonsteroidal anti-inflammatory drug-activated gene (NAG-1/GDF15) in glioma cell lines. Int J Cancer. 130(2):267-77, 2012. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/21437897) ]
  4. Wang X, Kingsley PJ, Marnett LJ, Eling TE. The role of NAG-1/GDF15 in the inhibition of intestinal polyps in APC/Min mice by sulindac. Cancer prevention research (Philadelphia, Pa.) 2011 4(1):150-60. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=21205743) ]
  5. Matsuoka, T., Adair, J.E., Lih, F.B., Hsi, L.C., Rubino, M., Eling, T.E., Tomer, K.B., Yashiro, M., Hirakawa, K., Olden, K., Roberts, J.D. Elevated dietary linoleic acid increases gastric carcinoma cell invasion and metastasis in mice. British journal of cancer. 103(8):1182-1191, 2010. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=20842125) ]
  6. Kang, H.S., ZeRuth, G., Lichti-Kaiser, K., Vasanth, S., Yin, Z., Kim, Y.S., and Jetten, A.M.: GLI-similar (GLIS) Krüppel-like zinc finger proteins: insights into their physiological functions and critical roles in neonatal diabetes and cystic renal disease. Histology and histopathology. 25(11):1481-1496, 2010. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=20865670) ]
  7. Shim, M., Foley, J., Anna, C., Mishina, Y., and Eling, T.: Embryonic expression of cyclooxygenase-2 causes malformations in axial skeleton. J. Biol. Chem. 285: 16206-16217, 2010. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/20236942) ]
  8. Ashwell, M.S., Ceddia, R.P., House, R.L., Cassady, J.P., Eisen, E.J., Eling, T.E., Collins, J.B., Grissom, S.F., and Odle, J.: Trans-10, cis-12-conjugated linoleic acid alters hepatic gene expression in a polygenic obese line of mice displaying hepatic lipidosis. J. Nutr. Biochem. 21: 848-855, 2010. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/19800780) ]
  9. Kambe, A., Yoshioka, H., Kamitani, H., Watanabe, T., Baek, S.J., and Eling, T.E.: The cyclooxygenase inhibitor sulindac sulfide inhibits EP4 expression and suppresses the growth of glioblastoma cells. Cancer Prev. Res. 2: 1088-1099, 2009. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/19934343) ]
  10. Cekanova, M., Lee, S.H., Donnell, R.L., Sukhthankar, M., Eling, T.E., Fischer, S.M., and Baek, S.J.: Nonsteroidal anti-inflammatory drug-activated gene-1 expression inhibits urethane-induced pulmonary tumorigenesis in transgenic mice. Cancer Prev. Res. 2: 450-458, 2009. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/19401523) ]
  11. Iguchi, G., Chrysovergis, K., Kambe, A., Langenbach, A., Baek, S.J., and. Eling, T.E.: A reciprocal relationship exists between nonsteroidal anti-inflammatory drug-activated gene-1 (NAG-1) and cyclooxygenase-2. Cancer Lett. 282: 152-158, 2009. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/19375854) ]
  12. Kang, H.J., Kim, H.J., Kwon, S.H., Kang, H., Eling, T.E., Lee, S.H., and Bae, I. BRCA1 modulates senstivity to 5F-203 by regulating xenobiotic stree-inducible protein levels and EROD activity. Cancer chemotherapy and pharmacology. 62(4):689-697, 2008. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18074135) ]
  13. Taniura, S., Kamitani, H., Watanabe, T., and Eling, T.E.: Induction of cyclooxygenase-2 expression by interleukin-1beta in human glioma cell line, U87MG. Neurol. Med. Chir. (Tokyo). 48: 500-505, 2008 [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/19029777?dopt=Abstract) ]
  14. Yoshioka, H., Kamitani, H., Watanabe, T., and Eling, T.E.: Nonsteroidal anti-inflammatory drug-activated gene (NAG-1/GDF15) expression is increased by the histone deacetylase inhibitor trichostatin A. J. Biol. Chem. 283: 33129-33137, 2008. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/18801729?dopt=Abstract) ]
  15. Zhu, H., Glasgow, W., George, M.D., Olden, K., Chrysovergis, K., Roberts, J., and Eling, T.E.: 15-Lipoxygenase-1 activates the tumor suppressor p53 independent of enzymatic activity in human colorectal cancer cells. Int. J. Cancer. 123: 2741-2749, 2008. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/18785202) ]
  16. Sukhthankar, M., Yamaguchi, K., Lee, S., McEntee, M.F., Eling, T.E., Hara, Y., and Baek, S.J.: A green tea component suppresses posttranslational expression of basic fibroblast growth factor in colorectal cancer. Gastroenterology. 134: 1972-1980, 2008. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/18549879) ]
  17. Kambe, A., Iguchi, G., Moon, Y. Kamitani, H., Watanabe, T., and Eling, T.: Suppression of the prostaglandin EP4 receptor expression by troglitazone requires phosphorylated Sp-1. Biochim. Biophys. Acta. 1783: 1211-1219, 2008. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/18346464?dopt=Abstract) ]
  18. Shim, M., Kim, J., and Eling, T.E.: Vitamin E succinate induces NAG-1 expression in prostate cancer cells via p-38 dependent increase in mRNA stability. Mol. Cancer. Ther. 7: 961-971, 2008. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/18413810?dopt=Abstract) ]
  19. Moon, Y., Kim, J.I., Yang, H., and Eling, T.E.: Growth compensatory role of sulindac sulfide-induced thrombospondin-1 linked with ERK1/2 and RhoA GTPase signaling pathways. Life Sci. 82: 591-599, 2008. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/18261746?dopt=Abstract) ]
  20. Tanno, T., Bhanu, N.V., Oneal, P.A., Goh, S.H., Staker, P., Lee, Y.T., Moroney, J.W., Reed, C.H., Luban, N.L., Wang, R.H., Eling, T.E., Childs, R., Ganz, T., Leitman, S.F., Fucharoen, S., and Miller, J.L.: High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nature medicine. 13(9):1096-1101, 2007. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17721544) ]
  21. Kang, H.J., Kim, H.J., Kwon, S.H., Kang, B.D., Eling, T.E., Lee, S.H., and Bae, I.: BRCA1 modulates sensitivity to 5F-203 by regulating xenobiotic stress-inducible protein levels and EROD activity. Cancer Chemother. Pharm. 2007. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/18074135) ]
  22. Tanno, T., Bhanu, N.V., Oneal, P.A., Goh, S., Staker, P., Lee, Y.T., Moroney, J.W., Reed, C.H., Luban N. L., Wang, R., Eling, T.E., Childs, R., Ganz, T., Leitman, S.F., Fucharoen, S., and Miller, J.L.: High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat. Med. 13: 1096-1101, 2007. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/17721544) ]
  23. Lee, C.R., Bottone, F.G. Jr., Krahn, J.M., Li, L., Mohrenweiser, H.W., Cook, M.E., Petrovich, R.M., Bell, D.A., Eling, T.E., and Zeldin, D.C.: Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1). Pharmacogenetics and Genomics. 17: 145-160, 2007. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/17301694?dopt=Abstract) ]
  24. Eling, T.E., Baek, S.J., Shim, M., and Lee, C.: NSAID activated gene (NAG-1), a modulator for tumorigenesis. J. Biochem. Mol. Biol. 39: 649-655, 2006. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/17129398?dopt=Abstract) ]
  25. Baek, S.J., Okazaki, R., Lee, S., Martinez, J., Kim, J., Yamaguchi, K., Mishina Y., Martin, D.W., Shoieb, A., McEntee, M.F., and Eling, T.E.: Nonsteroidal anti-inflammatory drug activated gene-1 overexpression in transgenic mice suppresses intestinal neoplasia. Gastroenterology. 131: 1553-1560, 2006. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/17101328?dopt=Abstract) ]
  26. Lambert, J.R., Kelly, J.A., Shim, M., Huffer, W.E., Nordeen, S.K., Baek, S.J., Eling, T.E., and Lucia, M.S.: Prostate derived factor in human prostate cancer cells: gene induction by vitamin D via a p53-dependent mechanism and inhibition of prostate cancer cell growth. J. Cell Physiol. 208: 566-574, 2006. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/16741990?dopt=Abstract) ]
  27. Yamaguchi, K., Lee, S., Eling, T.E., and Baek, S.J.: A novel peroxisome proliferator-activated receptor gamma ligand, MCC-555, induces apoptosis via posttranscriptional regulation of NAG-1 in colorectal cancer cells. Mol. Cancer Ther. 5: 1352-1361, 2006. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/16731769?dopt=Abstract) ]
  28. Martinez, J.M., Sali, T., Okazaki, R., Anna, C., Hollingshead, M., Hose, C., Monks, A., Walker, N.J., Baek, S.J., and Eling, T.E.: Drug-induced expression of nonsteroidal anti-inflammatory drug-activated gene/macrophage inhibitory cytokine-1/prostate-derived factor, a putative tumor suppressor, inhibits tumor growth. J. Pharm. Exp. Ther. 318: 899-906, 2006. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/16714403?dopt=Abstract) ]
  29. Okazaki, R., Moon, Y., Norimura, T., and Eling, T.: Ionizing radiation enhances the expression of the nonsteroidal anti-inflammatory drug-activated gene (NAG1) by increasing the expression of TP53 in human colon cancer cells. Radiation Res. 165: 125-130, 2006. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/16435911?dopt=Abstract) ]
  30. Baek, S.J. and Eling, T.E.: Changes in gene expression contribute to cancer prevention by COX inhibitors. Prog. Lipid Res. 45: 1-16, 2006. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/16337272?dopt=Abstract) ]
  31. Lee, S., Yamaguchi, K., Kim, J., Eling, T.E., Safe, S., Park, Y., and Baek, S.J.: Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific manner. Carcinogenesis. 27: 972-981, 2006. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/16286461?dopt=Abstract) ]
  32. Moon, Y., Bottone, F.G. Jr., McEntee, M.F., and Eling, T.E.: Suppression of tumor cell invasion by cyclooxygenase inhibitors is mediated by thrombospondin-1 via the early growth response gene Egr-1. Mol. Cancer Ther. 4: 1551-1558, 2005. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/16227405) ]
  33. Malathi, K., Paranjape, J., Bulanova, E., Shim, M., Guenther-Johnson, J.M., Faber, P.W., Eling, T.E., Williams, B.R., and Silverman, R.H.: A transcriptional signaling pathway in IFN system mediated by 2’-5’-oligoadenylate activation of RNase L. Proc. Nat. Acad. Sci. USA. 102: 14533-14538, 2005. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/16203993) ]
  34. Kim, J., Baek, S.J., Bottone, F.G. Jr., Sali, T., and Eling T.E.: Overexpression of 15-lipoxygenase-1 induces growth arrest through phosphorylation of p53 in human colorectal cancer cells. Mol. Cancer Res. 3: 511-517, 2005. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/16179498?dopt=Abstract) ]
  35. Moon, Y., Glasgow, W.C., and Eling, T.E.: Curcumin suppresses interleukin 1β-mediated microsomal prostaglandin E synthase 1 by altering early growth response gene 1 and other signaling pathways. J. Pharm. Exp. Ther. 315: 788-795, 2005. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/16081677) ]
  36. Bottone, F.G. Jr., Moon, Y., Alston-Mills, B., and Eling, T.E.: Transcriptional regulation of activating transcription factor 3 involves the early growth response-1 gene. J. Pharm. Exp. Ther. 315: 668-677, 2005. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/16079301?dopt=Abstract) ]
  37. Bottone, F.G. Jr., Moon, Y., Kim, J.S., Alston-Mills, B., Ishibashi, M., and Eling, T.E.: The anti-invasive activity of cyclooxygenase inhibitors are regulated by the transcription factor ATF3 (activating transcription factor 3). Mol. Cancer Ther. 4: 693-703, 2005. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15897233?dopt=Abstract) ]
  38. House, R.L., Cassady, J.P., Eisen, E.J., Eling, T.E., Collins, J.B., Grissom, S.F., and Odle, J.: Functional genomic characterization of delipidation elicited by trans-10, cis-12-conjugated linoleic acid (t10c12-CLA) in a polygenic obese line of mice. Physiol. Genomics. 21: 351-361, 2005. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15888570) ]

Back to Top