Baek, S.J., Wilson, L.C., Hsi, L.C., Eling, T.E. Troglitazone, a Peroxisome Proliferator-activated Receptor ? (PPAR?) Ligand, Selectively Induces the Early Growth Response-1 Gene Independently of PPAR?. J. Biol. Chem., 278: 5845-5853, 2003. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12475986)
Newman, D., Morito, S., Koo, J.S., Kim, K., Baek, S.J., Eling, T., and Jetten, A.M. Differential Regulation of Nonsteroidal Anti-Inflammatory Drug-Activated Gene in Normal Human Tracheobronchial Epithelial and Lung Carcinoma Cells by Retinoids. Mol. Pharmacol., 63: 557-564, 2003. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12606762)
Wilson, L.C., Baek, S.J., Call, A., Eling, T.E. Nonsteroidal Anti-Inflammatory Drug-Activated Gene (NAG-1) is Induced by Genistein Through the Expression of p53 in Colorectal Cancer Cells. Int. J. Cancer, 105: 747-753, 2003. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12767058)
Nixon, J.B., Kamitani, H., Baek, S.J., Eling, T.E. Evaluation of Eicosanoids and NSAIDs as PPAR? Ligands in Colorectal Carcinoma Cells. Prostaglandins Leukot Essent Fatty Acids, 68: 323-330, 2003. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12711249)
Amin, R., Kamitani, H., Sultana, H., Taniura, S., Islam, A., Sho, A., Ishibashi, M., Eling, T.E. and Watanabe, T. Aspirin and indomethacin exhibit antiproliferative effects and induce apoptosis in T98G human glioblastoma cells. Neurol Res., 25:370-376, 2003. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12870263)
Bottone, Jr., F.B., Martinez, J.M., Collins, J.B., Afshari , C.A., and Eling,T.E. Gene Modulation by the Cyclooxygenase Inhibitor, Sulindac Sulfide, in Human Colorectal Carcinoma Cells: Possible Link to Apoptosis. J. Biol. Chem., 278:25790-25801, 2003. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12734198)
Nixon, J.B., Kim, K., Lamb, P.W., Bottone, Jr., F.B. and Eling, T.E., 15-Lipoxygenase-1 has anti-tumorigenic effects in colorectal cancer. Prostaglandins. Leuk. Essent. Fatty Acids, 70, 7-15, 2004. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14643174)
Lee, C., Jang, Y., Sun-Ju.Y, Her, Moon, Y., Baek, S., Eling, E. Nordihydroguaiaretic acid, an antioxidant, inhibits transforming growth factor-β activity through the inhibition of Smad signaling pathway. Exp. Cell Res.289: 335-341, 2003. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14499634)
Bottone, Jr., F.B., Martinez, J.M., Alston-Mills, B. and Eling, T.E. Gene Modulation by Cox-1 and Cox-2 Specific Inhibitors in Human Colorectal Carcinoma Cancer Cells. Carcinogenesis, 25: 349-357, 2004. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14633654)
Wang, T.,Qin, L., Liu,Y., Wilson, B., Eling, T.E., Langenbach, R., Taniura, S., and Hong, J. Role of reactive oxygen species in LPS-induced production of prostaglandin E2 in microglia. J. Neurochem. 88:939-947, 2004. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14756815)
Baek, S., Kim, J., Nixon, J.B., DiAugustine, R.P. and Eling, T.E. Expression of NAG-1, a Transforming Growth Factor-β Superfamily Member, by Troglitazone Requires the Early Growth Response Gene, EGR-1. J. Biol. Chem. 279:6883-6892, 2004. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14662774)
Jain, A.K., Moore, S.M., Yamaguchi, K., Eling, T.E., Baek, S.J. Selective Nonsteroidal Anti-inflammatory Drugs Induce Thymosin Beta-4 and Alter Actin Cytoskeletal Organization in Human Colorectal Cancer Cells. J Pharmacol. Exp Ther.311:885-91, 2004. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15292456)
Baek, S.J., Kim, J.S., Jackson, F.R., Eling, T.E., McEntee, M.F., Lee, S.H.E. Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells. Carcinogenesis: 25, 2425-2432, 2004. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15308587)
Martinez, J.M., Baek, S.J., Mays, D.M., Tithof, P.K., Eling, T.E., Walker, N.J. EGR1 Is a Novel Target for AhR Agonists in Human Lung Epithelial Cells. Toxicol. Sci. 82: 429-435, 2004. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15342960)
Ishibashi, M., Bottone, F.G., Taniura, S., Kamitani, H., Watanabe, T, and Eling. T.E, The Cyclooxygenase Inhibitor Indomethacin Modulates Gene Expression and Represses the Extracellular Matrix Protein Laminin ?1 in Human Glioblastoma Cells. Exp. Cell Res.302:244-252, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15561105)
Kim, J.S., Yoon, J., Kim, J.K., Baek, S.J., Eling, T.E., Leeg, W.J., Ryug, J., Leea, J.G., Jong-Bum, Yooa J. Cyclooxygenase inhibitors induce apoptosis in oral cavity cancer cells by increased expression of nonsteroidal anti-inflammatory drug-activated gene. Biochem Biophys. Res. Comm. 325:1298-1303, 2004. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15555568)
Yamaguchi, K., Lee, S., Eling, T., and Baek, S., Identification of Nonsteroidal Anti-Inflammatory Drug-activated gene (NAG-1) as a Novel Downstream Target of Phosphatidylinositol 3-Kinase/AKT/GSK-3? pathway. J. Biol. Chem. 279: 49617-49623, 2004. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15377673)
Seung Joon Baek, Jong-Sik Kim, Scott M. Moore, Seong-Ho Lee, Jeanelle Martinez, and Thomas E. Eling, Cycloxygenase inhibitors induce the expression of the tumor suppressor gene, EGR-1 which results in the up-regulation of NAG-1, an anti-tumorigenic protein. Mol. Pharm: 67: 356-364, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15509713)
Seung-Ho Lee, Jing-Sik Kim, Kiyoshi Yamaguchi. Thomas E. Eling and Seung Joon Baek. Indole-3-carbinol and 3,3’-diindolylmethane induce expression of NAG-1 in a p53-independent manner. Biochem. Biophy. Res. Comm. 328: 63-69, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15670751)
Minsub Shim and Thomas E. Eling, PKC-dependent Regulation of NAG-1/PLAB/MIC-1 Expression in LNCaP Prostate Carcinoma Cells. J. Biol. Chem.280: 18636-18642, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15757899)
Frank G. Bottone, Jr., Yuseok Moon, Jong Sik Kim, Brenda Alston-Mills, Minako Ishibashi, and Thomas E. Eling, The anti-invasive activity of Cox inhibitors are regulated by the transcription factor Activating Transcription Factor 3 (ATF3). Mol. Canc. Ther. 4: 693-703, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15897233)
Jong-Sik Kim, Seung Joon Baek, Tina Sali and Thomas Eling. The conventional NSAID sulindac sulfide arrests ovarian cancer cell growth through NAG-1/MIC-1/GDF-15. Mole Can. Ther. 4: 487-493, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15767558)
House RL, Cassady JP, Eisen EJ, Eling TE, Collins JB, Grissom SF, Odle J. Functional genomic characterization of delipidation elicited by trans-10, cis-12-conjugated linoleic acid (t10c12-CLA) in a polygenic obese line of mice. Physiol Genomics, 21:351-361, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15888570)
Frank G. Bottone, Jr., Yuseok Moon, Brenda Alston-Mills, and Thomas E. Eling. Transcriptional Regulation of Activating Transcription Factor 3 (ATF3) Involves the Early Growth Response-1 (Egr-1) Gene. J. Pharmacol. Exp. Ther.315, 668-677, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16079301)
Yuseok Moon, Wayne C. Glasgow and Thomas E. Eling, Curcumin suppresses interleukin 1β-mediated microsomal prostaglandin E synthase 1 (mPGES-1) by altering early growth response gene EGR-1 and other signaling pathways. J. Pharmacol. Exp Ther.315, 788-795, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16081677)
Krishnamurthy Malathi, Jayashree Paranjapee, Elena Bulanova, Minsub Shim, Jeanna M. Guenther-Johnson,Thomas Eling, Bryan Williams and Robert H. Silverman, A transcriptional signaling pathway in IFN system mediated by 2’-5’-oligoadenylate activation of RNase L. Proc. Nat. Acad. Sci. 102, 14533-14538, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16203993)
Kim, J.S., Baek, S.J., Bottone, F.G. Jr, Sali, T., and Eling T.E. Overexpression of 15-lipoxygenase-1 induces growth arrest through phosphorylation of p53 in human colorectal cells. Mol. Cancer Res 9, 511-517, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16179498)
Yuseok, Moon, Frank G. Bottone, Jr., Michael F. McEntee, and Thomas, E. Eling, Suppression of tumor cell invasion by cyclooxygenase inhibitors is mediated by Thrombospondin-1 via the early growth response gene, Egr-1. Mol Cancer Ther. 4,1551-8, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16227405)
Ryuji, Okazaki, Yuseok, Moon, Toshiyuki, Norimura, and Thomas Eling. Ionizing Radiation Enhances the Expression of the Nonsteroidal Anti-inflammatory Drug-Activated Gene (NAG1) by Increasing the Expression of TP53 in Human Colon Cancer Cells Radiation Res. 165, 125-130, 2006. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16435911)
Lee, S.H., Yamaguchi, K., Kim, J.S., Eling, T.E., Safe, S., Park, Y. and Baek, S.J. Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific manner. Carcinogenesis. 27:972-81, 2006. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16286461)
Baek, S.J. and Eling, T.E. Changes in gene expression contribute to cancer prevention by COX inhibitors. Prog. Lipid Res. 45:1-16, 2006. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16337272)
Martinez, J.M., Sali, T., Okazaki, R., Anna, C., Hollingshead, M., Hose, C., Monks, A., Walker, N.J., Baek, S,J. and Eling, T.E. Drug-induced expression of nonsteroidal anti-inflammatory drug-activated gene/macrophage inhibitory cytokine-1/prostate-derived factor, a putative tumor suppressor, inhibits tumor growth. J. Pharmacol. Exp Ther. 318:899-906, 2006. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16714403)
Yamaguchi, K., Lee, S.H., Eling, T.E. and Baek, S.J. A novel peroxisome proliferator-activated receptor gamma ligand, MCC-555, induces apoptosis via posttranscriptional regulation of NAG-1 in colorectal cancer cells. Mol Cancer Ther. 5:1352-61, 2006. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16731769)
Lambert, J.R., Kelly, J.A., Shim, M., Huffer, W.E., Nordeen, S.K., Baek, S.J., Eling, T.E. and Lucia, M.S. Prostate derived factor in human prostate cancer cells: Gene induction by vitamin D via a p53-dependent mechanism and inhibition of prostate cancer cell growth. J. Cell Physiol. 208 566-574, 2006. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16741990)
Baek S, Okazaki R., Lee, S., Martinez, J., Kim, J., Yamaguchi, K., Mishina, Y., Martin, D., Shoieb, A., McEntee, M., and Eling, T. Nonsteroidal anti-inflammatory drug activated gene-1 overexpression in transgenic mice suppresses intestinal neoplasia. Gastroenterology, 131(5): 1553-60, 2006. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17101328)
Lee, C., Bottone, F., Krahn, J., Li, L., Mohrenweiser, H., Cook, M., Petrovich, R., Bell, D., Eling,T. and Zeldin, D., Identification and Functional Characterization of Polymorphisms in Human Cyclooxygenase-1 (PTGS1), Pharmacogenetics and Genomics, 17(2): 145-60, 2007. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17301694)
Kambe, A., Iguchi, G., Moon, Y., Kamitani, H., Watanabe, T. and Eling T. Suppression of the Prostaglandin EP4 Receptor Expression by Troglitazone requires Phosphorylated Sp-1. Cancer Research, Submitted.
Eling, T.E., Baek, S.J., Shim, M., Lee, C.H. NSAID activated gene (NAG-1), a modulator of tumorigenesis. Journal of biochemistry and molecular biology 39(6):649-655, 2006. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17129398)
Kambe, A., Iguchi, G., Moon, Y., Kamitani, H., Watanabe, T., Eling, T.E. Regulation of EP4 expression via the Sp-1 transcription factor: Inhibition of expression by anti-cancer agents. Biomedica biochimica acta 1783(6):1211-1219, 2008. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18346464)
Moon, Y., Kim, J.I., Yang, H., Eling, T.E. Growth compensatory role of sulindac sulfide-induced thrombospondin-1 linked with ERK1/2 and RhoA GTPase signaling pathways. Life sciences 82(11-12):591-599, 2008. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18261746)
Shim, M., Eling, T.E. Vitamin E succinate (VES) induces NAG-1 expression in a p38 kinase-dependent mechanism. Molecular cancer therapeutics 7(4):961-971, 2008. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18413810)
Yoshioka, H., Kamitani, H., Watanabe, T., Eling, T.E. Nonsteroidal anti-inflammatory drug-activated gene(NAG-1/GDF15) expression is increased by the histone deacetylase inhibitor trichostatin A. The Journal of biological chemistry 283(48):33129-33137, 2008. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18801729)
Taniura, S., Kamitani, H., Watanabe, T., Eling, T. Induction of cyclooxygenase-2 expression by interleukin-1beta in human glioma cell line, U87MG. Neurologia medico-chirurgica 48(11):500-505, 2008. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=19029777)
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