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Mark F. Cesta, D.V.M., Ph.D., D.A.C.V.P.

NTP Pathology Group

Mark Cesta, D.V.M., Ph.D., D.A.C.V.P.
Mark F. Cesta, D.V.M., Ph.D., D.A.C.V.P.
Staff Scientist/NTP Pathologist
Tel (919) 541-3229
Fax (919) 541-7666
cesta@niehs.nih.gov
P.O. Box 12233
Mail Drop B3-06
Research Triangle Park, North Carolina 27709
Delivery Instructions

Research Summary

Mark Cesta, D.V.M., Ph.D., D.A.C.V.P., is a staff scientist and board certified pathologist working with David Malarkey, Ph.D., in the NTP Pathology Group. His current research focuses on growth factors involved in the pulmonary fibrotic effects of single- and multi-walled carbon nanotubes in rats and the contribution of pre-exposure to bacterial endotoxin. This work is being conducted in collaboration with scientists at North Carolina State University and The Hamner Institutes for Health Sciences in Research Triangle Park, North Carolina. Other projects include pathology oversight and preparation of the technical report for the NTP studies of b-myrcene, 1-bromopropane, methyl trans-styryl ketone, Cimstar 3800 and Trim SC210 (metal working fluids), and trimethylolpropane triacrylate, collaboration on the Wistar Han rat background lesion atlas and an atlas of reproductive lesions in rodents, and immunohistochemical characterization of urinary bladder tumors in rats exposed to o-nitroanisole.

Research Interests

  • Toxicologic pathology, especially of the respiratory and cardiopulmonary systems
  • Pulmonary fibrosis
    • Animal models of pulmonary fibrosis
    • Growth factors involved in pulmonary fibrosis
  • Pathology of genetically-engineered laboratory animals


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Biography

After graduating from veterinary school at Colorado State University, Dr. Cesta returned to his home state of Arizona and worked in private practice for three years. In August of 2000, he began his residency in veterinary anatomic pathology and a concurrent graduate research program in cell biology at North Carolina State University. In 2003 he completed his residency and accepted a position as an IRTA fellow at NIEHS in the CMPB/NTP Toxicologic Pathology Training Program. He received his board certification from the American College of Veterinary Pathologists in 2004. Cesta began working as a toxicologic pathologist at Integrated Laboratory Systems, Inc. in 2005 where he served as a contractor for one and a half years, conducting Pathology Working Groups for the NTP and providing pathology services for NIEHS- and industry-sponsored research projects. In January of 2007, Cesta became the newest member of the Cellular and Molecular Pathology Branch’s staff, accepting a position as an NIEHS staff scientist/NTP pathologist.


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Selected Publications

  1. Surh I , Rao DB, Cesta MF, H├ębert CD, Mann JF, Cunny H, Kissling GE, Malarkey D, Chhabra RS. Species and gender differences in the carcinogenic activity of trimethylolpropane triacrylate in rats and mice. Food and chemical toxicology 2014 66:254-261.[Abstract ]
  2. Cesta MF, Malarkey DE, Herbert RA, Brix A, Hamlin MH 2nd, Singletary E, Sills RC, Bucher JR, Birnbaum LS. The National Toxicology Program Web-based nonneoplastic lesion atlas: a global toxicology and pathology resource. Toxicologic pathology 2014 42(2):458-460. [Abstract] 
  3. Morgan DL, Nyska A, Harbo SJ, Grumbein SL, Dill JA, Roycroft JH, Kissling GE, Cesta MF. Multisite carcinogenicity and respiratory toxicity of inhaled 1-bromopropane in rats and mice. Toxicologic pathology 2011 39(6):938-948.[Abstract ]
  4. Gwinn WM, Kapita MC, Wang PM, Cesta MF, Martin WJ 2nd. Synthetic Liposomes are Protective from Bleomycin-Induced Lung Toxicity. American journal of physiology. Lung cellular and molecular physiology. 2011 301(2):L207-17.[Abstract ]  
  5. Ramot Y, Steiner M, Morad V, Leibovitch S, Amouyal N, Cesta MF, Nyska A. Pulmonary thrombosis in the mouse following intravenous administration of quantum dot-labeled mesenchymal cells. Nanotoxicology. 2010 4(1):98-105.[Abstract ]  
  6. Ryman-Rasmussen JP, Tewksbury EW, Moss OR, Cesta MF, Wong BA, Bonner JC. Inhaled multiwalled carbon nanotubes potentiate airway fibrosis in murine allergic asthma. American journal of respiratory cell and molecular biology. 2009 40(3):349-358.[Abstract ]  
  7. Mangum JB, Turpin EA, Antao-Menezes A, Cesta MF, Bermudez E, Bonner JC. Single-walled carbon nanotube (SWCNT)-induced interstitial fibrosis in the lungs of rats is associated with increased levels of PDGF mRNA and the formation of unique intercellular carbon structures that bridge alveolar macrophages in situ. Part Fibre Toxicol. 2006 Nov 29;3:15.[Abstract ]  
  8. Cesta MF. Normal structure, function, and histology of mucosa-associated lymphoid tissue. Toxicol Pathol. 2006;34(5):599-608. Review.[Abstract ]  
  9. Cesta MF. Normal structure, function, and histology of the spleen. Toxicol Pathol. 2006;34(5):455-65. Review.[Abstract ]

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