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Selected Publications

NTP Pathology Group


Monographs/Reviews/Technical

  1. Cesta MF, Malarkey DE, Herbert RA, Brix A, Hamlin MH 2nd, Singletary E, Sills RC, Bucher JR, Birnbaum LS. The National Toxicology Program Web-based nonneoplastic lesion atlas: a global toxicology and pathology resource. Toxicologic pathology 2014 42(2):458-460. [Abstract] 
  2. Hoenerhoff, M and Malarkey, DE.  (2013) Toxicogenomics in Toxicologic Pathology. In Pritam, PS, Popp, JA, Hardisty, JF and Gopinath, C (Eds.), Toxicologic Pathology:Nonclinical Safety Assessment.  CRC Press, NY, pp. 175.
  3. Malarkey, D.E., Hoenerhoff, M., Maronpot, R.R. (2013) Carcinogenesis: Mechanisms and Manifestations. In: Haschek, W.M., Rousseaux, C.G., Wallig, M.A. (Eds.), Haschek and Rousseaux's Handbook of Toxicologic Pathology. Elsevier Inc., Academic Press, pp. 107.
  4. Hall AP, Elcombe CR, Foster JR, Harada T, Kaufmann W, Knipple A, Kutttler K, Malarkey DE, Maronpot RR, Nishikawa A, Nolte T, Schulte A, Strauss V, York MJ. (2012) Liver Hypertrophy: A Review of Adaptive (Adverse and Non-adverse) Changes--Conclusions from the 3rd International ESTP Expert Workshop. Toxicologic Pathology. 2012 Jun 21. [Epub ahead of print]
  5. Jokinen, MP, Lieuallen, WG, Boyle, MC, Johnson, CL, Malarkey, DE, and Nyska, A.  (2011)  Morphologic aspects of rodent cardiotoxicity in a retrospective evaluation of NTP studies. Toxicologic Pathology 39(5):850 - 860.
  6. 6. Thoolen B, Maronpot RR, Harada T, Nyska A, Rousseaux C, Nolte T, Malarkey DE, Kaufmann W, Küttler K, Deschl U, Nakae D, Gregson R, Vinlove MP, Brix AE, Singh B, Belpoggi F, Ward JM. (2010) Proliferative and nonproliferative lesions of the rat and mouse hepatobiliary system. Toxicologic Pathology 38(7 Suppl):5S-81S. Review.
  7. Merrick BA, Auerbach SS, Stockton PS, Foley JF, Malarkey DE, Sills RC, Irwin RD, Tice RR. (2012) Testing an aflatoxin B1 gene signature in rat archival tissues. Chemical research in toxicology.  25(5):1132-44.[Abstract ]
  8. Rao DB, Little PB, Malarkey DE, Herbert RA, Sills RC. (2011) Histopathological Evaluation of the Nervous System in Routine National Toxicology Program Rodent Studies: A Modified Approach. Toxicologic Pathology 39(3):463-470.[Abstract ]
  9. Chandra SA, Nolan MW, Malarkey DE. (2010) Chemical carcinogenesis of the gastrointestinal tract in rodents: an overview with emphasis on NTP carcinogenesis bioassays. Toxicologic Pathol 38(1):188-197.[Abstract ]
  10. Law M, Elmore S. (2008) Mechanisms of Cell Death. Edited by Robert C. Smart and Ernest Hodgson in : Molecular and Biochemical Toxicology, 4,th Edition. John Wiley & Sons, Inc. Hoboken, New Jersey. Chapter 16, pages 287-317.
  11. Petiet AE, Kaufman MH, Goddeeris MM, Brandenburg J, Elmore SA, Johnson GA (2008) High-resolution magnetic resonance histology of the embryonic and neonatal mouse: A 4D atlas and morphologic database. PNAS 105, 12331-12336.[Abstract ]
  12. Elmore SA, Travlos GS. (2008; submitted) Chemically Induced Histopathological Changes of the Bone Marrow. Toxicology of the blood and bone marrow – 2nd edition Edited by Jacques Descotes in: Target Organ Toxicology Series (Series Editors John A Thomas, A Wallace Hayes and Donald E Gardner, CRC Press/Taylor and Francis.
  13. Tischler AS, Nyska A, Elmore SA (2008, submitted) Toxic Responses of the Adrenal Medulla in: Volume 11 of Comprehensive Toxicology, 2nd Edition Edited by I. Glenn Sipes, Charlene A. McQueen and A. Jay Gandolfi. Elsevier, New York, NY.
  14. Hardisty JF, Elwell MR, Ernst H, Greaves P, Kolenda-Roberts H, Malarkey DE, Mann PC, Tellier PA. (2007) Histopathology of hemangiosarcomas in mice and hamsters and liposarcomas/fibrosarcomas in rats associated with PPAR agonists. Toxicologic Pathology 35(7):928-941.[Abstract ]
  15. Elmore, SA. (2007) Apoptosis: a review of programmed cell death. Toxicologic pathology 4 (495-516)[Abstract ]
  16. Cesta, M.F. (2006) Normal structure, function, and histology of the spleen. Toxicol Pathol 34(5), 455-465.[Abstract ]
  17. Cesta, M.F. (2006) Normal structure, function, and histology of mucosa-associated lymphoid tissue. Toxicol Pathol 34(5), 599-608.[Abstract ]
  18. Gerrish, K and Malarkey DE. 2007. Genomic profiles of liver injury. Chapter in Hepatotoxicity: From genomics to in-vitro and in-vivo, S Sahu, editor.
  19. Elmore SA (2007) Apoptosis: a review of programmed cell death (invited review) Toxicol Pathol 35 (1-22)
  20. Elmore SA (2006) Enhanced histopathology of mucosa-associated lymphoid tissue. Toxicol Pathol 34, 687-96. [Abstract ]
  21. Elmore SA (2006) Enhanced histopathology of the bone marrow. Toxicol Pathol 34, 666-86.[Abstract ]
  22. Elmore SA (2006) Enhanced histopathology of the thymus. Toxicol Pathol 34, 656-65.[Abstract ]
  23. Elmore SA (2006) Enhanced histopathology of the spleen. Toxicol Pathol 34, 648-55. [Abstract ]
  24. Elmore SA (2006) Enhanced histopathology of the lymph nodes. Toxicol Pathol 34, 634-47.[Abstract ]
  25. Elmore SA (2006) Histopathology of the lymph nodes. Toxicol Pathol 34, 425-54.[Abstract ]
  26. Malarkey DE, Maronpot RR (2005) Carcinogenesis. In Encyclopedia of Toxicology; 2nd edition; Edited by Philip Wexler; Academic press, San Diego. pp 445-466.
  27. Malarkey DE, Johnson K, Ryan L, Boorman G, Maronpot RR. (2005) New insights into functional aspects of liver morphology. Tox Path 33(1):27-34. [Abstract ]

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Toxicological Pathology

  1. Behl M, Elmore SA, Hejtmancik MR, Gerken DK, Chhabra RS. Perinatal toxicity and carcinogenicity studies of styrene-acrylonitrile trimer, a ground water contaminant. Toxicology 2013 314(1):84-94.[Abstract ]
  2. Surh I, Rao DB, Cesta MF, Hébert CD, Mann JF, Cunny H, Kissling GE, Malarkey D, Chhabra RS. (2014) Species and gender differences in the carcinogenic activity of trimethylolpropane triacrylate in rats and mice. Food and Chemical Toxicology
  3. Blystone CR, Elmore SA, Witt KL, Malarkey DE , Foster PMD. (2011) Toxicity and carcinogenicity of androstenedione in F344/N rats and B6C3F1 mice. Food and Chemical Toxicology 49(9):2116-2124.[Abstract ]
  4. Singh BP, Nyska A, Kissling GE, Lieuallen W, Johansson SL, Malarkey DE, Hooth MJ. (2010) Urethral carcinoma and hyperplasia in male and female B6C3F1 mice treated with 3,3',4,4'-tetrachloroazobenzene (TCAB) Toxicologic pathology 38(3):372-381.[Abstract ]
  5. Auerbach SS, Bristol DW, Peckham JC, Travlos GS, Hebert CD, Chhabra RS. (Accepted 2009) Toxicity and carcinogenicity studies of methylene blue trihydrate in F344N rats and B6C3F1 mice. Food Chem. Toxicol Epub 2009 Oct 3 (Epub ahead of print)
  6. Stout MD, Nyska A, Collins BJ, Witt KL, Kissling GE, Malarkey DE, Hooth MJ. (2009) Chronic toxicity and carcinogenicity studies of chromium picolinate monohydrate administered in feed to F344/N rats and B6C3F1 mice for 2 years. Food and chemical toxicology 47(4):729-733.[Abstract ]
  7. Hard GC, Flake GP, Sills RC. (2009) Re-evaluation of kidney histopathology from 13-week toxicity and two-year carcinogenicity studies of melamine in the F344 rat: morphologic evidence of retrograde nephropathy. Vet Pathol 46:1248-1257.
  8. Stout MD, Herbert RA, Kissling GE, Collins BJ, Travlos GS, Witt KL, Melnick RL, Abdo KM, Malarkey DE, Hooth MJ. (2008) Hexavalent chromium is carcinogenic to F344/N rats and B6C3F1 mice following chronic oral exposure. Environ. Health Perspec 117(5):716-22. 2009. Epub 31 December 2008.
  9. Lewis DN, Nyska M, Johnson K, Malarkey DE, Ward S, Streiker M, Peddada S, Shabat S, Nyska A. (2005) 2-Butoxyethanol female-rat model of hemolysis and disseminated thrombosis: X-ray characterization of osteonecrosis and growth plate suppression. Tox Path 33(2):272-282. [Abstract ]
  10. Nyska A, Jokinen, Brix, Sells, Wyde, Orzech, Haseman, Flake, Walker. (2004) Exocrine pancreatic pathology in female Harlan Sprague-Dawley rats after chronic treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin and dioxin-like compounds. Environ Health Perspect 112:903-909.[Abstract ]
  11. Doi AM, Peckham JC, Chou BJ, Dill JA, Renne RA, Grumbein SL, Chhabra RS. (2004) Development of a2u-Globulin Nephropathy and Adrenal Medullary Pheochromocytomas in Male Rats Following Exposure to Stoddard Solvent IIC, Inhalation Toxicology 16(5):247-257. [Abstract ]

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Animal Models of Environmental Disease

  1. Surh I , Rao DB, Cesta MF, H├ębert CD, Mann JF, Cunny H, Kissling GE, Malarkey D, Chhabra RS. Species and gender differences in the carcinogenic activity of trimethylolpropane triacrylate in rats and mice. Food and chemical toxicology 2014 66:254-261.[Abstract ]
  2. Ellis, JM, Paul, DS, DePetrillo, MA, Singh, BP, Malarkey, DE, and Coleman, RA. (2012) Mice deficient in glycerol-3-phosphate acyltransferase-1 have a reduced susceptibility to liver cancer. Toxicologic Pathology 40(3):513-21.
  3. Hoenerhoff MJ, Hong HH, Ton T, Lahousse SA, Sills RC. (2009) A Review of the Molecular Mechanisms of Chemically Induced Neoplasia in Rat and Mouse Models in National Toxicology Program Bioassays and Their Relevance to Human Cancer. Toxicol Pathol. 37(7):835-48.[Abstract ]
  4. Ramot Y, Nyska A, Lieuallen W, Maly A, Flake G, Kissling GE, Brix A, Malarkey D, Hooth M. (2009) Inflammatory and chloracne-like skin lesions in B6C3F1 mice exposed to tetrachloroazobenzene(TCAB)for 2 years. Toxicology 265(1-2):1-9.[Abstract ]
  5. Wakamatsu N, Hong HL, Devereux TR, Sills RC. (2007) Overview of the molecular carcinogenesis of mouse lung tumor models of human lung cancer. Toxicologic Pathology, 35:75-80. [Abstract ]

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Toxicogenomics/Proteomics

  1. Lobenhofer EK, Auman JT, Blackshear PE, Boorman GA, Bushel PR, Cunningham ML, Fostel JM, Gerrish K, Heinloth AN, Irwin RD, Malarkey DE, Merrick BA, Sieber SO, Tucker CJ, Ward SM, Wilson RE, Hurban P, Tennant RW, Paules RS. Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype. Genome Biol. 2008;9(6):R100. Epub 2008 Jun 20.[Abstract ]
  2. Gerrish, K and Malarkey DE. 2007. Genomic profiles of liver injury. Chapter in Hepatotoxicity: From genomics to in-vitro and in-vivo, S Sahu, editor.
  3. Bushel PR, Heinloth AN, Li J, Huang L, Chou JW, Boorman GA, Malarkey DE, Houle CD, Ward SM, Wilson RE, Fannin RD, Russo MW, Watkins PB, Tennant RW, Paules RS. (2007) Blood gene expression signatures predict exposure levels. Proceedings of the National Academy of Sciences of the United States of America 104(46): 18211-18216.[Abstract ]
  4. Lobenhofer EK, Boorman GA, Phillips KL, Heinloth AN, Malarkey DE, Blackshear PE, Houle C, Parker JS, Hurban P. (2006) Application of visualization tools to the analysis of histopathological data enhances biological insight and interpretation. Tox Path 34(7):921-928.[Abstract ]
  5. Malarkey DE, Parker JS, Turman CA, Scott AM, Paules RS, Maronpot RR. (2005) Microarray data analysis of mouse neoplasia. Tox Path 33(1): 127-135.[Abstract ]

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Infectious Diseases

  1. Stout MD, Kissling GE, Suárez FA, Malarkey DE, Herbert RA, Bucher JR. (2008) Influence of helicobacter hepaticus infection and diet on the chronic toxicity and carcinogenicity of triethanolamine in B6C3F1 mice. Toxicologic pathology 36(6):783-794.[Abstract ]

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Nanotoxicology

  1. Ramot Y, Steiner M, Morad V, Leibovitch S, Amouyal N, Cesta MF, Nyska A. (In Press) (Accepted 5 November 2009) Pulmonary thrombosis in the mouse following intravenous administration of quantum dot-labeled mesenchymal cells. Nanotoxicol
  2. Ryman-Rasmussen JP, Tewksbury EW, Moss OR, Cesta MF, Wong BA, Bonner JC. Inhaled multiwalled carbon nanotubes potentiate airway fibrosis in murine allergic asthma. American journal of respiratory cell and molecular biology. 2009 40(3):349-358.[Abstract ]
  3. Ryman-Rasmussen JP, Cesta MF, Brody AR, Shipley-Phillips JK, Everitt JI, Tewksbury EW, Moss OR, Wong BA, Dodd DE, Andersen ME, Bonner JC. (2009) Inhaled carbon nanotubes reach the subpleural tissue in mice. Nat Nanotechnol 4(11), 747-51.
  4. Cesta MF, Ryman-Rasmussen JP, Wallace DG, Masinde T, Hurlburt G, Taylor AJ, Bonner JC. (2009) Bacterial Lipopolysaccharide Enhances PDGF Signaling and Pulmonary Fibrosis in Rats Exposed to Carbon Nanotubes. Am J Respir Cell Mol Biol ( AJRCMB Articles in Press. Published on September 8, 2009 as doi:10.1165/rcmb.2009-0113OC)
  5. Ryman-Rasmussen JP, Tewksbury EW, Moss OR, Cesta MF, Wong BA, Bonner JC. Inhaled Multi-walled Carbon Nanotubes Potentiate Airway Fibrosis in Murine Allergic Asthma. Am J Respir Cell Mol Biol 2008 Sep 11. [Epub ahead of print][Abstract ]
  6. Mangum JB, Turpin EA, Antao-Menezes A, Cesta MF, Bermudez E, Bonner JC. (2006) Single-Walled Carbon Nanotube (SWCNT)-Induced interstitial fibrosis in the lungs of rats is associated with increased levels of PDGF mRNA and the formation of unique intercellular carbon structures that bridge alveolar macrophages in situ. Part Fibre Toxicol (in press)[Abstract ]

Herbals/Supplements

  1. Pandiri AR, Sills, RC, Hoenerhoff, MJK,Peddada, SD, Ton,T-Vt, Hong H-H, Flake, GP, Malarkey, DE, Olsen, GR, Pogribny, I, Walker, NJ, and Boudreau MD. (2011) Aloe vera non-decolorized whole leaf extract-induced large intestinal tumors in F344 rats share similar molecular pathways with human sporadic colorectal tumors.  Toxicologic Pathology 39(7):1065-74
  2. Chan PC, Peckham JC, Malarkey DE, Kissling GE, Travlos GS, Fu PP. (2011) Two-Year Toxicity and Carcinogenicity Studies of Panax Ginseng in Fisher 344 Rats and B6C3F1 Mice. The American Journal of Chinese Medicine 39(4):779-788.[Abstract ]
  3. Blystone, C.R., Elmore, S.A., Witt, K.L., Malarkey, D.E., Foster, P.M.D. (2011). Toxicity and carcinogenicity of androstenedione in F344/N rats and B6C3F1 mice. Food and Chemical Toxicology 49(9):2116-2124.[Abstract ]

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