Selected Publications

NTP Pathology Group

Monographs/Reviews

1. Elmore SA. (2007) Apoptosis: a review of programmed cell death. Toxicologic pathology 4 (495-516). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17562483)
2. Peckham, J.C. and Thomassen, R.W. (2007).The Dog: pathology. In: Animal Models in Toxicology (S.C. Gad, Ed.), pp. 588-645. Taylor & Francis Group, LLC, Boca Raton, Fl.
3. Peckham, J.C (2007).The Guinea Pig: pathology. In: Animal Models in Toxicology (S.C. Gad, Ed.), pp 371-400. Taylor & Francis Group, LLC, Boca Raton, Fl.
4. Peckham, J.C. (2007).The Rabbit: pathology. In: Animal Models in Toxicology (S.C. Gad, Ed.), pp. 449-475. Taylor & Francis Group, LLC, Boca Raton, Fl.
5. Cesta MF. (2006). Normal structure, function, and histology of the spleen. Toxicol Pathol 34(5), 455-465.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17067939)
6. Cesta MF. (2006). Normal structure, function, and histology of mucosa-associated lymphoid tissue. Toxicol Pathol 34(5), 599-608.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17067945)
7. Elmore, S. A. (2007). Apoptosis: a review of programmed cell death (invited review). Toxicol Pathol 35 (1-22).
8. Elmore, S. A. (2006). Enhanced histopathology of mucosa-associated lymphoid tissue. Toxicol Pathol 34, 687-96.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17067953)
9. Elmore, S. A. (2006). Enhanced histopathology of the bone marrow. Toxicol Pathol 34, 666-86.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17067952)
10. Elmore, S. A. (2006). Enhanced histopathology of the thymus. Toxicol Pathol 34, 656-65.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17067951)
11. Elmore, S. A. (2006). Enhanced histopathology of the spleen. Toxicol Pathol 34, 648-55.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17067950)
12. Elmore, S. A. (2006). Enhanced histopathology of the lymph nodes. Toxicol Pathol 34, 634-47.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17067949)
13. Elmore, S. A. (2006). Histopathology of the lymph nodes. Toxicol Pathol 34, 425-54.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17067938)
14. Malarkey, DE and Maronpot, RR. (2005). Carcinogenesis. In Encyclopedia of Toxicology; 2nd edition; Edited by Philip Wexler; Academic press, San Diego. pp 445-466.

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Toxicological Pathology

1. Hardisty JF, Elwell MR, Ernst H, Greaves P, Kolenda-Roberts H, Malarkey DE, Mann PC, Tellier PA. (2007) Histopathology of hemangiosarcomas in mice and hamsters and liposarcomas/fibrosarcomas in rats associated with PPAR agonists. Toxicologic Pathology 35(7):928-941. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18098039)
2. Kissling, G, Malarkey, DE, Hejtmancik, MR, Vallant, MK, Smith, CA, Herbert, RA, and Boorman, GA. Evaluation of dichloroacetic acid for carcinogenicity in genetically modified TgAC and p53 haploinsufficient mice. Tox Sci (in press).
3. Carcinogenesis studies of Benzophenone in Rats and Mice. Rhodes, M. C., Bucher, J. R., Peckham, J. C., Kissling, G. E., Hejtmancik, M. R., and Chhabra, R. S. (2007) Food and Chemical Toxicology, 45(5): 843-851.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17187913)
4. Kissling GE, Malarkey DE, Vallant MK, Johnson JD, Hejtmancik MR, Herbert RA, Boorman GA. (2006) Evaluation of dichloroacetic acid for carcinogenicity in genetically modified Tg.AC hemizygous and p53 haploinsufficient mice. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 2-3: 89-99. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16996724)
5. Elmore, S., Lanning, L., Allison, N., Vallant, M., and Nyska, A. (2006). The transduction of rat submandibular glands by an adenoviral vector carrying the human growth hormone gene is associated with limited and reversible changes at the infusion site. Toxicol Pathol 34: 385-92.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16844666)
6. Zheng, C., Voutetakis, A., Kok, M. R., Goldsmith, C. M., Smith, G. B., Elmore, S., Nyska, A., Vallant, M., Irwin, R. D., and Baum, B. J. (2006). Toxicity and biodistribution of a first-generation recombinant adenoviral vector, in the presence of hydroxychloroquine, following retroductal delivery to a single rat submandibular gland. Oral Dis 12: 137-44.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16476034)
7. Malarkey, DE , Johnson, K, Ryan,, L, Boorman, G and Maronpot, RR.(2005). New insights into functional aspects of liver morphology. Tox Path 33(1): 27-34.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15805053)
8. Lewis, DN, Nyska, M, Johnson, K, Malarkey, DE, Ward, S, Streiker, M, Peddada, S, Shabat, S, Nyska, A. (2005). 2-Butoxyethanol female-rat model of hemolysis and disseminated thrombosis: X-ray characterization of osteonecrosis and growth plate suppression. Tox Path 33(2): 272-282.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15902971)
9. Walker, DM, Malarkey, DE, Seilkop, SK, Ruecker, FA, Funk, KA, Wolfe MJ, Treanor, CP, Foley, JF, Hahn, FF, Hardisty, JF, and VE Walker (2007). Transplacental carcinogenicity of 3-azido-3-deoxythymidine in B6C3F1 mice and F344 rats. Environmental and Molecular Mutagenesis 48(3-4):283-98.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17358026)
10. Nyska A, Jokinen, Brix, Sells, Wyde, Orzech, Haseman, Flake, and Walker. (2004) Exocrine pancreatic pathology in female Harlan Sprague-Dawley rats after chronic treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin and dioxin-like compounds. Environ Health Perspect 112: 903-909.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15175180)
11. Doi, A. M., Peckham, J. C., Chou, B. J., Dill, J. A., Renne, R. A., Grumbein, S. L., and Chhabra, R., S. (2004) Development of a2u-Globulin Nephropathy and Adrenal Medullary Pheochromocytomas in Male Rats Following Exposure to Stoddard Solvent IIC, Inhalation Toxicology 16(5): 247-257.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15371178)

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Animal Models of Environmental Diseases

1. Morrison JP, Satoh H, Foley J, Horton JL, Dunnick JK, Kissling GE , Malarkey DE. N-ethyl-N-nitrosourea (ENU)-induced meningiomatosis and meningioma in p16INK4a/p19ARF tumor suppressor gene deficient mice. Toxicologic Pathology 2007 35(6):838-845. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17943659)
2. Trempus, C. J., Morris, R. J., Elmore, A., Ehinger, M., Bortner, C. D., Ito, M., Cotsarelis G., Peckham, J., Flagler, N., Kissling, G., Humble, M. M., King, L. C., Adams, L. D., Desai, D., Amin, S., and Tennant, R. W. (2007) CD34 Expression by Hair Follicle Stem Cells is Required for Skin Tumor Development in Mice. Cancer Research 67(9):4173-4181.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17483328)
3. Wakamatsu N, Hong HL, Devereux TR, Sills RC. (2007) Overview of the molecular carcinogenesis of mouse lung tumor models of human lung cancer. Toxicologic Pathology, 35:75-80.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17325975)
4. Dang, H, Trempus, C, Malarkey, DE, Wei, S, Humble, M, Morris, RJ, and Tennant, RW. (2006). Identification of genes and gene ontology processes critical to skin papilloma development iin Tg.AC transgenic mice. Molecular Carcinogenesis Feb;45(2):126-140.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16329151)
5. Emmen, J. M., Couse, J. F., Elmore, S. A., Yates, M. M., Kissling, G. E., and Korach, K. S. (2005). In vitro growth and ovulation of follicles from ovaries of estrogen receptor (ER){alpha} and ER{beta} null mice indicate a role for ER{beta} in follicular maturation. Endocrinology 146, 2817-26.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15731357)
6. Mangum JB, Turpin EA, Antao-Menezes A, Cesta MF, Bermudez E, Bonner JC. (2006). Single-Walled Carbon Nanotube (SWCNT)-Induced interstitial fibrosis in the lungs of rats is associated with increased levels of PDGF mRNA and the formation of unique intercellular carbon structures that bridge alveolar macrophages in situ. Part Fibre Toxicol (in press).  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17134509)

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Toxicogenomics

1. Gerrish, K and Malarkey DE. (2006). Genomic profiles of liver injury. Chapter in Hepatotoxicity: From genomics to in-vitro and in-vivo, S Sahu, editor. (in press).
2. Bushel, PR, Heinloth, AN, Li, J, Huang, L, Chou, JW, Boorman, GA, Malarkey, DE, Houle CD, Ward SM, Wilson RE, Fannin RD, Russo MW, Watkins PB, Tennant RW, and Paules, RS (2007) Blood gene expression signatures predict exposure levels to rat hepatotoxin acetaminophen. (in press).
3. Lobenhofer, EK, Boorman, GA, Phillips, KL, Heinloth, AN, Malarkey, DE, Blackshear, PE, Houle, C, Parker, JS, and Hurban, P. (2006). Application of visualization tools to the analysis of histopathological data enhances biological insight and interpretation. Tox Path 34(7):921-928.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17178692)
4. Malarkey, DE, Parker, JS, Turman, CA, Scott, AM, Paules, RS and Maronpot, RR. (2005). Microarray data analysis of mouse neoplasia. Tox Path 33(1): 127-135.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15805064)
5. Boorman, G, Blackshear, PE. Parker, JS, Lobenhofer, EK, Malarkey, DE, Vallant, M, Gerkin, DK, and Irwin, RD. (2005). Hepatic gene expression changes throughout the day in the Fisher rat: Implications for toxicogenomics experiments. Tox Sci 86(1):185-193.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15814895)
6. Irwin, RD, Boorman GA, Cunningham, ML, Heinloth, AN, Malarkey, DE, and Paules, R. (2004). Application of toxicogenomics to toxicology: Basic concepts in the analysis of microarray data. Tox Path 32(Suppl. 1):72-83.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15209406)

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