Selected Publications

Molecular Pathology Group

Genetic Alternations in Animal Models of Cancer

1. Hong H.H., Ton T.T., Kim Y., Wakamatsu N., Clayton N.P., Chan P.C., Sills R.C., Lahousse S.A.: Genetic alterations in K-ras and p53 cancer genes in lung neoplasms from B6C3F1 mice exposed to cumene. Tox. Path. 36: 720, 2008.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18648094)
2. Wakamatsu, N., Hong, H.L., Devereux, T.R., Sills, R.C.: Overview of the molecular carcinogenesis of mouse lung tumor models of human lung cancer. Tox. Path. 35: 75, 2007.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17325975)
3. Hong, H.L., Houle, C.D., Ton, T.T., Sills, R.C.: K-ras mutations in lung tumors and tumors from other organs are consistent with a common mechanism of ethylene oxide tumorigenesis in the B6C3F1 mouse. Tox. Path. 35: 81, 2007.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17325976)
4. Hong, H.H., Dunnick, J., Herbert, R., Devereux, T.R., Kim, Y., Sills, R.C.: Genetic alterations in K-ras and p53 cancer genes in lung neoplasms of Swiss (CD-1) male mice exposed transplacentally to AZT. Environmental and Molecular Mutagenesis. 48: 299, 2007.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16395694)
5. Houle, C.D., Ton, T., Clayton, N., Huff, J., Hong, H.L., Sills, R.C.: Frequent p53 and H-ras mutations in benzene- and ethylene oxide-induced mammary carcinomas from B6C3F1 mice. Tox. Path. 34: 752, 2006.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17162533)
6. Ton, T., Hong, H.H., Devereux, T.R., Melnick, R.L., Sills, R.C., Kim Y.: Evaluation of genetic alterations in cancer-related genes in lung and brain tumors from B6C3F1 mice exposed to 1,3-butadiene or chloroprene. Chem Biol Interactions. 166: 112, 2006.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16860786)
7. Kim, Y., Ton, T.V., DeAngello, T., Morgan, K., Devereux, T.R., Anna, C., Collins, J.B., Paules, R.S., Crosby, L.M., Sills, R.C.: Major carcinogenic pathways and genes identified by gene expression analysis of peritoneal mesotheliomas following chemical treatment in F344 rats. Toxicol Appl Pharmacol. 214: 144, 2006.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16460773)
8. Lambertini, L., Surin, K., Ton, T.V., Clayton, N., Dunnick, J.K., Kim, Y., Hong, H.H., Devereux, T.R., Sills, R.C.: Analysis of p53 tumor suppressor gene, H-ras protooncogene and proliferating cell nuclear antigen (PCNA) in squamous cell carcinomas of HRA/Skh mice following exposure to 8-methoxypsoralen (8-MOP) and UVA radiation (PUVA therapy). Tox. Path. 33: 292, 2005.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15902973)
9. Kim, Y., Hong, H.H., Lachat, Y., Clayton, N.P., Devereux, T.R., Melnick, R.L., Hegi, M.E., Sills, R.C.: Genetic alterations in brain tumors following 1,3-butadiene exposure in B6C3F1 mice. Tox. Path. 33: 307, 2005.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15814359)
10. Iida, M., Anna, C.H., Holliday, W.M., Collins, J.B., Cunningham, M.L., Sills, R.C., Devereux, T.R.: Unique patterns of gene expression changes in liver after treatment of mice for 2 weeks with different known carcinogens and non-carcinogens. Carcinogenesis. 26: 689, 2005.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618236)
11. Sills, R.C., Hong, H.L., Flake, G., Moomaw, C., Clayton, N., Boorman, G.A., Dunnick, J., Devereux, T.R.: O-Nitrotoluene-induced large intestinal tumors in B6C3F1 mice model human colon cancer in their molecular pathogenesis. Carcinogenesis, 25: 605, 2004.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14688030)
12. Wakamatsu, N., Collins, J.B., Parker, J.S., Tessema, M., Clayton, N.P., Ton, T.V., Hong, H.H., Belinsky, S., Devereux, T.R., Sills ,R.C., Lahoousse, S.A.: Gene expression studies demonstrate that the K-ras/Erk MAP kinase signal transduction pathway and other novel pathways contribute to the pathogenesis of cumene-induced lung tumors. Toxicologic Pathology, 36: 743, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18648096)

Neuropathology Research in Animal Models

1. Moser, V., Phillips, P.M., McDaniel, K.L., Sills, R.C.: Neurotoxicological evaluation of two disinfection by-products, bromodichloromethane and dibromoacetonitrile in rats. Toxicology. 230: 137, 2007.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17157428)
2. Herr, D.W., Graff, J.E., Moser, V.C., Crofton, K.M., Little, P.B., Morgan, D.L., Sills, R.C.: Inhalational exposure to carbonyl sulfide (COS) produces altered brainstem auditory (BAER) and somatosensory (SEP) evoked potentials in F344 rats. Toxicological Sciences. 95: 118, 2007.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17079700)
3. Cesta, M.F., Mozzachio, P., Little, P.B., Olby, N.J., Sills, R.C., Brown T.T.: Neuronal ceriod lipofuscinosis in a vietnamese pot-bellied pig (Sus Scrofa). Vet Pathol. 43: 556, 2006.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16847000)
4. Sills, R.C., Harry, G.J., Valentine, W.M., Morgan, D.L.: Interdisciplinary neurotoxicity inhalation studies: Carbon disulfide and carbonyl sulfide research in F344 rats. Toxicol Appl Pharmacol, 207 (2 Suppl): 245, 2005.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16002115)
5. Sills, R.C., Morgan, D.L., Herr, D.W., Little, P.B., George, N.M., Ton, T.V., Love, N.E., Maronpot, R.R., Johnson, G.A.: Contribution of magnetic resonance microscopy in the 12-week neurotoxicity evaluation of carbonyl sulfide in Fischer 344 rats. Tox. Path. 32: 501, 2004.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15603534)
6. Morgan, D.L., Little, P.B., Herr, D.W., Moser, V.C., Collins, B., Herbert, R., Johnson, G.A., Maronpot, R.R., Harry, G.J., Sills, R.C.: Neurotoxicity of carbonyl sulfide in F344 rats following inhalation exposure for up to 12 weeks. Toxicol Appl Pharmacol. 200: 131, 2004.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15476866)
7. Moser, V.C., Phillips, P.M., Levine, A.B., McDaniel, K.L., Sills, R.C., Jortner, B.S., Butt, M.T.: Neurotoxicity produced by dibromoacetic acid in drinking water of rats. Toxicol Sci. 79: 112, 2004.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14976349)
8. Sills, R.C., Valentine, W.M., Moser, V., Graham, D.G., Morgan, D.L.: Characterization of carbon disulfide neurotoxicity in C57BL6 mice: Behavioral, morphological and molecular effects. Tox. Path., 28: 142, 2000.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10669001)
9. Sills, R.C., Hailey, J.R., Neal, J., Boorman, G.A., Haseman, J.K., Melnick, R.L.: Examination of low incidence brain tumor responses in F344 rats following chemical exposures in National Toxicology Program Studies. Tox. Path., 27: 589, 1999.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10528639)

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