Laboratory of Experimental Pathology

The Laboratory of Experimental Pathology (LEP) conducts research on spontaneous and chemically induced lesions and the mechanisms by which they are induced. It also manages, evaluates, reviews and reports all pathology data generated during the conduct of National Toxicology Program (NTP) (http://ntp.niehs.nih.gov/) toxicity and carcinogenicity studies. In addition, the LEP maintains state-of the-science histology, electron microscopy, clinical pathology and special techniques core laboratories and provides diagnostic pathology support to all NIEHS investigators and the NIEHS laboratory animal colony.

LEP is comprised of six groups—led by Laboratory Chief Robert Sills, D.V.M., Ph.D.(http://www.niehs.nih.gov/research/atniehs/labs/lep/mole-path/index.cfm), and provides the following services:

• Develops and defines in vivo and in vitro models of experimental carcinogenesis and toxicology
• Develops new methods and technologies in pathobiology
• Establishes standards, terminology and diagnostic criteria for rodent pathology
• Maintains the NTP archives and provides laboratory animal medicine support for the NTP
• Core laboratory services including:
  • Hematology
  • Clinical chemistry
  • Histology
  • Immunohistochemistry (IHC)
  • Electron Microscopy (TEM)
  • Laser Microdissection
  • In situ hybridization (ISH)
  • Image analysis, slide scanning
  • Phenotyping
  • Other Special Techniques – necropsy, frozen sections, & more

Scientific Support Staff

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