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Selected Publications

Treatment of Lead-Exposed Children Trial (TLC)

The Treatment of Lead-Exposed Children Trial generated data that the Epidemiology Branch and its collaborators published in a peer-reviewed journal articles. To find out more about the study, please click the following links to the journal articles and abstracts.

  1. Rhoads GG, Rogan WJ. Re: Treatment of lead-exposed children (letter). Pediatr 98:162-163, 1996.
  2. Treatment of Lead-exposed Children Trial Group. The Treatment of Lead-exposed Children (TLC) Trial: Design and recruitment for a study of the effect of oral chelation on growth and development in toddlers. Paediatr Perinat Epidemiol 12:313-333, 1998. [Abstract] (http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9690266&dopt=Abstract) Exit NIEHS
  3. Rich DQ, Yiin L-H, Rhoads GG, Glueck DH, Weisel C, Lioy PJ. A field comparison of two methods for sampling lead in household dust. J Expo Anal Environ Epidemiol 2:106-112, 1999. Abstract [Abstract] (ttp://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10321350&dopt=Abstract) Exit NIEHS
  4. Serwint JR, Damokosh AI, Berger OG, Chisolm JJ Jr, Gunter EW, Jones RL, Rhoads GG, Rogan WJ No difference in iron status between children with low and moderate lead exposure. J Pediatr 135: 108-110, 1999. [Abstract] (http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10393615&dopt=Abstract) Exit NIEHS
  5. Rogan WJ, Ragan NB, Damokosh AI, Davoli C, Shaffer TR, Jones RL, Wilkens S, Heenehan MC, Ware JH, Henretig F. Recall of a lead-contaminated vitamin and mineral supplement in a clinical trial. Pharmacoepidemiol Drug Safety 8:343-350, 1999. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15073911) Exit NIEHS
  6. Treatment of Lead-exposed Children Trial Group. Safety and efficacy of succimer in toddlers with blood leads of 20-44 µg/dL. Pediatr Res 48:593-599, 2000. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=11044477&dopt=Abstract) Exit NIEHS [download the PDF] (http://www.pedresearch.org/cgi/reprint/48/5/593) Exit NIEHS
  7. Dietrich KN, Berger OG, Bhattacharya A. Symptomatic lead poisoning in infancy: A prospective case analysis. J Pediatr 137:568-571, 2000. [Abstract] (http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11035840&dopt=Abstract) Exit NIEHS [PDF] (http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WKR-45WRKF5-W-1&_cdi=6913&_user=10843&_orig=search&_coverDate=10%2F31%2F2000&_qd=1&_sk=998629995&view=c&wchp=dGLbVzz-zSkWb&md5=5da9ea60d29dbcbaf7b5ef64eae183cf&ie=/sdarticle.pdf)  Download Adobe Reader Exit NIEHS
  8. Rogan WJ, Dietrich KN, Ware JH, Dockery DW, Salganik M, Radcliffe J, Jones RL, Ragan NB, Chisolm JJ Jr, Rhoads GG, for the Treatment of Lead-Exposed Children Trial Group. The effect of chelation therapy with succimer on neuropsychological development in children exposed to lead. N Engl J Med 344:1421-1426, 2001. [Abstract] (http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11346806&dopt=Abstract) Exit NIEHS [Full Text] (http://content.nejm.org/cgi/content/full/344/19/1421) Exit NIEHS [download the PDF] (http://content.nejm.org/cgi/reprint/344/19/1421) Exit NIEHS [NEJM Editorial] (http://content.nejm.org/cgi/content/full/344/19/1470) Exit NIEHS
  9. Dietrich KN, Ware JH, Salganik M, Radcliffe J, Rogan WJ, Rhoads GG, Fay ME, Davoli CT, Denckla MB, Bornschein RL, Schwarz D, Dockery DW, Adubato S, Jones RL, Treatment of Lead-Exposed Children Clinical Trial Group. Effect of chelation therapy on the neuropsychological and behavioral development of lead-exposed children after school entry. Pediatrics 114:19-26, 2004. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15231903) Exit NIEHS [Full Text] (http://pediatrics.aappublications.org/cgi/content/full/114/1/19) Exit NIEHS [download the PDF] (http://pediatrics.aappublications.org/cgi/reprint/114/1/19) Exit NIEHS

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Last Reviewed: 17 May 2007