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Treatment of Lead-Exposed Children Trial (TLC)

Treatment of Lead-Exposed Children Trial

The Treatment of Lead-Exposed Children Trial is headed by principal investigator (PI) Walter Rogan, M.D., of the NIEHS Epidemiology Branch. Other collaborators include:


National Institute of Environmental Health Sciences



  • N. Beth Ragan, Epidemiology Branch, Project Officer
  • Xianchen Liu, Epidemiology Branch, Visiting Fellow (currently: Arizona State University, Tempe, Arizona)
  • Aimin Chen, Epidemiology Branch, Visiting Fellow (currently: Creighton University, Omaha, Nebraska)
  • Yang Cao, Epidemiology Branch, Visiting Fellow


Clinical Centers (PIs and Staff)
University of Cincinnati (Cincinnati, Ohio)


  • Robert Bornschein, Clinical Center PI
  • Omer Berger, Physician
  • Kim Dietrich, Psychologist
  • Sherry Wilkins, Study Coordinator


Kennedy-Krieger Institute (Baltimore, Maryland)


  • J. Julian Chisolm Jr., Clinical Center PI (deceased)
  • Martha Bridge Denckla, Psychologist
  • Cecelia Davoli, Physician
  • Mark Farfel, Environmental Investigator
  • Merrill Brophy, Study Coordinator


Children’s Hospital of Philadelphia (Philadelphia, Pennsylvania)


  • Don Schwarz, Clinical Center PI
  • Carla Campbell, Physician
  • Jerilynn Radcliffe, Psychologist
  • Judith Guinn, Study Coordinator


University of Medicine & Dentistry of New Jersey (Newark, New Jersey)


  • Richard Wedeen, Clinical Center PI
  • George Rhoads, Environmental Investigator
  • Susan Adubato, Psychologist
  • Mofida Elsafty, Physician
  • Marian Heenehan, Study Coordinator


Data Coordinating Center
Harvard School of Public Health (Boston, Massachusetts)


  • James Ware, Data Center PI
  • Douglas Dockery, Epidemiologist
  • Martha Fay, Data Manager
  • Tania Kotlov, Programmer
  • Misha Salganik, Programmer


Central Laboratory
Nutritional Biochemistry Branch, Centers for Disease Control and Prevention (CDC, Atlanta, Georgia)


  • Robert Jones, Laboratory PI


Central Pharmacy
HHS Program Support Center, Supply Service Center (Perry Point, Maryland)


  • Lorraine D'Angelo, Central Pharmacy PI
  • Tom Shaffer, Pharmacist


TLC Steering Committee


  • George Rhoads, Chairman
  • Jim Ware
  • Robert Jones
  • J Julian Chisolm (deceased)
  • Don Schwarz
  • Robert Bornschein
  • Richard Wedeen
  • Walter Rogan

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