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Studies

Epidemiology Branch

Members of the Epidemiology Branch are involved in the following studies.

 

Agricultural Health (AHS)

Agricultural Health Study ("/Rhythmyx/assembler/render?sys_contentid=35054&sys_revision=4&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35054" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35054" sys_siteid="" sys_folderid="")

The Agricultural Health Study (AHS) explores a wide range of health outcomes among licensed pesticide applicators, their spouses and children potentially exposed to pesticides and other agricultural hazards. 

Family

AHS African-American Farmers and Farm Workers ("/Rhythmyx/assembler/render?sys_contentid=33996&sys_revision=3&sys_variantid=1173&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="1173" sys_dependentid="33996" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="33996" sys_siteid="" sys_folderid="")

Approximately 1,100 African-American farmers and farm workers from eastern North Carolina were followed for mortality and cancer incidence along with the AHS Study.

Agricultural Health (AHS)

AHS Neurobehavioral Study

In collaboration with Frederic Gerr, M.D., University of Iowa, 800 cohort participants will receive neurobehavioral tests and provide biological samples to evaluate whether long-term, low-level exposures to pesticides have neurological consequences.

Amyotrophic Lateral Sclerosis Study

Amyotrophic Lateral Sclerosis Study ("/Rhythmyx/assembler/render?sys_contentid=35070&sys_revision=1&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35070" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35070" sys_siteid="" sys_folderid="")

The Amyotrophic Lateral Sclerosis (ALS) Study explores potential associations of ALS with exposure to lead and other neurotoxins, lifestyle factors and genetic polymorphisms affecting neurologic function or lead metabolism.

Carolina Lupus Study

Carolina Lupus Study ("/Rhythmyx/assembler/render?sys_contentid=35125&sys_revision=3&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35125" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35125" sys_siteid="" sys_folderid="")

The Carolina Lupus Study examines the influence of hormonal and occupational exposures as well as genetics factors affecting immune function and metabolism on systemic lupus erythematosus.

Family

Chronic Renal Disease Study ("/Rhythmyx/assembler/render?sys_contentid=33996&sys_revision=3&sys_variantid=1173&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="1173" sys_dependentid="33996" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="33996" sys_siteid="" sys_folderid=#chronic"")

Risk factors for chronic renal disease were studied to determine past use of analgesic medications, occupational and environmental exposures, lifestyle factors and medical history.

Family

Czech Uranium Miners Study ("/Rhythmyx/assembler/render?sys_contentid=33996&sys_revision=3&sys_variantid=1173&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="1173" sys_dependentid="33996" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="33996" sys_siteid="" sys_folderid=#czech"")

Cancer incidence related to radon exposure was studied among a cohort of over 16,000 underground uranium miners from the Czech Republic followed from 1977–1996.

DDE & PCBs in the Collaborative Perinatal Project

DDE & PCBs in the Collaborative Perinatal Project ("/Rhythmyx/assembler/render?sys_contentid=35248&sys_revision=4&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35248" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35248" sys_siteid="" sys_folderid="")

The DDE & PCBs in the Collaborative Perinatal Project explores the health effects of in utero exposure to organochlorines such as DDE and polychlorinated biphenyls (PCBs) using biologic specimens from the Collaborative Perinatal Project (CPP).

DES Study (DES)

DES Study ("/Rhythmyx/assembler/render?sys_contentid=35374&sys_revision=1&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35374" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35374" sys_siteid="" sys_folderid="")

The DES Study was a follow-up of men and women born during a clinical trial of DES (diethystilbestrol) in the early 1950s. This follow-up study explores adult health effects of prenatal DES exposure.

Early Pregnancy Study (EPS)

Early Pregnancy Study ("/Rhythmyx/assembler/render?sys_contentid=35427&sys_revision=2&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35427" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35427" sys_siteid="" sys_folderid="")

The Early Pregnancy Study provides a detailed look at ovulation, conception and early pregnancy for a group of 221 women who provided daily diary and urine specimens before and during early pregnancy.

Farming & Movement Evaluation Study (FAME)

Farming & Movement Evaluation Study ("/Rhythmyx/assembler/render?sys_contentid=35471&sys_revision=1&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35471" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35471" sys_siteid="" sys_folderid="")

The Farming and Movement Evaluation (FAME) Study examines the relationship between Parkinson's disease and exposure to pesticides, other neurotoxicants and soil pathogens.

Farmworkers Health Study (FWHS)

Farmworkers Health Study ("/Rhythmyx/assembler/render?sys_contentid=35483&sys_revision=1&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35483" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35483" sys_siteid="" sys_folderid="")

The Farmworkers Health Study examines the association of long-term pesticide exposure in farm workers with deficits in cognitive and psychomotor function.

Fibroid Growth Study

Fibroid Growth Study ("/Rhythmyx/assembler/render?sys_contentid=35514&sys_revision=2&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35514" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35514" sys_siteid="" sys_folderid="")

The Fibroid Growth Study examines the variation in fibroid growth, the biological differences between growing and non-growing fibroids, and the relationship between fibroid growth and symptom severity.

Growth and Puberty Study (GAP)

Growth and Puberty Study ("/Rhythmyx/assembler/render?sys_contentid=33996&sys_revision=3&sys_variantid=1173&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="1173" sys_dependentid="33996" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="33996" sys_siteid="" sys_folderid=#gap"")

The Growth and Puberty Study (GAP) study is exploring the use of more sensitive hormonal measures of puberty onset and exploring factors associated with timing of puberty in children of licensed applicators from Iowa enrolled in the Agricultural Health Study.

GuLF STUDY

GuLF STUDY ("/Rhythmyx/assembler/render?sys_contentid=6846&sys_revision=19&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="6846" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="6846" sys_siteid="" sys_folderid="")

The Gulf Long-term Follow-up Study (GuLF STUDY) will investigate potential health effects associated with clean-up activities following the 2010 Deepwater Horizon disaster in the Gulf of Mexico. Study researchers expect to enroll 55,000 adults who performed any oil-spill clean-up-related work, including those directly involved in the cleanup, support personnel, such as office workers and food providers, and those who received safety training but did not work. The majority of participants will reside in Louisiana, Mississippi, Alabama, and Florida, the four Gulf States most affected by the spill. Recruitment will begin in March 2011.


Family

Leukemia Study ("/Rhythmyx/assembler/render?sys_contentid=33996&sys_revision=3&sys_variantid=1173&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="1173" sys_dependentid="33996" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="33996" sys_siteid="" sys_folderid=#leukemia"")

A case-control study of risk factors for acute leukemia in adults was carried out with collaboration from Cancer and Leukemia Group B, a cooperative cancer treatment group.

LIFE and VALID Lung Studies

LIFE & VALID Lung Studies ("/Rhythmyx/assembler/render?sys_contentid=35609&sys_revision=1&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35609" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35609" sys_siteid="" sys_folderid="")

The LIFE study's objective is to evaluate the effectiveness of Lung Imaging Fluorescence Endoscopy (LIFE) in detecting and following early lung lesions in patients at high risk for developing lung cancer. The VALID study, a companion to the LIFE study, evaluates the effect of initial arterial ligation versus venous ligation during surgery on the risk of distant metastases in lung cancer patients.

Family

Menstrual & Reproductive Health Study ("/Rhythmyx/assembler/render?sys_contentid=33996&sys_revision=3&sys_variantid=1173&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="1173" sys_dependentid="33996" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="33996" sys_siteid="" sys_folderid=#mrhs"")

The Menstrual & Reproductive Health Study examines the association between menstrual and reproductive factors and morbidity and mortality resulting from chronic diseases including heart disease, diabetes and osteoporosis. The cohort consisted of 997 white college-educated women who prospectively recorded menstrual cycle data for as many as 50 years, beginning in 1934. Information on lifestyle factors and medical history was obtained through a mail survey conducted in the early 1990s.

Mexico Childhood Asthma

Mexico Childhood Asthma Study ("/Rhythmyx/assembler/render?sys_contentid=35223&sys_revision=4&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35223" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35223" sys_siteid="" sys_folderid="")

The Mexico Childhood Asthma Study is a case-parent triad study of childhood allergic asthma in Mexico City.

North Carolina Infant Feeding Study

North Carolina Infant Feeding Study ("/Rhythmyx/assembler/render?sys_contentid=35940&sys_revision=5&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35940" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35940" sys_siteid="" sys_folderid="")

The North Carolina Infant Feeding Study is a prospective birth cohort study that enrolled about 900 North Carolina families between 1978 and 1982. The study was designed to see whether PCBs or DDE in mother's milk produced changes in growth, development, or illnesses in the children. The study measured PCBs and DDE in breast milk, formula, and maternal blood. The design also allowed examination of the transplacental effects of the compounds, as well as the effect of the compounds on age at weaning.

North Carolina Menopause Study

North Carolina Menopause Study ("/Rhythmyx/assembler/render?sys_contentid=36024&sys_revision=1&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="36024" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="36024" sys_siteid="" sys_folderid="")

The North Carolina Menopause Study is a prospective study designed to assess timing of menopause among mothers who originally participated in the North Carolina Infant Feeding Study. The study examines the age of menopause in relation to organochlorine exposures, with exposure measurements taken during the reproductive years.

Norway Facial Clefts Study (NCL)

Norway Facial Clefts Study ("/Rhythmyx/assembler/render?sys_contentid=36031&sys_revision=1&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="36031" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="36031" sys_siteid="" sys_folderid="")

This population-based, case-control, parent-triad study explores the environmental and genetic causes of cleft lip and palate.

Norwegian Mother and Child Cohort Study

Norwegian Mother & Child Cohort Study ("/Rhythmyx/assembler/render?sys_contentid=35222&sys_revision=2&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35222" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35222" sys_siteid="" sys_folderid="")

The Norwegian Mother & Child study (MoBa) is an ongoing long-term prospective cohort study of 110,000 pregnant women and their babies. In collaboration with the Norwegian National Public Health Institute (NIPH), NIEHS is supporting the collection of additional biologic specimens from the pregnant women.

Family

OBOZ Study ("/Rhythmyx/assembler/render?sys_contentid=35220&sys_revision=2&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35220" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35220" sys_siteid="" sys_folderid="")

The OBOZ Study will investigate whether obesity affects respiratory response to ozone. It is a collaborative effort between London’s group and investigators from the Center for Environmental Medicine and Lung Biology (CEMALB) at the University of North Carolina at Chapel Hill.

Parkinson’s, Genes & Environment (PAGE)

Parkinson’s, Genes & Environment ("/Rhythmyx/assembler/render?sys_contentid=36107&sys_revision=2&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="36107" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="36107" sys_siteid="" sys_folderid="")

The Parkinson’s, Genes & Environment (PAGE) study is designed to investigate the roles of diet, lifestyle, environmental factors and genes in Parkinson’s disease and their potential interactions in causing the illness.

Postpartum Uterine Regression Study (PUR)

Postpartum Uterine Regression Study ("/Rhythmyx/assembler/render?sys_contentid=36111&sys_revision=1&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="36111" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="36111" sys_siteid="" sys_folderid="")

The Postpartum Uterine Regression Study documents any fibroids present in early to mid-pregnancy and measures fibroid size after postpartum uterine regression. Investigators hypothesize that small fibroids will have disappeared, and large fibroids will remain essentially unchanged in size.

Family

Radon Study ("/Rhythmyx/assembler/render?sys_contentid=33996&sys_revision=3&sys_variantid=1173&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="1173" sys_dependentid="33996" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="33996" sys_siteid="" sys_folderid="")

A case-control study involving 1475 incident lung cancer cases aged 40-79 from Connecticut, Utah and southern Idaho. Population controls were carried out on 1811 cases to evaluate the risk associated with residential exposure to radon. Complete residential histories and information on known and potential lung cancer risk factors were obtained by in-person and telephone interviews. Radon was measured on multiple levels of past and current homes using 12-month alpha-track etch detectors.

SEAD Soy Study

SEAD Soy Study ("/Rhythmyx/assembler/render?sys_contentid=36114&sys_revision=2&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="36114" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="36114" sys_siteid="" sys_folderid="")

The SEAD (Study of Estrogen Activity and Development) Soy Study is a series of cross-sectional pilot studies designed to establish methods for future larger studies on the estrogenic effects of soy infant formulas on the developing infant.

SELF study

Study of Environment, Lifestyle & Fibroids (SELF) ("/Rhythmyx/assembler/render?sys_contentid=36437&sys_revision=2&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="36437" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="36437" sys_siteid="" sys_folderid="")

The Study of Environment, Lifestyle & Fibroids is designed to prospectively identify new cases of uterine fibroids and follow fibroid growth. The goal is to identify risk factors for fibroid development in order to discover new strategies for prevention.

Singapore Chinese Health

Singapore Chinese Health Study ("/Rhythmyx/assembler/render?sys_contentid=36437&sys_revision=2&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="36437" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="36437" sys_siteid="" sys_folderid="")

The Singapore Chinese Health Study examines the environmental, dietary and genetic risk factors for respiratory disease. The study will also examine gene-environment and gene-diet interactions with respect to respiratory symptoms and illness.

Sister Study

The Sister Study ("/Rhythmyx/assembler/render?sys_contentid=36268&sys_revision=2&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="36268" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="36268" sys_siteid="" sys_folderid="")

The Sister Study will prospectively examine environmental and familial risk factors for breast cancer and other diseases in a cohort of 50,000 sisters of women who have had breast cancer. The study should enhance the group’s ability to understand the interplay of genes and environment in breast cancer risk and to identify potentially preventable risk factors.

Treatment of Lead-Exposed Children Trial

Treatment of Lead-Exposed Children Trial ("/Rhythmyx/assembler/render?sys_contentid=35392&sys_revision=2&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35392" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35392" sys_siteid="" sys_folderid="")

The Treatment of Lead-Exposed Children (TLC) clinical trial compared the effect of lead chelation with succimer to placebo therapy on a variety of cognitive, behavioral, and neuromotor endpoints in children of school age with baseline blood lead levels of 20-44 µg/dl.

Uterine Fibroid Study

Uterine Fibroid Study ("/Rhythmyx/assembler/render?sys_contentid=36371&sys_revision=1&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="36371" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="36371" sys_siteid="" sys_folderid="")

The Uterine Fibroid Study was designed to determine the prevalence of fibroids, identify risk factors for fibroids, identify biological changes in tumor tissue and describe women's experience of symptoms and their change over time.

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